Article ; Online: Presence of CD34
2018 Volume 33, Issue 1, Page(s) 277–280
Abstract: Background/aim: Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSS-R) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and ...
| Abstract | Background/aim: Although risk stratification using the Prognostic Scores Systems (IPSS, WPSS and IPSS-R) incorporate key information about prognosis of patients with Myelodysplastic syndromes (MDS), patients classified as low-risk may evolve rapidly and aggressively, despite a "favorable" prognostic stratification. The aim of this study was to identify biomarkers for predicting prognosis, and for better stratification and management of these patients. Materials and methods: Expression of CD34 and p53 in megakaryocytes was examined by immunohistochemistry in 71 MDS patients classified as low-risk. Results: CD34 staining in megakaryocytes was associated with p53 expression (p=0.0166). CD34 and p53 expression were associated to worse overall survival in patients (p=0.0281). Conclusion: The presence of CD34 in megakaryocytes is associated with p53 expression and an adverse prognosis for MDS patients. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Antigens, CD34/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Megakaryocytes/metabolism ; Megakaryocytes/pathology ; Middle Aged ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/metabolism ; Myelodysplastic Syndromes/pathology ; Prognosis ; Risk Assessment ; Risk Factors ; Tumor Suppressor Protein p53/genetics | |||||
| Chemical Substances | Antigens, CD34 ; TP53 protein, human ; Tumor Suppressor Protein p53 | |||||
| Language | English | |||||
| Publishing date | 2018-12-18 | |||||
| Publishing country | Greece | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 807031-3 | |||||
| ISSN | 1791-7549 ; 0258-851X | |||||
| ISSN (online) | 1791-7549 | |||||
| ISSN | 0258-851X | |||||
| DOI | 10.21873/invivo.11472 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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