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Article ; Online: IL-23 induces CLEC5A

Furuya, Hiroki / Nguyen, Cuong Thach / Chan, Trevor / Marusina, Alina I / Merleev, Alexander A / Garcia-Hernandez, Maria de la Luz / Hsieh, Shie-Liang / Tsokos, George C / Ritchlin, Christopher T / Tagkopoulos, Ilias / Maverakis, Emanual / Adamopoulos, Iannis E

Journal of autoimmunity

2024 Volume 143, Page(s) 103167

Abstract: IL-23-activation of IL-17 producing T cells is involved in many rheumatic diseases. Herein, we investigate the role of IL-23 in the activation of myeloid cell subsets that contribute to skin inflammation in mice and man. IL-23 gene transfer in WT, IL- ... ...

Abstract	IL-23-activation of IL-17 producing T cells is involved in many rheumatic diseases. Herein, we investigate the role of IL-23 in the activation of myeloid cell subsets that contribute to skin inflammation in mice and man. IL-23 gene transfer in WT, IL-23R
MeSH term(s)	Humans ; Arthritis, Psoriatic/pathology ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Neutrophils/metabolism ; Psoriasis ; Skin/pathology ; Dermatitis/pathology ; Inflammation ; Interleukin-23/genetics ; Interleukin-23/metabolism ; Receptors, Cell Surface/metabolism ; Lectins, C-Type/genetics
Chemical Substances	Interleukin-17 ; Interleukin-23 ; CLEC5A protein, human ; Receptors, Cell Surface ; Lectins, C-Type
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	639452-8
ISSN	1095-9157 ; 0896-8411
ISSN (online)	1095-9157
ISSN	0896-8411
DOI	10.1016/j.jaut.2024.103167
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Zs.A 2368: Show issues

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Article ; Online: Sodium-Glucose Cotransporter-2 Inhibitor, Empagliflozin, Suppresses the Inflammatory Immune Response to Influenza Infection.

Constantinesco, Nicholas J / Chinnappan, Baskaran / DeVito, Louis J / Moras, Crystal / Srikanth, Sashwath / Garcia-Hernandez, Maria de la Luz / Rangel-Moreno, Javier / Gopal, Radha

ImmunoHorizons

2023 Volume 7, Issue 12, Page(s) 861–871

Abstract: Influenza is a highly contagious, acute respiratory disease that causes significant public health and economic threats. Influenza infection induces various inflammatory mediators, IFNs, and recruitment of inflammatory cells in the host. This inflammatory ...

Abstract	Influenza is a highly contagious, acute respiratory disease that causes significant public health and economic threats. Influenza infection induces various inflammatory mediators, IFNs, and recruitment of inflammatory cells in the host. This inflammatory "cytokine storm" is thought to play a role in influenza-induced lung pathogenesis. Empagliflozin is a drug primarily used to lower blood glucose in type II diabetes patients by inhibiting the sodium-glucose cotransporter-2 (SGLT-2) found in the proximal tubules in the kidneys. In this study, we have investigated the effects of empagliflozin on the pulmonary immune response to influenza infection. C57BL/6 mice (wild type) were infected with influenza A/PR/8/34 and treated with empagliflozin, and the disease outcomes were analyzed. Empagliflozin treatment decreased the expression of the inflammatory cytokines IL-1β, IL-6, and CCL2; the percentage of inflammatory monocytes and inducible NO synthase-positive macrophages; and IFN response genes Stat1 and CXCL9 during influenza infection. Further, empagliflozin treatment decreases the expression of IL-6, CCL2, and CCL5 in RAW264.7 macrophages and bone marrow-derived macrophages. However, empagliflozin treatment increased influenza viral titer during infection. Despite fostering an increased viral burden, treatment with empagliflozin decreases the mortality in wild type and high fat diet-induced atherosclerotic LDLR-/- mice. Based on our findings, empagliflozin may have therapeutic implications for use in patients to prevent lung damage and acute respiratory illness.
MeSH term(s)	Humans ; Mice ; Animals ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Diabetes Mellitus, Type 2 ; Influenza, Human/drug therapy ; Interleukin-6 ; Mice, Inbred C57BL ; Blood Glucose ; Immunity ; Sodium/therapeutic use
Chemical Substances	empagliflozin (HDC1R2M35U) ; Sodium-Glucose Transporter 2 Inhibitors ; Interleukin-6 ; Blood Glucose ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ISSN	2573-7732
ISSN (online)	2573-7732
DOI	10.4049/immunohorizons.2300077
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Article ; Online: Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis.

