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  1. Article ; Online: Perceived Stress and Life Events in Patients Affected by Schizophrenia and Schizoaffective and Bipolar Disorder: Is There a Role for Self-Reported Basic Symptoms?

    Parmigiani, Giovanna / Mandarelli, Gabriele / Tarsitani, Lorenzo / Roselli, Valentina / Gaviano, Ilaria / Buscajoni, Andrea / Biondi, Massimo / Girardi, Paolo / Ferracuti, Stefano

    Psychopathology

    2021  Volume 54, Issue 3, Page(s) 136–143

    Abstract: Introduction: The stress-diathesis model of psychotic disorders describes, in vulnerable individuals, the role of psychosocial stress in the onset and exacerbation of psychotic symptoms. Another interesting approach to the study of vulnerability in the ... ...

    Abstract Introduction: The stress-diathesis model of psychotic disorders describes, in vulnerable individuals, the role of psychosocial stress in the onset and exacerbation of psychotic symptoms. Another interesting approach to the study of vulnerability in the development of psychosis is represented by the basic symptoms concept.
    Objective: The present study aims at proposing an integration between these two models and investigating possible associations between psychotic symptoms, basic symptoms, perceived stress, and life events in a sample of patients affected by schizophrenia (SZ), schizoaffective (SA), and bipolar disorder with and without psychotic symptoms.
    Methods: 112 patients were recruited in two university hospitals. Severity of psychiatric symptoms (Positive and Negative Syndrome Scale, PANSS), basic symptoms (Frankfurt Complaint Questionnaire, FCQ), perceived stress (Stress-related Vulnerability Scale, SVS), and life events (Paykel's interview for recent life events) were assessed.
    Results: Patients affected by bipolar disorder (both with and without psychotic symptoms) showed a higher number of independent life events (p < 0.01) and tended to report more frequently at least 1 life event in the previous 6 months (p < 0.01) than patients affected by SZ or SA disorder. No differences emerged between the study groups in perceived stress nor in measures of basic symptoms. In the whole sample, a logistic regression analysis showed that the SVS total score (p < 0.05) and PANSS total score (p < 0.001) were associated with the presence of psychotic symptoms.
    Conclusions: In the study sample, life events and basic symptoms did not play a major role in influencing psychotic symptoms, compared to the subjective perception of stress and the severity of psychopathology. Taken together, these results can be informative for rehabilitation therapies aimed at enhancing resilience and coping strategies in this vulnerable group of patients.
    MeSH term(s) Adult ; Bipolar Disorder/psychology ; Female ; Humans ; Male ; Middle Aged ; Psychotic Disorders/diagnosis ; Schizophrenia/diagnosis ; Self Report
    Language English
    Publishing date 2021-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605604-0
    ISSN 1423-033X ; 0254-4962
    ISSN (online) 1423-033X
    ISSN 0254-4962
    DOI 10.1159/000514926
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  2. Article ; Online: Timing and Outcomes of Noninvasive Ventilation in 307 ARDS COVID-19 Patients: An Observational Study in an Italian Third Level COVID-19 Hospital.

    Tetaj, Nardi / Piselli, Pierluca / Zito, Sara / De Angelis, Giada / Marini, Maria Cristina / Rubino, Dorotea / Gaviano, Ilaria / Antonica, Maria Vittoria / Agostini, Elisabetta / Porcelli, Candido / Stazi, Giulia Valeria / Garotto, Gabriele / Busso, Donatella / Scarcia, Silvana / Navarra, Assunta / Cimaglia, Claudia / Topino, Simone / Iacomi, Fabio / D'Abramo, Alessandra /
    Pinnetti, Carmela / Gualano, Gina / Capone, Alessandro / Villanacci, Alberta / Antinori, Andrea / Palmieri, Fabrizio / D'Offizi, Gianpiero / Ianniello, Stefania / Taglietti, Fabrizio / Campioni, Paolo / Vaia, Francesco / Nicastri, Emanuele / Girardi, Enrico / Marchioni, Luisa / On Behalf Of The ReCOVeRI Study Group

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 8

    Abstract: Background and Objectives: Background: Coronavirus disease 2019 (COVID-19) is a novel cause of Acute Respiratory Distress Syndrome (ARDS). Noninvasive ventilation (NIV) is widely used in patients with ARDS across several etiologies. Indeed, with the ... ...

