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  1. Book ; Online: Atlas of hybrid imaging

    Leporace, Mario / Clabria, Ferdinando / Gaudio, Eugenio

    sectional anatomy for PET/CT, PET/MRI, and SPECT/CT

    2023  

    Author's details Mario Leporace, Ferdinando Clabria, Eugenio Gaudio [und 3 weitere]
    Language English
    Dates of publication 2023-2023
    Size 3 Online-Ressourcen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online
    HBZ-ID HT030701226
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Atlas of hybrid imaging / Vol. 3

    Leporace, Mario / Calabria, Ferdinando / Gaudio, Eugenio / Schillaci, Orazio / Ciaccio, Alfonso / Bagnato, Antonio

    sectional anatomy for PET/CT, PET/MRI and SPECT/CT

    2023  

    Author's details Mario Leporace, Ferdinando Calabria, Eugenio Gaudio, Orazio Schillaci, Alfonso Ciaccio, Antonio Bagnato
    Collection Atlas of hybrid imaging
    Language English
    Size 1 Online-Ressource (xi, 277 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London ; © 2023
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030701278
    ISBN 9780443188190 ; 978-0-433-18819-0 ; 9780443188183 ; 044318819X ; 0-433-18819-7 ; 0443188181
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Book ; Online ; E-Book: Atlas of hybrid imaging / Vol. 2

    Leporace, Mario / Calabria, Ferdinando / Gaudio, Eugenio / Schillaci, Orazio / Ciaccio, Alfonso / Bagnato, Antonio

    sectional anatomy for PET/CT, PET/MRI and SPECT/CT

    2023  

    Author's details Mario Leporace, Ferdinando Calabria, Eugenio Gaudio, Orazio Schillaci, Alfonso Ciaccio, Antonio Bagnato
    Collection Atlas of hybrid imaging
    Language English
    Size 1 Online-Ressource (xii, 343 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London ; © 2023
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030701268
    ISBN 978-0-443-18815-2 ; 9780443187339 ; 0-443-18815-7 ; 0443187339
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Book ; Online ; E-Book: Atlas of hybrid imaging / Vol. 1

    Leporace, Mario / Calabria, Ferdinando / Gaudio, Eugenio / Schillaci, Orazio / Ciaccio, Alfonso / Bagnato, Antonio

    sectional anatomy for PET/CT, PET/MRI and SPECT/CT

    2023  

    Author's details Mario Leporace, Ferdinando Calabria, Eugenio Gaudio, Orazio Schillaci, Alfonso Ciaccio, Antonio Bagnato
    Collection Atlas of hybrid imaging
    Language English
    Size 1 Online-Ressource (xi, 184 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030701246
    ISBN 978-0-323-90455-1 ; 9780323904544 ; 0-323-90455-6 ; 0323904548
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  5. Article ; Online: Cellular Interactions and Crosstalk Facilitating Biliary Fibrosis in Cholestasis.

    Ceci, Ludovica / Gaudio, Eugenio / Kennedy, Lindsey

    Cellular and molecular gastroenterology and hepatology

    2024  Volume 17, Issue 4, Page(s) 553–565

    Abstract: Biliary fibrosis is seen in cholangiopathies, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). In PBC and PSC, biliary fibrosis is associated with worse outcomes and histologic scores. Within the liver, both hepatic ... ...

    Abstract Biliary fibrosis is seen in cholangiopathies, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). In PBC and PSC, biliary fibrosis is associated with worse outcomes and histologic scores. Within the liver, both hepatic stellate cells (HSCs) and portal fibroblasts (PFs) contribute to biliary fibrosis, but their roles can differ. PFs reside near the bile ducts and may be the first responders to biliary damage, whereas HSCs may be recruited later and initiate bridging fibrosis. Indeed, different models of biliary fibrosis can activate PFs and HSCs to varying degrees. The portal niche can be composed of cholangiocytes, HSCs, PFs, endothelial cells, and various immune cells, and interactions between these cell types drive biliary fibrosis. In this review, we discuss the mechanisms of biliary fibrosis and the roles of PFs and HSCs in this process. We will also evaluate cellular interactions and mechanisms that contribute to biliary fibrosis in different models and highlight future perspectives and potential therapeutics.
    MeSH term(s) Humans ; Endothelial Cells/pathology ; Cholestasis/pathology ; Liver Diseases/pathology ; Fibrosis
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2024.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Tumour Suppressor Fhit Protein Activates C-Raf Ubiquitination and Degradation in Human Melanoma Cells by Interacting with Hsp90.

