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  1. Article ; Online: Re: The FDA Initiative to Assure Racial and Ethnic Diversity in Clinical Trials.

    Bohler, Forrest / Aggarwal, Nikhil D / Peters, Garrett W

    Journal of the American Board of Family Medicine : JABFM

    2024  Volume 36, Issue 6, Page(s) 1095–1096

    MeSH term(s) Humans ; United States ; Ethnicity ; Minority Groups ; Racial Groups
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Letter
    ZDB-ID 2239939-2
    ISSN 1558-7118 ; 1557-2625
    ISSN (online) 1558-7118
    ISSN 1557-2625
    DOI 10.3122/jabfm.2023.230210R0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2626: Show issues Location:
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  2. Article ; Online: COVID-19

    Garrett W Brown

    BMJ Global Health, Vol 5, Iss

    time for paradigm shift in the nexus between local, national and global health

    2020  Volume 4

    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Can health disparities be addressed by giving rural minorities dual consideration in the medical school admission process?

    Forrest Bohler / Garrett W. Peters / Varna Taranikanti

    Medical Education Online, Vol 28, Iss

    2023  Volume 1

    Keywords Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A MacIntyrean account of chronic moral injury: Assessing the implications of bad management and marginalized practices at work.

    Abadal, Lily M / Potts, Garrett W

    Frontiers in sociology

    2022  Volume 7, Page(s) 1019804

    Abstract: In this article, we engage with a theory of management advanced by MacIntyrean scholars of business ethics and organization studies to develop an account of "chronic moral injury" in the workplace. In contrast to what we call "acute moral injury," which ... ...

    Abstract In this article, we engage with a theory of management advanced by MacIntyrean scholars of business ethics and organization studies to develop an account of "chronic moral injury" in the workplace. In contrast to what we call "acute moral injury," which focuses on grave, traumatic events, chronic moral injury results from poor institutional form-when an individual desiring excellence must function within a vicious institution that impedes the acquisition of virtues and marginalizes practices. In other words, chronic moral injury occurs when practitioners who pursue excellence in their practice work within corrupt or malformed organizations. To demonstrate this point, we recount the events associated with the rise and fall of the biotech company, Theranos. This case study advances an empirical contribution to MacIntyrean studies by demonstrating how chronic moral injury can happen under such conditions and what the negative consequences may entail for workers.
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2297-7775
    ISSN (online) 2297-7775
    DOI 10.3389/fsoc.2022.1019804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Taking Systems Thinking to the Global Level: Using the WHO Building Blocks to Describe and Appraise the Global Health System in Relation to COVID-19.

    Borghi, Josephine / Brown, Garrett W

    Global policy

    2022  Volume 13, Issue 2, Page(s) 193–207

    Abstract: Adequately preparing for and containing global shocks, such as COVID-19, is a key challenge facing health systems globally. COVID-19 highlights that health systems are multilevel systems, a continuum from local to global. Goals and monitoring indicators ... ...

    Abstract Adequately preparing for and containing global shocks, such as COVID-19, is a key challenge facing health systems globally. COVID-19 highlights that health systems are multilevel systems, a continuum from local to global. Goals and monitoring indicators have been key to strengthening national health systems but are missing at the supranational level. A framework to strengthen the global system-the global health actors and the governance, finance, and delivery arrangements within which they operate-is urgently needed. In this article, we illustrate how the World Health Organization Building Blocks framework, which has been used to monitor the performance of national health systems, can be applied to describe and appraise the global health system and its response to COVID-19, and identify potential reforms. Key weaknesses in the global response included: fragmented and voluntary financing; non-transparent pricing of medicines and supplies, poor quality standards, and inequities in procurement and distribution; and weak leadership and governance. We also identify positive achievements and identify potential reforms of the global health system for greater resilience to future shocks. We discuss the limitations of the Building Blocks framework and future research directions and reflect on political economy challenges to reform.
    Language English
    Publishing date 2022-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2548469-2
    ISSN 1758-5899 ; 1758-5880
    ISSN (online) 1758-5899
    ISSN 1758-5880
    DOI 10.1111/1758-5899.13081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: SMARCB1-Deficient Cancers: Novel Molecular Insights and Therapeutic Vulnerabilities.

    Cooper, Garrett W / Hong, Andrew L

    Cancers

    2022  Volume 14, Issue 15

    Abstract: SMARCB1 is a critical component of the BAF complex that is responsible for global chromatin remodeling. Loss of SMARCB1 has been implicated in the initiation of cancers such as malignant rhabdoid tumor (MRT), atypical teratoid rhabdoid tumor (ATRT), and, ...

    Abstract SMARCB1 is a critical component of the BAF complex that is responsible for global chromatin remodeling. Loss of SMARCB1 has been implicated in the initiation of cancers such as malignant rhabdoid tumor (MRT), atypical teratoid rhabdoid tumor (ATRT), and, more recently, renal medullary carcinoma (RMC). These SMARCB1-deficient tumors have remarkably stable genomes, offering unique insights into the epigenetic mechanisms in cancer biology. Given the lack of druggable targets and the high mortality associated with SMARCB1-deficient tumors, a significant research effort has been directed toward understanding the mechanisms of tumor transformation and proliferation. Accumulating evidence suggests that tumorigenicity arises from aberrant enhancer and promoter regulation followed by dysfunctional transcriptional control. In this review, we outline key mechanisms by which loss of SMARCB1 may lead to tumor formation and cover how these mechanisms have been used for the design of targeted therapy.
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14153645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Who is "anti-science"?

