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  1. Article ; Online: Evaluation of Clastogenic/Aneugenic Damage Using the FISH Micronucleus Assay in Mice Exposed to Chromium (VI).

    Del Carmen García-Rodríguez, María / Santiago-Moreno, Yolanda / Molina-Alvarez, Bertha / Altamirano-Lozano, Mario

    In vivo (Athens, Greece)

    2023  Volume 37, Issue 4, Page(s) 1666–1671

    Abstract: Background/aim: Exposure to chromium (VI) [Cr(VI)] has been postulated to be associated with the induction of cancer. In vivo studies utilizing biomarkers of genotoxic damage could aid in elucidating the mechanisms underlying the genotoxic effects of Cr( ...

    Abstract Background/aim: Exposure to chromium (VI) [Cr(VI)] has been postulated to be associated with the induction of cancer. In vivo studies utilizing biomarkers of genotoxic damage could aid in elucidating the mechanisms underlying the genotoxic effects of Cr(VI) and their relationship with carcinogenesis. In this study, the origin (clastogenic and/or aneugenic damage) and kinetics of micronuclei (MN) induced by Cr(VI) were investigated.
    Materials and methods: Hsd:ICR female mice were divided into groups of five individuals each. MN kinetics were measured in groups treated with 20 or 25 mg/kg CrO
    Results: Total MN were quantified and the clastogenic/aneugenic effects of Cr(VI) were evaluated based on the proportion of MNK+ versus micronuclei without centromeric DNA (MNK-). There was a significant increase in MN frequencies beginning at 12 h in the Cr(VI)-treated groups demonstrating its genotoxicity. When calculating the MNK+ as a percentage of the total MN, the increase was significant beginning 12 h after treatment.
    Conclusion: The fact that the MNK+ and MNK- were observed at both evaluation times corroborates Cr(VI) as a genotoxic agent and demonstrates that both clastogenic and aneugenic damages are involved in the formation of MN.
    MeSH term(s) Female ; Animals ; Mice ; Mutagens ; Micronucleus Tests ; In Situ Hybridization, Fluorescence ; Aneugens ; Mice, Inbred ICR ; DNA Damage ; DNA
    Chemical Substances Mutagens ; chromium hexavalent ion (18540-29-9) ; Aneugens ; DNA (9007-49-2)
    Language English
    Publishing date 2023-06-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of green tea polyphenols against metal-induced genotoxic damage: underlying mechanistic pathways.

    García-Rodríguez, María Del Carmen / Hernández-Cortés, Lourdes Montserrat / Mendoza-Núñez, Víctor Manuel / Arenas-Huertero, Francisco

    Journal of toxicology and environmental health. Part B, Critical reviews

    2023  Volume 26, Issue 7, Page(s) 371–386

    Abstract: This review is based upon evidence from the published effects of green tea polyphenols (GTP) on genotoxic damage induced by metals with carcinogenic potential. First, the relationship between GTP and antioxidant defense system is provided. Subsequently, ... ...

    Abstract This review is based upon evidence from the published effects of green tea polyphenols (GTP) on genotoxic damage induced by metals with carcinogenic potential. First, the relationship between GTP and antioxidant defense system is provided. Subsequently, the processes involved in the oxidative stress generated by metals and their relationship to oxidative DNA damage is examined. The review demonstrated that GTP generally decrease oxidative DNA damage induced by exposure to metals such as arsenic (As), cadmium (Cd), cobalt (Co), copper (Cu), chromium (Cr), iron (Fe), and lead (Pb). The pathways involved in these effects are related to: (1) direct scavenging of free radicals (FR); (2) activation of mechanisms to repair oxidative DNA damage; (3) regulation of the endogenous antioxidant system; and (4) elimination of cells with genetic damage via apoptosis. The results obtained in the studies reviewed demonstrate potential for possible use of GTP to prevent and treat oxidative damage in populations exposed to metals. Further, GTP may be considered as adjuvants to treatments for metal-associated diseases related to oxidative stress and DNA damage.
    MeSH term(s) Antioxidants/pharmacology ; Oxidative Stress ; Metals/toxicity ; DNA Damage ; Polyphenols/pharmacology ; Tea ; Guanosine Triphosphate/metabolism ; Guanosine Triphosphate/pharmacology
    Chemical Substances Antioxidants ; Metals ; Polyphenols ; Tea ; Guanosine Triphosphate (86-01-1)
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1415246-0
    ISSN 1521-6950 ; 1093-7404
    ISSN (online) 1521-6950
    ISSN 1093-7404
    DOI 10.1080/10937404.2023.2224119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Music therapy for adolescents with psychiatric disorders: An overview.

