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  1. Article ; Online: The role of complement activation in COPD exacerbation recovery

    John-Paul Westwood / Alexander J. Mackay / Gavin Donaldson / Samuel J. Machin / Jadwiga A. Wedzicha / Marie Scully

    ERJ Open Research, Vol 2, Iss

    2016  Volume 4

    Keywords Medicine ; R
    Language English
    Publishing date 2016-10-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19

    Linzy Houchen-Wolloff / Sally Singh / Jennifer K Quint / Michael Marks / Nicholas Hart / Matthew Richardson / Ling-Pei Ho / Charlotte E Bolton / Rachael A Evans / Amit Kulkarni / Amisha Singapuri / Felicity Evison / Sarah Wallace / Betty Raman / Trudie Chalder / Claire Marie Nolan / William Man / Ewen Harrison / Nazir I Lone /
    Chris Brightling / Julie Whitney / James Chalmers / Enya Daynes / Neil J Greening / Annemarie Docherty / Gavin Donaldson / Janet Scott / Camilla Dawson / Tom Yates / Louise V Wain / Marco Sereno / Krisnah Poinasamy / Gemma Clunie / Hamish McAuley / Alex Robert Horsley / Melitta McNarry / Sallyanne Duncan / Olivia C Leavy / Elneima Omer / Aarti Shikotra / Ruth M Saunders / Victoria C Harris / Dan Gower Wootton / Jack Sargent / John Pimm / Lettie Bishop / Neil Sharma / Margaret Coffey

    BMJ Open Respiratory Research, Vol 10, Iss

    the PHOSP-COVID analysis

    2023  Volume 1

    Abstract: Objective Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.Design Multicentre prospective observational cohort study using questionnaire data at visit 1 (2–7 months post ... ...

    Abstract Objective Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.Design Multicentre prospective observational cohort study using questionnaire data at visit 1 (2–7 months post discharge) and visit 2 (10–14 months post discharge) from hospitalised patients in the UK. Lasso logistic regression analysis was undertaken to identify associations.Setting 64 UK acute hospital Trusts.Participants Adults aged >18 years, discharged from an admissions unit or ward at a UK hospital with COVID-19.Main outcome measures Self-reported swallow, communication, voice and cognitive compromise.Results Compromised swallowing post intensive care unit (post-ICU) admission was reported in 20% (188/955); 60% with swallow problems received invasive mechanical ventilation and were more likely to have undergone proning (p=0.039). Voice problems were reported in 34% (319/946) post-ICU admission who were more likely to have received invasive (p<0.001) or non-invasive ventilation (p=0.001) and to have been proned (p<0.001). Communication compromise was reported in 23% (527/2275) univariable analysis identified associations with younger age (p<0.001), female sex (p<0.001), social deprivation (p<0.001) and being a healthcare worker (p=0.010). Cognitive issues were reported by 70% (1598/2275), consistent at both visits, at visit 1 respondents were more likely to have higher baseline comorbidities and at visit 2 were associated with greater social deprivation (p<0.001).Conclusion Swallow, communication, voice and cognitive problems were prevalent post hospitalisation for COVID-19, alongside whole system compromise including reduced mobility and overall health scores. Research and testing of rehabilitation interventions are required at pace to explore these issues.
    Keywords Medicine ; R ; Diseases of the respiratory system ; RC705-779
    Subject code 360
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: The prevalence of heat-related cardiorespiratory symptoms: the vulnerable groups identified from the National FINRISK 2007 Study

    Näyhä, Simo / Hannu Rintamäki / Gavin Donaldson / Juhani Hassi / Pekka Jousilahti / Tiina Laatikainen / Jouni J. K. Jaakkola / Tiina M. Ikäheimo

    International journal of biometeorology. 2017 Apr., v. 61, no. 4

    2017  

    Abstract: The prevalence of heat-related cardiorespiratory symptoms among vulnerable groups is not well known. We therefore estimated the prevalence of heat-related cardiorespiratory symptoms among the Finnish population and their associations with social and ... ...

