Article ; Online: Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8
2021 Volume 164, Issue 4, Page(s) 754–765
Abstract: The severity of lesions that develop in patients infected by Leishmania braziliensis is mainly associated with a highly cytotoxic and inflammatory cutaneous environment. Recently, we demonstrated that senescent T and NK cells play a role in the ... ...
| Abstract | The severity of lesions that develop in patients infected by Leishmania braziliensis is mainly associated with a highly cytotoxic and inflammatory cutaneous environment. Recently, we demonstrated that senescent T and NK cells play a role in the establishment and maintenance of this tissue inflammation. Here, we extended those findings using transcriptomic analyses that demonstrate a strong co-induction of senescence and pro-inflammatory gene signatures in cutaneous leishmaniasis (CL) lesions. The senescence-associated signature was characterized by marked expression of key genes such as ATM, Sestrin 2, p16, p21 and p38. The cell type identification from deconvolution of bulk sequencing data showed that the senescence signature was linked with CD8 |
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| MeSH term(s) | Biomarkers ; Biopsy ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Computational Biology/methods ; Cytokines/genetics ; Cytokines/metabolism ; Databases, Genetic ; Disease Susceptibility/immunology ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Immunosenescence/genetics ; Inflammation Mediators/metabolism ; Leishmania braziliensis/immunology ; Leishmaniasis, Cutaneous/etiology ; Leishmaniasis, Cutaneous/metabolism ; Leishmaniasis, Cutaneous/pathology ; Parasite Load ; Skin/pathology ; Transcriptome |
| Chemical Substances | Biomarkers ; Cytokines ; Inflammation Mediators |
| Language | English |
| Publishing date | 2021-09-01 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 80124-0 |
| ISSN | 1365-2567 ; 0019-2805 ; 0953-4954 |
| ISSN (online) | 1365-2567 |
| ISSN | 0019-2805 ; 0953-4954 |
| DOI | 10.1111/imm.13410 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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