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Article: Recurrent Ureterosciatic Herniation Causing Right Obstructive Uropathy.

García-Rico, Eduardo / Ortega-Polledo, Luis Enrique / Carrion, Diego M / Quiroga-Valcarcel, Ana / Fernández Hernández, Laura

Cureus

2024 Volume 16, Issue 3, Page(s) e57128

Abstract: Sciatic hernias are unusual, challenging to diagnose, and can present some treatment dilemmas. Sciatic hernias containing the ureter are even less common. Symptoms are variable from renal fossa pain, mild or severe pelvic pain, neuropathic pain, or ... ...

Abstract	Sciatic hernias are unusual, challenging to diagnose, and can present some treatment dilemmas. Sciatic hernias containing the ureter are even less common. Symptoms are variable from renal fossa pain, mild or severe pelvic pain, neuropathic pain, or dysesthesias. Although stenting alone can be a treatment option for this condition, in cases where symptoms or ureteral obstruction relapse after initial treatment, sciatic hernioplasty must be considered as the definitive treatment. This article presents the case of a female patient who presented with a history of nonspecific abdominal pain and was diagnosed with a right-sided ureterosciatic hernia. This was managed with a ureteral stent for reduction of herniated ureteral content, but after recurrence, laparoscopic sciatic hernioplasty was performed. The patient was pain-free and without obstructive uropathy at the one-year follow-up.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.57128
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Surface-Enhanced Raman Scattering (SERS) Spectroscopy for Sensing and Characterization of Exosomes in Cancer Diagnosis.

Guerrini, Luca / Garcia-Rico, Eduardo / O'Loghlen, Ana / Giannini, Vincenzo / Alvarez-Puebla, Ramon A

Cancers

2021 Volume 13, Issue 9

Abstract: Exosomes are emerging as one of the most intriguing cancer biomarkers in modern oncology for early cancer diagnosis, prognosis and treatment monitoring. Concurrently, several nanoplasmonic methods have been applied and developed to tackle the challenging ...

Abstract	Exosomes are emerging as one of the most intriguing cancer biomarkers in modern oncology for early cancer diagnosis, prognosis and treatment monitoring. Concurrently, several nanoplasmonic methods have been applied and developed to tackle the challenging task of enabling the rapid, sensitive, affordable analysis of exosomes. In this review, we specifically focus our attention on the application of plasmonic devices exploiting surface-enhanced Raman spectroscopy (SERS) as the optosensing technique for the structural interrogation and characterization of the heterogeneous nature of exosomes. We summarized the current state-of-art of this field while illustrating the main strategic approaches and discuss their advantages and limitations.
Language	English
Publishing date	2021-04-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13092179
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Direct surface-enhanced Raman scattering (SERS) spectroscopy of nucleic acids: from fundamental studies to real-life applications.

Garcia-Rico, Eduardo / Alvarez-Puebla, Ramon A / Guerrini, Luca

Chemical Society reviews

2018 Volume 47, Issue 13, Page(s) 4909–4923

Abstract: Plasmonic optical biosensors for the analysis of nucleic acids have drawn a great deal of interest in nanomedicine because of their capability to overcome major limitations of conventional methods. Within this realm, surface-enhanced Raman scattering ( ... ...

Abstract	Plasmonic optical biosensors for the analysis of nucleic acids have drawn a great deal of interest in nanomedicine because of their capability to overcome major limitations of conventional methods. Within this realm, surface-enhanced Raman scattering (SERS)-based sensing is progressively emerging as a powerful analytical tool beyond the basic grounds of academia to viable commercial products. SERS benefits from the synergistic combination between the intrinsic structural specificity and experimental flexibility of Raman spectroscopy, the extremely high sensitivity provided by plasmonic nanomaterials, and the tremendous advances in nanofabrication techniques and spectroscopic instrumentation. SERS application to nucleic acids analysis has been largely restricted to indirect sensing approaches, where a SERS reporter and oligonucleotide ligands are typically combined onto the nanomaterials to enable extrinsic detection of the target sequences. On the other hand, the acquisition of the intrinsic SERS vibrational fingerprint of nucleic acids (direct sensing) has traditionally suffered from major limitations. However, recent years have witnessed a burst of interest in this area, largely driven by the efforts to address key reproducibility and sensitivity issues. In this tutorial review, we summarize and discuss the most recent cutting-edge research in the field of direct SERS sensing of nucleic acids by coherently organising the diverse data reported in the literature in a structurally logical fashion.
MeSH term(s)	Nucleic Acids/analysis ; Spectrum Analysis, Raman/methods ; Surface Properties
Chemical Substances	Nucleic Acids
Language	English
Publishing date	2018-07-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/c7cs00809k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endourological panorama and current state of training in endourology among European teaching hospitals.

