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  1. Article: Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia.

    Salazar-Ramírez, Felipe / Ramos-Mondragón, Roberto / García-Rivas, Gerardo

    Frontiers in cell and developmental biology

    2021  Volume 8, Page(s) 623381

    Abstract: ... ...

    Abstract Ca
    Language English
    Publishing date 2021-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.623381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prediction of Insulin Resistance Based on Anthropometric and Clinical Variables in Children with Overweight or Obesity at a Tertiary Center in Northeast Mexico.

    Rodríguez-Gutiérrez, Nora / Villareal-Calderón, José R / Castillo, Elena Cristina / García-Rivas, Gerardo

    Metabolic syndrome and related disorders

    2022  Volume 20, Issue 3, Page(s) 174–181

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Body Mass Index ; Child ; Cross-Sectional Studies ; Humans ; Insulin Resistance ; Mexico/epidemiology ; Obesity/diagnosis ; Obesity/epidemiology ; Overweight/diagnosis ; Overweight/epidemiology ; ROC Curve ; Retrospective Studies
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2021.0094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Therapeutic Effects of WT1 Silencing via Respiratory Administration of Neutral DOPC Liposomal-siRNA in a Lung Metastasis Melanoma Murine Model.

    Ramos-Gonzalez, Martin R / Vazquez-Garza, Eduardo / Garcia-Rivas, Gerardo / Rodriguez-Aguayo, Cristian / Chavez-Reyes, Arturo

    Non-coding RNA

    2023  Volume 9, Issue 2

    Abstract: The lungs represent a frequent target for metastatic melanoma as they offer a high-oxygen environment for tumor development. The overexpression of the WT1 protein has been associated with the occurrence of melanoma. In this study, we evaluated the ... ...

    Abstract The lungs represent a frequent target for metastatic melanoma as they offer a high-oxygen environment for tumor development. The overexpression of the WT1 protein has been associated with the occurrence of melanoma. In this study, we evaluated the effects of silencing the WT1 protein by siRNA in both in vitro in the B16F10 melanoma cell line and in vivo in a murine model of lung metastatic melanoma. We did this by implementing a novel respiratory delivery strategy of a neutral DOPC liposomal-siRNA system (L-siRNA). In vitro studies showed an effective silencing of the WT1 protein in the siRNAs' WT1-treated cells when compared with controls, resulting in a loss of the cell's viability and proliferation by inducing G1 arrest, the inhibition of the migration and invasion capacities of the cells, as well as the induction of apoptosis. In vivo, the respiratory administration of L-WT1 siRNA showed an efficient biodistribution on the lungs. After two weeks of treatment, the silencing of the WT1 protein resulted in an important antitumor activity that reduced the tumor weight. In the survival study, L-WT1 treatment could significantly delay the death of the animals. This work demonstrates the efficacy of the L-siRNA respiratory administration as a novel therapy to reduce pulmonary tumors and to increase survivability by silencing specific cancer oncogenes as WT1.
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813993-8
    ISSN 2311-553X ; 2311-553X
    ISSN (online) 2311-553X
    ISSN 2311-553X
    DOI 10.3390/ncrna9020021
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  4. Article ; Online: Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction.

    Fernández-Mendoza, Gemma / Méndez-Fernández, Abraham / Alves-Figueiredo, Hugo J / García-Rivas, Gerardo / Santillán, Moisés

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0292687

    Abstract: Heart failure with reduced ejection fraction (HFrEF) is accompanied by disregulation of cardiovascular function. Heart rate variability (HRV) is commonly used to assess autonomic dysfunction in HFrEF. However, analysis of stroke volume variability (SVV) ... ...

    Abstract Heart failure with reduced ejection fraction (HFrEF) is accompanied by disregulation of cardiovascular function. Heart rate variability (HRV) is commonly used to assess autonomic dysfunction in HFrEF. However, analysis of stroke volume variability (SVV) may provide additional insights. We examined HRV and SVV in a mouse model of HFrEF. HFrEF mice exhibited reduced stroke volume and ejection fraction versus controls, confirming cardiac contractile dysfunction. HRV was preserved in HFrEF mice. However, SVV was markedly diminished, indicating dissociation between HRV and SVV regulation. Using a mathematical model, we propose that Frank-Starling mechanism abnormalities in HFrEF disrupt SVV independent of HRV. Assessing SVV could thus provide unique insights beyond HRV into cardiovascular control deficits in HFrEF.
    MeSH term(s) Mice ; Animals ; Stroke Volume/physiology ; Heart Failure ; Disease Models, Animal ; Heart Rate/physiology ; Ventricular Dysfunction, Left ; Prognosis
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0292687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting the mitochondrial Ca

    Lozano, Omar / Marcos, Patricio / Salazar-Ramirez, Felipe de Jesús / Lázaro-Alfaro, Anay F / Sobrevia, Luis / García-Rivas, Gerardo

    Acta physiologica (Oxford, England)

    2023  Volume 237, Issue 4, Page(s) e13946

    Abstract: Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common mitochondrial dysfunction, in specific a dysregulation of ... ...