    Abstract Background and Objectives: Background: Coronavirus disease 2019 (COVID-19) is a novel cause of Acute Respiratory Distress Syndrome (ARDS). Noninvasive ventilation (NIV) is widely used in patients with ARDS across several etiologies. Indeed, with the increase of ARDS cases due to the COVID-19 pandemic, its use has grown significantly in hospital wards. However, there is a lack of evidence to support the efficacy of NIV in patients with COVID-19 ARDS. Materials and Methods: We conducted an observational cohort study including adult ARDS COVID-19 patients admitted in a third level COVID-center in Rome, Italy. The study analyzed the rate of NIV failure defined by the occurrence of orotracheal intubation and/or death within 28 days from starting NIV, its effectiveness, and the associated relative risk of death. The factors associated with the outcomes were identified through logistic regression analysis. Results: During the study period, a total of 942 COVID-19 patients were admitted to our hospital, of which 307 (32.5%) presented with ARDS at hospitalization. During hospitalization 224 (23.8%) were treated with NIV. NIV failure occurred in 84 (37.5%) patients. At 28 days from starting NIV, moderate and severe ARDS had five-fold and twenty-fold independent increased risk of NIV failure (adjusted odds ratio, aOR = 5.01, 95% CI 2.08−12.09, and 19.95, 95% CI 5.31−74.94), respectively, compared to patients with mild ARDS. A total of 128 patients (13.5%) were admitted to the Intensive Care Unit (ICU). At 28-day from ICU admission, intubated COVID-19 patients treated with early NIV had 40% lower mortality (aOR 0.60, 95% CI 0.25−1.46, p = 0.010) compared with patients that underwent orotracheal intubation without prior NIV. Conclusions: These findings show that NIV failure was independently correlated with the severity category of COVID-19 ARDS. The start of NIV in COVID-19 patients with mild ARDS (P/F > 200 mmHg) appears to increase NIV effectiveness and reduce the risk of orotracheal intubation and/or death. Moreover, early NIV (P/F > 200 mmHg) treatment seems to reduce the risk of ICU mortality at 28 days from ICU admission.
    MeSH term(s) Adult ; COVID-19/complications ; Cohort Studies ; Hospitals ; Humans ; Intensive Care Units ; Noninvasive Ventilation ; Pandemics ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Respiratory Insufficiency/etiology
    Language English
    Publishing date 2022-08-15
    Publishing country Switzerland
    Document type Journal Article ; Observational Study
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58081104
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  3. Article: Measuring depression with questions about well-being: a study on psychiatric outpatients.

    Tarolla, Emanuele / Biondi, Massimo / Fabi, Elisa / Gaviano, Ilaria / Gigantesco, Antonella / Tarsitani, Lorenzo / Picardi, Angelo

    Rivista di psichiatria

    2012  Volume 47, Issue 4, Page(s) 304–308

    Abstract: Background: Most depression rating scales are characterized by negatively-phrased questions, exploring the presence of various symptoms. Questions such as those regarding suicidal ideation or painful experiences may reduce accept-ability or even lead ... ...

    Abstract Background: Most depression rating scales are characterized by negatively-phrased questions, exploring the presence of various symptoms. Questions such as those regarding suicidal ideation or painful experiences may reduce accept-ability or even lead the reader to withdraw participation in the study. Although positively-worded items may be useful, it should be acknowledged that without formal testing they cannot be assumed to be equivalent to negatively-worded ones. The aim of the present study was to test the reliability and validity of a depression rating scale including only positively-phrased items.
    Methods: Two groups were enrolled in the study: the first comprised 104 adult psychiatric outpatients, the second 88 undergraduate students. All participants completed the depression scale of the Patient Health Questionnaire, the Zung Self-Rating Depression Scale, and the Positively-phrased Depression Scale (PDS), a 10-item self-report instrument in which the items are phrased in a positive way to reflect the absence of symptoms. Psychiatric outpatients also were rated by their clinician on the Hamilton Depression Rating Scale.
    Results: The internal consistency of the PDS was satisfactory. The correlations between scores on the PDS and on the other depression scales were moderate to high. Mean PDS scores of patients with a diagnosis of depressive disorder were significantly higher than those of patients with other mental disorders.
    Conclusions: Despite some limitations, this study suggests that the PDS a valid and reliable instrument which might prove particularly useful for the assessment of depressive symptoms in studies where issues of acceptability are important, such as studies on non-clinical populations, occupational samples, and patients drawn from non-psychiatric settings.
    MeSH term(s) Depression/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Outpatients ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2012-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205570-3
    ISSN 0035-6484
    ISSN 0035-6484
    DOI 10.1708/1139.12557
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  4. Article: Outcomes and Timing of Bedside Percutaneous Tracheostomy of COVID-19 Patients over a Year in the Intensive Care Unit.