    Freitas, Carina / Fernández-Company, José Fernando / Pita, Marisela Figueira / García-Rodríguez, María

    Clinical child psychology and psychiatry

    2022  Volume 27, Issue 3, Page(s) 895–910

    Abstract: Background: Although it is true that adolescence is a stage of evolutionary development in which there are innumerable windows of opportunity, it is also the peak age at which some psychiatric disorders may appear. On the other hand, music is an ... ...

    Abstract Background: Although it is true that adolescence is a stage of evolutionary development in which there are innumerable windows of opportunity, it is also the peak age at which some psychiatric disorders may appear. On the other hand, music is an auditory stimulus that interests and motivates youngsters, as it is used for identity, social connection, and emotional regulation.
    Methods: We conducted a strategic search by consulting scientific databases. The following search terms were employed: Music Therapy AND Psychology AND Psychiatry AND Adolescents. The following international electronic databases were searched: Medline, Ovid, and Cochrane Library.
    Results: A total of 142 sources were identified from which 9 papers on music therapy published exclusively in scientific journals specialized in psychology or child psychiatry were selected. The total number of participants was 651. The studies reported that music therapy interventions have the potential to improve self-esteem, social engagement, decrease social isolation, and depressive and anxiety symptoms in psychiatric adolescents (both in inpatient and outpatient settings).
    Conclusion: Given the heterogeneity and methodological quality of the few studies included, it is complex to extrapolate and generalize results. More quality research is needed to expand music therapy interventions on youth mental health.
    MeSH term(s) Adolescent ; Humans ; Mental Disorders/therapy ; Music Therapy
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324235-0
    ISSN 1461-7021 ; 1359-1045
    ISSN (online) 1461-7021
    ISSN 1359-1045
    DOI 10.1177/13591045221079161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antigenotoxicidad de la isoflavona de soya genisteína en ratones expuestos a compuestos cancerígenos del cromo hexavalente.

    García-Rodríguez, María Del Carmen / Valle-Castillo, Gabriela Abigail / Hernández-Cortés, Lourdes Montserrat

    Nutricion hospitalaria

    2022  Volume 40, Issue 1, Page(s) 151–159

    Abstract: Introduction: Introduction: the consumption of antioxidant-rich foods such as soy isoflavones may be an alternative in the protection and modulation against metal-induced genotoxicity with carcinogenic potential associated with oxidative stress. ... ...