    Paduano, Francesco / Gaudio, Eugenio / Trapasso, Francesco

    Biomedicines

    2022  Volume 10, Issue 10

    Abstract: Fhit protein expression is reduced in the majority of human tumors; moreover, its restoration both triggers apoptosis of cancer cells and suppresses tumor formation in a large number of preclinical models of cancers. In the following study, we observed ... ...

    Abstract Fhit protein expression is reduced in the majority of human tumors; moreover, its restoration both triggers apoptosis of cancer cells and suppresses tumor formation in a large number of preclinical models of cancers. In the following study, we observed that Fhit expression is significantly reduced in human melanoma cells, and their in vivo growth is blocked by a recombinant adenovirus carrying the
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10102551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Anesthetic effects of dexmedomidine-ketamine sedation followed by isoflurane induction and maintenance in the Saker falcon (Falco cherrug)

    Gaudio, Eugenio / Franceschinis, Cristiano / McKinney, Peter / Azmanis, Panagiotis

    Journal of Exotic Pet Medicine. 2023 July 19,

    2023  

    Abstract: Avian anesthesia can be challenging due to birds’ anatomical and physiological peculiarities. Because of paucity of information on falcon anesthesia most drug doses and combinations are empirical. The objective of this study was to evaluate the ... ...

    Abstract Avian anesthesia can be challenging due to birds’ anatomical and physiological peculiarities. Because of paucity of information on falcon anesthesia most drug doses and combinations are empirical. The objective of this study was to evaluate the anesthetic quality and physiological changes after dexmedetomidine-ketamine sedation and isoflurane anesthesia in 12 saker falcons (Falco cherrug), weighing (mean ± standard deviation) 915 ± 175 g. Pre-sedation heart rate (HR) and respiratory rate (fR) were assessed. A combination of ketamine (3 mg kg⁻¹) and dexmedetomidine (25 µg kg⁻¹) was administered intramuscularly. Sedation times were recorded, physiological variables assessed, and various blood parameters measured with a blood gas analyzer providing electrolyte levels, blood gas, glucose, hemoglobin and hematocrit. Induction was performed with isoflurane at 2% for 2 minutes and anesthesia was maintained at 1%. During maintenance, physiological variables were assessed at 5-minute intervals and blood parameters were re-evaluated before administration of atipamezole (250 µg kg⁻¹). Recovery times were documented. Quality of sedation, maintenance, and recovery were assessed. Maximum sedation effect was observed within 2.9 ± 1.0 minutes and quality of sedation and maintenance had a median score of « excellent » in all falcons. HR values decreased during sedation (pre-sedation value: 137 ± 38 versus sedated value: 99 ± 13 beats minute⁻¹; mean difference = -33; 95% confidence interval [CI] [-65; -10]; p = 0.001) and remained constant during maintenance. No significant differences were seen in fR from pre-sedation values (pre-sedation value: 23 ± 5 versus sedated value: 31 ± 13 breaths minute⁻¹; mean difference = 8; 95% CI [-1.7; 17.7]; p = 0.1). Mean arterial blood pressure (203 ± 14 versus 168 ± 22 mmHg; mean difference = -35.8; 95% CI [-51.1; -20.6]; p < 0.001) and cloacal temperature (40.3 ± 0.8 versus 38.9 ± 1.0°C; mean difference = -1.4; 95% CI [-2.2; -0.6]; p < 0.001) decreased after induction. Hypoxemia was observed in the sedated falcons but resolved during maintenance (65.9 ± 6.1 versus 402.2 ± 142.3 mmHg; mean difference = 336.3; 95% CI [227.4; 447.2]; p < 0.001), while hypercarbia (35.0 ± 5.8 versus 54.2 ± 11.5 mmHg; mean difference = 19.3; 95% CI [9.9; 28.7]; p < 0.001) and acidemia (pH 7.42 ± 0.06 versus 7.28 ± 0.036; mean difference = -0.13; 95% CI [-0.8; -0.08]; p < 0.001) developed. Full recovery was quick (12.3 ± 3.9 minutes). The proposed drug combination provided for high quality sedation and maintenance, and a satisfactory recovery. Nevertheless, alterations in the falcons’ physiology were documented, thus careful monitoring is mandatory.
    Keywords Falco cherrug ; anesthesia ; blood ; blood gases ; blood pressure ; cloaca ; confidence interval ; dexmedetomidine ; electrolytes ; falcons ; glucose ; heart rate ; hematocrit ; hemoglobin ; hypoxia ; isoflurane ; ketamine ; medicine ; pH ; pets ; respiratory rate ; sedation ; standard deviation ; temperature ; avian ; birds of prey ; saker falcon
    Language English
    Dates of publication 2023-0719
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 2228614-7
    ISSN 1557-5063
    ISSN 1557-5063
    DOI 10.1053/j.jepm.2023.07.004
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Editorial: Protein-Protein Interactions: Drug Discovery for the Future.

