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  1. Article ; Online: A cortical circuit for audio-visual predictions.

    Garner, Aleena R / Keller, Georg B

    Nature neuroscience

    2021  Volume 25, Issue 1, Page(s) 98–105

    Abstract: Learned associations between stimuli in different sensory modalities can shape the way we perceive these stimuli. However, it is not well understood how these interactions are mediated or at what level of the processing hierarchy they occur. Here we ... ...

    Abstract Learned associations between stimuli in different sensory modalities can shape the way we perceive these stimuli. However, it is not well understood how these interactions are mediated or at what level of the processing hierarchy they occur. Here we describe a neural mechanism by which an auditory input can shape visual representations of behaviorally relevant stimuli through direct interactions between auditory and visual cortices in mice. We show that the association of an auditory stimulus with a visual stimulus in a behaviorally relevant context leads to experience-dependent suppression of visual responses in primary visual cortex (V1). Auditory cortex axons carry a mixture of auditory and retinotopically matched visual input to V1, and optogenetic stimulation of these axons selectively suppresses V1 neurons that are responsive to the associated visual stimulus after, but not before, learning. Our results suggest that cross-modal associations can be communicated by long-range cortical connections and that, with learning, these cross-modal connections function to suppress responses to predictable input.
    MeSH term(s) Acoustic Stimulation ; Animals ; Auditory Cortex/physiology ; Learning ; Mice ; Photic Stimulation ; Visual Cortex/physiology
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-021-00974-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Generation of a Synthetic Memory Trace

    Garner, Aleena R / Bryan L. Roth / Cliff Kentros / David C. Rowland / Karsten Baumgaertel / Mark Mayford / Sang Youl Hwang

    Science. 2012 Mar. 23, v. 335, no. 6075

    2012  

    Abstract: We investigated the effect of activating a competing, artificially generated, neural representation on encoding of contextual fear memory in mice. We used a c-fos–based transgenic approach to introduce the hM3Dq DREADD receptor (designer receptor ... ...

    Abstract We investigated the effect of activating a competing, artificially generated, neural representation on encoding of contextual fear memory in mice. We used a c-fos–based transgenic approach to introduce the hM3Dq DREADD receptor (designer receptor exclusively activated by designer drug) into neurons naturally activated by sensory experience. Neural activity could then be specifically and inducibly increased in the hM3Dq-expressing neurons by an exogenous ligand. When an ensemble of neurons for one context (ctxA) was artificially activated during conditioning in a distinct second context (ctxB), mice formed a hybrid memory representation. Reactivation of the artificially stimulated network within the conditioning context was required for retrieval of the memory, and the memory was specific for the spatial pattern of neurons artificially activated during learning. Similar stimulation impaired recall when not part of the initial conditioning.
    Keywords drugs ; fearfulness ; genetically modified organisms ; hybrids ; ligands ; memory ; mice ; neurons
    Language English
    Dates of publication 2012-0323
    Size p. 1513-1516.
    Publishing place American Association for the Advancement of Science
    Document type Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1214985
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Generation of a synthetic memory trace.

    Garner, Aleena R / Rowland, David C / Hwang, Sang Youl / Baumgaertel, Karsten / Roth, Bryan L / Kentros, Cliff / Mayford, Mark

    Science (New York, N.Y.)

    2012  Volume 335, Issue 6075, Page(s) 1513–1516

    Abstract: We investigated the effect of activating a competing, artificially generated, neural representation on encoding of contextual fear memory in mice. We used a c-fos-based transgenic approach to introduce the hM(3)D(q) DREADD receptor (designer receptor ... ...

    Abstract We investigated the effect of activating a competing, artificially generated, neural representation on encoding of contextual fear memory in mice. We used a c-fos-based transgenic approach to introduce the hM(3)D(q) DREADD receptor (designer receptor exclusively activated by designer drug) into neurons naturally activated by sensory experience. Neural activity could then be specifically and inducibly increased in the hM(3)D(q)-expressing neurons by an exogenous ligand. When an ensemble of neurons for one context (ctxA) was artificially activated during conditioning in a distinct second context (ctxB), mice formed a hybrid memory representation. Reactivation of the artificially stimulated network within the conditioning context was required for retrieval of the memory, and the memory was specific for the spatial pattern of neurons artificially activated during learning. Similar stimulation impaired recall when not part of the initial conditioning.
    MeSH term(s) Amygdala/physiology ; Animals ; Behavior, Animal ; Brain/physiology ; CA1 Region, Hippocampal/physiopathology ; Clozapine/analogs & derivatives ; Clozapine/pharmacology ; Conditioning, Psychological ; Cues ; Electroshock ; Fear ; Genes, fos ; Learning ; Memory ; Mental Recall ; Mice ; Mice, Transgenic ; Nerve Net/physiology ; Neurons/physiology ; Promoter Regions, Genetic ; Receptor, Muscarinic M3/genetics ; Receptor, Muscarinic M3/metabolism
    Chemical Substances Receptor, Muscarinic M3 ; Clozapine (J60AR2IKIC) ; clozapine N-oxide (MZA8BK588J)
    Language English
    Publishing date 2012-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1214985
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  4. Article ; Online: A survey of new temperature-sensitive, embryonic-lethal mutations in C. elegans: 24 alleles of thirteen genes.

