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  1. Article ; Online: Computer programs used in the field of hospital pharmacy for the management of dangerous drugs: systematic review of literature.

    Climent-Ballester, Seira / García-Salom, Pedro / Sanz-Valero, Javier

    Frontiers in public health

    2023  Volume 11, Page(s) 1233264

    Abstract: Background: This review wants to highlight the importance of computer programs used to control the steps in the management of dangerous drugs. It must be taken into account that there are phases in the process of handling dangerous medicines in pharmacy ...

    Abstract Background: This review wants to highlight the importance of computer programs used to control the steps in the management of dangerous drugs. It must be taken into account that there are phases in the process of handling dangerous medicines in pharmacy services that pose a risk to the healthcare personnel who handle them. Objective: To review the scientific literature to determine what computer programs have been used in the field of hospital pharmacy for the management of dangerous drugs (HDs).
    Methods: The following electronic databases were searched from inception to July 30, 2021: MEDLINE (via PubMed), Embase, Cochrane Library, Scopus, Web of Science, Latin American and Caribbean Literature in Health Sciences (LILACS) and Medicine in Spanish (MEDES). The following terms were used in the search strategy: "Antineoplastic Agents," "Cytostatic Agents," "Hazardous Substances," "Medical Informatics Applications," "Mobile Applications," "Software," "Software Design," and "Pharmacy Service, Hospital."
    Results: A total of 104 studies were retrieved form the databases, and 18 additional studies were obtained by manually searching the reference lists of the included studies and by consulting experts. Once the inclusion and exclusion criteria were applied, 26 studies were ultimately included in this review. Most of the applications described in the included studies were used for the management of antineoplastic drugs. The most commonly controlled stage was electronic prescription; 18 studies and 7 interventions carried out in the preparation stage focused on evaluating the accuracy of chemotherapy preparations.
    Conclusion: Antineoplastic electronic prescription software was the most widely implemented software at the hospital level. No software was found to control the entire HD process. Only one of the selected studies measured safety events in workers who handle HDs. Moreover, health personnel were found to be satisfied with the implementation of this type of technology for daily work with these medications. All studies reviewed herein considered patient safety as their final objective. However, none of the studies evaluated the risk of HD exposure among workers.
    MeSH term(s) Humans ; Caribbean Region ; Databases, Factual ; Ethnicity ; Mobile Applications ; Pharmacy Service, Hospital
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1233264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessing the risk of using hazardous drugs in Hospital-at-Home Units: a big data study protocol.

    Bernabeu-Martínez, Mari A / García-Salom, Pedro / Burgos-San José, Amparo / Álvarez-Sabucedo, Luis M / Wanden-Berghe, Carmina / Sanz-Valero, Javier

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2021  Volume 45, Issue 5, Page(s) 282–286

    Abstract: Objective: This article describes a study protocol for the implementation of quality and traceability control in the hazardous  medication circuit through an analysis of risks and the development and  introduction of a Big Data-based software ... ...

    Title translation Análisis de riesgos mediante modelos big data del uso de medicamentos peligrosos en Unidades de Hospitalización a Domicilio: protocolo de estudio.
    Abstract Objective: This article describes a study protocol for the implementation of quality and traceability control in the hazardous  medication circuit through an analysis of risks and the development and  introduction of a Big Data-based software application aimed at performing  a continuous and dynamic audit of the whole system. Method: A standardized graphical modeling tool called Business Process Model Notation will be used to generate a detailed description of each of the stages in the hazardous medication circuit with a view to  ensuring full traceability of the system. The information on each stage will  be collected in a flowchart, which will be used -together with each event's likelihood of occurrence and severity- as a basis to calculate the  criticality index of the different control points established and to determine  any control measures that may be required. The flowcharts will  also be used to develop the technological support needed to capture  all such data as may be relevant to the model. Proper quality control of the process will be ensured by client software agents intended to allow  automatic applica tion of efficient data processing tools at the different  phases. In addition, Big Data methodologies, in particular machine  learning, will be used to develop algorithms based on the repository of  generated data to come up with patterns capable of improving the  protocols to be applied. Lastly, proper operation of the process will be  ensured by means of clinicalpharmaceutical verification and a full  technical-documentary review of control and registration systems.
    Conclusions: The development of a risk management system based on  mobile technology will allow integration of hazardous drugs into a standardized system, ensuring the safety, quality, and traceability of the hazardous medication handling process.
    MeSH term(s) Big Data ; Hospitals ; Humans ; Pharmaceutical Preparations ; Software
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-06-10
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1122680-8
    ISSN 2171-8695 ; 1130-6343
    ISSN (online) 2171-8695
    ISSN 1130-6343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3450: Show issues Location:
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  3. Article ; Online: Perception of risk of exposure in the management of hazardous drugs in home hospitalization and hospital units.