Ortega Polledo, Luis E / Mantica, Guglielmo / Carrión, Diego M / Khelif, Adrian / Subiela Henríquez, José D / González Padilla, Daniel A / Sanchís Bonet, Ángeles / Tamayo Ruiz, Juan C / García Rico, Eduardo / Alonso Gregorio, Sergio / Gómez Rivas, Juan / Esperto, Francesco / Scoffone, Cesare M / Cracco, Cecilia M / Checcucci, Enrico

Minerva urology and nephrology

2023 Volume 76, Issue 1, Page(s) 5–8

Language	English
Publishing date	2023-12-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.23.05646-X
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Article: SERS Quantification and Characterization of Proteins and Other Biomolecules

Feliu, Neus / Alvarez-Puebla Ramon / Cui Daxiang / Garcia Rico Eduardo / Hassan Moustapha / Parak Wolfgang

Langmuir. 2017 Sept. 26, v. 33, no. 38

2017

Abstract: Changes in protein expression levels and protein structure may indicate genomic mutations and may be related to some diseases. Therefore, the precise quantification and characterization of proteins can be used for disease diagnosis. Compared with several ...

Abstract	Changes in protein expression levels and protein structure may indicate genomic mutations and may be related to some diseases. Therefore, the precise quantification and characterization of proteins can be used for disease diagnosis. Compared with several other alternative methods, surface-enhanced Raman scattering (SERS) spectroscopy is regarded as an excellent choice for the quantification and structural characterization of proteins. Herein, we review the main advance of using plasmonic nanostructures as SERS sensing platform for this purpose. Three design approaches, including direct SERS, indirect SERS, and SERS-encoded nanoparticles, are discussed in the direction of developing new precise approaches of quantification and characterization of proteins. While this Review is focused on proteins, in order to highlight concepts of SERS-based sensors also detection of other biomolecules will be discussed.
Keywords	disease diagnosis ; mutation ; nanoparticles ; protein structure ; protein synthesis ; proteins ; Raman spectroscopy
Language	English
Dates of publication	2017-0926
Size	p. 9711-9730.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021%2Facs.langmuir.7b01567
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: SERS Quantification and Characterization of Proteins and Other Biomolecules.

Feliu, Neus / Hassan, Moustapha / Garcia Rico, Eduardo / Cui, Daxiang / Parak, Wolfgang / Alvarez-Puebla, Ramon

Langmuir : the ACS journal of surfaces and colloids

2017 Volume 33, Issue 38, Page(s) 9711–9730

Abstract	Changes in protein expression levels and protein structure may indicate genomic mutations and may be related to some diseases. Therefore, the precise quantification and characterization of proteins can be used for disease diagnosis. Compared with several other alternative methods, surface-enhanced Raman scattering (SERS) spectroscopy is regarded as an excellent choice for the quantification and structural characterization of proteins. Herein, we review the main advance of using plasmonic nanostructures as SERS sensing platform for this purpose. Three design approaches, including direct SERS, indirect SERS, and SERS-encoded nanoparticles, are discussed in the direction of developing new precise approaches of quantification and characterization of proteins. While this Review is focused on proteins, in order to highlight concepts of SERS-based sensors also detection of other biomolecules will be discussed.
MeSH term(s)	Nanoparticles ; Nanostructures ; Proteins/chemistry ; Spectrum Analysis, Raman
Chemical Substances	Proteins
Language	English
Publishing date	2017-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.7b01567
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Smelling, Seeing, Tasting-Old Senses for New Sensing.

Guerrini, Luca / Garcia-Rico, Eduardo / Pazos-Perez, Nicolas / Alvarez-Puebla, Ramon A

ACS nano

2017 Volume 11, Issue 6, Page(s) 5217–5222

Abstract: The senses are the physiological mechanisms of perception that enable an organism to interact with the surrounding media. For centuries, humans have utilized these senses in science; vision and olfaction have been used the most extensively in ... ...

