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  1. Article ; Online: Reply to "Letter to the Editor Concerning the Article-Ex Vivo Heart Perfusion After Cardiocirculatory Death; a Porcine Model".

    García Sáez, Diana / Lezberg, Paul / Simon, Andre R

    The Journal of surgical research

    2018  Volume 237, Page(s) 91–92

    MeSH term(s) Animals ; Death ; Heart ; Organ Preservation ; Swine
    Language English
    Publishing date 2018-02-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2017.12.032
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    Zs.A 178: Show issues Location:
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  2. Article ; Online: How to save a life: the multidevice patient.

    Monteagudo Vela, Maria / Garcia Saez, Diana / Panoulas, Vasileios / Simon, Andre

    European heart journal

    2018  Volume 40, Issue 8, Page(s) 677

    MeSH term(s) Cardiomyopathy, Dilated/diagnostic imaging ; Cardiomyopathy, Dilated/therapy ; Echocardiography, Transesophageal ; Extracorporeal Membrane Oxygenation ; Heart-Assist Devices ; Humans ; Male ; Middle Aged ; Renal Replacement Therapy
    Language English
    Publishing date 2018-09-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy602
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  3. Article ; Online: Ex vivo lung perfusion made easy.

    Mohite, Prashant N / Umakumar, Kabeer / Maunz, Olaf / Jothidasan, Anand / Zych, Bartlomiej / Smail, Hassiba / Garcia Saez, Diana / Simon, Andre R

    Multimedia manual of cardiothoracic surgery : MMCTS

    2021  Volume 2021

    Abstract: Ex vivo lung perfusion is an indispensable tool in the armamentarium of any lung transplant center. It helps to increase an already shrinking donor pool by offering a chance to assess suboptimal donor lungs in a systematic manner and improve them by ... ...

    Abstract Ex vivo lung perfusion is an indispensable tool in the armamentarium of any lung transplant center. It helps to increase an already shrinking donor pool by offering a chance to assess suboptimal donor lungs in a systematic manner and improve them by treating them with low-molecular-weight perfusate. We offer a stepwise guide to carry out ex vivo lung perfusion on the donor lungs and criteria to accept them for transplants.
    MeSH term(s) Donor Selection/methods ; Extracorporeal Circulation/methods ; Humans ; Lung/pathology ; Lung/physiology ; Lung/physiopathology ; Lung Transplantation ; Male ; Middle Aged ; Organ Preservation/methods ; Perfusion/methods ; Tissue Donors
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Case Reports ; Video-Audio Media
    ZDB-ID 2280156-X
    ISSN 1813-9175 ; 1813-9175
    ISSN (online) 1813-9175
    ISSN 1813-9175
    DOI 10.1510/mmcts.2021.018
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  4. Article ; Online: Sternal sparing bilateral symmetrical thoracotomy for implantation of left ventricular assist device.

    Mohite, Prashant Nanasaheb / Husain, Mubassher / Monteagudo-Vela, Maria / Umakumar, Kabeer / Garcia Saez, Diana / Jothidasan, Anand / Simon, Andre R

    Multimedia manual of cardiothoracic surgery : MMCTS

    2021  Volume 2021

    Abstract: Reopening the chest in patients with left ventricular assist devices at the time of a heart transplant is challenging due to adhesions and the possibility of injury to vital structures. The sternal sparing bilateral thoracotomy approach utilized to ... ...

    Abstract Reopening the chest in patients with left ventricular assist devices at the time of a heart transplant is challenging due to adhesions and the possibility of injury to vital structures. The sternal sparing bilateral thoracotomy approach utilized to implant a left ventricular assist device minimizes the chances of such injuries and offers a cosmetically better outcome. We demonstrate a procedure for implanting a left ventricular assist device in a 54-year-old man diagnosed with dilated cardiomyopathy who suffered rapid decompensation despite maximum medical therapy.
    MeSH term(s) Heart Failure/surgery ; Heart-Assist Devices ; Humans ; Male ; Middle Aged ; Prosthesis Implantation ; Sternum ; Thoracotomy ; Treatment Outcome
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Case Reports ; Video-Audio Media
    ZDB-ID 2280156-X
    ISSN 1813-9175 ; 1813-9175
    ISSN (online) 1813-9175
    ISSN 1813-9175
    DOI 10.1510/mmcts.2021.044
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  5. Article ; Online: Heart Transplantation in Adult Congenital Heart Disease with the Organ Care System Use: A 4-Year Single-Center Experience.

