Article: ATF4 Expression in Thermogenic Adipocytes is Required for Cold-Induced Thermogenesis in Mice via FGF21-Independent Mechanisms.
bioRxiv : the preprint server for biology
2023
Abstract: In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for ... ...
| Abstract | In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is required for thermoregulation, partially via upregulation of FGF21. In the present study, we tested the hypothesis that |
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| Language | English |
| Publishing date | 2023-09-13 |
| Publishing country | United States |
| Document type | Preprint |
| DOI | 10.1101/2023.03.09.531964 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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