    Tetaj, Nardi / Maritti, Micaela / Stazi, Giulia / Marini, Maria Cristina / Centanni, Daniele / Garotto, Gabriele / Caravella, Ilaria / Dantimi, Cristina / Fusetti, Matteo / Santagata, Carmen / Macchione, Manuela / De Angelis, Giada / Giansante, Filippo / Busso, Donatella / Di Lorenzo, Rachele / Scarcia, Silvana / Carucci, Alessandro / Cabas, Ricardo / Gaviano, Ilaria /
    Petrosillo, Nicola / Antinori, Andrea / Palmieri, Fabrizio / D'Offizi, Gianpiero / Ianniello, Stefania / Campioni, Paolo / Pugliese, Francesco / Vaia, Francesco / Nicastri, Emanuele / Ippolito, Giuseppe / Marchioni, Luisa / Icu Covid-Study Group

    Journal of clinical medicine

    2021  Volume 10, Issue 15

    Abstract: Background: The benefits and timing of percutaneous dilatational tracheostomy (PDT) in Intensive Care Unit (ICU) COVID-19 patients are still controversial. PDT is considered a high-risk procedure for the transmission of SARS-CoV-2 to healthcare workers ( ...

    Abstract Background: The benefits and timing of percutaneous dilatational tracheostomy (PDT) in Intensive Care Unit (ICU) COVID-19 patients are still controversial. PDT is considered a high-risk procedure for the transmission of SARS-CoV-2 to healthcare workers (HCWs). The present study analyzed the optimal timing of PDT, the clinical outcomes of patients undergoing PDT, and the safety of HCWs performing PDT.
    Methods: Of the 133 COVID-19 patients who underwent PDT in our ICU from 1 April 2020 to 31 March 2021, 13 patients were excluded, and 120 patients were enrolled. A trained medical team was dedicated to the PDT procedure. Demographic, clinical history, and outcome data were collected. Patients who underwent PDT were stratified into two groups: an early group (PDT ≤ 12 days after orotracheal intubation (OTI) and a late group (>12 days after OTI). An HCW surveillance program was also performed.
    Results: The early group included 61 patients and the late group included 59 patients. The early group patients had a shorter ICU length of stay and fewer days of mechanical ventilation than the late group (
    Conclusions: PDT was safe and effective for COVID-19 patients since it improved respiratory support parameters, reduced ICU length of stay and duration of mechanical ventilation, and optimized the weaning process. The procedure was safe for all HCWs involved in the dedicated medical team. The development of standardized early PDT protocols should be implemented, and PDT could be considered a first-line approach in ICU COVID-19 patients requiring prolonged mechanical ventilation.
    Language English
    Publishing date 2021-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10153335
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  5. Article ; Online: Epidemiology of ventilator-associated pneumonia in ICU COVID-19 patients: an alarming high rate of multidrug-resistant bacteria.

    Tetaj, Nardi / Capone, Alessandro / Stazi, Giulia Valeria / Marini, Maria Cristina / Garotto, Gabriele / Busso, Donatella / Scarcia, Silvana / Caravella, Ilaria / Macchione, Manuela / De Angelis, Giada / Di Lorenzo, Rachele / Carucci, Alessandro / Antonica, Maria Vittoria / Gaviano, Ilaria / Inversi, Carlo / Agostini, Elisabetta / Canichella, Flaminia / Taloni, Giorgia / Evangelista, Francesca /
    Onnis, Ilaria / Mogavero, Giulia / Lamanna, Maria Elena / Rubino, Dorotea / Di Frischia, Mattia / Porcelli, Candido / Cesi, Elena / Antinori, Andrea / Palmieri, Fabrizio / D'Offizi, Gianpiero / Taglietti, Fabrizio / Nisii, Carla / Cataldo, Maria Adriana / Ianniello, Stefania / Campioni, Paolo / Vaia, Francesco / Nicastri, Emanuele / Girardi, Enrico / Marchioni, Luisa