Garcia-Hernandez, Maria de la Luz / Rangel-Moreno, Javier / Garcia-Castaneda, Maricela / Kenney, H Mark / Paine, Ananta / Thullen, Michael / Anandarajah, Allen P / Schwarz, Edward M / Dirksen, Robert T / Ritchlin, Christopher T

Frontiers in immunology

2022 Volume 13, Page(s) 1026574

Abstract: Objective: Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) is essential for the formation of fully functional multinucleated osteoclasts. DC-STAMP deficient mice, under physiological conditions, exhibit osteopetrosis and develop systemic ... ...

Abstract	Objective: Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) is essential for the formation of fully functional multinucleated osteoclasts. DC-STAMP deficient mice, under physiological conditions, exhibit osteopetrosis and develop systemic autoimmunity with age. However, the function of DC-STAMP in inflammation is currently unknown. We examined whether genetic ablation of DC-STAMP attenuates synovitis and bone erosion in TNF transgenic (Tg) and K/BxN serum-induced murine rheumatoid arthritis. Methods: We evaluated arthritis onset in Tg(hTNF) mice lacking DC-STAMP and 50:50 chimeric mice by visual examination, measurement of ankle width, micro-CT-scan analysis and quantitation of the area occupied by osteoclasts in bone sections. To further investigate the cellular and molecular events modulated by DC-STAMP, we measured serum cytokines, determined changes in cytokine mRNA expression by monocytes activated with IL4 or LPS/IFNγ and enumerated immune cells in inflamed mouse joints. Results: Synovitis, bone loss and matrix destruction are markedly reduced in Dcstamp Conclusion: These results reveal that DC-STAMP modulates both bone resorption and inflammation and may serve as an activity biomarker and therapeutic target in inflammatory arthritis and metabolic bone disease.
MeSH term(s)	Animals ; Mice ; Membrane Proteins/metabolism ; Bone Resorption/metabolism ; Synovitis ; Arthritis, Rheumatoid/metabolism ; Dendritic Cells/metabolism ; Inflammation ; Cytokines
Chemical Substances	Membrane Proteins ; Cytokines
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1026574
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Article ; Online: Inducible Bronchus-Associated Lymphoid Tissue (iBALT) Attenuates Pulmonary Pathology in a Mouse Model of Allergic Airway Disease.

Hwang, Ji Young / Silva-Sanchez, Aaron / Carragher, Damian M / Garcia-Hernandez, Maria de la Luz / Rangel-Moreno, Javier / Randall, Troy D

Frontiers in immunology

2020 Volume 11, Page(s) 570661

Abstract: Inducible Bronchus Associated Lymphoid Tissue (iBALT) is an ectopic lymphoid tissue associated with severe forms of chronic lung diseases, including chronic obstructive pulmonary disease, rheumatoid lung disease, hypersensitivity pneumonitis and asthma, ... ...

Abstract	Inducible Bronchus Associated Lymphoid Tissue (iBALT) is an ectopic lymphoid tissue associated with severe forms of chronic lung diseases, including chronic obstructive pulmonary disease, rheumatoid lung disease, hypersensitivity pneumonitis and asthma, suggesting that iBALT may exacerbate these clinical conditions. However, despite the link between pulmonary pathology and iBALT formation, the role of iBALT in pathogenesis remains unknown. Here we tested whether the presence of iBALT in the lung prior to sensitization and challenge with a pulmonary allergen altered the biological outcome of disease. We found that the presence of iBALT did not exacerbate Th2 responses to pulmonary sensitization with ovalbumin. Instead, we found that mice with iBALT exhibited delayed Th2 accumulation in the lung, reduced eosinophil recruitment, reduced goblet cell hyperplasia and reduced mucus production. The presence of iBALT did not alter Th2 priming, but instead delayed the accumulation of Th2 cells in the lung following challenge and altered the spatial distribution of T cells in the lung. These results suggest that the formation of iBALT and sequestration of effector T cells in the context of chronic pulmonary inflammation may be a mechanism by which the immune system attenuates pulmonary inflammation and prevents excessive pathology.
MeSH term(s)	Animals ; Bronchi/immunology ; Disease Models, Animal ; Humans ; Hypersensitivity/immunology ; Immunity, Mucosal ; Inflammation/immunology ; Lung/immunology ; Lymphocyte Activation ; Lymphoid Tissue/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Respiratory System/immunology ; Th2 Cells/immunology
Keywords	covid19
Language	English
Publishing date	2020-09-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.570661
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Article ; Online: Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth.

