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  1. Article ; Online: Toward a molecular microbial blood test for tuberculosis infection.

    Martineau, Adrian R / Chandran, Shruthi / Palukani, Winnie / Garrido, Patricia / Mayito, Jonathan / Reece, Stephen T / Tiwari, Divya

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 141S, Page(s) 106988

    Abstract: The World Health Organization's aim to end the global tuberculosis (TB) epidemic by 2050 cannot be achieved without taking measures to identify people with asymptomatic Mycobacterium tuberculosis (Mtb) infection and offer them an intervention to reduce ... ...

    Abstract The World Health Organization's aim to end the global tuberculosis (TB) epidemic by 2050 cannot be achieved without taking measures to identify people with asymptomatic Mycobacterium tuberculosis (Mtb) infection and offer them an intervention to reduce the risk of disease progression, such as preventive antimicrobial therapy. Implementation of this strategy is limited by the fact that existing tests for Mtb infection, which use immunosensitization to Mtb-specific antigens as a proxy for infection, have low positive predictive value for progression to TB. A blood test that detects Mtb deoxyribonucleic acid (DNA) could allow preventive therapy to be targeted at individuals with microbiological evidence of persistent infection. In this review, we summarize recent advances in the development of molecular microbial blood tests for Mtb infection and discuss potential explanations for discordance between their results and those of immunodiagnostic tests in adults with recent exposure to an infectious index case. We also present a roadmap for further development of molecular microbial blood tests for Mtb infection, and highlight the potential for research in this area to provide novel insights into the biology of Mtb infection and yield new tools to support efforts to control the global TB epidemic.
    MeSH term(s) Adult ; Humans ; Tuberculosis/microbiology ; Latent Tuberculosis/microbiology ; Mycobacterium tuberculosis/genetics ; Predictive Value of Tests ; Hematologic Tests
    Language English
    Publishing date 2024-02-28
    Publishing country Canada
    Document type Review ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.106988
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
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  2. Article: First report of

    Toaza, Alexander / Caiza, Rosa Beatriz / Garrido, Francisco Javier / Garrido, Patricia / Ramos, Luis / Flores, Francisco

    Plant disease

    2023  

    Abstract: Banana ( ...

    Abstract Banana (
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-08-23-1575-PDN
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    In stock of ZB MED Bonn / Germany

    Z 2043: Show issues

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  3. Article ; Online: Complete Genome Sequence of

    Flores, Francisco / Garrido, Patricia / Guevara, Fiama / Granda, Roberto

    Microbiology resource announcements

    2019  Volume 8, Issue 26

    Abstract: In this work, we present the complete genome sequence ... ...

    Abstract In this work, we present the complete genome sequence of
    Language English
    Publishing date 2019-06-27
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00368-19
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  4. Article ; Online: Correction to: Molecular characterization and complete genome of alstroemeria mosaic virus (AlMV).

    Mosquera-Yuqui, Francisco / Garrido, Patricia / Flores, Francisco J

    Virus genes

    2019  Volume 56, Issue 1, Page(s) 94

    Abstract: The original version of this article unfortunately contained an error in the length of AIMV genome sequence. ...

    Abstract The original version of this article unfortunately contained an error in the length of AIMV genome sequence.
    Language English
    Publishing date 2019-11-27
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 639496-6
    ISSN 1572-994X ; 0920-8569
    ISSN (online) 1572-994X
    ISSN 0920-8569
    DOI 10.1007/s11262-019-01717-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2397: Show issues Location:
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  5. Article ; Online: Molecular characterization and complete genome of alstroemeria mosaic virus (AlMV).

    Mosquera-Yuqui, Francisco / Garrido, Patricia / Flores, Francisco J

    Virus genes

    2019  Volume 56, Issue 1, Page(s) 87–93

    Abstract: Even though alstroemeria mosaic virus (AlMV) is one of the most important viruses affecting alstroemeria plants, its genome is only partially available in public sequence databases. High throughput sequencing (HTS) of RNA from alstroemeria plants with ... ...

    Abstract Even though alstroemeria mosaic virus (AlMV) is one of the most important viruses affecting alstroemeria plants, its genome is only partially available in public sequence databases. High throughput sequencing (HTS) of RNA from alstroemeria plants with symptoms of mosaic and streaking, collected in Lasso-Ecuador, indicated the presence of AlMV and lily symptomless virus. In this study, we aimed to assemble and characterize the complete genome sequence of AlMV. Reads from Illumina sequencing of ribosomal RNA-depleted total RNA were assembled into contigs that were mapped to the sunflower chlorotic mottle virus genome, revealing the 9774 [corrected] bp complete genome sequence of AlMV. Multiple sequence alignment of the AlMV polyprotein with close homologs allowed the identification of ten mature proteins P1, HC-Pro, P3, 6K1, CI, 6K2, NIa-VPg, NIa-Pro, NIb and CP. Furthermore, several potyvirus motifs were identified in the AlMV polyprotein including those related to potyvirus aphid transmission
    MeSH term(s) Alstroemeria/virology ; Base Sequence ; Genome, Viral ; Phylogeny ; Plant Diseases/virology ; Potyvirus/classification ; Potyvirus/genetics ; Potyvirus/isolation & purification ; Viral Proteins/genetics
    Chemical Substances Viral Proteins
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639496-6
    ISSN 1572-994X ; 0920-8569
    ISSN (online) 1572-994X
    ISSN 0920-8569
    DOI 10.1007/s11262-019-01712-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2397: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: The jigsaw of dual hepatocellular-intrahepatic cholangiocarcinoma tumours.

