Article ; Online: Reduced levels of vasopressin, an independent mechanism in the obesity paradox in patients with chronic heart failure: Insights from the DAMOCLES study.
International journal of cardiology
2018 Volume 276, Page(s) 171–176
Abstract: Background: An "obesity paradox" has been described in patients with chronic heart failure (CHF), obese patients having a better survival. Vasopressin is elevated in patients with CHF, and higher levels are associated with worsening severity of the ... ...
| Abstract | Background: An "obesity paradox" has been described in patients with chronic heart failure (CHF), obese patients having a better survival. Vasopressin is elevated in patients with CHF, and higher levels are associated with worsening severity of the disease. We aimed at evaluating the relationship between body mass index (BMI), obesity (BMI ≥30 kg/m Methods: We included 1132 consecutive CHF patients referred to a multidisciplinary CHF unit. BMI and vasopressin levels were measured at baseline, and their association was evaluated using multivariable linear and logistic regression models. Death was evaluated after a median follow-up of 2.93 years and using Cox regression analyses. Results: Mean age was 73 years, 43% women, mean BMI 28 kg/m Conclusions: Reduced levels of vasopressin may represent an independent mechanism in the survival paradox in obese patients with CHF. Studies including larger samples of patients BMI ≥35 kg/m |
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| MeSH term(s) | Aged ; Aged, 80 and over ; Biomarkers/blood ; Chronic Disease ; Cohort Studies ; Female ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Humans ; Male ; Middle Aged ; Neurophysins/blood ; Obesity/blood ; Obesity/diagnosis ; Obesity/physiopathology ; Prospective Studies ; Protein Precursors/blood ; Vasopressins/blood |
| Chemical Substances | AVP protein, human ; Biomarkers ; Neurophysins ; Protein Precursors ; Vasopressins (11000-17-2) |
| Language | English |
| Publishing date | 2018-10-29 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 779519-1 |
| ISSN | 1874-1754 ; 0167-5273 |
| ISSN (online) | 1874-1754 |
| ISSN | 0167-5273 |
| DOI | 10.1016/j.ijcard.2018.10.094 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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