Taya, Manisha / Garcia-Hernandez, Maria de la Luz / Rangel-Moreno, Javier / Minor, Briaunna / Gibbons, Erin / Hammes, Stephen R

Endocrine-related cancer

2020 Volume 27, Issue 4, Page(s) 261–274

Abstract: Chronic inflammation promotes progression of many cancers, with circulating myeloid-derived suppressor cell (MDSC) levels correlating with poor prognosis. Here we examine effects of MDSCs on lymphangioleiomyomatosis (LAM), a rare disease occurring almost ...

Abstract	Chronic inflammation promotes progression of many cancers, with circulating myeloid-derived suppressor cell (MDSC) levels correlating with poor prognosis. Here we examine effects of MDSCs on lymphangioleiomyomatosis (LAM), a rare disease occurring almost exclusively in women whereby estrogen-sensitive metastatic TSC2-null tumors grow throughout the lungs, markedly reducing pulmonary function. The LAM cell origin remains unknown; however, previous work demonstrated that Tsc2 inactivation in the mouse uterus induced estrogen-dependent myometrial tumors with nearly all features of LAM. Half of these animals developed metastatic myometrial tumors in the lungs, suggesting that LAM cells might originate from the myometrium, possibly explaining its overwhelming female prevalence and estrogen-sensitivity. Here we report that MDSC levels, and in particular granulocytic myeloid cell levels, are elevated in the periphery and in tumors of uterine-specific Tsc2-null mice. Importantly, MDSC depletion or inhibition of their recruitment impairs myometrial tumor growth. RNA and protein analysis of Tsc2-null myometrial tumors and xenografts demonstrate high expression and activity of the serine protease neutrophil elastase (NE), with selective qPCR studies indicating a stromal origin of the NE. Notably, treatment with sivelestat, a known NE inhibitor already approved for human use in some countries, reduces tumor growth similar to MDSC depletion. Furthermore, NE promotes Tsc2-null tumor cell growth, migration, and invasion in vitro. Finally, NE-expressing myeloid cells are present throughout the lungs of LAM patients but not controls. These data suggest that NE derived from granulocytic myeloid cells might directly promote LAM tumor cell progression and could be a novel therapeutic target for LAM.
MeSH term(s)	Animals ; Cell Proliferation ; Humans ; Leukocyte Elastase/metabolism ; Lymphangioleiomyomatosis/metabolism ; Mice ; Myeloid Cells/metabolism ; Rats ; Tuberous Sclerosis Complex 2 Protein/genetics
Chemical Substances	Tuberous Sclerosis Complex 2 Protein ; Leukocyte Elastase (EC 3.4.21.37)
Language	English
Publishing date	2020-01-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1218450-0
ISSN	1479-6821 ; 1351-0088
ISSN (online)	1479-6821
ISSN	1351-0088
DOI	10.1530/ERC-19-0431
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Zs.A 4192: Show issues

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Article ; Online: Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems.

Castillo, Rochelle L / Sidhu, Ikjot / Dolgalev, Igor / Chu, Tinyi / Prystupa, Aleksandr / Subudhi, Ipsita / Yan, Di / Konieczny, Piotr / Hsieh, Brandon / Haberman, Rebecca H / Selvaraj, Shanmugapriya / Shiomi, Tomoe / Medina, Rhina / Girija, Parvathy Vasudevanpillai / Heguy, Adriana / Loomis, Cynthia A / Chiriboga, Luis / Ritchlin, Christopher / Garcia-Hernandez, Maria De La Luz /

Carucci, John / Meehan, Shane A / Neimann, Andrea L / Gudjonsson, Johann E / Scher, Jose U / Naik, Shruti

Science immunology

2023 Volume 8, Issue 84, Page(s) eabq7991

Abstract: Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context and systemic impact remain poorly understood. We thus profiled human psoriasis (PsO) as a prototypic immune-mediated condition ... ...