    Abstract The prevalence of heat-related cardiorespiratory symptoms among vulnerable groups is not well known. We therefore estimated the prevalence of heat-related cardiorespiratory symptoms among the Finnish population and their associations with social and individual vulnerability factors. The data came from the National FINRISK 2007 Study, in which 4007 men and women aged 25–74 answered questions on heat-related cardiorespiratory symptoms in the Oulu Cold and Heat Questionnaire 2007. Logistic regression was used to calculate odds ratios (ORs), their 95 % confidence intervals (CIs), and model-predicted prevalence figures. The prevalence of heat-related cardiorespiratory symptoms was 12 %. It increased with age, from 3 % at the age of 25 years to 28 % at the age of 75 years. The symptoms were associated with pre-existing lung (OR 3.93; CI 3.01–5.13) and cardiovascular diseases (OR 2.27; 1.78–2.89); being a pensioner (OR 2.91; 1.65–5.28), unemployed (OR 2.82; 1.47–5.48), or working in agriculture (OR 2.27; 1.14–4.46) compared with working in industry; having only basic vs academic education (OR 1.98; 1.31–3.05); being female (OR 1.94; 1.51–2.50); being heavy vs light alcohol consumer (OR 1.89; 1.02–3.32); undertaking hard vs light physical work (OR 1.48;1.06–2.07); and being inactive vs active in leisure time (OR 1.97; 1.39–2.81). The adjusted prevalence of symptoms showed a wide range of variation, from 3 to 61 % depending on sex, age, professional field, education, and pre-existing lung and cardiovascular diseases. In conclusion, heat-related cardiorespiratory symptoms are commonly perceived among people with pre-existing lung or cardiovascular disease, agricultural workers, unemployed, pensioners, and people having only basic education. This information is needed for any planning and targeting measures to reduce the burden of summer heat.
    Keywords alcohols ; bioclimatology ; cardiovascular diseases ; confidence interval ; education ; farm labor ; females ; heat ; industry ; men ; odds ratio ; planning ; questionnaires ; regression analysis ; summer ; women
    Language English
    Dates of publication 2017-04
    Size p. 657-668.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 127361-9
    ISSN 0067-8902 ; 0020-7128
    ISSN 0067-8902 ; 0020-7128
    DOI 10.1007/s00484-016-1243-7
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

    Martin A Bewley / Kylie B R Belchamber / Kirandeep K Chana / Richard C Budd / Gavin Donaldson / Jadwiga A Wedzicha / Christopher E Brightling / Iain Kilty / Louise E Donnelly / Peter J Barnes / Dave Singh / Moira K B Whyte / David H Dockrell / COPDMAP

    PLoS ONE, Vol 11, Iss 9, p e

    2016  Volume 0163139

    Abstract: Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecule ... ...

    Abstract Pulmonary inflammation and bacterial colonization are central to the pathogenesis of chronic obstructive pulmonary disease (COPD). Defects in macrophage phagocytosis of both bacteria and apoptotic cells contribute to the COPD phenotype. Small molecule inhibitors with anti-inflammatory activity against p38 mitogen activated protein kinases (MAPKs), phosphatidyl-inositol-3 kinase (PI3K) and Rho kinase (ROCK) are being investigated as novel therapeutics in COPD. Concerns exist, however, about off-target effects. We investigated the effect of p38 MAPK inhibitors (VX745 and SCIO469), specific inhibitors of PI3K α (NVS-P13K-2), δ (NVS-P13K-3) or γ (NVS-P13K-5) and a ROCK inhibitor PF4950834 on macrophage phagocytosis, early intracellular killing of bacteria and efferocytosis of apoptotic neutrophils. Alveolar macrophages (AM) obtained from broncho-alveolar lavage (BAL) or monocyte-derived macrophages (MDM) from COPD patients (GOLD stage II/III) enrolled from a well characterized clinical cohort (MRC COPD-MAP consortium) or from healthy ex-smoker controls were studied. Both COPD AM and MDM exhibited lower levels of bacterial phagocytosis (using Streptococcus pneumoniae and non-typeable Haemophilus influenzae) and efferocytosis than healthy controls. None of the inhibitors altered bacterial internalization or early intracellular bacterial killing in AM or MDM. Conversely PF4950834, but not other inhibitors, enhanced efferocytosis in COPD AM and MDM. These results suggest none of these inhibitors are likely to exacerbate phagocytosis-related defects in COPD, while confirming ROCK inhibitors can enhance efferocytosis in COPD.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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