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  1. Book ; Online ; Thesis: Einfluss der perizellulären Matrix auf die Produktion extrazellulärer Matrix von nativen porcinen Chondrozyten im 3D-Bioprinting in Agarose-Hydrogelen \(in\) \(vitro\)

    Gastberger, Katharina [Verfasser] / Blunk, Torsten [Gutachter]

    2024  

    Author's details Katharina Gastberger ; Gutachter: Torsten Blunk
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article: Current Molecular and Clinical Landscape of ATRT - The Link to Future Therapies.

    Gastberger, Katharina / Fincke, Victoria E / Mucha, Marlena / Siebert, Reiner / Hasselblatt, Martin / Frühwald, Michael C

    Cancer management and research

    2023  Volume 15, Page(s) 1369–1393

    Abstract: ATRT is a highly aggressive and rare pediatric CNS tumor of very young children. Its genetic hallmark is bi-allelic inactivation ... ...

    Abstract ATRT is a highly aggressive and rare pediatric CNS tumor of very young children. Its genetic hallmark is bi-allelic inactivation of
    Language English
    Publishing date 2023-12-07
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S379451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Survivors of infant atypical teratoid/rhabdoid tumors present with severely impaired cognitive functions especially for fluid intelligence and visual processing: data from the German brain tumor studies.

    Traunwieser, Thomas / Loos, Elena / Ottensmeier, Holger / Gastberger, Katharina / Nemes, Karolina / Mynarek, Martin / Bison, Brigitte / Kandels, Daniela / Neumayer, Petra / Neumann-Holbeck, Anne / Lüttich, Peggy / Baust, Katja / Faulstich-Ritter, Kristin / John, Rainer / Kreisch, Andrea / Landmann, Judyta / Manteufel, Eva / Nest, Alexandra / Prüfe, Jenny /
    Schubert, Lisa / Stamm, Walther / Timmermann, Beate / Gerss, Joachim / Rutkowski, Stefan / Schlegel, Paul-Gerhardt / Eyrich, Matthias / Gnekow, Astrid K / Frühwald, Michael C

    Pediatric blood & cancer

    2024  Volume 71, Issue 5, Page(s) e30910

    Abstract: Background: The contribution of tumor type, multimodal treatment, and other patient-related factors upon long-term cognitive sequelae in infant brain tumor survivors remains undefined. We add our retrospective analysis of neuropsychological and quality ... ...

    Abstract Background: The contribution of tumor type, multimodal treatment, and other patient-related factors upon long-term cognitive sequelae in infant brain tumor survivors remains undefined. We add our retrospective analysis of neuropsychological and quality of survival (QoS) outcome data of survivors of atypical teratoid/rhabdoid tumors (ATRT) and extracranial malignant rhabdoid tumors of the soft tissues (eMRT) and kidneys (RTK) treated within the same framework. Neuropsychological data from children with ATRT were compared to data from children with non-irradiated low-grade glioma (LGG).
    Patients and methods: Following surgery, patients (0-36 months at diagnosis) had received radio-chemotherapy (up to 54 Gy; ATRT: n = 13; eMRT/RTK: n = 7), chemotherapy only (LGG: n = 4; eMRT/RTK: n = 1) or had been observed (LGG: n = 11). Neuropsychological evaluation employing comparable tests was performed at median 6.8 years (ATRT), 6.6 years (eMRT/RTK), and 5.2 years (LGG) post diagnosis.
    Results: We detected sequelae in various domains for all tumor types. Group comparison showed impairments, specifically in fluid intelligence (p = .041; d = 1.11) and visual processing (p = .001; d = 2.09) in ATRT patients when compared to LGG patients. Results for psychomotor speed and attention abilities were significantly below the norm for both groups (p < .001-.019; d = 0.79-1.90). Diagnosis predicted impairments of cognitive outcome, while sex- and age-related variables did not. QoS outcome for all rhabdoid patients displayed impairments mainly in social (p = .008; d = 0.74) and school functioning (p = .048; d = 0.67), as well as lower overall scores in psychosocial functioning (p = .023; d = 0.78) and quality of life (p = .006; d = 0.79) compared to healthy controls.
    Conclusion: Survivors of infant ATRT experience various late effects in cognition and QoS following multimodal treatment, while infant LGG patients without radiotherapy demonstrated comparable impairments in psychomotor and attention abilities. Early onset and multimodal treatment of rhabdoid tumors require close monitoring of neuropsychological and QoS sequelae.
    MeSH term(s) Child ; Infant ; Humans ; Rhabdoid Tumor/complications ; Rhabdoid Tumor/therapy ; Retrospective Studies ; Quality of Life ; Teratoma/complications ; Teratoma/therapy ; Brain Neoplasms/complications ; Brain Neoplasms/therapy ; Central Nervous System Neoplasms/pathology ; Glioma ; Disease Progression ; Visual Perception ; Cognition ; Neoplasms, Neuroepithelial ; Survivors
    Language English
    Publishing date 2024-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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