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  1. AU="Garcia, Paula"
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  1. Article: Chemical Composition, Fatty Acid Profile, and Optimization of the Sacha Inchi (

    Bocanegra Morales, Nelsy / Galeano Garcia, Paula

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 18

    Abstract: This study aimed to optimize the roasting conditions for sacha inchi ( ...

    Abstract This study aimed to optimize the roasting conditions for sacha inchi (
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12183405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Polypropylene

    Garcia, Paula

    properties, uses, and benefits

    (Polymer science and technology)

    2016  

    Author's details Paula Garcia, editor
    Series title Polymer science and technology
    Keywords Polypropylene.
    Language English
    Size xi, 224 :, illustrations ;, 23 cm.
    Document type Book
    ISBN 9781536100082 ; 1536100080
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Analysis of the Prescription of Antibiotics During the Implementation of COVID-19 Personal Protection Measures in a Regional Health System.

    Rojas-Garcia, Paula / Antoñanzas, Fernando

    ClinicoEconomics and outcomes research : CEOR

    2021  Volume 13, Page(s) 927–936

    Abstract: Introduction: The rational consumption of antibiotics is a valuable goal for developed countries. Antibiotic resistance (AMR) was the main health threat before the coronavirus-19 (COVID-19) pandemic. To restrict COVID-19 transmission, the Spanish ... ...

    Abstract Introduction: The rational consumption of antibiotics is a valuable goal for developed countries. Antibiotic resistance (AMR) was the main health threat before the coronavirus-19 (COVID-19) pandemic. To restrict COVID-19 transmission, the Spanish government implemented personal protection measures, including the decree of a lockdown. The objective of this study is to analyze the prescription of antibiotics during the implementation of COVID-19 personal protection measures in primary care in a Spanish region.
    Materials and methods: Primary monthly official dispensations of antibacterials for systemic use (J01) were analyzed, disaggregating by clinical (active principle, age and sex of the patient) and socio-economic variables (basic health zone and level of income). Defined daily doses per thousand inhabitants (DID) prescribed in 2020 were compared with the prescription in 2019 using Chi-square test.
    Results: In 2020, the prescription of antibiotics (11.37 DID) was significantly lower (-23.73%) than in 2019 (14.91 DID). The main reduction in the amount prescribed was found in May (-42.64%). However, the prescription was significantly higher (71.34%) in February 2020 than in the same month in 2019 in nursing homes. In March 2020, prescriptions were lower (-13.71%) than in the same month in 2019, except for the middle-income group, in which prescriptions were higher (9.67%), as well as azithromycin (10.11%). In April and May 2020, prescriptions were significantly lower than in 2019 in all age groups and both in women and men.
    Conclusion: Personal protection measures against COVID-19 transmission (lockdown, mask, social distance and increased hygiene) coincide in time with the greatest reduction in antibiotic prescription.
    Language English
    Publishing date 2021-11-15
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520698-9
    ISSN 1178-6981
    ISSN 1178-6981
    DOI 10.2147/CEOR.S337621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Systematic Review on Assessing Assessments: Unveiling Psychometric Properties of Instruments for Reactive Attachment Disorder and Disinhibited Social Engagement Disorder in Minors under Protective Measures.

    Talmón-Knuser, Florencia / Soler, Miriam / González-Sala, Francisco / Lacomba-Trejo, Laura / Samper-García, Paula

    Children (Basel, Switzerland)

    2024  Volume 11, Issue 2

    Abstract: Background: Reactive attachment disorder (RAD) and disinhibited social engagement disorder (DSED) manifest in individuals facing attachment system challenges, particularly observed in minors under protective measures. The lack of standardized tools for ... ...

    Abstract Background: Reactive attachment disorder (RAD) and disinhibited social engagement disorder (DSED) manifest in individuals facing attachment system challenges, particularly observed in minors under protective measures. The lack of standardized tools for assessing these difficulties and uncertainty about the most effective instruments from a psychometric perspective prompted this study.
    Aim: Using the COSMIN checklist, we systematically reviewed instruments assessing RAD, adhering to PRISMA.
    Methodology: Examined tools included the Disturbance Attachment Interview, Preschool Age Psychiatric Assessment, Relationship Patterns Questionnaire, Assessment of RAD and DSED, Development and Well-Being Assessment, and Reactive Attachment Disorder Questionnaire.
    Results: Of the 10 articles analyzed, the results highlight a research emphasis on internal consistency and structural and construct validity, sidelining other properties.
    Conclusion: Most articles review structural validity and internal consistency. These measures are satisfactory but insufficiently evaluated. It is necessary to evaluate these tools using other indicators such as cross-cultural validity, measurement error, or responsiveness in adolescents under protective measures.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children11020144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Direct Affinity Ligand Immobilization onto Bare Iron Oxide Nanoparticles Enables Efficient Magnetic Separation of Antibodies.