    Bernabeu-Martínez, Mari Ángeles / Sánchez-Tormo, Julia / García-Salom, Pedro / Sanz-Valero, Javier / Wanden-Berghe, Carmina

    PloS one

    2021  Volume 16, Issue 7, Page(s) e0253909

    Abstract: Objective: To assess the perception of risk of exposure in the management of hazardous drugs (HDs) through home hospitalization and hospital units.: Material and methods: A questionnaire was released, at the national level, to health professionals ... ...

    Abstract Objective: To assess the perception of risk of exposure in the management of hazardous drugs (HDs) through home hospitalization and hospital units.
    Material and methods: A questionnaire was released, at the national level, to health professionals with HD management expertise. Questionnaire included 21 questions that were scored using a Likert scale: 0 (null probability) to 4 (very high probability). The internal consistency and reliability of the questionnaire were calculated using Cronbach's alpha and the intraclass correlation coefficient, respectively.
    Results: 144 questionnaires (response rate 70.2%) were obtained: 65 (45.1%) were nurses, 42 (28.9%) occupational physicians, and 37 (26.1%) were pharmacists. Cronbach's alpha was 0.93, and intraclass correlation coefficient was 0.94 (95% CI 0.91-0.97; p-value < 0.001). The mean probability was 1.95 ± 1.02 (median 1.9; minimum: 0.05; 1st quartile 1.1; 3rd quartile 2.6; and maximum 4). Differences were observed in scoring among professional groups (occupational physicians versus nurses (1.6/2.1, p = 0.044); pharmacists versus nurses (1.7/2.1, p = 0.05); and occupational physicians versus pharmacists (1.6/1.7, p = 0.785), due mainly to the administration stage (p = 0.015).
    Conclusions: The perception of risk of exposure was moderate, being higher for nurses. It would be advisable to integrate HDs into a standardized management system (risk management model applicable to any healthcare center) to improve the safety of health professionals.
    MeSH term(s) Attitude of Health Personnel ; Hazardous Substances/toxicity ; Health Personnel/psychology ; Health Personnel/statistics & numerical data ; Home Care Services, Hospital-Based/statistics & numerical data ; Hospital Units/statistics & numerical data ; Humans ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control ; Perception ; Psychometrics/statistics & numerical data ; Risk Management ; Surveys and Questionnaires/statistics & numerical data
    Chemical Substances Hazardous Substances
    Language English
    Publishing date 2021-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0253909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Consensus to identify the dangerous drugs risks in hospital pharmacy services.

    Bernabeu-Martínez, María Ángeles / García-Salom, Pedro / Burgos-San José, Amparo / Navarro-Ruiz, Andrés / Sanz-Valero, Javier / Wanden-Berghe, Carmina

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2020  Volume 44, Issue 2, Page(s) 51–61

    Abstract: Objective: To identify the hazards and define the theoretical  occupational risks arising from the process of handling hazard drugs in  hospital pharmacy services on the basis of expert consensus.: Method: An expert consensus was conducted (nominal ... ...

    Title translation Consenso para identificar los riesgos de los medicamentos peligrosos en los servicios de farmacia hospitalaria.
    Abstract Objective: To identify the hazards and define the theoretical  occupational risks arising from the process of handling hazard drugs in  hospital pharmacy services on the basis of expert consensus.
    Method: An expert consensus was conducted (nominal group and documentary techniques) using a mixed method of two face-to-face rounds (meeting of participants and approval of proposals) and  three masked rounds (individualized review). The analysis was applied  to the field of hospital pharmacy. The stages of the process were  designed using the standardized graphical Business Process Model and Notation.
    Results: A specific flowchart was obtained for the management and  traceability of hazardous drugs. All general process phases were  characterized. A management chart included operations addressing the  reception and storage, compounding, conservation, and dispensation of  hazardous drugs in hospital pharmacy services. This chart provides a  description of the chemical hazards and exposure routes.
    Conclusions: The hazardous drug process should be integrated in a standard management system to improve the safety of patients and  healthcare professionals. Efficiency can maximized and procedural  incidents minimized, thereby ensuring the quality and the safety of  hazardous drugs handling in hospital pharmacy services. Once hazards  are identified, risk assessment should be implemented using a  systematic and preventative methodology to minimize the risk and  severity of any adverse event.
    MeSH term(s) Adult ; Consensus ; Drug Compounding ; Drug Storage ; Female ; Hazardous Substances ; Humans ; Male ; Occupational Exposure/adverse effects ; Pharmaceutical Preparations ; Pharmacists ; Pharmacy Service, Hospital/organization & administration ; Risk Assessment/methods ; Software Design
    Chemical Substances Hazardous Substances ; Pharmaceutical Preparations
    Language English
    Publishing date 2020-03-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1122680-8
    ISSN 2171-8695 ; 1130-6343
    ISSN (online) 2171-8695
    ISSN 1130-6343
    DOI 10.7399/fh.11290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3450: Show issues Location:
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  5. Article ; Online: Design and biopharmaceutical preclinical characterisation of a new thermosensitive hydrogel for the removal of gastric polyps.