    Title translation Antigenotoxicity of the soy isoflavone genistein in mice exposed to carcinogenic hexavalent chromium compounds.
    Abstract Introduction: Introduction: the consumption of antioxidant-rich foods such as soy isoflavones may be an alternative in the protection and modulation against metal-induced genotoxicity with carcinogenic potential associated with oxidative stress. Objective: to evaluate the antigenotoxic effects of soy isoflavone genistein in mice exposed to carcinogenic compounds of hexavalent chromium (Cr[VI]). Material and method: twenty-five male Hsd:ICR mice were divided into five groups treated as follows: a) vehicle 1 (sterile distilled water, intraperitoneally); b) vehicle 2 (corn oil for fat-soluble compounds, orally); c) 15 mg/kg of genistein, orally; d) 20 mg/kg of CrO3, intraperitoneally; and e) 15 mg/kg of genistein four hours before the application of 20 mg/kg of CrO3. Evaluations of micronuclei (MN), apoptosis, ratio of polychromatic/normochromatic erythrocytes (EPC/ENC) and cell viability in peripheral blood obtained at 0, 24, 48 and 72 hours were performed. Results: the treatment with genistein reduced MN when administered prior to treatment with CrO3, the effect being greater at 48 hours (reduction of 84 %). Cell viability was reduced with genistein and CrO3 treatments alone, the effect being greater in the latter. Conclusions: genistein effectively blocked the genotoxic action of CrO3. The fact that MN and apoptosis were reduced in the group treated with genistein and CrO3 suggests that genistein could have inhibited the oxidative damage of Cr(VI) since, as there were no cells with damage, the apoptotic pathways were not activated.
    MeSH term(s) Mice ; Male ; Animals ; Genistein/pharmacology ; Carcinogens ; Mice, Inbred ICR ; Chromium/toxicity ; Chromium Compounds ; Isoflavones/pharmacology
    Chemical Substances Genistein (DH2M523P0H) ; chromium hexavalent ion (18540-29-9) ; Carcinogens ; Chromium (0R0008Q3JB) ; Chromium Compounds ; Isoflavones
    Language Spanish
    Publishing date 2022-09-22
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1481223-x
    ISSN 1699-5198 ; 0212-1611
    ISSN (online) 1699-5198
    ISSN 0212-1611
    DOI 10.20960/nh.04163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Impact of Metabolic Syndrome Risk Factors on Lung Function Impairment: Cross-Sectional Study.

    Molina-Luque, Rafael / Molina-Recio, Guillermo / de-Pedro-Jiménez, Domingo / Álvarez Fernández, Carlos / García-Rodríguez, María / Romero-Saldaña, Manuel

    JMIR public health and surveillance

    2023  Volume 9, Page(s) e43737

    Abstract: Background: Metabolic syndrome (MetS) is a constellation of risk factors increasingly present in the world's population. People with this syndrome are at an increased risk of cardiovascular disease and type 2 diabetes mellitus. Moreover, evidence has ... ...

    Abstract Background: Metabolic syndrome (MetS) is a constellation of risk factors increasingly present in the world's population. People with this syndrome are at an increased risk of cardiovascular disease and type 2 diabetes mellitus. Moreover, evidence has shown that it affects different organs. MetS and its risk factors are independently associated with impaired lung function, which can be quantified through spirometric variables.
    Objective: This study aims to determine whether a high number of MetS criteria is associated with increased lung function decline.
    Methods: We conducted a descriptive cross-sectional study with a random sample of 1980 workers. Workers with acute respiratory pathology (eg, influenza), chronic respiratory pathology (eg, chronic bronchitis), or exposure to substances harmful to the lungs (eg, organic and inorganic dust) were not included. MetS was established based on harmonized criteria, and lung function was assessed according to spirometric variables. On the basis of these, classification into restrictive lung disease (RLD), obstructive lung disease, and mixed lung disease (MLD) was performed. In addition, the association between MetS and lung function was established based on analysis of covariance, linear trend analysis, and multiple linear regression.
    Results: MetS was associated with worse lung function according to all the spirometric parameters analyzed (percentage of predicted forced expiratory volume in 1 second: mean 83, SD 13.8 vs mean 89.2, SD 12.8; P<.001 and percentage of predicted forced vital capacity: mean 85.9, SD 11.6 vs mean 92, SD 11.3; P<.001). Moreover, those diagnosed with MetS had a higher prevalence of lung dysfunction (41% vs 21.9%; P<.001), RLD (23.4% vs 11.2%; P<.001), and MLD (7.3% vs 2.2%; P<.001). Furthermore, an increasing number of MetS criteria was associated with a greater impairment of pulmonary mechanics (P<.001). Similarly, with an increasing number of MetS criteria, there was a significant linear trend (P<.001) in the growth of the prevalence ratio of RLD (0 criteria: 1, 1: 1.46, 2: 1.52, 3: 2.53, 4: 2.97, and 5: 5.34) and MLD (0 criteria: 1, 1: 2.68, 2: 6.18, 3: 9.69, and 4: 11.37). Regression analysis showed that the alteration of all MetS risk factors, adjusted for various explanatory variables, was significantly associated with a worsening of spirometric parameters, except for forced expiratory volume in 1 second/forced vital capacity.
    Conclusions: The findings have shown that an increase in cardiometabolic risk factors is associated with a more significant worsening of spirometric variables and a higher prevalence of RLD and MLD. As spirometry could be a crucial tool for monitoring patients at risk of developing chronic pathologies, we conclude that this inexpensive and easily accessible test could help detect changes in lung function in patients with cardiometabolic disorders. This highlights the need to consider the importance of cardiometabolic health in lung function when formulating public health policies.
    MeSH term(s) Humans ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 ; Risk Factors ; Cardiovascular Diseases ; Lung ; Lung Diseases
    Language English
    Publishing date 2023-09-05
    Publishing country Canada
    Document type Journal Article
    ISSN 2369-2960
    ISSN (online) 2369-2960
    DOI 10.2196/43737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Development of a Predictive Model of Cardiovascular Risk in a Male Population from the Peruvian Amazon.