    Zimmermann, Ines / Kaveh-Baghbaderani, Yasmin / Eilts, Friederike / Kohn, Nadja / Fraga-García, Paula / Berensmeier, Sonja

    ACS applied bio materials

    2024  

    Abstract: Magnetic separation is a promising alternative to chromatography for enhancing the downstream processing (DSP) of monoclonal antibodies (mAbs). However, there is a lack of efficient magnetic particles for successful application. Aiming to fill this gap, ... ...

    Abstract Magnetic separation is a promising alternative to chromatography for enhancing the downstream processing (DSP) of monoclonal antibodies (mAbs). However, there is a lack of efficient magnetic particles for successful application. Aiming to fill this gap, we demonstrate the suitability of bare iron oxide nanoparticles (BION) with physical site-directed immobilization of an engineered Protein A affinity ligand (rSpA) as an innovative magnetic material. The rSpA ligand contains a short peptide tag that enables the direct and stable immobilization onto the uncoated BION surface without commonly required laborious particle activation. The resulting BION@rSpA have beneficial characteristics outperforming conventional Protein A-functionalized magnetic particles: a simple, fast, low-cost synthesis, a particle size in the nanometer range with a large effective specific surface area enabling large immunoglobulin G (IgG) binding capacity, and a high magnetophoretic velocity advantageous for fast processing. We further show rapid interactions of IgG with the easily accessible rSpA ligands. The binding of IgG to BION@rSpA is thereby highly selective and not impeded by impurity molecules in perfusion cell culture supernatant. Regarding the subsequent acidic IgG elution from BION@rSpA@IgG, we observed a hampering pH increase caused by the protonation of large iron oxide surfaces after concentrating the particles in 100 mM sodium acetate buffer. However, the pH can be stabilized by adding 50 mM glycine to the elution buffer, resulting in recoveries above 85% even at high particle concentrations. Our work shows that BION@rSpA enable efficient magnetic mAb separation and could help to overcome emerging bottlenecks in DSP.
    Language English
    Publishing date 2024-05-13
    Publishing country United States
    Document type Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.4c00280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free Solution for Pediatric Delivery.

    Bedogni, Giselle / Garcia, Paula / Seremeta, Katia / Okulik, Nora / Salomon, Claudio

    Pharmaceutics

    2023  Volume 15, Issue 8

    Abstract: To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5-10 mg/kg), which since it is only available as tablets, hinders its administration to pediatric patients. Praziquantel is a poorly water- ... ...

    Abstract To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5-10 mg/kg), which since it is only available as tablets, hinders its administration to pediatric patients. Praziquantel is a poorly water-soluble drug which represents a challenge for its formulation in solution, particularly for the pediatric population. Thus, this study aimed to develop a palatable solution for praziquantel using pharmaceutical-accepted co-solvent systems. A design of experiments approach was applied to identify the optimal conditions for achieving a suitable amount of praziquantel in solution using co-solvent mixtures. Thus, praziquantel solubility increased from 0.38 up to 43.50 mg/mL in the optimized system. A taste masking assay in healthy human volunteers confirmed a successful reduction of drug bitterness after the addition of selected flavors and a sweetener. Stability studies were also conducted at different temperatures (4, 25, and 40 °C) for 12 months Even though the presence of the three known impurities of praziquantel was observed, their amounts never exceeded the acceptance criteria of the USP. Thus, this novel approach should be considered a valuable alternative for further preclinical studies considering the high prevalence of this infection worldwide.
    Language English
    Publishing date 2023-07-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15082050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Systematic Observation of Emotional Regulation in the School Classroom: A Contribution to the Mental Health of New Generations.

    Alarcón-Espinoza, Marina / Samper-Garcia, Paula / Anguera, M Teresa

    International journal of environmental research and public health

    2023  Volume 20, Issue 8

    Abstract: Emotional regulation is a developmental milestone, as it promotes well-being throughout life. Children between 10 and 12 years old are expected to reach capacities that allow them to regulate themselves emotionally, the school context being a natural ... ...

    Abstract Emotional regulation is a developmental milestone, as it promotes well-being throughout life. Children between 10 and 12 years old are expected to reach capacities that allow them to regulate themselves emotionally, the school context being a natural setting for this challenge. With the objective of analyzing the forms of expression and regulation of emotions that are observed in the school classroom, this research was conducted through a
    MeSH term(s) Child ; Humans ; Mental Health ; Emotional Regulation ; Emotions ; Schools ; Students/psychology
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20085595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antagonistas del factor de necrosis tumoral (TNF) en la enfermedad inflamatoria intestinal pediátrica: Una revisión sistemática.

    Martín-García, Paula / Alonso-Arroyo, Adolfo / Catalá-López, Ferrán

    Medicina clinica

    2023  Volume 160, Issue 11, Page(s) 501–516

    Abstract: Inflammatory bowel disease includes two chronic inflammatory diseases, ulcerative colitis and Crohn's disease. The burden of disease is increasing worldwide. A few reviews evaluating the paediatric use of tumour necrosis factor (TNF) antagonists have ... ...

