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  1. Article ; Online: Can treatment adverse events be optimized by switching between different sphingosine 1-phosphate receptor modulators in multiple sclerosis? A case series.

    Guerrieri, Simone / Rubin, Martina / Gattuso, Irene / Zanetta, Chiara / Genchi, Angela / Preziosa, Paolo / Rocca, Maria Assunta / Filippi, Massimo / Moiola, Lucia

    Journal of neurology

    2024  

    Language English
    Publishing date 2024-04-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-024-12342-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ocrelizumab extended-interval dosing in multiple sclerosis during SARS-CoV-2 pandemic: a real-world experience.

    Guerrieri, Simone / Bucca, Chiara / Nozzolillo, Agostino / Genchi, Angela / Zanetta, Chiara / Cetta, Ilaria / Rugarli, Giulia / Gattuso, Irene / Azzimonti, Matteo / Rocca, Maria Assunta / Moiola, Lucia / Filippi, Massimo

    European journal of neurology

    2023  Volume 30, Issue 9, Page(s) 2859–2864

    Abstract: Background and purpose: During the COVID-19 pandemic, ocrelizumab administration was frequently postponed because of a lack of safety information and to favour vaccination. The clinical implications of ocrelizumab administration delay in multiple ... ...

    Abstract Background and purpose: During the COVID-19 pandemic, ocrelizumab administration was frequently postponed because of a lack of safety information and to favour vaccination. The clinical implications of ocrelizumab administration delay in multiple sclerosis (MS) patients were assessed.
    Methods: Relapsing (RMS) and primary progressive (PPMS) MS patients receiving ocrelizumab for at least 6 months at our centre were retrospectively classified, according to the possible occurrence of a delay (≥4 weeks) in treatment administration. Patients were categorized in the extended-interval dosing (EID) group in the presence of at least one delayed infusion; otherwise they were considered as part of the standard interval dosing (SID) cohort. MS history, magnetic resonance imaging examinations and B-cell counts were also retrospectively collected and analysed.
    Results: A total of 213 RMS and 61 PPMS patients were enrolled; 115 RMS and 29 PPMS patients had been treated according to the SID regimen, whilst 98 RMS and 32 PPMS patients were included in the EID cohort. Average follow-up after delay was 1.28 ± 0.7 years in the EID cohort. In RMS, comparing SID and EID patients, no differences were found considering the occurrence of clinical relapses (9.6% vs. 16.3%, p = 0.338), magnetic resonance imaging activity (9.8% vs. 14.1%, p = 0.374) or disability progression (11.3% vs. 18.4%, p = 0.103). Similar findings were observed in PPMS patients. In the pooled EID group, treatment delay correlated with CD19-positive relative (r = 0.530, p < 0.001) and absolute (r = 0.491, p < 0.001) cell counts, without implications on disease activity.
    Conclusions: Sporadic ocrelizumab administration delay granted sustained treatment efficacy in our cohort. Prospective data should be obtained to confirm these observations and set up systematic extended-interval regimens.
    MeSH term(s) Humans ; Multiple Sclerosis/drug therapy ; SARS-CoV-2 ; Pandemics ; Retrospective Studies ; Prospective Studies ; Immunologic Factors/therapeutic use ; Immunologic Factors/adverse effects ; COVID-19 ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Multiple Sclerosis, Chronic Progressive/drug therapy
    Chemical Substances ocrelizumab (A10SJL62JY) ; Immunologic Factors
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.15891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4738: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 592: Show issues

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  3. Article: Microchimerism in multiple sclerosis: The association between sex of offspring and MRI features in women with multiple sclerosis.

    Bianchi, Alessia / Aprile, Maria / Schirò, Giuseppe / Gasparro, Claudia / Iacono, Salvatore / Andolina, Michele / Marrale, Maurizio / Gattuso, Irene / La Tona, Giuseppe / Midiri, Massimo / Gagliardo, Cesare / Salemi, Giuseppe / Ragonese, Paolo

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1091955

    Abstract: Aims: During pregnancy, fetal cells can migrate to the mother : Methods: We recruited 26 nulliparous MS patients (NPp), 20 patients with at least one male son (XYp), and 8 patients with only daughters (XXp). Each patient underwent brain MR scan to ... ...

    Abstract Aims: During pregnancy, fetal cells can migrate to the mother
    Methods: We recruited 26 nulliparous MS patients (NPp), 20 patients with at least one male son (XYp), and 8 patients with only daughters (XXp). Each patient underwent brain MR scan to acquire 3D-T2w FLAIR FatSat and 3D-T1w FSPGR/TFE. Lesion Segmentation Tool (LST) and FreeSurfer were used to obtain quantitative data from MRI. Additional data were collected using medical records. Multiple regression models were applied to evaluate the association between sex of offspring and MS data.
    Results: Comparing NPp and XXp, we found that NPp had larger 4th ventricle volume (2.02 ± 0.59 vs. 1.70 ± 0.41;
    Discussion: Our findings suggested an association between the sex of offspring and brain atrophy. Considering the sex of offspring as an indirect marker of fMCs, we speculated that fMCs could accumulate in different brain areas modulating MS neuropathological processes.
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1091955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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