    Verzelloni Sef, Alessandra / Sef, Davorin / Garcia Saez, Diana / Trkulja, Vladimir / Walker, Christopher / Mitchell, Jerry / McGovern, Ian / Stock, Ulrich

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2021  Volume 67, Issue 8, Page(s) 862–868

    Abstract: Recent advances in the management of patients with adult congenital heart disease (ACHD) have led to an increased number of patients who may develop heart failure and require heart transplantation (HTx). The purpose of this study was to evaluate early ... ...

    Abstract Recent advances in the management of patients with adult congenital heart disease (ACHD) have led to an increased number of patients who may develop heart failure and require heart transplantation (HTx). The purpose of this study was to evaluate early and mid-term postoperative outcomes after HTx with the use of Organ Care System (OCS) in a cohort of ACHD patients transplanted at our tertiary center. All consecutive HTx performed from January 2015 to January 2019 at our institution were analyzed. Donor and recipient preoperative characteristics, intraoperative course, and perioperative clinical outcomes were evaluated. Nine patients with median age of 44 years (range 17-61 years) underwent isolated HTx for end-stage ACHD during the study period. Mean cold ischemic time was 84 ± 17 minutes. Postoperatively, four patients (44%) needed venoarterial extracorporeal membrane oxygenation (1-7 days). One patient (11%) required surgical re-exploration for bleeding. Thirty-day and 1-year mortality were 11% and 22%, respectively. In our experience, despite the challenges of transplantation in ACHD, these patients can be successfully transplanted with the use of the OCS in a highly specialized center. Careful donor and recipient selection are of paramount importance.
    MeSH term(s) Adolescent ; Adult ; Extracorporeal Membrane Oxygenation ; Heart Defects, Congenital/surgery ; Heart Failure ; Heart Transplantation/adverse effects ; Humans ; Middle Aged ; Retrospective Studies ; Risk Factors ; Tissue Donors ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001482
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  6. Article: Lung donor shortage - how to overcome it?

    Zych, Bartłomiej / Garcia-Saez, Diana / Simon, Andre R

    Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

    2016  Volume 13, Issue 3, Page(s) 195–197

    Language English
    Publishing date 2016-09-30
    Publishing country Poland
    Document type Editorial
    ZDB-ID 2237053-5
    ISSN 1897-4252 ; 1731-5530
    ISSN (online) 1897-4252
    ISSN 1731-5530
    DOI 10.5114/kitp.2016.62603
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  7. Article ; Online: Direct Procurement of Donor Heart With Normothermic Regional Perfusion of Abdominal Organs.

    Mohite, Prashant N / García Sáez, Diana / Butler, Andrew J / Watson, Christopher J E / Simon, Andre

    The Annals of thoracic surgery

    2019  Volume 108, Issue 2, Page(s) 597–600

    Abstract: Purpose: We wanted to evaluate if direct procurement of the heart is possible in combination with normothermic regional perfusion of abdominal organs in donors after circulatory death.: Description: A donation after circulatory death pathway was used ...

    Abstract Purpose: We wanted to evaluate if direct procurement of the heart is possible in combination with normothermic regional perfusion of abdominal organs in donors after circulatory death.
    Description: A donation after circulatory death pathway was used for a 41-year-old woman after an irreversible brain injury. After meeting criteria for the organ donation, the heart was retrieved and re-animated on ex situ perfusion system, and abdominal organs were perfused with normothermic regional perfusion.
    Evaluation: All the donated organs and their recipients had excellent short-term outcome.
    Conclusions: We demonstrated a successful combination of direct procurement of the heart and normothermic regional perfusion of the abdominal organs.
    MeSH term(s) Adult ; Female ; Heart Transplantation ; Humans ; Liver Transplantation ; Organ Preservation/methods ; Perfusion/methods ; Tissue Donors ; Tissue and Organ Procurement/methods
    Language English
    Publishing date 2019-03-23
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2019.01.087
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
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  8. Article ; Online: Combined Use of Left Ventricular Assist Device, Extra Corporeal Life Support and Impella RP.

    Monteagudo-Vela, Maria / Panoulas, Vasileios / Fernandez-Garda, Rita / Garcia-Saez, Diana / Simon, Andre

    Cardiovascular revascularization medicine : including molecular interventions

    2019  Volume 20, Issue 11S, Page(s) 67–69

    MeSH term(s) Adult ; Extracorporeal Membrane Oxygenation ; Female ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Heart Failure/therapy ; Heart-Assist Devices ; Humans ; Prosthesis Design ; Prosthesis Implantation/instrumentation ; Recovery of Function ; Treatment Outcome ; Ventricular Function, Left ; Ventricular Function, Right
    Language English
    Publishing date 2019-09-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2212113-4
    ISSN 1878-0938 ; 1553-8389
    ISSN (online) 1878-0938
    ISSN 1553-8389
    DOI 10.1016/j.carrev.2019.09.007
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    Zs.A 5562: Show issues Location:
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  9. Article: Current approaches in retrieval and heart preservation.

