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  1. Book ; Online: Entre science et culture : Introduction à la philosophie des sciences

    Gauthier, Yvon

    2005  

    Abstract: La philosophie des sciences définit les critères de scientificité qui permettent dévaluer la validité et la pertinence des théories scientifiques. Elle a donc une vocation critique. Cet ouvrage propose une analyse de la pratique scientifique aussi bien ... ...

    Abstract La philosophie des sciences définit les critères de scientificité qui permettent dévaluer la validité et la pertinence des théories scientifiques. Elle a donc une vocation critique. Cet ouvrage propose une analyse de la pratique scientifique aussi bien dans les sciences exactes que dans les sciences sociales et humaines, et ce, à partir dune perspective constructiviste qui donne un accès direct à la logique interne de lentreprise scientifique. Après avoir fait la génèse du savoir scientifique contemporain, lauteur examine plus particulièrement les deux grandes théories du XXe siècle, soit la théorie de la relativité et la mécanique quantique. Il ouvre ensuite une voie singulière vers les sciences humaines qui débouchera sur un tour dhorizon éclairé du structuralisme et des thématiques du langage dans les sciences sociales et humaines. De Hegel à Gadamer et de Lévi-Strauss à Foucault, la rétrospective critique qui se déploie apparaît ici comme un complément nécessaire à la discussion du constructivisme contemporain. Cette introduction à la philosophie des sciences sadresse tout aussi bien aux philosophes et aux scientifiques intéressés au problème des fondements quaux étudiants en philosophie
    Keywords Philosophy (General)
    Size 1 electronic resource ( pages)
    Publisher Presses de l'Université de Montréal
    Document type Book ; Online
    Note French ; Open Access
    HBZ-ID HT020322538
    ISBN 9791036502408
    DOI 10.4000/books.pum.10434
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Shared histological and immunohistological findings in two patients with generalized vitiligo associated with autoimmune atrophic gastritis.

    Ghalamkarpour, Fariba / André, Muriel Cario / Gauthier, Yvon

    Clinical case reports

    2022  Volume 10, Issue 9, Page(s) e6346

    Abstract: The prevalence of autoimmune atrophic gastritis (AAG) in vitiligo patients was estimated at about 15%. In both conditions, a release of specific antibodies and an autoimmune destruction of target cells (melanocytes in vitiligo, parietal cells (PC) in AAG) ...

    Abstract The prevalence of autoimmune atrophic gastritis (AAG) in vitiligo patients was estimated at about 15%. In both conditions, a release of specific antibodies and an autoimmune destruction of target cells (melanocytes in vitiligo, parietal cells (PC) in AAG) mediated by CD8-T lymphocytes was demonstrated to perform a comparative histological study of vitiligo skin and AAG mucosa. In two patients with concomitant vitiligo and AAG, biopsies from the vitiligo lesions and gastric mucosa from corpus fundus were performed. Sections were immunostained with E-cadherin, Coll IV, CD8, CD20, CD4 antibodies. The skin sections also were stained with HES, HMB45, MITF. Common histological findings were found in both diseases. Adhesivity impairment with down expression of E-cadherin and Coll IV was objectivated. The protruding MITF+melanocytes and the detached PC were surrounded by an infiltrate including CD8 and CD4. CD8 was infiltrating the epidermis in close contact with the remaining melanocytes and the gastric glands around the remaining PC. In both diseases, the autoimmune process could be preceded by a detachment of either melanocytes in vitiligo or PC in AAG possibly in relation to an initial adhesivity impairment of these cells. Common autoimmune mechanisms could be suggested for both diseases.
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Bachelard et Brunschvicg la Logique Interne du Discours Scientifique Bachelard und Brunschvicg die Innere Logik des Wissenschaftlichen Diskurses Bachelard y Brunschvicg la Lógica Interna del Discurso Científico.

    Gauthier, Yvon

    Revue de synthese

    2013  Volume 134, Issue 3, Page(s) 343–353

    Abstract: Bachelard is seen as sharing with Brunschvicg an "internalist" epistemology of mathematics and exact sciences. Brunschvicg's notion of constructive idealism concurs with Bachelard's surrationalism. Both philosophers defended the idea of an internal logic ...

    Title translation Brunschvicg, bachelard and the internal logic of scientific discourse.
    Abstract Bachelard is seen as sharing with Brunschvicg an "internalist" epistemology of mathematics and exact sciences. Brunschvicg's notion of constructive idealism concurs with Bachelard's surrationalism. Both philosophers defended the idea of an internal logic of scientific discourse which discloses the dialectics inherent in the dynamics of reason. The aim of philosophy is then to emphasize the genesis and progress of rationality in the historical development of science.
    Language French
    Publishing date 2013
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2485186-3
    ISSN 0035-1776
    ISSN 0035-1776
    DOI 10.1007/s11873-013-0225-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Towards an Arithmetical Logic

    Gauthier, Yvon

    The Arithmetical Foundations of Logic

    (Studies in Universal Logic)

    2015  

    Abstract: This book offers an original contribution to the foundations of logic and mathematics and focuses on the internal logic of mathematical theories, from arithmetic or number theory to algebraic geometry. Arithmetical logic is the term used to refer to the ... ...

