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  1. Article ; Online: Complexes of tubulin oligomers and tau form a viscoelastic intervening network cross-bridging microtubules into bundles.

    Kohl, Phillip A / Song, Chaeyeon / Fletcher, Bretton J / Best, Rebecca L / Tchounwou, Christine / Garcia Arceo, Ximena / Chung, Peter J / Miller, Herbert P / Wilson, Leslie / Choi, Myung Chul / Li, Youli / Feinstein, Stuart C / Safinya, Cyrus R

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2362

    Abstract: The axon-initial-segment (AIS) of mature neurons contains microtubule (MT) fascicles (linear bundles) implicated as retrograde diffusion barriers in the retention of MT-associated protein (MAP) tau inside axons. Tau dysfunction and leakage outside of the ...

    Abstract The axon-initial-segment (AIS) of mature neurons contains microtubule (MT) fascicles (linear bundles) implicated as retrograde diffusion barriers in the retention of MT-associated protein (MAP) tau inside axons. Tau dysfunction and leakage outside of the axon is associated with neurodegeneration. We report on the structure of steady-state MT bundles in varying concentrations of Mg
    MeSH term(s) Microtubules/metabolism ; Scattering, Small Angle ; tau Proteins/metabolism ; Tubulin/metabolism ; X-Ray Diffraction ; Humans
    Chemical Substances tau Proteins ; Tubulin ; MAPT protein, human
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46438-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM.

    Boyle, Evan A / Goldberg, Gabriela / Schmok, Jonathan C / Burgado, Jillybeth / Izidro Layng, Fabiana / Grunwald, Hannah A / Balotin, Kylie M / Cuoco, Michael S / Chang, Keng-Chi / Ecklu-Mensah, Gertrude / Arakaki, Aleena K S / Ahmed, Noorsher / Garcia Arceo, Ximena / Jagannatha, Pratibha / Pekar, Jonathan / Iyer, Mallika / Yeo, Gene W

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0293322

    Abstract: Disparities for women and minorities in science, technology, engineering, and math (STEM) careers have continued even amidst mounting evidence for the superior performance of diverse workforces. In response, we launched the Diversity and Science Lecture ... ...

    Abstract Disparities for women and minorities in science, technology, engineering, and math (STEM) careers have continued even amidst mounting evidence for the superior performance of diverse workforces. In response, we launched the Diversity and Science Lecture series, a cross-institutional platform where junior life scientists present their research and comment on diversity, equity, and inclusion in STEM. We characterize speaker representation from 79 profiles and investigate topic noteworthiness via quantitative content analysis of talk transcripts. Nearly every speaker discussed interpersonal support, and three-fifths of speakers commented on race or ethnicity. Other topics, such as sexual and gender minority identity, were less frequently addressed but highly salient to the speakers who mentioned them. We found that significantly co-occurring topics reflected not only conceptual similarity, such as terms for racial identities, but also intersectional significance, such as identifying as a Latina/Hispanic woman or Asian immigrant, and interactions between concerns and identities, including the heightened value of friendship to the LGBTQ community, which we reproduce using transcripts from an independent seminar series. Our approach to scholar profiles and talk transcripts serves as an example for transmuting hundreds of hours of scholarly discourse into rich datasets that can power computational audits of speaker diversity and illuminate speakers' personal and professional priorities.
    MeSH term(s) Female ; Humans ; Diversity, Equity, Inclusion ; Ethnicity ; Minority Groups ; Technology
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0293322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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