    O'Rourke, Sean M / Carter, Clayton / Carter, Luke / Christensen, Sara N / Jones, Minh P / Nash, Bruce / Price, Meredith H / Turnbull, Douglas W / Garner, Aleena R / Hamill, Danielle R / Osterberg, Valerie R / Lyczak, Rebecca / Madison, Erin E / Nguyen, Michael H / Sandberg, Nathan A / Sedghi, Noushin / Willis, John H / Yochem, John / Johnson, Eric A /
    Bowerman, Bruce

    PloS one

    2011  Volume 6, Issue 3, Page(s) e16644

    Abstract: To study essential maternal gene requirements in the early C. elegans embryo, we have screened for temperature-sensitive, embryonic lethal mutations in an effort to bypass essential zygotic requirements for such genes during larval and adult germline ... ...

    Abstract To study essential maternal gene requirements in the early C. elegans embryo, we have screened for temperature-sensitive, embryonic lethal mutations in an effort to bypass essential zygotic requirements for such genes during larval and adult germline development. With conditional alleles, multiple essential requirements can be examined by shifting at different times from the permissive temperature of 15°C to the restrictive temperature of 26°C. Here we describe 24 conditional mutations that affect 13 different loci and report the identity of the gene mutations responsible for the conditional lethality in 22 of the mutants. All but four are mis-sense mutations, with two mutations affecting splice sites, another creating an in-frame deletion, and one creating a premature stop codon. Almost all of the mis-sense mutations affect residues conserved in orthologs, and thus may be useful for engineering conditional mutations in other organisms. We find that 62% of the mutants display additional phenotypes when shifted to the restrictive temperature as L1 larvae, in addition to causing embryonic lethality after L4 upshifts. Remarkably, we also found that 13 out of the 24 mutations appear to be fast-acting, making them particularly useful for careful dissection of multiple essential requirements. Our findings highlight the value of C. elegans for identifying useful temperature-sensitive mutations in essential genes, and provide new insights into the requirements for some of the affected loci.
    MeSH term(s) Alleles ; Amino Acid Sequence ; Animals ; Caenorhabditis elegans/embryology ; Caenorhabditis elegans/enzymology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/chemistry ; Caenorhabditis elegans Proteins/genetics ; Embryo, Nonmammalian/metabolism ; Embryo, Nonmammalian/pathology ; Genes, Helminth/genetics ; Genes, Lethal/genetics ; Larva/genetics ; Molecular Sequence Data ; Mutation/genetics ; Phenotype ; Sequence Analysis, DNA ; Temperature
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2011-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0016644
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  5. Article ; Online: Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.

    Madisen, Linda / Garner, Aleena R / Shimaoka, Daisuke / Chuong, Amy S / Klapoetke, Nathan C / Li, Lu / van der Bourg, Alexander / Niino, Yusuke / Egolf, Ladan / Monetti, Claudio / Gu, Hong / Mills, Maya / Cheng, Adrian / Tasic, Bosiljka / Nguyen, Thuc Nghi / Sunkin, Susan M / Benucci, Andrea / Nagy, Andras / Miyawaki, Atsushi /
    Helmchen, Fritjof / Empson, Ruth M / Knöpfel, Thomas / Boyden, Edward S / Reid, R Clay / Carandini, Matteo / Zeng, Hongkui

    Neuron

    2013  Volume 85, Issue 5, Page(s) 942–958

    MeSH term(s) Animals ; Gene Targeting/methods ; Hippocampus/chemistry ; Hippocampus/physiology ; Integrases/biosynthesis ; Integrases/genetics ; Mice ; Mice, Transgenic ; Neurons/chemistry ; Neurons/physiology ; Optogenetics/methods ; Organ Culture Techniques ; Visual Cortex/chemistry ; Visual Cortex/physiology
    Chemical Substances Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2013-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2015.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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