    Series title Studies in Universal Logic
    Abstract This book offers an original contribution to the foundations of logic and mathematics and focuses on the internal logic of mathematical theories, from arithmetic or number theory to algebraic geometry. Arithmetical logic is the term used to refer to the internal logic of classical arithmetic, here called Fermat-Kronecker arithmetic and combines Fermat's method of infinite descent with Kronecker's general arithmetic of homogeneous polynomials. The book also includes a treatment of theories in physics and mathematical physics to underscore the role of arithmetic from a constructivist viewpoint. The scope of the work intertwines historical, mathematical, logical and philosophical dimensions in a unified critical perspective; as such, it will appeal to a broad readership from mathematicians to logicians, to philosophers interested in foundational questions. Researchers and graduate students in the fields of philosophy and mathematics will benefit from the author's critical approach to the foundations of logic and mathematics. Yvon Gauthier has taught formal logic and philosophy of science at the Universities of Sudbury, Toronto and Montreal for fifty years. He has studied philosophy in Heidelberg and he has been a Research Fellow in mathematics in Berkeley and Leningrad (St-Petersburg). Author of fifteen books, he has published extensively in foundations of mathematics and foundations of physics in specialized journals. The present book aims at a synthesis of his recent work.
    Keywords Technik / Wissen Mathematik
    Language English
    Size Online-Ressource
    Edition 1. Aufl.
    Publisher Birkhäuser
    Publishing place s.l.
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 3319220861 ; 9783319220864
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Book ; Online: Towards an Arithmetical Logic

    Gauthier, Yvon

    The Arithmetical Foundations of Logic

    (Studies in Universal Logic)

    2015  

    Abstract: This book offers an original contribution to the foundations of logic and mathematics, and focuses on the internal logic of mathematical theories, from arithmetic or number theory to algebraic geometry. Arithmetical logic is the term used to refer to the ...

    Author's details by Yvon Gauthier
    Series title Studies in Universal Logic
    Abstract This book offers an original contribution to the foundations of logic and mathematics, and focuses on the internal logic of mathematical theories, from arithmetic or number theory to algebraic geometry. Arithmetical logic is the term used to refer to the internal logic of classical arithmetic, here called Fermat-Kronecker arithmetic, and combines Fermat’s method of infinite descent with Kronecker’s general arithmetic of homogeneous polynomials. The book also includes a treatment of theories in physics and mathematical physics to underscore the role of arithmetic from a constructivist viewpoint. The scope of the work intertwines historical, mathematical, logical and philosophical dimensions in a unified critical perspective; as such, it will appeal to a broad readership from mathematicians to logicians, to philosophers interested in foundational questions. Researchers and graduate students in the fields of philosophy and mathematics will benefit from the author’s critical approach to the foundations of logic and mathematics
    Keywords Mathematical logic ; Mathematics
    Language English
    Size Online-Ressource (XI, 184 p. 9 illus), online resource
    Publisher Springer International Publishing
    Publishing place Cham ;s.l
    Document type Book ; Online
    ISBN 9783319220864 ; 9783319220871 ; 3319220861 ; 331922087X
    DOI 10.1007/978-3-319-22087-1
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article ; Online: The quality of the relationship as a factor of change. Discussion of paper: "Challenges working with infants and their families: Symptoms and meanings-two approaches of infant-parent psychotherapy".

    Gauthier, Yvon

    Infant mental health journal

    2011  Volume 32, Issue 6, Page(s) 650–652

    Language English
    Publishing date 2011-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 225602-2
    ISSN 1097-0355 ; 0163-9641
    ISSN (online) 1097-0355
    ISSN 0163-9641
    DOI 10.1002/imhj.20324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Child analysis in a changing world. In the face of a paradigm shift from the mind to the brain: Can we meet the challenge?

    Gauthier, Yvon

    Infant mental health journal

    2011  Volume 32, Issue 6, Page(s) 583–595

    Abstract: Child analysts and child therapists are now practicing in a new environment where an increased emphasis is made on identifying the symptoms and finding the shortest possible way to get rid of them, from the knowledge of brain functioning. From that ... ...

