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  1. AU="García-García, Ana"
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  1. Article ; Online: Exámenes médicos en el contexto de la vigilancia de la salud en el lugar de trabajo en España: ¿para qué?

    García García, Ana María

    Archivos de prevencion de riesgos laborales

    2023  Volume 26, Issue 2, Page(s) 101–105

    Title translation Medical examinations in the context of workplace health surveillance in Spain: what for?
    MeSH term(s) Humans ; Spain ; Workplace ; Occupational Diseases/epidemiology ; Working Conditions
    Language Spanish
    Publishing date 2023-04-15
    Publishing country Spain
    Document type Editorial
    ZDB-ID 2682372-X
    ISSN 1578-2549 ; 1578-2549
    ISSN (online) 1578-2549
    ISSN 1578-2549
    DOI 10.12961/aprl.2022.26.02.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Salud laboral desde los servicios de la administración sanitaria: las oportunidades de la "perspectiva laboral" para el ejercicio de la salud pública.

    García García, Ana María

    Archivos de prevencion de riesgos laborales

    2020  Volume 23, Issue 3, Page(s) 309–314

    Title translation Occupational health from the health administration services: the "occupational perspective" opportunities for the exercise of Public Health.
    MeSH term(s) Exercise ; Health Services ; Humans ; Occupational Health ; Occupational Health Services ; Public Health
    Language Spanish
    Publishing date 2020-07-15
    Publishing country Spain
    Document type Editorial
    ISSN 1578-2549
    ISSN (online) 1578-2549
    DOI 10.12961/aprl.2020.23.03.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Molecular Research on Genes Involved in Metabolic Diseases.

    Lara-Hernandez, Francisco / Alvarez, Luis / Chaves, Javier / Garcia-Garcia, Ana-Barbara

    Biomedicines

    2023  Volume 11, Issue 6

    Abstract: Numerous genes involved in different metabolic diseases have been identified, and this number is increasing [ ... ]. ...

    Abstract Numerous genes involved in different metabolic diseases have been identified, and this number is increasing [...].
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11061671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: TBS-pyrrole as an "universal" reference to quantify artemisinin and structurally-diverse natural products in plants extracts by NMR.

    García-García, Ana L / Hernández, Dácil / Santana-Mayor, Álvaro / Jiménez-Arias, David / Boto, Alicia

    Frontiers in plant science

    2023  Volume 14, Page(s) 1255512

    Abstract: The commercial production of artemisinin and other valuable bioactive natural products depends on their plant sources, which may provide variable amounts of the compound depending on plant variety, the period of the year, abiotic stress and other factors. ...

    Abstract The commercial production of artemisinin and other valuable bioactive natural products depends on their plant sources, which may provide variable amounts of the compound depending on plant variety, the period of the year, abiotic stress and other factors. Therefore, it requires a method for large-scale, low-cost natural product quantification. The standard HPLC and UHPLC methods are accurate but the analysis are costly and require different optimization for structurally-diverse products. An alternative method using NMR with TBS-pyrrole as a novel "universal" reference affords a simple, fast method to quantify many different products. The method is shown with antimalarial artemisinin, whose yield using conventional and novel extraction procedures was determined by standard UHPLC-MS procedures and by our NMR protocol, with similar quantification results. The novel reference compound does not interfere with artemisinin or extract signals, only needs a small amount of the extract, is accurate and operationally simple, and a large volume of samples can be processed in little time. Moreover, bioactive terpenes, steroids, alkaloids, aromatic compounds, and quinones, among others, were quantified in a model vegetal extract with this "universal" reference with excellent accuracy.
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1255512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Essential Role of Water Molecules in the Reaction Mechanism of Protein O-Fucosyltransferase 2.

    Sanz-Martínez, Ignacio / García-García, Ana / Tejero, Tomás / Hurtado-Guerrero, Ramón / Merino, Pedro

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 48, Page(s) e202213610

    Abstract: Protein O-fucosyltransferase 2 (PoFUT2) is an inverting glycosyltransferase (GT) that fucosylates thrombospondin repeats (TSRs) from group 1 and 2. PoFUT2 recognizes a large and diverse number of TSRs through a dynamic network of water-mediated ... ...

