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  1. Article ; Online: New Inhibitors of Respiratory Syncytial Virus (RSV) Replication Based on Monoterpene-Substituted Arylcoumarins.

    Khomenko, Tatyana M / Shtro, Anna A / Galochkina, Anastasia V / Nikolaeva, Yulia V / Garshinina, Anzhelika V / Borisevich, Sophia S / Korchagina, Dina V / Volcho, Konstantin P / Salakhutdinov, Nariman F

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 6

    Abstract: Respiratory syncytial virus (RSV) causes annual epidemics of respiratory infection. Usually harmless to adults, the RSV infection can be dangerous to children under 3 years of age and elderly people over 65 years of age, often causing serious problems, ... ...

    Abstract Respiratory syncytial virus (RSV) causes annual epidemics of respiratory infection. Usually harmless to adults, the RSV infection can be dangerous to children under 3 years of age and elderly people over 65 years of age, often causing serious problems, even death. At present, there are no vaccines and specific chemotherapeutic agents for the treatment of this disease, so the search for low-molecular weight compounds to combat RSV is a challenge. In this work, we have shown, for the first time, that monoterpene-substituted arylcoumarins are efficient RSV replication inhibitors at low micromolar concentrations. The most active compound has a selectivity index of about 200 and acts most effectively at the early stages of infection. The F protein of RSV is a potential target for these compounds, which is also confirmed by molecular docking and molecular dynamics simulation data.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Aged ; Molecular Docking Simulation ; Antibodies, Viral ; Viral Fusion Proteins ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/drug therapy ; Virus Replication
    Chemical Substances Antibodies, Viral ; Viral Fusion Proteins
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28062673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification and Study of the Action Mechanism of Small Compound That Inhibits Replication of Respiratory Syncytial Virus.

    Shtro, Anna A / Klabukov, Artem M / Garshinina, Anzhelika V / Galochkina, Anastasia V / Nikolaeva, Yulia V / Khomenko, Tatyana M / Bobkov, Danila E / Lozhkov, Aleksey A / Sivak, Konstantin V / Yakovlev, Kirill S / Komissarov, Andrey B / Borisevich, Sophia S / Volcho, Konstantin P / Salakhutdinov, Nariman F

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: Respiratory syncytial virus (RSV) is known to cause annual epidemics of respiratory infections; however, the lack of specific treatment options for this disease poses a challenge. In light of this, there has been a concerted effort to identify small ... ...

    Abstract Respiratory syncytial virus (RSV) is known to cause annual epidemics of respiratory infections; however, the lack of specific treatment options for this disease poses a challenge. In light of this, there has been a concerted effort to identify small molecules that can effectively combat RSV. This article focuses on the mechanism of action of compound K142, which was identified as a primary screening leader in the earlier stages of the project. The research conducted demonstrates that K142 significantly reduces the intensity of virus penetration into the cells, as well as the formation of syncytia from infected cells. These findings show that the compound's interaction with the surface proteins of RSV is a key factor in its antiviral activity. Furthermore, pharmacological modeling supports that K142 effectively interacts with the F-protein. However, in vivo studies have shown only weak antiviral activity against RSV infection, with a slight decrease in viral load observed in lung tissues. As a result, there is a need to enhance the bioavailability or antiviral properties of this compound. Based on these findings, we hypothesize that further modifications of the compound under study could potentially increase its antiviral activity.
    MeSH term(s) Humans ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Tract Infections ; Antiviral Agents/pharmacology ; Biological Availability
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cationic Perylene Antivirals with Aqueous Solubility for Studies In Vivo.

    Shtro, Anna A / Garshinina, Anzhelika V / Alferova, Vera A / Kamzeeva, Polina N / Volok, Viktor P / Kolpakova, Ekaterina S / Nikitin, Timofei D / Chistov, Alexey A / Belyaev, Evgeny S / Korshun, Vladimir A / Kozlovskaya, Liubov I / Aralov, Andrey V

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 10

    Abstract: Perylene-based compounds are attracting significant attention due to their high broad-spectrum antiviral activity against enveloped viruses. Despite unambiguous results of in vitro studies and high selectivity index, the poor water solubility of these ... ...

    Abstract Perylene-based compounds are attracting significant attention due to their high broad-spectrum antiviral activity against enveloped viruses. Despite unambiguous results of in vitro studies and high selectivity index, the poor water solubility of these compounds prevented in vivo evaluation of their antiviral properties. In this work, we synthesized a series of compounds with a perylene pharmacophore bearing positively charged substituents to improve the aqueous solubility of this unique type of antivirals. Three types of charged groups were introduced: (1) quaternary morpholinium salts (
    Language English
    Publishing date 2022-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15101178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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