    Abstract Child analysts and child therapists are now practicing in a new environment where an increased emphasis is made on identifying the symptoms and finding the shortest possible way to get rid of them, from the knowledge of brain functioning. From that perspective, the history of the symptom, of the child who owns it, and of the family in which this child is being raised are not emphasized as strongly. Searching for a specific meaning of such symptoms seems to be of no more interest. How can such a heavy trend be met? Major changes also have occurred within the psychoanalytic milieu. Advances from the observational world, from Spitz (1945) to Bowlby's (1987) attachment theory, provide essential knowledge to the field of early child-parent interactions. Longitudinal research in recent decades has shown close ties between early development and future outcomes. Such new knowledge is inspiring child analysis with very young children as well as with severely disturbed, older children. Early intervention with disadvantaged populations is showing the importance of the nonspecific aspects of the therapeutic relationship as a factor of change. In light of recent neurobiologic research on the influence of a specific environment-attachment experiences-on early development of the brain, it is now possible to speak of the social brain (Cozolino, 2006).
    Language English
    Publishing date 2011-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 225602-2
    ISSN 1097-0355 ; 0163-9641
    ISSN (online) 1097-0355
    ISSN 0163-9641
    DOI 10.1002/imhj.20317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The first transepidermal transplantation of non-cultured epidermal suspension using a dermarolling system in vitiligo: A sequential histological and clinical study.

    Benzekri, Laila / Gauthier, Yvon

    Pigment cell & melanoma research

    2017  Volume 30, Issue 5, Page(s) 493–497

    Abstract: The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here, we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves ... ...

    Abstract The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here, we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves preparation of a keratinocyte/melanocyte suspension prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermaroller equipped with 0.2-mm needles. Dermarolling leads to epidermal microinjuries without, however, causing pain or inflammation. The technique was applied to facial depigmented areas of five patients with stable vitiligo that were resistant to conventional UV/tacrolimus treatment. The efficacy of cell delivery was analysed histologically on punch biopsies, and repigmentation was evaluated photographically and by clinical assessment. We found that the transplanted keratinocytes rapidly degenerated, leading to keratinization, but melanocytes survived and integrated appropriately into the basal layer of the epidermis, leading to excellent repigmentation after 6 months in three cases and mild repigmentation in two cases. Although based on a small number of patients, we anticipate this technique to become a valid addition to the arsenal of therapeutic approaches to repigmentation in depigmenting disorders.
    MeSH term(s) Adult ; Cells, Cultured ; Epidermis/transplantation ; Epidermis/ultrastructure ; Female ; Humans ; Male ; Skin Pigmentation ; Suspensions ; Vitiligo/pathology ; Vitiligo/therapy
    Chemical Substances Suspensions
    Language English
    Publishing date 2017-07-04
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2409570-9
    ISSN 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
    ISSN (online) 1755-148X ; 1600-0749
    ISSN 0893-5785 ; 1755-1471
    DOI 10.1111/pcmr.12600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2444: Show issues Location:
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  9. Article ; Online: Clinical markers of vitiligo activity.

    Benzekri, Laila / Gauthier, Yvon

    Journal of the American Academy of Dermatology

    2017  Volume 76, Issue 5, Page(s) 856–862

    Abstract: Background: Current modalities of understanding disease state (active/stable) are limited when considering treatment of vitiligo.: Objective: We sought to develop a rapid, accurate, and noninvasive assessment of vitiligo state.: Methods: In ... ...

    Abstract Background: Current modalities of understanding disease state (active/stable) are limited when considering treatment of vitiligo.
    Objective: We sought to develop a rapid, accurate, and noninvasive assessment of vitiligo state.
    Methods: In daylight and Wood's light examinations, 2 common clinical types of vitiligo were identified as amelanotic with sharply demarcated borders and hypomelanotic with poorly defined borders. Photographs were taken at the time of examination and a skin biopsy at the edge of a vitiligo lesion was performed. One year after the initial visit, the vitiligo was classified as stable if no new lesions had appeared, and as active if the number, size, or both of existing vitiligo lesions were increased. Skin biopsy specimens from 71 patients were stained and immunostained for melanocytes, CD8
    Results: The active lesions were associated with hypomelanotic appearance with poorly defined borders (P < .001), and histologically with an infiltration of CD8
    Limitation: The fact that this was a single-center study and that activity was sometimes site-dependent are limitations.
    Conclusion: The hypomelanotic with poorly defined borders type could be a good indicator of the actual activity of a vitiligo lesion.
    MeSH term(s) Adolescent ; Adult ; Biopsy ; CD8-Positive T-Lymphocytes ; Cadherins/analysis ; Child ; Cross-Sectional Studies ; Female ; Humans ; Lymphocyte Count ; Male ; Melanocytes ; Photography ; Prospective Studies ; Skin/pathology ; Ultraviolet Rays ; Vitiligo/diagnostic imaging ; Vitiligo/metabolism ; Vitiligo/pathology ; Young Adult
    Chemical Substances Cadherins
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2016.12.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1540: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article: Commentary to When attachment disorder presents with symptoms of gender identity disorder: case discussion.

    Gauthier, Yvon

    Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

    2009  Volume 18, Issue 2, Page(s) 138

    Language English
    Publishing date 2009-05-29
    Publishing country Canada
    Document type Comment ; Journal Article
    ZDB-ID 2381637-5
    ISSN 2293-6122 ; 1719-8429
    ISSN (online) 2293-6122
    ISSN 1719-8429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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