    Abstract Protein O-fucosyltransferase 2 (PoFUT2) is an inverting glycosyltransferase (GT) that fucosylates thrombospondin repeats (TSRs) from group 1 and 2. PoFUT2 recognizes a large and diverse number of TSRs through a dynamic network of water-mediated interactions. By X-ray structural studies of C. elegans PoFUT2 complexed to a TSR of group 2, we demonstrate that this GT recognizes similarly the 3D structure of TSRs from both groups 1 and 2. Its active site is highly exposed to the solvent, suggesting that water molecules might also play an essential role in the fucosylation mechanism. We applied QM/MM methods using human PoFUT2 as a model, and found that HsPoFUT2 follows a classical S
    MeSH term(s) Humans ; Animals ; Fucose/chemistry ; Water ; Caenorhabditis elegans/metabolism ; Glycosylation ; Galactoside 2-alpha-L-fucosyltransferase
    Chemical Substances Fucose (28RYY2IV3F) ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-11-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202213610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Assessing wineries' performance in managing critical control points for arsenic, lead, and cadmium contamination risk in the wine-making industry: A survey-based analysis utilizing performance indicators as a results tool.

    López-Santiago, Jesús / García García, Ana Isabel / Villarino, Alejandro Gómez / Som, Amelia Md / Gómez-Villarino, María Teresa

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e22962

    Abstract: Human health hazards appear in wine production. Wineries have implemented food safety management systems to control food hazards through Hazard Analysis Critical Control Point (HACCP). Wine-making industry applies HACCP by evaluating Critical Control ... ...

    Abstract Human health hazards appear in wine production. Wineries have implemented food safety management systems to control food hazards through Hazard Analysis Critical Control Point (HACCP). Wine-making industry applies HACCP by evaluating Critical Control Points (CCPs). One of the CCPs that exhibits inadequate control is the potential contamination risk of arsenic, cadmium, and lead throughout the winemaking procedure. Wineries performance level about controlling CCPs related to contamination risk by arsenic, cadmium and lead in the winemaking were analyzed. A sixteen-question questionnaire was made to achieve this research. Three indicators were calculated for training, legislation, and analysis performance components in CCPs control. Results revealed that wineries fault in analysis and legislation components. Identification and updating of legislation about As, Cd and Pb contamination risk is in starting performance level for wineries that produce less than 250,000 L/year wineries. Analysis performance level is even lower than legislation. Only one out of every three wineries possess information regarding the concentrations of arsenic, cadmium, and lead in the soils of vineyards where grapes are cultivated. Furthermore, the availability of data on their available concentrations in the soil solution is even more limited. Those wineries that controlled As, Cd and Pb concentrations make it according to official recommendations using techniques based on atomic absorption spectrometry. However, there is a lack of this spectrometry equipment in the wineries own laboratories.
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e22962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Silbergraues Haar und neurologische Symptome bei einem 21 Monate alten Jungen.

    Rusiñol, Lluís / Baselga, Eulàlia / Garcia-Garcia, Ana / Armstrong, Judith / Prat, Carolina / Vicente, Asunción / Ivars, Marta

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 9, Page(s) 1043–1045

    Language German
    Publishing date 2023-08-08
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15109_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Silvery hair and neurologic impairment in a 21-month-old boy.

    Rusiñol, Lluís / Baselga, Eulàlia / Garcia-Garcia, Ana / Armstrong, Judith / Prat, Carolina / Vicente, Asunción / Ivars, Marta

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 9, Page(s) 1043–1045

    MeSH term(s) Male ; Humans ; Infant ; Hair ; Pigmentation Disorders ; Nervous System Diseases/diagnosis
    Language English
    Publishing date 2023-06-09
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15109
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Root treatment with a vitamin K3 derivative: a promising alternative to synthetic fungicides against Botrytis cinerea in tomato plants

    García‐Machado, Francisco J / García‐García, Ana L / Borges, Andrés A / Jiménez‐Arias, David

    Pest management science. 2022 Mar., v. 78, no. 3

    2022  

    Abstract: BACKGROUND: Botrytis cinerea, the causal agent of gray mold has a great economic impact on several important crops. This necrotrophic fungus causes disease symptoms during vegetative growth and also into postharvest stages. The current method to combat ... ...

