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  1. AU="Gavin JD Smith"
  2. AU=Singh Chauhan Prakram
  3. AU="Mase, Hiroki"
  4. AU="Grinta, Roberto"
  5. AU="Feller, Georges"
  6. AU=Rimmer Abi
  7. AU=Liu Xixi
  8. AU="Liguori, Valerio"
  9. AU="Skelly, B L"
  10. AU="Tolman, Nathanial"
  11. AU="Thompson, J. P."
  12. AU="Owens, Raymond J."
  13. AU="Djurisic, A B"
  14. AU="Bronstein, Judith L"
  15. AU="Mohamed Joma"
  16. AU="Zia, Hamidreza"
  17. AU=Strlin Kristoffer AU=Strlin Kristoffer
  18. AU="Heldstab, Jaimie"
  19. AU="Shultz, Tamar"

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  1. Artikel ; Online: Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes

    Barnaby E Young / Wycliffe E Wei / Siew-Wai Fong / Tze-Minn Mak / Danielle E Anderson / Yi-Hao Chan / Rachael Pung / Cheryl SY Heng / Li Wei Ang / Adrian Kang Eng Zheng / Bernett Lee / Shirin Kalimuddin / Surinder Pada / Paul A Tambyah / Purnima Parthasarathy / Seow Yen Tan / Louisa Sun / Gavin JD Smith / Raymond Tzer Pin Lin /
    Yee-Sin Leo / Laurent Renia / Lin-Fa Wang / Lisa FP Ng / Sebastian Maurer-Stroh / David Chien Lye / Vernon J Lee

    EBioMedicine, Vol 66, Iss , Pp 103319- (2021)

    An observational study

    2021  

    Abstract: Background: Host determinants of severe coronavirus disease 2019 include advanced age, comorbidities and male sex. Virologic factors may also be important in determining clinical outcome and transmission rates, but limited patient-level data is available. ...

    Abstract Background: Host determinants of severe coronavirus disease 2019 include advanced age, comorbidities and male sex. Virologic factors may also be important in determining clinical outcome and transmission rates, but limited patient-level data is available. Methods: We conducted an observational cohort study at seven public hospitals in Singapore. Clinical and laboratory data were collected and compared between individuals infected with different SARS-CoV-2 clades. Firth's logistic regression was used to examine the association between SARS-CoV-2 clade and development of hypoxia, and quasi-Poisson regression to compare transmission rates. Plasma samples were tested for immune mediator levels and the kinetics of viral replication in cell culture were compared. Findings: 319 patients with PCR-confirmed SARS-CoV-2 infection had clinical and virologic data available for analysis. 29 (9%) were infected with clade S, 90 (28%) with clade L/V, 96 (30%) with clade G (containing D614G variant), and 104 (33%) with other clades ‘O’ were assigned to lineage B.6. After adjusting for age and other covariates, infections with clade S (adjusted odds ratio (aOR) 0·030 (95% confidence intervals (CI): 0·0002–0·29)) or clade O (B·6) (aOR 0·26 (95% CI 0·064–0·93)) were associated with lower odds of developing hypoxia requiring supplemental oxygen compared with clade L/V. Patients infected with clade L/V had more pronounced systemic inflammation with higher concentrations of pro-inflammatory cytokines, chemokines and growth factors. No significant difference in the severity of clade G infections was observed (aOR 0·95 (95% CI: 0·35–2·52). Though viral loads were significantly higher, there was no evidence of increased transmissibility of clade G, and replicative fitness in cell culture was similar for all clades. Interpretation: Infection with clades L/V was associated with increased severity and more systemic release of pro-inflammatory cytokines. Infection with clade G was not associated with changes in severity, and despite higher ...
    Schlagwörter COVID-19 ; SARS-CoV-2 ; Clade ; D614G ; Severity ; Transmission ; Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The contrasting phylodynamics of human influenza B viruses

    Dhanasekaran Vijaykrishna / Edward C Holmes / Udayan Joseph / Mathieu Fourment / Yvonne CF Su / Rebecca Halpin / Raphael TC Lee / Yi-Mo Deng / Vithiagaran Gunalan / Xudong Lin / Timothy B Stockwell / Nadia B Fedorova / Bin Zhou / Natalie Spirason / Denise Kühnert / Veronika Bošková / Tanja Stadler / Anna-Maria Costa / Dominic E Dwyer /
    Q Sue Huang / Lance C Jennings / William Rawlinson / Sheena G Sullivan / Aeron C Hurt / Sebastian Maurer-Stroh / David E Wentworth / Gavin JD Smith / Ian G Barr

    eLife, Vol

    2015  Band 4

    Abstract: A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an ... ...

    Abstract A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
    Schlagwörter influenza virus ; evolution ; epidemiology ; antigenic drift ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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