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  1. Article ; Online: Impact of Time to Intervention on Catheter-Directed Therapy for Pulmonary Embolism.

    Lehr, Andrew / Guichet, Phillip / Garimella, Bhaskara / Krolikowski, Kelsey / Amoroso, Nancy / Sista, Akhilesh / Brosnahan, Shari B

    Critical care explorations

    2023  Volume 5, Issue 1, Page(s) e0828

    Abstract: Cather-directed therapies (CDTs) are an evolving therapeutic option for patients with intermediate-risk pulmonary embolism (PE). Although many techniques have been studied, there is limited evidence for the impact of timing of intervention on patient ... ...

    Abstract Cather-directed therapies (CDTs) are an evolving therapeutic option for patients with intermediate-risk pulmonary embolism (PE). Although many techniques have been studied, there is limited evidence for the impact of timing of intervention on patient outcomes. Our objective was to assess the association between time to CDT in patients presenting with PE on patient-related outcomes such as length of stay (LOS) and mortality.
    Design: Retrospective cohort study.
    Setting: Single academic center.
    Patients: We identified patients for which the PE response team had been activated from January 2014 to October 2021. Patients were split into two cohorts depending on whether they went to CDT less than 24 hours from admission (early) versus greater than 24 hours (late).
    Interventions: None.
    Measurements and main results: Data on demographics, timing of interventions, pulmonary hemodynamics, and outcomes were collected. Sixty-four patients were included in analysis. Thirty-nine (63.8%) underwent their procedure less than 24 hours from admission, whereas 25 (36.2%) underwent the procedure after 24 hours. The time from admission to CDT was 15.9 hours (9.1-20.3 hr) in the early group versus 33.4 (27.9-41) in the late group (
    Conclusions: Patients who underwent CDT within 24 hours of admission were more likely to have shorter hospital and ICU LOS. The magnitude of change in LOS between the two cohorts was not fully explained by the difference in time to CDT. There were modest improvements in pulmonary hemodynamics in the patients who underwent CDT earlier.
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structural Modifications in Epitaxial Graphene on SiC Following 10 keV Nitrogen Ion Implantation

    Priya Darshni Kaushik / Gholam Reza Yazdi / Garimella Bhaskara Venkata Subba Lakshmi / Grzegorz Greczynski / Rositsa Yakimova / Mikael Syväjärvi

    Applied Sciences, Vol 10, Iss 4013, p

    2020  Volume 4013

    Abstract: Modification of epitaxial graphene on silicon carbide (EG/SiC) was explored by ion implantation using 10 keV nitrogen ions. Fragments of monolayer graphene along with nanostructures were observed following nitrogen ion implantation. At the initial ... ...

    Abstract Modification of epitaxial graphene on silicon carbide (EG/SiC) was explored by ion implantation using 10 keV nitrogen ions. Fragments of monolayer graphene along with nanostructures were observed following nitrogen ion implantation. At the initial fluence, sp 3 defects appeared in EG; higher fluences resulted in vacancy defects as well as in an increased defect density. The increased fluence created a decrease in the intensity of the prominent peak of SiC as well as of the overall relative Raman intensity. The X-ray photoelectron spectroscopy (XPS) showed a reduction of the peak intensity of graphitic carbon and silicon carbide as a result of ion implantation. The dopant concentration and level of defects could be controlled both in EG and SiC by the fluence. This provided an opportunity to explore EG/SiC as a platform using ion implantation to control defects, and to be applied for fabricating sensitive sensors and nanoelectronics devices with high performance.
    Keywords ion implantation ; Raman ; AFM ; XPS ; graphene ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 530
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Inhaled pulmonary vasodilators are not associated with improved gas exchange in mechanically ventilated patients with COVID-19: A retrospective cohort study.

    Lubinsky, Anthony Steven / Brosnahan, Shari B / Lehr, Andrew / Elnadoury, Ola / Hagedorn, Jacklyn / Garimella, Bhaskara / Bender, Michael T / Amoroso, Nancy / Artigas, Antonio / Bos, Lieuwe D J / Kaufman, David

    Journal of critical care

    2022  Volume 69, Page(s) 153990

    Abstract: Purpose: Measure the effect of inhaled pulmonary vasodilators on gas exchange in mechanically ventilated patients with COVID-19.: Methods: A retrospective observational cohort study at three New York University Hospitals was performed including ... ...

    Abstract Purpose: Measure the effect of inhaled pulmonary vasodilators on gas exchange in mechanically ventilated patients with COVID-19.
    Methods: A retrospective observational cohort study at three New York University Hospitals was performed including eighty-four mechanically ventilated SARS Cov-2 nasopharyngeal PCR positive patients, sixty nine treated with inhaled nitric oxide (iNO) and fifteen with inhaled epoprostenol (iEPO). The primary outcomes were change in P
    Results: There was no significant change in P
    Conclusion: Inhaled pulmonary vasodilators were not associated with significant improvement in gas exchange in mechanically ventilated patients with COVID-19.
    MeSH term(s) Administration, Inhalation ; COVID-19/drug therapy ; Epoprostenol ; Humans ; Nitric Oxide ; Pulmonary Gas Exchange ; Respiration, Artificial ; Retrospective Studies ; Vasodilator Agents/therapeutic use
    Chemical Substances Vasodilator Agents ; Nitric Oxide (31C4KY9ESH) ; Epoprostenol (DCR9Z582X0)
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2022.153990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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