    Paul, Elisabeth / Brown, Garrett W / Ridde, Valéry / Sturmberg, Joachim P

    Public health in practice (Oxford, England)

    2024  Volume 7, Page(s) 100493

    Abstract: Objectives: "Anti-science" accusations are common in medicine and public health, sometimes to discredit scientists who hold opposing views. However, there is no such thing as "one science". Epistemology recognizes that any "science" is sociologically ... ...

    Abstract Objectives: "Anti-science" accusations are common in medicine and public health, sometimes to discredit scientists who hold opposing views. However, there is no such thing as "one science". Epistemology recognizes that any "science" is sociologically embedded, and therefore contextual and intersubjective. In this paper, we reflect on how "science" needs to adopt various perspectives to give a comprehensive and nuanced understanding of a phenomenon.
    Study design: Opinion paper.
    Methods: Based on a targeted literature survey, we first clarify the known limits of traditional scientific methods and then reflect on how the scientific reporting about Covid-19 mRNA vaccines has evolved.
    Results: The first reports of the Covid-19 mRNA vaccines randomised controlled trial results showed impressive efficacy. Nevertheless, an abundant literature has since depicted a far more nuanced picture of the effectiveness and safety of those vaccines over the medium-term. We organise them around five themes: (i) differentiating between relative and absolute reduction; (ii) taking account of time in reporting effectiveness; (iii) taking account of all outcomes, including adverse effects; (iv) stratifying effectiveness and considering other decision criteria (efficiency, equity, and acceptance); (v) changing the outcome of concern and assessing vaccines' effectiveness on mortality.
    Conclusions: Science offers a wide range of perspectives on a given study object. Only the process of deliberation amongst scientists and other stakeholders can result in accepted new knowledge useful to support decision-making. Unfortunately, by trying to reduce "science" to simple messages set in stone, scientists can become the worse enemies of science.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ISSN 2666-5352
    ISSN (online) 2666-5352
    DOI 10.1016/j.puhip.2024.100493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Rosacea pathogenesis and therapeutics: current treatments and a look at future targets.

    Fisher, Garrett W / Travers, Jeffrey B / Rohan, Craig A

    Frontiers in medicine

    2023  Volume 10, Page(s) 1292722

    Abstract: Rosacea is a chronic inflammatory skin condition associated with a significant health and economic burden from costs and loss of productivity due to seeking medical treatment. The disease encompasses multiple phenotypic manifestations involving a complex ...

    Abstract Rosacea is a chronic inflammatory skin condition associated with a significant health and economic burden from costs and loss of productivity due to seeking medical treatment. The disease encompasses multiple phenotypic manifestations involving a complex and multi-variate pathogenesis. Although the pathophysiology of rosacea is not completely understood, ongoing research is continually elucidating its mechanisms. In this review, current concepts of rosacea pathogenesis will be addressed which involve skin barrier and permeability dysfunction, the innate and adaptive immune systems, and the neurovascular system. More specifically, the cathelicidin pathway, transient potential receptor channels, mast cells, and the NLRP3 inflammasome pathway are various targets of current pharmacologic regimens. Future therapies may seek different mechanisms to act on current treatment targets, like the potential use of JAK/STAT inhibitors in ameliorating skin barrier dysfunction or TLR antagonists in alleviating cathelicidin mediated inflammation. Other potential treatments aim for entirely different molecular targets such as microvesicle particle mediated local and systemic inflammation. Ultimately rosacea is associated with a significant health and economic burden which warrants deeper research into its pathogenesis and resultant new treatment discovery.
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1292722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mapping internal strain fields of fused filament fabrication metal filled polylactic acid structure using digital volume correlation.

    Goyal, Abhinav / Timpano, Cristofaro S / Melenka, Garrett W

    Journal of composite materials

    2023  Volume 57, Issue 14, Page(s) 2311–2324

    Abstract: With the advancement in Fused Filament Fabrication (FFF), its application is increasing widely across different industries such as aeronautical, biomedical, robotics, etc. The internal structure is becoming more complex and intricate with varying ... ...

    Abstract With the advancement in Fused Filament Fabrication (FFF), its application is increasing widely across different industries such as aeronautical, biomedical, robotics, etc. The internal structure is becoming more complex and intricate with varying materials of reinforcement which are used to improve mechanical properties. Current measurement techniques like Digital Image Correlation (DIC) are non-destructive testing methods that do not provide enough information on the behaviour of internal microstructure for anisotropic FFF materials. Digital Volume Correlation (DVC) is non-destructive testing technique which provides full field internal 3D deformation and strain fields. Copper particle filled PLA samples manufactured using FFF method with 20, 40, 60 and 80 infill percentages were loaded in tension inside Micro-CT. X-rays were passed through the sample to get a volumetric dataset for different loadings. Using DVC method on the dataset, internal displacement and strain fields were generated for 20, 40, 60 and 80 infill percentage FFF sample.
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2081924-9
    ISSN 1530-793X ; 0021-9983
    ISSN (online) 1530-793X
    ISSN 0021-9983
    DOI 10.1177/00219983231171658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Can health disparities be addressed by giving rural minorities dual consideration in the medical school admission process?

    Bohler, Forrest / Peters, Garrett W / Taranikanti, Varna

    Medical education online

    2023  Volume 28, Issue 1, Page(s) 2200549

    MeSH term(s) Humans ; Schools, Medical ; Minority Groups ; School Admission Criteria ; Rural Population
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2052877-2
    ISSN 1087-2981 ; 1087-2981
    ISSN (online) 1087-2981
    ISSN 1087-2981
    DOI 10.1080/10872981.2023.2200549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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