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Article ; Online: Eosinophil to lymphocyte ratio may predict OCS reduction and change in quality of life (AQLQ) resulting from asthma biological treatment.

Branicka, Olga / Gawlik, Radosław / Glück, Joanna

2024 Volume 46, Issue 2, Page(s) 212–217

Abstract: Objectives: Simple clinical parameters that could be helpful in choice of monoclonal antibodies and prediction of their effectiveness are being sought. The aim was to assess if neutrophil-to-lymphocyte, eosinophil-to-lymphocyte and platelet-to- ... ...

Abstract	Objectives: Simple clinical parameters that could be helpful in choice of monoclonal antibodies and prediction of their effectiveness are being sought. The aim was to assess if neutrophil-to-lymphocyte, eosinophil-to-lymphocyte and platelet-to-lymphocyte ratios may predict outcomes of biologic therapy for severe asthma. Methods: Retrospective, single-center study including severe asthma patients treated with three different biologics. The blood ratios were assessed at initiation of treatment (point 0) and after six months (point 1). The chi-square test was used to analyze differences in nominal variables. Quantitative variables were compared by Student's Results: 53 patients with severe asthma were included, among them 21 patients (40%) treated with omalizumab and 32 patients (60%) with mepolizumab or benralizumab. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios did not change during six-month-course of biological treatment. Eosinophil-to-lymphocyte ratio was higher at the point 0 ( Conclusions: Pretreatment eosinophil-to-lymphocyte ratio may predict oral corticosteroid dose reduction resulting from omalizumab treatment and change in quality of life and asthma control resulting from anti-IL-5 and IL-5R treatment.
MeSH term(s)	Humans ; Omalizumab ; Eosinophils ; Anti-Asthmatic Agents ; Quality of Life ; Retrospective Studies ; Asthma ; Lymphocytes ; Adrenal Cortex Hormones/therapeutic use
Chemical Substances	Omalizumab (2P471X1Z11) ; Anti-Asthmatic Agents ; Adrenal Cortex Hormones
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.1080/08923973.2023.2300300
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Article ; Online: Omalizumab added to allergen immunotherapy increased the effect of therapy in patients with severe local allergic rhinitis.

Bozek, Andrzej / Kozłowska, Renata / Misiołek, Maciej / Ścierski, Wojciech / Gawlik, Radosław

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 6, Page(s) 2097818

Abstract: Background: Allergen immunotherapy (AIT) is effective in patient with local allergic rhinitis (LAR). However, AIT may not always achieve the optimal treatment effect.: Objective: To present short study with clinical cases of LAR combined therapy with ...

Abstract	Background: Allergen immunotherapy (AIT) is effective in patient with local allergic rhinitis (LAR). However, AIT may not always achieve the optimal treatment effect. Objective: To present short study with clinical cases of LAR combined therapy with sublingual immunotherapy (SLIT) and omalizumab in patients with house dust mite (HDM) allergy and compared it to therapy with omalizumab alone. Methods: Patients with severe LAR and hypersensitivity to HDMs were included. SLIT for HDMs was launched in a perennial protocol using SQ-HDM SLIT tablets with omalizumab. The total rhinitis symptom score (TRSS), total medication score (TMS) and combined total score (CTS) were assessed after one year. Results: After 12 months, significant improvements in all analyzed parameters in the patients on SLIT+ omalizumab therapy were observed: a reduction in the TRSS from 1.21 ± 0.33 to 0.6 ± 0.28 ( Conclusion: Omalizumab may be a valuable treatment that increases the effectiveness of immunotherapy in patients with severe LAR.
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2022.2097818
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Article ; Online: A case of anaphylactic reaction following oyster mushroom (

Branicka, Olga / Rozłucka, Lesia / Gawlik, Radosław

International journal of occupational medicine and environmental health

2021 Volume 34, Issue 4, Page(s) 575–579

Abstract: Oyster mushroom ( ...