    Abstract BACKGROUND: Botrytis cinerea, the causal agent of gray mold has a great economic impact on several important crops. This necrotrophic fungus causes disease symptoms during vegetative growth and also into postharvest stages. The current method to combat this disease is fungicide application, with high economic costs and environmentally unsustainable impacts. Moreover, there is an increasing general public health concern about these strategies of crop protection. We studied the protection of tomato plants against B. cinerea by previous root treatment with menadione sodium bisulfite (MSB), a known plant defense activator. RESULTS: Root treatment 48 h before inoculation with MSB 0.6 mmol L⁻¹ reduced leaf lesion diameter by 30% and notably cell deaths, compared to control plants 72 h after inoculation. We studied the expression level of several pathogenesis‐related (PR) genes from different defense transduction pathways, and found that MSB primes higher PR1 expression against B. cinerea. However, this stronger induced resistance was impaired in transgenic salicylic acid‐deficient NahG line. Additionally, in the absence of pathogen challenge, MSB increased tomato plant growth by 28% after 10 days. Our data provide evidence that MSB protects tomato plants against B. cinerea by priming defense responses through the salicylic acid (SA)‐dependent signaling pathway and reducing oxidative stress. CONCLUSION: This work confirms the efficacy of MSB as plant defense activator against B. cinerea and presents a novel alternative to combat gray mold in important crops.
    Keywords Botrytis cinerea ; economic impact ; fungi ; fungicide application ; genetically modified organisms ; gray mold ; induced resistance ; leaves ; menadione ; oxidative stress ; pathogens ; plant protection ; public health ; salicylic acid ; sodium bisulfite ; tomatoes ; vegetative growth
    Language English
    Dates of publication 2022-03
    Size p. 974-981.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.6707
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2731: Show issues

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  10. Article ; Online: Association of carotid atheroma plaque with IL-18 levels and with polymorphisms in the IL-18 receptor gene in a Mediterranean population.

    Palanca, Ana / Bartual-Rodrigo, Amparo / Cuenca, Carolina / Mayo-López, Oscar D / Ampudia-Blasco, Francisco Javier / González-Navarro, Herminia / Ascaso, Juan F / García-García, Ana Bárbara / Chaves, Felipe Javier / Real, José T / Martínez-Hervás, Sergio

    Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

    2024  

    Abstract: Background: Atherosclerosis is an inflammatory disease. Interleukin 18 (IL-18) is an inflammatory molecule that has been linked to the development of atherosclerosis and cardiovascular disease.: Objective: To evaluate the possible relationship ... ...

    Title translation Asociación de la placa de ateroma carotídea con los niveles plasmáticos de IL-18 y con polimorfismos en el gen del receptor de la IL-18 en la población mediterránea.
    Abstract Background: Atherosclerosis is an inflammatory disease. Interleukin 18 (IL-18) is an inflammatory molecule that has been linked to the development of atherosclerosis and cardiovascular disease.
    Objective: To evaluate the possible relationship between plasma levels of IL-18 and the presence of atherosclerosis evaluated at the carotid level, as well as to analyze the possible modulation by different polymorphisms in a Mediterranean population.
    Material and methods: Seven hundred and forty-six individuals from the metropolitan area of Valencia were included, recruited over a period of 2 years. Hydrocarbon and lipid metabolism parameters were determined using standard methodology and IL-18 using ELISA. In addition, carotid ultrasound was performed and the genotype of four SNPs related to the IL-18 signaling pathway was analyzed.
    Results: Patients with higher plasma levels of IL-18 had other associated cardiovascular risk factors. Elevated IL-18 levels were significantly associated with higher carotid IMT and the presence of atheromatous plaques. The genotype with the A allele of the SNP rs2287037 was associated with a higher prevalence of carotid atheromatous plaque. On the contrary, the genotype with the C allele of the SNP rs2293224 was associated with a lower prevalence of atheromatous plaque.
    Conclusions: High levels of IL-18 were significantly associated with a higher carotid IMT and the presence of atheromatous plaques, which appear to be influenced by genetic factors, as evidenced by associations between SNPs in the IL-18 receptor gene and the presence of atheroma plaque.
    Language Spanish
    Publishing date 2024-01-11
    Publishing country Spain
    Document type Journal Article
    ISSN 1578-1879
    ISSN (online) 1578-1879
    DOI 10.1016/j.arteri.2023.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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