    Munoz-Garrido, Patricia / Rodrigues, Pedro M

    Nature reviews. Gastroenterology & hepatology

    2019  Volume 16, Issue 11, Page(s) 653–655

    MeSH term(s) Bile Duct Neoplasms ; Carcinoma, Hepatocellular ; Cholangiocarcinoma ; Genomics ; Humans ; Liver Neoplasms ; Transcriptome
    Language English
    Publishing date 2019-07-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-019-0185-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6020: Show issues Location:
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    Zs.MG 97: Show issues

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  7. Article ; Online: Molecular Targets in Cholangiocarcinoma.

    O'Rourke, Colm J / Munoz-Garrido, Patricia / Andersen, Jesper B

    Hepatology (Baltimore, Md.)

    2020  Volume 73 Suppl 1, Page(s) 62–74

    Abstract: Cholangiocarcinoma (CCA) encompasses a heterogeneous collection of malignancies for which diagnostic biomarkers are lacking and population screening is infeasible because of its status as a rare disease. Coupled with high postsurgical recurrence rates ... ...

    Abstract Cholangiocarcinoma (CCA) encompasses a heterogeneous collection of malignancies for which diagnostic biomarkers are lacking and population screening is infeasible because of its status as a rare disease. Coupled with high postsurgical recurrence rates among the minority of patients diagnosed at resectable stages, systemic clinical management will inevitably be required for the majority of patients with CCA with recurrent and advanced disease. In this review, we discuss the therapeutic potential of different classes of molecular targets at various stages of development in CCA, including those targeted to the tumor epithelia (oncogenic, developmental, metabolic, epigenomic) and tumor microenvironment (angiogenesis, checkpoint regulation). Furthermore, we discuss the successes and failures of CCA-targeted therapies, emphasizing key lessons learned that should pave the way for future molecular target evaluation in this uncommon yet bona fide target-rich disease.
    MeSH term(s) Bile Duct Neoplasms/drug therapy ; Cholangiocarcinoma/drug therapy ; Epigenome ; ErbB Receptors/antagonists & inhibitors ; Humans ; Molecular Targeted Therapy ; Receptor, Fibroblast Growth Factor, Type 2/antagonists & inhibitors ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Tumor Microenvironment/drug effects
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 2 (EC 2.7.10.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31278
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
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  8. Article: The Meaning of Lymphadenopathies During Adjuvant Durvalumab After Chemoradiotherapy for Lung Cancer: Thinking Beyond Disease Progression.

    Pantarotto, Marcos / Barata, Rita / Coelho, Ricardo / Carvalheiro, Catarina / Rolim, Ines / Garrido, Patricia / GIl, Nuno / Duarte-Ramos, Filipa / Tonin, Fernanda S

    Cureus

    2022  Volume 14, Issue 7, Page(s) e26729

    Abstract: Immune-checkpoint inhibitors (ICIs) have become the mainstay of treatment for many malignancies. With this new strategy, relevant immune-related adverse events (irAEs) have been reported, some of which can be mistaken for disease progression. To better ... ...

    Abstract Immune-checkpoint inhibitors (ICIs) have become the mainstay of treatment for many malignancies. With this new strategy, relevant immune-related adverse events (irAEs) have been reported, some of which can be mistaken for disease progression. To better illustrate the current challenges in diagnosing and managing a patient under adjuvant ICI treatment, we present the case of a 67-year-old female patient with stage IIIB unresectable, epidermal growth factor receptor (EGFR)-mutated, non-small-cell lung cancer who was initially treated with chemoradiotherapy, followed by immunotherapy with durvalumab. During the course of immunotherapy, the patient presented with madarosis and erythematous and endured skin lesions, in addition to lymphadenopathies and pulmonary infiltrates. She was started on first-line palliative treatment with an EGFR tyrosine kinase inhibitor. After reviewing the case, a multidisciplinary team meeting suggested diagnostic procedures, including a transbronchial needle aspiration from mediastinal lymph nodes. The histologic examination showed chronic systemic inflammation and non-caseating granulomas of the sarcoid type. In this case, palliative treatment was suspended and systemic therapy with prednisolone was initiated. The patient became asymptomatic and the previously observed radiologic abnormalities resolved. This case highlights the importance of early recognition and appropriate treatment of irAEs, mainly because these conditions remain poorly understood and are probably underdiagnosed. Considering differential diagnosis is paramount to guide clinical management, despite curative or palliative treatment intent.
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.26729
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  9. Article: Santa Isabel Program for psycho-motor function in normal and pathological aging during current times of COVID-19 confinement in a long-term care

    Castillo-Mariqueo, Lidia Valenzuela-Garrido Patricia Gimenez-Llort Lydia

    International Psychogeriatrics

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #881815
    Database COVID19

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  10. Article: Correction: The Meaning of Lymphadenopathies During Adjuvant Durvalumab After Chemoradiotherapy for Lung Cancer: Thinking Beyond Disease Progression.

    Pantarotto, Marcos / Barata, Rita / Coelho, Ricardo / Sousa, Virginia / Carvalheiro, Catarina / Rolim, Ines / Garrido, Patricia / GIl, Nuno / Duarte-Ramos, Filipa / Tonin, Fernanda S

    Cureus

    2023  Volume 15, Issue 2, Page(s) c101

    Abstract: This corrects the article DOI: 10.7759/cureus.26729.]. ...

    Abstract [This corrects the article DOI: 10.7759/cureus.26729.].
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.c101
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