Abstract	The senses are the physiological mechanisms of perception that enable an organism to interact with the surrounding media. For centuries, humans have utilized these senses in science; vision and olfaction have been used the most extensively in laboratories followed by gustation and somatosensation, whereas audition has only rarely been employed. Most of these applications of senses were developed spontaneously based on the natural behavior of the chemistry of the reactants producing changes in scent, taste, or color. In recent years, by exploiting the outstanding properties of nanoparticles, many groups have demonstrated alternative sensing scenarios where the detection limits are remarkably improved, enabling the recognition of hazardous substances by mere sight, smell, or taste. Such alternative sensing approaches can be divided into two main groups: (i) methods that identify a single analyte by engineering a reaction that promotes a change in color or the generation of a characteristic scent, and (ii) methods that emulate or even improve mammalian senses, especially those related to taste and smell. In this Perspective, we discuss the context of each technology, present prominent examples, and evaluate the complexities, potential pitfalls, and opportunities presented by different re-engineering strategies.
MeSH term(s)	Animals ; Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; Colorimetry/instrumentation ; Colorimetry/methods ; Escherichia coli/isolation & purification ; Escherichia coli Infections/microbiology ; Humans ; Mercury/analysis ; Nanoparticles/chemistry ; Smell ; Taste ; Vision, Ocular
Chemical Substances	Mercury (FXS1BY2PGL)
Language	English
Publishing date	2017-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.7b03176
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Conformational SERS Classification of K-Ras Point Mutations for Cancer Diagnostics.

Morla-Folch, Judit / Gisbert-Quilis, Patricia / Masetti, Matteo / Garcia-Rico, Eduardo / Alvarez-Puebla, Ramon A / Guerrini, Luca

Angewandte Chemie (International ed. in English)

2017 Volume 56, Issue 9, Page(s) 2381–2385

Abstract: Point mutations in Ras oncogenes are routinely screened for diagnostics and treatment of tumors (especially in colorectal cancer). Here, we develop an optical approach based on direct SERS coupled with chemometrics for the study of the specific ... ...

Abstract	Point mutations in Ras oncogenes are routinely screened for diagnostics and treatment of tumors (especially in colorectal cancer). Here, we develop an optical approach based on direct SERS coupled with chemometrics for the study of the specific conformations that single-point mutations impose on a relatively large fragment of the K-Ras gene (141 nucleobases). Results obtained offer the unambiguous classification of different mutations providing a potentially useful insight for diagnostics and treatment of cancer in a sensitive, fast, direct and inexpensive manner.
MeSH term(s)	DNA/genetics ; DNA Mutational Analysis/methods ; Genes, ras ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics ; Point Mutation ; Spectrum Analysis, Raman/methods
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2017-01-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201611243
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: Metabolic pathway for the universal fluorescent recognition of tumor cells.

Fernandez-Carrascal, Ana / Garcia-Algar, Manuel / Nazarenus, Moritz / Torres-Nuñez, Alicia / Guerrini, Luca / Feliu, Neus / Parak, Wolfgang J / Garcia-Rico, Eduardo / Alvarez-Puebla, Ramon A

Oncotarget

2019 Volume 10, Issue 61, Page(s) 6643

Abstract: This corrects the article DOI: 10.18632/oncotarget.18551.]. ...

Abstract	[This corrects the article DOI: 10.18632/oncotarget.18551.].
Language	English
Publishing date	2019-11-12
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.27314
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Article: Adaptive metabolic pattern biomarker for disease monitoring and staging of lung cancer with liquid biopsy.

Garcia-Algar, Manuel / Fernandez-Carrascal, Ana / Olano-Daza, Ana / Guerrini, Luca / Feliu, Neus / Parak, Wolfgang J / Guimera, Roger / Garcia-Rico, Eduardo / Alvarez-Puebla, Ramon A

NPJ precision oncology

2018 Volume 2, Page(s) 16

Abstract: In this manuscript, we demonstrate the applicability of a metabolic liquid biopsy for the monitoring and staging of patients with lung cancer. This method provides an unbiased detection strategy to establish a more precise correlation between CTC ... ...

Abstract	In this manuscript, we demonstrate the applicability of a metabolic liquid biopsy for the monitoring and staging of patients with lung cancer. This method provides an unbiased detection strategy to establish a more precise correlation between CTC quantification and the actual burden of disease, therefore improving the accuracy of staging based on current imaging techniques. Also, by applying statistical analysis techniques and probabilistic models to the metabolic status and distribution of peripheral blood mononuclear cell (PBMC) populations "perturbed" by the presence of CTCs, a new category of adaptive metabolic pattern biomarker (AMPB) is described and unambiguously correlated to the different clinical stages of the patients. In fact, this strategy allows for classification of different categories of disease within a single stage (stage IV) before computed tomography (CT) and positron emission tomography (PET) scans and with lower uncertainty.
Language	English
Publishing date	2018-08-08
Publishing country	England
Document type	Journal Article
ISSN	2397-768X
ISSN	2397-768X
DOI	10.1038/s41698-018-0059-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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