    Title translation Tumour necrosis factor (TNF) antagonist therapy for paediatric inflammatory bowel disease: A systematic review.
    Abstract Inflammatory bowel disease includes two chronic inflammatory diseases, ulcerative colitis and Crohn's disease. The burden of disease is increasing worldwide. A few reviews evaluating the paediatric use of tumour necrosis factor (TNF) antagonists have been published, although these mostly include observational studies and do not consider economic evaluations. This systematic review evaluated the available evidence regarding the efficacy, safety, and cost-effectiveness of TNF antagonist therapy for paediatric inflammatory bowel disease. We searched PubMed/MEDLINE, Embase, and Cochrane Central (up to May 2022). Nine randomized clinical trials and four economic evaluations that examined any anti-TNF drugs (e.g., infliximab, adalimumab, golimumab, and certolizumab) against different alternatives were included. In studies evaluating the efficacy of anti-TNF drugs in Crohn's disease, most assessed the efficacy of maintenance regimen in patients who had previously responded to induction (response=28%-63%, and clinical remission=17%-83% depending on dose, drug, and follow-up). In ulcerative colitis, maintenance treatment with anti-TNF drugs reported clinical remission rates between 17% and 44%. Nine studies reported information on adverse events. No clinical trials comparing different anti-TNF drugs were found. The findings from this review suggest that maintenance treatment with anti-TNF drugs (such as infliximab and adalimumab) in paediatric inflammatory bowel disease is probably effective and safe. However, the economic evaluations reported contradictory results of the cost-effectiveness ratios. Protocol registry: Open Science Framework: https://osf.io/wjmvf.
    MeSH term(s) Humans ; Child ; Adalimumab/therapeutic use ; Infliximab/therapeutic use ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Crohn Disease/drug therapy ; Colitis, Ulcerative/drug therapy ; Tumor Necrosis Factor-alpha ; Inflammatory Bowel Diseases/drug therapy
    Chemical Substances Adalimumab (FYS6T7F842) ; Infliximab (B72HH48FLU) ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha
    Language Spanish
    Publishing date 2023-03-24
    Publishing country Spain
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2023.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.279: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Effectiveness of copper as a preventive tool in health care facilities. A systematic review.

    Aillón-García, Paula / Parga-Landa, Blanca / Guillén-Grima, Francisco

    American journal of infection control

    2023  Volume 51, Issue 9, Page(s) 1038–1048

    Abstract: Introduction: Hospital-acquired infections (HAIs) are a significant clinical and economic burden on health systems worldwide. Copper alloys have been certified by the US EPA as solid antimicrobial materials, but their effectiveness in reducing HAIs is ... ...

    Abstract Introduction: Hospital-acquired infections (HAIs) are a significant clinical and economic burden on health systems worldwide. Copper alloys have been certified by the US EPA as solid antimicrobial materials, but their effectiveness in reducing HAIs is not well established OBJECTIVES: This systematic review aimed to assess copper surfaces in situ efficacy in reducing health care's microbial burden compared to control surfaces.
    Materials and methods: A literature search was conducted using three electronic databases: Web of Science, PubMed, and Scopus, with the keywords "copper" and "surfaces" and "antimicrobial" and "antibacterial" and "infections." Studies from 2010 to 2022 were included. The quality of the studies was independently screened and assessed using the Newcastle Ottawa Scale.
    Results: A total of 56 articles were screened, with 8 included in the review and 7, added from references. Two third of the studies report a significant reduction in the microbial burden on copper objects compared to control objects. The 2 studies with the highest scores on NOS evaluation indicated that using copper or copper alloys in healthcare settings can effectively decrease the number of bacterial contaminations on touch surfaces.
    Conclusions: The results suggest the potential effectiveness of copper as a preventive tool in healthcare facilities, but further studies and longer trials are needed to establish a relationship between copper and reduced nosocomial infections.
    MeSH term(s) Humans ; Copper ; Anti-Infective Agents ; Health Facilities ; Cross Infection/prevention & control ; Cross Infection/microbiology ; Alloys ; Delivery of Health Care
    Chemical Substances Copper (789U1901C5) ; Anti-Infective Agents ; Alloys
    Language English
    Publishing date 2023-02-25
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2023.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1773: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Gold-iron oxide nanohybrids: insights into colloidal stability and surface-enhanced Raman detection.

    Schwaminger, Sebastian P / Bauer, David / Fraga-García, Paula

    Nanoscale advances

    2021  Volume 3, Issue 22, Page(s) 6438–6445

    Abstract: Nanoparticles are acquiring an ever increasing role in analytical technologies for enhanced applications such as signalling of hazardous dyes. One challenge for the synthesis of hybrid nanomaterials is to control their shape, size and properties. The ... ...

    Abstract Nanoparticles are acquiring an ever increasing role in analytical technologies for enhanced applications such as signalling of hazardous dyes. One challenge for the synthesis of hybrid nanomaterials is to control their shape, size and properties. The colloidal and interfacial properties of initial nanoparticles are decisive for the formation, growth and characteristics of nanohybrids. Our objective is to combine the advantages of iron oxide nanoparticles for magnetic separation with nanoscale gold for a surface enhanced Raman scattering (SERS) effect which could be used
    Language English
    Publishing date 2021-09-08
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d1na00455g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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