    Journal of Anesthesia, Analgesia and Critical Care (Online)

    2022  Volume 2, Issue 1, Page(s) 36

    Abstract: Background: COVID‑19 is a novel cause of acute respiratory distress syndrome (ARDS) that leads patients to intensive care unit (ICU) admission requiring invasive ventilation, who consequently are at risk of developing of ventilator‑associated pneumonia ( ...

    Abstract Background: COVID‑19 is a novel cause of acute respiratory distress syndrome (ARDS) that leads patients to intensive care unit (ICU) admission requiring invasive ventilation, who consequently are at risk of developing of ventilator‑associated pneumonia (VAP). The aim of this study was to assess the incidence, antimicrobial resistance, risk factors, and outcome of VAP in ICU COVID-19 patients in invasive mechanical ventilation (MV).
    Methods: Observational prospective study including adult ICU admissions between January 1, 2021, and June 31, 2021, with confirmed COVID-19 diagnosis were recorded daily, including demographics, medical history, ICU clinical data, etiology of VAPs, and the outcome. The diagnosis of VAP was based on multi-criteria decision analysis which included a combination of radiological, clinical, and microbiological criteria in ICU patients in MV for at least 48 h.
    Results: Two hundred eighty-four COVID-19 patients in MV were admitted in ICU. Ninety-four patients (33%) had VAP during the ICU stay, of which 85 had a single episode of VAP and 9 multiple episodes. The median time of onset of VAP from intubation were 8 days (IQR, 5-13). The overall incidence of VAP was of 13.48 episodes per 1000 days in MV. The main etiological agent was Pseudomonas aeruginosa (39.8% of all VAPs) followed by Klebsiella spp. (16.5%); of them, 41.4% and 17.6% were carbapenem resistant, respectively. Patients during the mechanical ventilation in orotracheal intubation (OTI) had a higher incidence than those in tracheostomy, 16.46 and 9.8 episodes per 1000-MV day, respectively. An increased risk of VAP was reported in patients receiving blood transfusion (OR 2.13, 95% CI 1.26-3.59, p = 0.005) or therapy with Tocilizumab/Sarilumab (OR 2.08, 95% CI 1.12-3.84, p = 0.02). The pronation and PaO
    Conclusions: COVID-19 patients have a higher incidence of VAP compared to the general ICU population, but it is similar to that of ICU ARDS patients in the pre-COVID-19 period. Interleukin-6 inhibitors and blood transfusions may increase the risk of VAP. The widespread use of empirical antibiotics in these patients should be avoided to reduce the selecting pressure on the growth of multidrug-resistant bacteria by implementing infection control measures and antimicrobial stewardship programs even before ICU admission.
    Language English
    Publishing date 2022-08-19
    Publishing country England
    Document type Journal Article
    ISSN 2731-3786
    ISSN (online) 2731-3786
    DOI 10.1186/s44158-022-00065-4
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  6. Article: Development and validation of the Italian version of the 15-item dispositional resilience scale.

    Picardi, Angelo / Bartone, Paul T / Querci, Raffaella / Bitetti, Daniela / Tarsitani, Lorenzo / Roselli, Valentina / Maraone, Annalisa / Fabi, Elisa / De Michele, Francesco / Gaviano, Ilaria / Flynn, Brian / Ursano, Robert / Biondi, Massimo

    Rivista di psichiatria

    2012  Volume 47, Issue 3, Page(s) 231–237

    Abstract: Studies have shown that psychological hardiness is an important stress resilience resource for individuals. The 15-items Dispositional Resilience Scale (DRS-15) is a short, reliable and valid self-report instrument to measure hardiness that is not ... ...