Abstract	Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context and systemic impact remain poorly understood. We thus profiled human psoriasis (PsO) as a prototypic immune-mediated condition with a high predilection for extracutaneous involvement. Spatial transcriptomics (ST) analyses of 25 healthy, active lesion, and clinically uninvolved skin biopsies and integration with public single-cell transcriptomics data revealed marked differences in immune microniches between healthy and inflamed skin. Tissue-scale cartography further identified core disease features across all active lesions, including the emergence of an inflamed suprabasal epidermal state and the presence of B lymphocytes in lesional skin. Both lesional and distal nonlesional samples were stratified by skin disease severity and not by the presence of systemic disease. This segregation was driven by macrophage-, fibroblast-, and lymphatic-enriched spatial regions with gene signatures associated with metabolic dysfunction. Together, these findings suggest that mild and severe forms of PsO have distinct molecular features and that severe PsO may profoundly alter the cellular and metabolic composition of distal unaffected skin sites. In addition, our study provides a valuable resource for the research community to study spatial gene organization of healthy and inflamed human skin.
MeSH term(s)	Humans ; Ecosystem ; Transcriptome ; Skin/pathology ; Psoriasis/genetics ; Patient Acuity
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.abq7991
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Article ; Online: Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control.

Nature immunology

2023 Volume 24, Issue 5, Page(s) 855–868

Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global cause of death. Granuloma-associated lymphoid tissue (GrALT) correlates with protection during TB, but the mechanisms of protection are not understood. During TB, the ... ...

Abstract	Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global cause of death. Granuloma-associated lymphoid tissue (GrALT) correlates with protection during TB, but the mechanisms of protection are not understood. During TB, the transcription factor IRF4 in T cells but not B cells is required for the generation of the T
MeSH term(s)	Mice ; Animals ; Mycobacterium tuberculosis ; T-Lymphocytes, Helper-Inducer ; B-Lymphocytes ; Lymphoid Tissue ; Germinal Center ; Transcription Factors ; Tuberculosis
Chemical Substances	Transcription Factors
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01476-3
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article ; Online: Bi-Reporter Vaccinia Virus for Tracking Viral Infections

Chiem, Kevin / Lorenzo, Maria M / Rangel-Moreno, Javier / Garcia-Hernandez, Maria De La Luz / Park, Jun-Gyu / Nogales, Aitor / Blasco, Rafael / Martínez-Sobrido, Luis

Microbiology spectrum

2021 Volume 9, Issue 3, Page(s) e0160121

Abstract: Recombinant viruses expressing reporter genes allow visualization and quantification of viral infections and can be used as valid surrogates to identify the presence of the virus in infected cells and animal models. However, one of the limitations of ... ...

Abstract	Recombinant viruses expressing reporter genes allow visualization and quantification of viral infections and can be used as valid surrogates to identify the presence of the virus in infected cells and animal models. However, one of the limitations of recombinant viruses expressing reporter genes is the use of either fluorescent or luciferase proteins that are used alternatively for different purposes. Vaccinia virus (VV) is widely used as a viral vector, including recombinant (r)VV singly expressing either fluorescent or luciferase reporter genes that are useful for specific purposes. In this report, we engineered two novel rVV stably expressing both fluorescent (Scarlet or GFP) and luciferase (Nluc) reporter genes from different loci in the viral genome.
MeSH term(s)	Animals ; Cell Line ; Female ; Fluorescence ; Gene Expression ; Genes, Reporter ; Genome, Viral ; Humans ; In Vitro Techniques ; Lung/diagnostic imaging ; Lung/pathology ; Mice ; Mice, Inbred BALB C ; Staining and Labeling ; Vaccines, Synthetic ; Vaccinia virus/genetics ; Virus Diseases/pathology ; Virus Diseases/prevention & control ; Virus Replication
Chemical Substances	Vaccines, Synthetic
Language	English
Publishing date	2021-11-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/Spectrum.01601-21
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Article ; Online: Small Molecule Inhibitors of Nuclear Export and the Amelioration of Lupus by Modulation of Plasma Cell Generation and Survival.

Rangel-Moreno, Javier / Garcia-Hernandez, Maria de la Luz / Owen, Teresa / Barnard, Jennifer / Becerril-Villanueva, Enrique / Kashyap, Trinayan / Argueta, Christian / Gamboa-Dominguez, Armando / Tamir, Sharon / Landesman, Yosef / Goldman, Bruce I / Ritchlin, Christopher T / Anolik, Jennifer H

Arthritis & rheumatology (Hoboken, N.J.)