    Abstract Cardiovascular diseases (CVDs), the leading cause of death worldwide, share in common mitochondrial dysfunction, in specific a dysregulation of Ca
    MeSH term(s) Humans ; Calcium Channels/genetics ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/metabolism ; Mitochondria/metabolism ; Oxidative Stress ; Protein Processing, Post-Translational ; Calcium/metabolism
    Chemical Substances Calcium Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218636-0
    ISSN 1748-1716 ; 1748-1708
    ISSN (online) 1748-1716
    ISSN 1748-1708
    DOI 10.1111/apha.13946
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs 229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: A Systematic Review of the Mechanisms Involved in Immune Checkpoint Inhibitors Cardiotoxicity and Challenges to Improve Clinical Safety.

    Rubio-Infante, Nestor / Ramírez-Flores, Yoel Adbel / Castillo, Elena Cristina / Lozano, Omar / García-Rivas, Gerardo / Torre-Amione, Guillermo

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 851032

    Abstract: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block CTLA-4, PD-1, or PD-L1 and induce the activation of the immune system against cancer. Despite the efficacy of ICIs, which has improved the oncotherapy for patients with a variety of ...

    Abstract Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block CTLA-4, PD-1, or PD-L1 and induce the activation of the immune system against cancer. Despite the efficacy of ICIs, which has improved the oncotherapy for patients with a variety of malignancies, several immune-related adverse events (irAEs) have been described, including those affecting the heart. Cardiac irAEs after ICI therapies, including myocarditis, can become life-threatening, and their pathogenic mechanisms remain unclear. Here, a systematic analysis was performed regarding the potential immune mechanisms underlying cardiac irAEs based on the immune adverse events induced by the ICIs: 1) recruitment of CD4
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.851032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Estrogen signaling as a bridge between the nucleus and mitochondria in cardiovascular diseases.

    Guajardo-Correa, Emanuel / Silva-Agüero, Juan Francisco / Calle, Ximena / Chiong, Mario / Henríquez, Mauricio / García-Rivas, Gerardo / Latorre, Mauricio / Parra, Valentina

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 968373

    Abstract: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Epidemiological studies indicate that pre-menopausal women are more protected against the development of CVDs compared to men of the same age. This effect is ... ...

    Abstract Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Epidemiological studies indicate that pre-menopausal women are more protected against the development of CVDs compared to men of the same age. This effect is attributed to the action/effects of sex steroid hormones on the cardiovascular system. In this context, estrogen modulates cardiovascular function in physiological and pathological conditions, being one of the main physiological cardioprotective agents. Here we describe the common pathways and mechanisms by which estrogens modulate the retrograde and anterograde communication between the nucleus and mitochondria, highlighting the role of genomic and non-genomic pathways mediated by estrogen receptors. Additionally, we discuss the presumable role of bromodomain-containing protein 4 (BRD4) in enhancing mitochondrial biogenesis and function in different CVD models and how this protein could act as a master regulator of estrogen protective activity. Altogether, this review focuses on estrogenic control in gene expression and molecular pathways, how this activity governs nucleus-mitochondria communication, and its projection for a future generation of strategies in CVDs treatment.
    Language English
    Publishing date 2022-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.968373
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  8. Article ; Online: Methodological and reporting issues for meta-analysis of immune checkpoint inhibitor-associated cardiotoxicity. Letter regarding the article 'Cardiotoxicity associated with immune checkpoint inhibitor therapy: a meta-analysis'. Reply.

    Rubio-Infante, Nestor / Ramírez-Flores, Yoel A / Castillo, Elena C / Lozano, Omar / García-Rivas, Gerardo / Torre-Amione, Guillermo

    European journal of heart failure

    2022  Volume 24, Issue 8, Page(s) 1450–1451

    MeSH term(s) Cardiotoxicity/etiology ; Heart Failure ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Neoplasms/drug therapy
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-07-19
    Publishing country England
    Document type Letter ; Meta-Analysis ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2611
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5299: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Synthesis and Characterization of Rutile TiO

    Santos-Aguilar, Pamela / Bernal-Ramírez, Judith / Vázquez-Garza, Eduardo / Vélez-Escamilla, Lydia Yerid / Lozano, Omar / García-Rivas, Gerardo de Jesús / Contreras-Torres, Flavio F

    ACS omega

    2023  Volume 8, Issue 21, Page(s) 19024–19036

    Abstract: The widespread use of titanium dioxide ( ... ...

    Abstract The widespread use of titanium dioxide (TiO
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c01771
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  10. Article ; Online: Cellular shortening and calcium dynamics are improved by noisy stimulus in a model of cardiomyopathy.

    Morales-Rubio, Russell / Bernal-Ramírez, Judith / Rubio-Infante, Nestor / Luévano-Martínez, Luis A / Ríos, Amelia / Escalante, Bruno A / García-Rivas, Gerardo / Rodríguez González, Jesús

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 14898

    Abstract: Noise is present in cell biology. The capability of cells to respond to noisy environment have become essential. This study aimed to investigate whether noise can enhance the contractile response and ... ...

    Abstract Noise is present in cell biology. The capability of cells to respond to noisy environment have become essential. This study aimed to investigate whether noise can enhance the contractile response and Ca
    MeSH term(s) Humans ; Calcium ; Calcium, Dietary ; Myocytes, Cardiac ; Cardiomyopathies ; Muscle Contraction
    Chemical Substances Calcium (SY7Q814VUP) ; Calcium, Dietary
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-41611-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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