    Alcaide-Leyva, Jose M / Romero-Saldaña, Manuel / García-Rodríguez, María / Molina-Luque, Rafael / Jiménez-Mérida, Rocío / Molina-Recio, Guillermo

    Journal of clinical medicine

    2023  Volume 12, Issue 9

    Abstract: Background: The coexistence of malnutrition due to over- and under-nutrition in the Peruvian Amazon increases chronic diseases and cardiovascular risk.: Methods: A cross-sectional study of a male population where anthropometric, clinical, and ... ...

    Abstract Background: The coexistence of malnutrition due to over- and under-nutrition in the Peruvian Amazon increases chronic diseases and cardiovascular risk.
    Methods: A cross-sectional study of a male population where anthropometric, clinical, and demographic variables were obtained to create a binary logistic regression predictive model of cardiovascular risk.
    Results: We compared two methods with good predictive results, finally choosing Model 4 (r
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A comparative study on chromium-induced micronuclei assessment in the peripheral blood of Hsd:ICR mice.

    García-Rodríguez, María Del Carmen / Hernández-Cortés, Lourdes Montserrat / Montaño-Rodríguez, Ana Rosa / Pereyra-Mejía, Pedro Salvador / Kacew, Sam

    Journal of applied toxicology : JAT

    2023  Volume 44, Issue 4, Page(s) 526–541

    Abstract: This study investigated the genotoxic effects of chromium (Cr) in Hsd:ICR mice, considering factors such as oxidative state, apoptosis, exposure pathway, duration, pregnancy, and transplacental exposure. Genotoxicity was assessed using the erythrocytes' ... ...

    Abstract This study investigated the genotoxic effects of chromium (Cr) in Hsd:ICR mice, considering factors such as oxidative state, apoptosis, exposure pathway, duration, pregnancy, and transplacental exposure. Genotoxicity was assessed using the erythrocytes' micronucleus (MN) assay, while apoptosis was evaluated in nucleated blood cells. The results showed that Cr(III) (CrK(SO
    MeSH term(s) Mice ; Male ; Female ; Pregnancy ; Animals ; Mice, Inbred ICR ; Chromium/toxicity ; Erythrocytes ; Micronucleus Tests
    Chemical Substances chromium hexavalent ion (18540-29-9) ; Chromium (0R0008Q3JB)
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604625-3
    ISSN 1099-1263 ; 0260-437X
    ISSN (online) 1099-1263
    ISSN 0260-437X
    DOI 10.1002/jat.4556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Thesis ; Online: Lower limb pain, muscle fatigue and prolonged standing at work

    Garcia Rodriguez, Maria G.