2022 Volume 74, Issue 8, Page(s) 1363–1375

Abstract: Objective: To investigate the hypothesis that selective inhibitors of nuclear export (SINE compounds), recently approved for treatment of refractory plasma cell (PC) malignancy, may have potential in the treatment of lupus.: Methods: Female NZB/NZW ... ...

Abstract	Objective: To investigate the hypothesis that selective inhibitors of nuclear export (SINE compounds), recently approved for treatment of refractory plasma cell (PC) malignancy, may have potential in the treatment of lupus. Methods: Female NZB/NZW mice were treated with the SINE compound KPT-350 or vehicle control. Tissue specimens were harvested and analyzed by flow cytometry, using standard markers. Nephritis was monitored by determining the proteinuria score and by histologic analysis of kidney specimens. Serum anti-double-stranded DNA (anti-dsDNA) levels were measured by enzyme-linked immunosorbent assay, and total numbers of IgG-secreting and dsDNA-specific antibody-secreting cells were assessed by enzyme-linked immunospot assay. Results: KPT-350 abrogated murine lupus nephritis at both early and late stages of the disease and rapidly impaired generation of autoreactive PCs in germinal centers (GCs). SINE compounds inhibited the production of NF-κB-driven homeostatic chemokines by stromal cells, altering splenic B and T cell strategic positioning and significantly reducing follicular helper T cell, GC B cell, and autoreactive PC counts. KPT-350 also decreased levels of cytokines and chemokines involved in PC survival and recruitment in the kidney of lupus-prone mice. Exportin 1, the target of SINE compounds, was detected in GCs of human tonsils, splenic B cells of lupus patients, and multiple B cell subsets in the kidneys of patients with lupus nephritis. Conclusion: Collectively, our results provide support for the therapeutic potential of SINE compounds, via their targeting of several molecular and cellular pathways critical in lupus pathogenesis, including autoantibody production by plasma cells.
MeSH term(s)	Active Transport, Cell Nucleus ; Animals ; Autoantibodies ; Disease Models, Animal ; Enzyme-Linked Immunospot Assay ; Female ; Humans ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Nephritis ; Mice ; Mice, Inbred NZB ; Plasma Cells
Chemical Substances	Autoantibodies
Language	English
Publishing date	2022-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42128
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Article: A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.

García-Hernández, María de la Luz / Uribe-Uribe, Norma Ofelia / Espinosa-González, Ricardo / Kast, W Martin / Khader, Shabaana A / Rangel-Moreno, Javier

Frontiers in immunology

2017 Volume 8, Page(s) 563

Abstract: Objective: Multiple solid cancers contain tertiary lymphoid organs (TLO). However, it is unclear whether they promote tumor rejection, facilitate tumor evasion, or simply whether they are a byproduct of chronic inflammation. We hypothesize that although ...

Abstract	Objective: Multiple solid cancers contain tertiary lymphoid organs (TLO). However, it is unclear whether they promote tumor rejection, facilitate tumor evasion, or simply whether they are a byproduct of chronic inflammation. We hypothesize that although chronic inflammation induces TLO formation, the tumor milieu can modulate TLO organization and functions in prostate cancer. Therefore, our study seeks to elucidate the cellular and molecular signatures in unique prostatectomy specimens from evanescent carcinoma patients to identify markers of cancer regression, which could be harnessed to modulate local immunosuppression or potentially enhance TLO function. Methods: We used multicolor immunofluorescence to stain prostate tissues, collected at different stages of cancer progression (prostatic intraepithelial neoplasia, intermediate and advanced cancer) or from patients with evanescent prostate carcinoma. Tissues were stained with antibodies specific for pro-inflammatory molecules (cyclooxygenase 2, CXCL10, IL17), tumor-infiltrating immune cells (mature DC-LAMP Results: Generally, inflammatory cells are located at the margins of tumors. Unexpectedly, we found TLO within prostate tumors from patients at different stages of cancer and in unique samples from patients with spontaneous cancer remission. In evanescent prostate carcinomas, accumulation of Treg was compromised, while Tbet Conclusion: Collectively, our results suggest that COX2 and Treg are attractive therapeutic targets that can be harnessed to enhance TLO-driven tumor immunity against prostate cancer. Specially, the presence of HEV and lymphatics indicate that TLO can be used as a platform for delivery of cell-based and/or COX2 blocking therapies to improve control of tumor growth in prostate cancer.
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.00563
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