    Monteagudo Vela, Maria / García Sáez, Diana / Simon, Andre R

    Annals of cardiothoracic surgery

    2017  Volume 7, Issue 1, Page(s) 67–74

    Abstract: Fifty years after the first successful heart transplantation, despite multiple advances in the treatment of advanced acute and chronic heart failure, there is still no equivalent to heart transplantation as a long-term treatment for end-stage heart ... ...

    Abstract Fifty years after the first successful heart transplantation, despite multiple advances in the treatment of advanced acute and chronic heart failure, there is still no equivalent to heart transplantation as a long-term treatment for end-stage heart failure. Transplantation is, however, limited by the scarcity and quality of heart allografts. Donors are nowadays significantly older, particularly in European countries, and traumatic head injury as the cause of death has been replaced by intracerebral hemorrhage or hypoxic brain damage in the majority of cases. In addition, many donors have undergone extensive resuscitation efforts. Recipient characteristics have progressively changed too within the last couple of decades; recipients are older, often with comorbidities and nearly half of them are bridged to transplant with a wide variety of mechanical circulatory support devices. These developments have resulted in heart transplant surgery becoming significantly more challenging with longer more complex surgery and increased ischemia times for organs that were previously considered to be borderline or non-transplantable in many cases. To address this, several options have been explored within the last years and as a result, novel strategies have been developed and tested in order to optimize graft preservation and potentially increase the donor pool. The two notable developments are the ability to procure hearts from donors after circulatory death and the advent of
    Language English
    Publishing date 2017-04-27
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs.2018.01.06
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  10. Article ; Online: Outcomes of heart transplantation in patients bridged with Impella 5.0: Comparison with native chest transplanted patients without preoperative mechanical circulatory support.

    Monteagudo-Vela, María / Panoulas, Vasileios / García-Saez, Diana / de Robertis, Fabio / Stock, Ulrich / Simon, Andre Rudiger

    Artificial organs

    2020  Volume 45, Issue 3, Page(s) 254–262

    Abstract: The Impella (Abiomed, Danvers, MA, USA) has become an important adjunct treatment modality in bridging patients with end-stage heart failure to recovery or orthotopic heart transplantation (HTx). We compared the outcome of patients directly bridged to ... ...

    Abstract The Impella (Abiomed, Danvers, MA, USA) has become an important adjunct treatment modality in bridging patients with end-stage heart failure to recovery or orthotopic heart transplantation (HTx). We compared the outcome of patients directly bridged to HTx with the Impella 5.0 versus patients without mechanical circulatory support (MCS). Patients with no previous sternotomy or MCS, who were transplanted between September 2014 and March 2019 were included in this retrospective analysis. Impella 5.0 was implanted using surgical access and transesophageal echocardiography guidance. Forty-two out of 155 transplanted patients fulfilled the insertion criteria. Eight (19%) were bridged with Impella 5.0 to HTx. Recipient and donor baseline characteristics were comparable in both groups. There were no significant differences in survival between the groups at 30-day (94% no MCS vs. 87.5% Impella group, P = .47) or 6 months (94% vs. 87.5%, P = .51). Patients on Impella 5.0 showed a significant recovery of hemodynamic parameters and end-organ function. Average duration of support to HTx was 16 ± 17 days. Impella 5.0, when used in suitable patients in a timely fashion can be a good strategy for bridging patients to HTx. The axillary approach allows for early extubation and mobilization. Outcomes of patients bridged to HTx with Impella 5.0 in acute cardiogenic shock are comparable to those of patients with no MCS.
    MeSH term(s) Adult ; Aged ; Echocardiography, Transesophageal ; Female ; Follow-Up Studies ; Heart Failure/etiology ; Heart Failure/mortality ; Heart Failure/surgery ; Heart Transplantation/statistics & numerical data ; Heart-Assist Devices/statistics & numerical data ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prosthesis Implantation/methods ; Prosthesis Implantation/statistics & numerical data ; Retrospective Studies ; Shock, Cardiogenic/complications ; Shock, Cardiogenic/mortality ; Shock, Cardiogenic/surgery ; Treatment Outcome ; United Kingdom/epidemiology ; Young Adult
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/aor.13816
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