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  1. Article ; Online: Chitosan-Coated Silver Nanoparticles Inhibit Adherence and Biofilm Formation of Uropathogenic

    Mendez-Pfeiffer, Pablo / Ballesteros-Monrreal, Manuel G / Juarez, Josue / Gastelum-Cabrera, Marisol / Martinez-Flores, Patricia / Taboada, Pablo / Valencia, Dora

    ACS infectious diseases

    2024  Volume 10, Issue 4, Page(s) 1126–1136

    Abstract: Urinary tract infections are commonly caused by ... ...

    Abstract Urinary tract infections are commonly caused by uropathogenic
    MeSH term(s) Animals ; Silver/pharmacology ; Uropathogenic Escherichia coli ; Chitosan/pharmacology ; Metal Nanoparticles ; Anti-Bacterial Agents/pharmacology ; Biofilms ; Mammals
    Chemical Substances Silver (3M4G523W1G) ; Chitosan (9012-76-4) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Biosynthesis of Silver Nanoparticles Using Seasonal Samples of Sonoran Desert Propolis: Evaluation of Its Antibacterial Activity against Clinical Isolates of Multi-Drug Resistant Bacteria.

    Mendez-Pfeiffer, Pablo / Ballesteros-Monrreal, Manuel G / Gaona-Ochoa, Jesus / Juarez, Josue / Gastelum-Cabrera, Marisol / Montaño-Leyva, Beatriz / Arenas-Hernández, Margarita / Caporal-Hernandez, Liliana / Ortega-García, Jesús / Barrios-Villa, Edwin / Velazquez, Carlos / Valencia, Dora

    Pharmaceutics

    2022  Volume 14, Issue 9

    Abstract: Multi-drug resistant (MDR) bacteria have gained importance as a health problem worldwide, and novel antibacterial agents are needed to combat them. Silver nanoparticles (AgNPs) have been studied as a potent antimicrobial agent, capable of countering MDR ... ...

    Abstract Multi-drug resistant (MDR) bacteria have gained importance as a health problem worldwide, and novel antibacterial agents are needed to combat them. Silver nanoparticles (AgNPs) have been studied as a potent antimicrobial agent, capable of countering MDR bacteria; nevertheless, their conventional synthesis methods can produce cytotoxicity and environmental hazards. Biosynthesis of silver nanoparticles has emerged as an alternative to reduce the cytotoxic and environmental problems derived from their chemical synthesis, using natural products as a reducing and stabilizing agent. Sonoran Desert propolis (SP) is a poplar-type propolis rich in polyphenolic compounds with remarkable biological activities, such as being antioxidant, antiproliferative, and antimicrobial, and is a suitable candidate for synthesis of AgNPs. In this study, we synthesized AgNPs using SP methanolic extract (SP-AgNPs) and evaluated the reduction capacity of their seasonal samples and main chemical constituents. Their cytotoxicity against mammalian cell lines and antibacterial activity against multi-drug resistant bacteria were assessed. Quercetin and galangin showed the best-reduction capacity for synthesizing AgNPs, as well as the seasonal sample from winter (SPw-AgNPs). The SPw-AgNPs had a mean size of around 16.5 ± 5.3 nm, were stable in different culture media, and the presence of propolis constituents was confirmed by FT-IR and HPLC assays. The SPw-AgNPs were non-cytotoxic to ARPE-19 and HeLa cell lines and presented remarkable antibacterial and antibiofilm activity against multi-drug resistant clinical isolates, with
    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14091853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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