    scientific insights for occupational ergonomics and health

    2017  

    Keywords SCHMERZEN (PATHOLOGIE) ; ARBEITSMEDIZIN + ARBEITSHYGIENE ; STEHEN + STEHENDE KÖRPERHALTUNG (ANATOMIE UND PHYSIOLOGIE) ; LOWER EXTREMITY MUSCLES (ANATOMY AND PHYSIOLOGY) ; ARBEITSMEDIZINISCHE PRÄVENTIVMASSNAHMEN ; MUSKELN DER UNTEREN EXTREMITÄTEN (ANATOMIE UND PHYSIOLOGIE) ; STANDING + STANDING POSITION (ANATOMY AND PHYSIOLOGY) ; PAIN (PATHOLOGY) ; OCCUPATIONAL MEDICINE + OCCUPATIONAL HYGIENE ; PREVENTIVE MEASURES IN OCCUPATIONAL MEDICINE ; LOWER LIMB DISORDERS (PATHOLOGY) ; KRANKHEITEN UND BESCHWERDEN DER UNTEREN EXTREMITÄTEN (PATHOLOGIE) ; info:eu-repo/classification/ddc/610 ; Medical sciences ; medicine
    Language English
    Publisher ETH Zürich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Pain assessment and management in the newborn: A systematized review.

    Garcia-Rodriguez, Maria Teresa / Bujan-Bravo, Sergio / Seijo-Bestilleiro, Rocio / Gonzalez-Martin, Cristina

    World journal of clinical cases

    2021  Volume 9, Issue 21, Page(s) 5921–5931

    Abstract: Background: Neonatal pain has been underdiagnosed due to several false beliefs.: Aim: To determine the status of neonatal pain in newborns who are admitted to intensive care units.: Methods: Different databases were searched. Literature reviews ... ...

    Abstract Background: Neonatal pain has been underdiagnosed due to several false beliefs.
    Aim: To determine the status of neonatal pain in newborns who are admitted to intensive care units.
    Methods: Different databases were searched. Literature reviews and research reports conducted in newborns that were written in English, Spanish, or Portuguese, published between 2010 and 2020, and having free access to the full text were selected. A total of 135 articles were found, and 18 articles were finally reviewed.
    Results: Newborns are exposed to numerous painful procedures. In order to assess their pain levels, several scales have been used, although they are sometimes not correctly interpreted. In terms of pain management, the nursing team plays a very important role based mainly on both pharmacological and non-pharmacological approaches.
    Conclusion: Nursing staff members must be well trained in order to identify pain and to interpret the scales correctly. Besides, they have an important role in performing non-pharmacological procedures for pain management.
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i21.5921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Protective Effect of Resveratrol against Hexavalent Chromium-Induced Genotoxic Damage in Hsd:ICR Male Mice.

    Nicolás-Méndez, Tonancy / Kacew, Sam / Ortiz-Muñiz, Alda Rocío / Mendoza-Núñez, Víctor Manuel / García-Rodríguez, María Del Carmen

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 13

    Abstract: The aim of this study is to examine the ability of resveratrol to counteract hexavalent chromium [Cr(VI)]-induced genetic damage, as well as the possible pathways associated with this protection. Hsd:ICR male mice are divided into groups of the following ...

    Abstract The aim of this study is to examine the ability of resveratrol to counteract hexavalent chromium [Cr(VI)]-induced genetic damage, as well as the possible pathways associated with this protection. Hsd:ICR male mice are divided into groups of the following five individuals each: (a) control 1, distilled water; (b) control 2, ethanol 30%; (c) resveratrol, 50 mg/kg by gavage; (d) CrO
    MeSH term(s) 8-Hydroxy-2'-Deoxyguanosine ; Animals ; Antioxidants/pharmacology ; Chromium/toxicity ; DNA Damage ; Male ; Mice ; Mice, Inbred ICR ; Resveratrol/pharmacology
    Chemical Substances Antioxidants ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27134028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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