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  1. Article ; Online: mTOR Signaling: Recent Progress.

    Gargalionis, Antonios N / Papavassiliou, Kostas A / Papavassiliou, Athanasios G

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: In the intricate landscape of human biology, the mechanistic target of rapamycin (mTOR) emerges as a key regulator, orchestrating a vast array of processes in health and disease [ ... ]. ...

    Abstract In the intricate landscape of human biology, the mechanistic target of rapamycin (mTOR) emerges as a key regulator, orchestrating a vast array of processes in health and disease [...].
    MeSH term(s) Humans ; Signal Transduction ; TOR Serine-Threonine Kinases
    Chemical Substances TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mechanotransduction Circuits in Human Pathobiology.

    Gargalionis, Antonios N / Papavassiliou, Kostas A / Papavassiliou, Athanasios G

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: It is widely acknowledged that mechanical forces exerted throughout the human body are critical for cellular and tissue homeostasis [ ... ]. ...

    Abstract It is widely acknowledged that mechanical forces exerted throughout the human body are critical for cellular and tissue homeostasis [...].
    MeSH term(s) Humans ; Mechanotransduction, Cellular
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Implication of mTOR Signaling in NSCLC: Mechanisms and Therapeutic Perspectives.

    Gargalionis, Antonios N / Papavassiliou, Kostas A / Papavassiliou, Athanasios G

    Cells

    2023  Volume 12, Issue 15

    Abstract: Mechanistic target of the rapamycin (mTOR) signaling pathway represents a central cellular kinase that controls cell survival and metabolism. Increased mTOR activation, along with upregulation of respective upstream and downstream signaling components, ... ...

    Abstract Mechanistic target of the rapamycin (mTOR) signaling pathway represents a central cellular kinase that controls cell survival and metabolism. Increased mTOR activation, along with upregulation of respective upstream and downstream signaling components, have been established as oncogenic features in cancer cells in various tumor types. Nevertheless, mTOR pathway therapeutic targeting has been proven to be quite challenging in various clinical settings. Non-small cell lung cancer (NSCLC) is a frequent type of solid tumor in both genders, where aberrant regulation of the mTOR pathway contributes to the development of oncogenesis, apoptosis resistance, angiogenesis, cancer progression, and metastasis. In this context, the outcome of mTOR pathway targeting in clinical trials still demonstrates unsatisfactory results. Herewith, we discuss recent findings regarding the mechanisms and therapeutic targeting of mTOR signaling networks in NSCLC, as well as future perspectives for the efficient application of treatments against mTOR and related protein molecules.
    MeSH term(s) Female ; Humans ; Male ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Sirolimus ; Lung Neoplasms/pathology ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Chemical Substances Sirolimus (W36ZG6FT64) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12152014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exosomes as Novel Diagnostic Biomarkers and Therapeutic Tools in Gliomas.

    Skouras, Panagiotis / Gargalionis, Antonios N / Piperi, Christina

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: Exosomes constitute small extracellular vesicles that contain lipids, proteins, nucleic acids, and glycoconjugates from the secreted cells and are capable of transmitting signals between cells and coordinating cellular communication. By this means, they ... ...

    Abstract Exosomes constitute small extracellular vesicles that contain lipids, proteins, nucleic acids, and glycoconjugates from the secreted cells and are capable of transmitting signals between cells and coordinating cellular communication. By this means, they are ultimately involved in physiology and disease, including development, homeostasis, and immune system regulation, as well as contributing to tumor progression and neurodegenerative diseases pathology. Recent studies have shown that gliomas secrete a panel of exosomes which have been associated with cell invasion and migration, tumor immune tolerance, potential for malignant transformation, neovascularization, and resistance to treatment. Exosomes have therefore emerged as intercellular communicators, which mediate the tumor-microenvironment interactions and exosome-regulated glioma cell stemness and angiogenesis. They may induce tumor proliferation and malignancy in normal cells by carrying pro-migratory modulators from cancer cells as well as many different molecular cancer modifiers, such as oncogenic transcripts, miRNAs, mutant oncoproteins, etc., which promote the communication of cancer cells with the surrounding stromal cells and provide valuable information on the molecular profile of the existing tumor. Moreover, engineered exosomes can provide an alternative system for drug delivery and enable efficient treatment. In the present review, we discuss the latest findings regarding the role of exosomes in glioma pathogenesis, their utility in non-invasive diagnosis, and potential applications to treatment.
    MeSH term(s) Humans ; Exosomes/metabolism ; Glioma/diagnosis ; Glioma/therapy ; Glioma/metabolism ; Neoplasms/pathology ; Extracellular Vesicles/metabolism ; Cell Communication/physiology ; Biomarkers/metabolism ; Tumor Microenvironment/physiology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241210162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting the YAP/TAZ mechanotransducers in solid tumour therapeutics.