    Abstract Studies have shown that psychological hardiness is an important stress resilience resource for individuals. The 15-items Dispositional Resilience Scale (DRS-15) is a short, reliable and valid self-report instrument to measure hardiness that is not available in Italian. The present study was undertaken to create an Italian version of the DRS-15, and evaluate its psychometric properties and validity in the Italian context. An Italian version was produced using multiple independent bilingual translators. This version was administered to a non-clinical sample of adults (N=150), along with measure o psychological well-being (PWB-18) and health. A sub-sample (N = 66) completed the DRS-15 again one month later. Results showed good reliability in terms of internal consistency and test-retest stability. With regard to the subscale, stability was high for all three subscales, whereas two subscales (Commitment and Control) showed marginal internal consistency. DRS-15 total and subscales scores showed a theoretically meaningful pattern of correlations with PWB-18 subscales, supporting the validity of the Italian DRS. Also, multiple regression analysis revealed a correlation between DRS-15 scores and self-rated general health, even after controlling for age and sex. The new Italian DRS-15 provides a valid, reliable and easy to use tool fr assessing stress resilience in clinical and research settings.
    MeSH term(s) Adaptation, Psychological ; Adult ; Female ; Humans ; Italy ; Language ; Male ; Surveys and Questionnaires
    Language English
    Publishing date 2012-05
    Publishing country Italy
    Document type Journal Article ; Validation Studies
    ZDB-ID 205570-3
    ISSN 0035-6484
    ISSN 0035-6484
    DOI 10.1708/1128.12446
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  7. Article ; Online: Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital.

    Mondi, Annalisa / Lorenzini, Patrizia / Castilletti, Concetta / Gagliardini, Roberta / Lalle, Eleonora / Corpolongo, Angela / Valli, Maria Beatrice / Taglietti, Fabrizio / Cicalini, Stefania / Loiacono, Laura / Di Gennaro, Francesco / D'Offizi, Gianpiero / Palmieri, Fabrizio / Nicastri, Emanuele / Agrati, Chiara / Petrosillo, Nicola / Ippolito, Giuseppe / Vaia, Francesco / Girardi, Enrico /
    Capobianchi, Maria Rosaria / Antinori, Andrea / Zito, Sara / Abbonizio, Maria Alessandra / Abdeddaim, Amina / Agostini, Elisabetta / Albarello, Fabrizio / Amadei, Gioia / Amendola, Alessandra / Antonica, Maria Assunta / Antonini, Mario / Bartoli, Tommaso Ascoli / Baldini, Francesco / Barbaro, Raffaella / Bartolini, Barbara / Bellagamba, Rita / Benigni, Martina / Bevilacqua, Nazario / Biava, Gianluigi / Bibas, Michele / Bordi, Licia / Bordoni, Veronica / Boumis, Evangelo / Branca, Marta / Buonomo, Rosanna / Busso, Donatella / Camici, Marta / Campioni, Paolo / Canichella, Flaminia / Capone, Alessandro / Caporale, Cinzia / Caraffa, Emanuela / Caravella, Ilaria / Carletti, Fabrizio / Cataldo, Adriana / Cerilli, Stefano / Cerva, Carlotta / Chiappini, Roberta / Chinello, Pierangelo / Cianfarani, Maria Assunta / Ciaralli, Carmine / Cimaglia, Claudia / Cinicola, Nicola / Ciotti, Veronica / Colavita, Francesca / Cristofaro, Massimo / Curiale, Salvatore / D'Abramo, Alessandra / Dantimi, Cristina / De Angelis, Alessia / De Angelis, Giada / De Palo, Maria Grazia / De Zottis, Federico / Di Bari, Virginia / Di Lorenzo, Rachele / Di Stefano, Federica / Donno, Davide / Evangelista, Francesca / Faraglia, Francesca / Farina, Anna / Ferraro, Federica / Fiorentini, Lorena / Frustaci, Andrea / Fusetti, Matteo / Galati, Vincenzo / Gallì, Paola / Garotto, Gabriele / Gaviano, Ilaria / Tekle, Saba Gebremeskel / Giancola, Maria Letizia / Giansante, Filippo / Giombini, Emanuela / Granata, Guido / Greci, Maria Cristina / Grilli, Elisabetta / Grisetti, Susanna / Gualano, Gina / Iacomi, Fabio / Iaconi, Marta / Iannicelli, Giuseppina / Inversi, Carlo / Lamanna, Maria Elena / Lanini, Simone / Lapa, Daniele / Lepore, Luciana / Libertone, Raffaella / Lionetti, Raffaella / Liuzzi, Giuseppina / Lucia, Andrea / Lufrani, Franco / Macchione, Manuela / Maffongelli, Gaetano / Marani, Alessandra / Marchioni, Luisa / Mariano, Andrea / Marini, Maria Cristina / Maritti, Micaela / Mastrobattista, Annelisa / Mastrorosa, Ilaria / Matusali, Giulia / Mazzotta, Valentina / Mencarini, Paola / Meschi, Silvia / Messina, Francesco / Micarelli, Sibiana / Mogavero, Giulia / Montalbano, Marzia / Montaldo, Chiara / Mosti, Silvia / Murachelli, Silvia / Musso, Maria / Nardi, Michela / Navarra, Assunta / Nocioni, Martina / Noto, Pasquale / Noto, Roberto / Oliva, Alessandra / Onnis, Ilaria / Ottou, Sandrine / Palazzolo, Claudia / Pallini, Emanuele / Palombi, Giulio / Pareo, Carlo / Passeri, Virgilio / Pelliccioni, Federico / Penna, Giovanna / Petrecchia, Antonella / Petrone, Ada / Pianura, Elisa / Pinnetti, Carmela / Pisciotta, Maria / Piselli, Pierluca / Pittalis, Silvia / Pontarelli, Agostina / Proietti, Costanza / Puro, Vincenzo / Ramazzini, Paolo Migliorisi / Rianda, Alessia / Rinonapoli, Gabriele / Rosati, Silvia / Rubino, Dorotea / Rueca, Martina / Ruggeri, Alberto / Sacchi, Alessandra / Sampaolesi, Alessandro / Sanasi, Francesco / Santagata, Carmen / Scarabello, Alessandra / Scarcia, Silvana / Schininà, Vincenzo / Scognamiglio, Paola / Scorzolini, Laura / Stazi, Giulia / Strano, Giacomo / Taibi, Chiara / Taloni, Giorgia / Nardi, Tetaj / Tonnarini, Roberto / Topino, Simone / Tozzi, Martina / Vairo, Francesco / Vergori, Alessandra / Vincenzi, Laura / Visco-Comandini, Ubaldo / Vita, Serena / Vittozzi, Pietro / Zaccarelli, Mauro / Zanetti, Antonella