    Rapposelli, Simona / Gaudio, Eugenio / Bertozzi, Fabio / Gul, Sheraz

    Frontiers in chemistry

    2021  Volume 9, Page(s) 811190

    Language English
    Publishing date 2021-11-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2021.811190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Autophagy impairment in human bile duct carcinoma cells.

    Petrungaro, Simonetta / de Franchis, Valerio / Filippini, Antonio / Facchiano, Antonio / Gaudio, Eugenio / Giampietri, Claudia

    Frontiers in physiology

    2023  Volume 14, Page(s) 1249264

    Abstract: Bile duct epithelial cells, named cholangiocytes, may undergo a neoplastic transformation leading to cholangiocarcinoma. The role autophagy plays in cancer is still debated and few information are available in cholangiocarcinoma. We ... ...

    Abstract Bile duct epithelial cells, named cholangiocytes, may undergo a neoplastic transformation leading to cholangiocarcinoma. The role autophagy plays in cancer is still debated and few information are available in cholangiocarcinoma. We report
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1249264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Recommendations on maximising the clinical value of tissue in the management of patients with intrahepatic cholangiocarcinoma.

    Kendall, Timothy / Overi, Diletta / Guido, Maria / Braconi, Chiara / Banales, Jesus / Cardinale, Vincenzo / Gaudio, Eugenio / Groot Koerkamp, Bas / Carpino, Guido

    JHEP reports : innovation in hepatology

    2024  Volume 6, Issue 6, Page(s) 101067

    Abstract: Background & aims: Patients with intrahepatic cholangiocarcinoma can now be managed with targeted therapies directed against specific molecular alterations. Consequently, tissue samples submitted to the pathology department must produce molecular ... ...

    Abstract Background & aims: Patients with intrahepatic cholangiocarcinoma can now be managed with targeted therapies directed against specific molecular alterations. Consequently, tissue samples submitted to the pathology department must produce molecular information in addition to a diagnosis or, for resection specimens, staging information. The pathologist's role when evaluating these specimens has therefore changed to accommodate such personalised approaches.
    Methods: We developed recommendations and guidance for pathologists by conducting a systematic review of existing guidance to generate candidate statements followed by an international Delphi process. Fifty-nine pathologists from 28 countries in six continents rated statements mapped to all elements of the specimen pathway from receipt in the pathology department to authorisation of the final written report. A separate survey of 'end-users' of the report including surgeons, oncologists, and gastroenterologists was undertaken to evaluate what information should be included in the written report to enable appropriate patient management.
    Results: Forty-eight statements reached consensus for inclusion in the guidance including 10 statements about the content of the written report that also reached consensus by end-user participants. A reporting proforma to allow easy inclusion of the recommended data points was developed.
    Conclusions: These guiding principles and recommendations provide a framework to allow pathologists reporting on patients with intrahepatic cholangiocarcinoma to maximise the informational yield of specimens required for personalised patient management.
    Impact and implications: Biopsy or resection lesional tissue from intrahepatic cholangiocarcinoma must yield information about the molecular abnormalities within the tumour that define suitability for personalised therapies in addition to a diagnosis and staging information. Here, we have developed international consensus guidance for pathologists that report such cases using a Delphi process that sought the views of both pathologists and 'end-users of pathology reports. The guide highlights the need to report cases in a way that preserves tissue for molecular testing and emphasises that reporting requires interpretation of histological characteristics within the broader clinical and radiological context. The guide will allow pathologists to report cases of intrahepatic cholangiocarcinoma in a uniform manner that maximises the value of the tissue received to facilitate optimal multidisciplinary patient management.
    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-5559
    ISSN (online) 2589-5559
    DOI 10.1016/j.jhepr.2024.101067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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