    Varela-Rey, Iria / de la Iglesia, Daniel / San Bruno-Ruz, Alba / Mejuto-Fernández, Rafael / Monteserín-Ron, Luzdivina / López-Diaz, Javier / García-Salom, Pedro / González-Cantalapiedra, Antonio / Manuel Brea, Jose / Piña-Márquez, Rocío / Díaz-Tomé, Victoria / González-Barcia, Miguel / Zarra-Ferro, Irene / Mondelo-García, Cristina / Dominguez-Muñoz, J Enrique / Otero-Espinar, Francisco J / Fernández-Ferreiro, Anxo

    International journal of pharmaceutics

    2023  Volume 635, Page(s) 122706

    Abstract: Background and aims: Submucosal injection agents are widely used solutions in gastric polyp resection techniques. Currently, many different solutions are used in clinical practice, but most are not authorised for this use or are not biopharmaceutical ... ...

    Abstract Background and aims: Submucosal injection agents are widely used solutions in gastric polyp resection techniques. Currently, many different solutions are used in clinical practice, but most are not authorised for this use or are not biopharmaceutical characterised. The objective of this multidisciplinary work is to test the efficacy of a novel thermosensitive hydrogel designed specifically for this indication.
    Methods: A mixture design of various components (Pluronic®, hyaluronic acid and sodium alginate) was carried out to select the combination with optimal properties for this use. Three final thermosensitive hydrogels were selected on which biopharmaceutical characterisation was performed and stability and biocompatibility were analysed. Efficacy in maintaining elevation was tested ex vivo on pig mucosa and in vivo in pigs RESULTS: The mixture design allowed selection of the ideal combinations of agents for the characteristics sought. The thermosensitive hydrogels studied showed high values of hardness and viscosity at 37 °C, maintaining good syringeability. One of them demonstrated superiority in maintaining polyp elevation in the ex vivo assay and non-inferiority in the in vivo assay.
    Conclusion: The thermosensitive hydrogel specifically designed for this use is promising both for its biopharmaceutical characteristics and for its demonstrated efficacy. This study lays the foundation for evaluating the hydrogel in humans.
    MeSH term(s) Humans ; Animals ; Swine ; Hydrogels ; Biological Products ; Temperature ; Poloxamer ; Mucous Membrane
    Chemical Substances Hydrogels ; Biological Products ; Poloxamer (106392-12-5)
    Language English
    Publishing date 2023-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2023.122706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1409: Show issues Location:
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  6. Article ; Online: Recomendaciones para la preparación de medicamentos estériles en las unidades de enfermería.

    Martín de Rosales Cabrera, Ana M / López Cabezas, Carmen / Pernía López, M Sagrario / Dávila Pousa, Carmela / Vila Clérigues, M Nieves / Alonso Herreros, José María / García Salom, Pedro / Lozano Blázquez, Ana

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2014  Volume 38, Issue 1, Page(s) 57–64

    Abstract: Objective: To develop a recommendations guide about the preparation of sterile medicines in medical wards, and to figure out the current situation of different Spanish hospitals, regarding the preparation of sterile medicines outside the pharmacy.: ... ...

    Title translation Recommendations for the safety preparation of sterile medicines in medical wards.
    Abstract Objective: To develop a recommendations guide about the preparation of sterile medicines in medical wards, and to figure out the current situation of different Spanish hospitals, regarding the preparation of sterile medicines outside the pharmacy.
    Methods: The authors reviewed the available international guidelines in order to summarize the main quality recommendations. To know about the current situation in Spanish hospitals, a 30 questions survey was designed and spread to 500 different hospitals. Answers were analysed with SurveyMonkey® platform in the period February-July 2012.
    Results: Based on the literature review, the authors agreed a recommendations list for the safe preparation of sterile medicines in medical wards, which was structured in 8 sections. Regarding the survey results, 8.4% of the hospitals answered, showing a great variability among centres in the quality requirements for sterile compounding outside the pharmacy. It should be pointed out the lack of assigned areas for drug preparation in wards, the lack of protocols to discern which kind of medicines can be compounded in wards as well as the poor recommendations about garment and aseptic technique.
    Conclusions: The authors confirm the absence of qualified practice standards to be applied in the preparation of sterile medicines in medical wards, as well as the great variability of diary practice. The implementation of quality and safety recommendations in the preparation of sterile medicines in medical wards may contribute to improve patient safety.
    MeSH term(s) Drug Compounding/standards ; Guidelines as Topic ; Hospitals/standards ; Pharmaceutical Preparations/standards ; Pharmacy Service, Hospital/standards ; Safety ; Sterilization/standards
    Chemical Substances Pharmaceutical Preparations
    Language Spanish
    Publishing date 2014-01-01
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1122680-8
    ISSN 0214-753X ; 2171-8695 ; 1130-6343
    ISSN (online) 0214-753X ; 2171-8695
    ISSN 1130-6343
    DOI 10.7399/FH.2014.38.1.1149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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