    Gargalionis, Antonios N / Papavassiliou, Kostas A / Papavassiliou, Athanasios G

    Journal of cellular and molecular medicine

    2023  Volume 27, Issue 13, Page(s) 1911–1914

    MeSH term(s) Humans ; Adaptor Proteins, Signal Transducing/metabolism ; Neoplasms/drug therapy ; Neoplasms/pathology ; Phosphoproteins/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Phosphoproteins
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Are YAP and TAZ valid prognostic signatures for NSCLC patients?

    Gargalionis, Antonios N / Papavassiliou, Kostas A / Papavassiliou, Athanasios G

    Journal of cellular and molecular medicine

    2023  Volume 28, Issue 2, Page(s) e17992

    MeSH term(s) Humans ; Prognosis ; Adaptor Proteins, Signal Transducing/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/genetics ; Phosphoproteins/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Transcription Factors ; Phosphoproteins
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Letter
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The potential of BRD4 inhibition in tumour mechanosignaling.

    Gargalionis, Antonios N / Papavassiliou, Kostas A / Papavassiliou, Athanasios G

    Journal of cellular and molecular medicine

    2023  Volume 27, Issue 24, Page(s) 4215–4218

    MeSH term(s) Humans ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Nuclear Proteins/genetics ; Neoplasms/drug therapy ; Adaptor Proteins, Signal Transducing/metabolism ; Phosphoproteins/metabolism ; Bromodomain Containing Proteins ; Cell Cycle Proteins/genetics
    Chemical Substances Transcription Factors ; Nuclear Proteins ; Adaptor Proteins, Signal Transducing ; Phosphoproteins ; BRD4 protein, human ; Bromodomain Containing Proteins ; Cell Cycle Proteins
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.18057
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Polycystins, mechanotransduction and cancer development.

    Papavassiliou, Kostas A / Gargalionis, Antonios N / Papavassiliou, Athanasios G

    Journal of cellular and molecular medicine

    2022  Volume 26, Issue 9, Page(s) 2741–2743

    MeSH term(s) Female ; Humans ; Male ; Mechanotransduction, Cellular/physiology ; Neoplasms/genetics ; Polycystic Kidney Diseases ; TRPP Cation Channels/genetics ; TRPP Cation Channels/metabolism
    Chemical Substances TRPP Cation Channels
    Language English
    Publishing date 2022-04-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17298
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Mechanobiology of solid tumors.

    Gargalionis, Antonios N / Papavassiliou, Kostas A / Papavassiliou, Athanasios G

    Biochimica et biophysica acta. Molecular basis of disease

    2022  Volume 1868, Issue 12, Page(s) 166555

    Abstract: Mechanical features of cancer cells emerge as a distinct trait during development and progression of solid tumors. Herein, we discuss recent key findings regarding the impact of various types of mechanical stresses on cancer cell properties. Data suggest ...

    Abstract Mechanical features of cancer cells emerge as a distinct trait during development and progression of solid tumors. Herein, we discuss recent key findings regarding the impact of various types of mechanical stresses on cancer cell properties. Data suggest that different mechanical forces, alterations of matrix rigidity and tumor microenvironment facilitate cancer hallmarks, especially invasion and metastasis. Moreover, a subset of mechanosensory proteins are responsible for mediating mechanically induced oncogenic signaling and response to chemotherapy. Delineating cancer dynamics and decoding of respective signal transduction mechanisms will provide new therapeutic strategies against solid tumors in the future.
    MeSH term(s) Biophysics ; Extracellular Matrix/metabolism ; Humans ; Neoplasms/pathology ; Stress, Mechanical ; Tumor Microenvironment
    Language English
    Publishing date 2022-09-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2022.166555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
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  10. Article ; Online: mTOR Signaling Components in Tumor Mechanobiology.

    Gargalionis, Antonios N / Papavassiliou, Kostas A / Basdra, Efthimia K / Papavassiliou, Athanasios G

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Mechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase, along with its upstream regulators and downstream substrates, is ... ...

    Abstract Mechanistic target of rapamycin (mTOR) is a central signaling hub that integrates networks of nutrient availability, cellular metabolism, and autophagy in eukaryotic cells. mTOR kinase, along with its upstream regulators and downstream substrates, is upregulated in most human malignancies. At the same time, mechanical forces from the tumor microenvironment and mechanotransduction promote cancer cells' proliferation, motility, and invasion. mTOR signaling pathway has been recently found on the crossroads of mechanoresponsive-induced signaling cascades to regulate cell growth, invasion, and metastasis in cancer cells. In this review, we examine the emerging association of mTOR signaling components with certain protein tools of tumor mechanobiology. Thereby, we highlight novel mechanisms of mechanotransduction, which regulate tumor progression and invasion, as well as mechanisms related to the therapeutic efficacy of antitumor drugs.
    MeSH term(s) Cell Proliferation ; Humans ; Mechanotransduction, Cellular ; Neoplasms ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; Tumor Microenvironment
    Chemical Substances MTOR protein, human (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-02-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031825
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