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  1. Article: Migratory intestinal stenosis by primary intestinal amyloidosis. A case report.

    Garcia-Sagué, Belén / Casalots, Alejandro / Cano, Carlota / Feijoo, Carlos / Piernas, Sonia / Brunet-Mas, Eduard

    Gastroenterologia y hepatologia

    2022  Volume 46, Issue 3, Page(s) 196–197

    MeSH term(s) Humans ; Constriction, Pathologic ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intestines ; Amyloidosis/complications ; Amyloidosis/diagnosis
    Language Spanish
    Publishing date 2022-06-07
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2022.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Economic impact of inflammatory bowel disease in Catalonia: a population-based analysis.

    Brunet-Mas, Eduard / Garcia-Sagué, Belen / Vela, Emli / Melcarne, Luigi / Llovet, Laura Patricia / Pontes, Caridad / García-Iglesias, Pilar / Puy, Anna / Lario, Sergio / Ramirez-Lazaro, Maria Jose / Villoria, Albert / Burisch, Johan / Kaplan, Gilaad G / Calvet, Xavier

    Therapeutic advances in gastroenterology

    2024  Volume 17, Page(s) 17562848231222344

    Abstract: Background: Inflammatory bowel disease (IBD) has a major economic impact on healthcare costs.: Objectives: The aim of this study was to evaluate the current healthcare expenditure associated with IBD in a population-wide study in Catalonia.: Design! ...

    Abstract Background: Inflammatory bowel disease (IBD) has a major economic impact on healthcare costs.
    Objectives: The aim of this study was to evaluate the current healthcare expenditure associated with IBD in a population-wide study in Catalonia.
    Design: Retrospective observational study.
    Methods: All patients with IBD included in the Catalan Health Surveillance System (CHSS) were considered eligible. The CHSS compiles data on more than 7 million individuals in 2020 (34,823 with IBD). Data on the use of healthcare resources and its economic impact were extracted applying the International Classification of Diseases, 10th revision, Clinical Modification codes (ICD-10-CM codes). Health expenditure, comorbidities, and hospitalization were calculated according to the standard costs of each service provided by the Department of Health of the Catalan government. The data on the IBD population were compared with non-IBD population adjusted for age, sex, and income level. IBD costs were recorded separately for Crohn's disease (CD) and ulcerative colitis (UC).
    Results: Prevalence of comorbidities was higher in patients with IBD than in those without. The risk of hospitalization was twice as high in the IBD population. The overall healthcare expenditure on IBD patients amounted to 164M€. The pharmacy cost represents the 60%. The average annual per capita expenditure on IBD patients was more than 3.4-fold higher (IBD 4200€, non-IBD 1200€). Average costs of UC were 3400€ and 5700€ for CD.
    Conclusion: The risk of comorbidities was twice as high in patients with IBD and their use of healthcare resources was also higher than that of their non-IBD counterparts. Per capita healthcare expenditure was approximately 3.4 times higher in the population with IBD.
    Trial registration: The study was not previously registered.
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848231222344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Incidence of Myelotoxicity and Other Adverse Effects Related to Thiopurine Starting in Patients with Inflammatory Bowel Disease: Retrospective Observational Study in a Third-Level Hospital.

    Grau, Gerard / Brunet-Mas, Eduard / Llovet, Laura Patricia / Pedregal, Patricia / Villoria, Albert / Melcarne, Luigi / Puy, Anna / Garcia-Sague, Belen / Frisancho, Luis Enrique / Ramírez-Lázaro, María José / Lario, Sergio / Calvet, Xavier

    Journal of clinical medicine

    2023  Volume 12, Issue 20

    Abstract: Background and objectives: Thiopurines are an effective treatment for the maintenance of remission in inflammatory bowel disease (IBD). They can present adverse effects (AEs), with myelotoxicity being the most relevant. This study aims to determine the ... ...

    Abstract Background and objectives: Thiopurines are an effective treatment for the maintenance of remission in inflammatory bowel disease (IBD). They can present adverse effects (AEs), with myelotoxicity being the most relevant. This study aims to determine the incidence of AEs related to the starting of thiopurines in our centre.
    Methodology: Retrospective study. The AEs in patients that were started on thiopurines between January 2016 and June 2020 were registered, with a two-year follow-up. The mean and standard deviation were used to describe the quantitative variables, and percentages and confidence intervals were used for the qualitative variables. The statistical significance was set at a
    Results: 98 patients were included, with 64 AEs detected in 48 patients (49%). Most of the AEs appeared in the first 6 months. The most relevant were: 21 neutropenia (21.4%), 19 hypertransaminasemia (19.4%), 13 digestive intolerances (13.2%), 6 acute pancreatitis (6.12%), 3 phototoxicity (3%), and 2 unknown origin fevers (2%). In 29 patients (29.4%) the treatment had to be suspended due to AEs. In 11 cases (11.2%), azathioprine (AZA) was switched to 6-mercaptopurine (6 MP) as 5 showed tolerance and 6 patients needed suspension due to AEs. Eight patients required hospital admission, but none of them needed intensive care unit admission. There were no fatal adverse effects.
    Conclusions: Thiopurines are a safe drug with few AEs, especially after the first months of treatment. These results suggest that periodic analytic follow-up may not be necessary after the initial period of treatment.
    Language English
    Publishing date 2023-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12206571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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