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 105, Page(s) 532–539

    Abstract: Background: Limited data are available about the predictors and outcomes associated with prolonged SARS-CoV-2 RNA shedding (VS).: Methods: A retrospective study including COVID-19 patients admitted to an Italian hospital between March 1 and July 1, ... ...

    Abstract Background: Limited data are available about the predictors and outcomes associated with prolonged SARS-CoV-2 RNA shedding (VS).
    Methods: A retrospective study including COVID-19 patients admitted to an Italian hospital between March 1 and July 1, 2020. Predictors of viral clearance (VC) and prolonged VS from the upper respiratory tract were assessed by Poisson regression and logistic regression analyses. The causal relation between VS and clinical outcomes was evaluated through an inverse probability weighted Cox model.
    Results: The study included 536 subjects. The median duration of VS from symptoms onset was 18 days. The estimated 30-day probability of VC was 70.2%. Patients with comorbidities, lymphopenia at hospital admission, or moderate/severe respiratory disease had a lower chance of VC. The development of moderate/severe respiratory failure, delayed hospital admission after symptoms onset, baseline comorbidities, or D-dimer >1000ng/mL at admission independently predicted prolonged VS. The achievement of VC doubled the chance of clinical recovery and reduced the probability of death/mechanical ventilation.
    Conclusions: Respiratory disease severity, comorbidities, delayed hospital admission and inflammatory markers negatively predicted VC, which resulted to be associated with better clinical outcomes. These findings highlight the importance of prompt hospitalization of symptomatic patients, especially where signs of severity or comorbidities are present.
    MeSH term(s) Adult ; Aged ; COVID-19/virology ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; RNA, Viral/analysis ; Respiratory System/virology ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Time Factors ; Virus Shedding
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-03-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.02.117
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