Abstract	Oyster mushroom (
MeSH term(s)	Adult ; Allergens ; Anaphylaxis ; Female ; Humans ; Pleurotus ; Skin Tests ; Spirometry
Chemical Substances	Allergens
Language	English
Publishing date	2021-02-19
Publishing country	Poland
Document type	Case Reports ; Journal Article
ZDB-ID	1199049-1
ISSN	1896-494X ; 0867-8383 ; 1232-1087
ISSN (online)	1896-494X
ISSN	0867-8383 ; 1232-1087
DOI	10.13075/ijomeh.1896.01610
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Article: Nasal cytology can predict clinical efficacy of subcutaneous immunotherapy in intermittent allergic rhinitis.

Jura-Szołtys, Edyta / Gawlik, Radosław / Branicka, Olga / Stryjewska-Makuch, Grażyna / Glück, Joanna

Postepy dermatologii i alergologii

2022 Volume 39, Issue 6, Page(s) 1110–1115

Abstract: Introduction: Allergen immunotherapy (AIT) is the only disease-modifying treatment option available for patients with IgE-mediated allergic rhinitis. The identification of specific biomarkers, which may predict response to AIT, is currently an active ... ...

Abstract	Introduction: Allergen immunotherapy (AIT) is the only disease-modifying treatment option available for patients with IgE-mediated allergic rhinitis. The identification of specific biomarkers, which may predict response to AIT, is currently an active field of research in the aspect of recommended personalization of medicine. Aim: To assess the changes in rhinological parameters in intermittent allergic rhinitis (IAR) patients resulting from subcutaneous immunotherapy (SCIT). Material and methods: Forty-two patients (female: 19; 45%) with IAR qualified for subcutaneous immunotherapy were enrolled in this study. Fourteen (33.3%) patients were desensitized with grass pollen allergen extracts, 12 (28.6%) with tree pollen allergen extracts, and 16 (38.1%) with grass and tree pollen allergen extracts. The patients were evaluated before AIT during the pollen season and in the next pollen season after introduction of subcutaneous immunotherapy. On both occasions, determination of total nasal symptom score (TNSS), rhinomanometry and nasal cytology were performed. Results: All examined parameters significantly improved after one course of allergen immunotherapy: the percentage of eosinophils in nasal mucosa, TNSS and nasal resistance decreased, whereas the nasal flow rate increased. The decrease in percentage of nasal eosinophils significantly correlated with improvement in TNSS ( Conclusions: The rhinological assessment confirmed high effectiveness of SCIT in intermittent allergic rhinitis. A high percentage of eosinophils in nasal cytology before subcutaneous immunotherapy can predict its clinical efficacy for intermittent allergic rhinitis, especially in grass pollen allergy.
Language	English
Publishing date	2022-07-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2022.117978
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Article ; Online: Exercise and physical activity for asthma management: The European Academy of Allergy and Clinical Immunology perspective.

Price, Oliver J / Del Giacco, Stefano / Gawlik, Radoslaw / Janson, Christer / Odemyr, Mikaela / Papadopoulos, Nikolaos G / Bonini, Matteo

Allergy

2023 Volume 78, Issue 11, Page(s) 2823–2825

MeSH term(s)	Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/therapy ; Asthma/diagnosis ; Asthma/therapy ; Exercise ; Allergy and Immunology
Language	English
Publishing date	2023-06-20
Publishing country	Denmark
Document type	News
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15789
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Article: Predictors of excessive short-acting β

Kupczyk, Maciej / Barg, Wojciech / Bochenek, Grażyna / Brożek, Grzegorz / D Browiecki, Piotr / Brzostek, Dorota / D Browski, Andrzej / Dobek, Rafał / Gawlik, Radosław / Kucharczyk, Aleksandra / Kupryś-Lipińska, Izabela / Mastalerz-Migas, Agnieszka / Kowalski, Marek L

Postepy dermatologii i alergologii

2024 Volume 40, Issue 6, Page(s) 790–797

Abstract: Introduction: Despite being linked to unfavourable outcomes, short-acting β: Aim: To analyse the prevalence and predictors of SABA overuse and exacerbations in patients with asthma in a nationwide database of prescription purchase records.: ... ...

Abstract	Introduction: Despite being linked to unfavourable outcomes, short-acting β Aim: To analyse the prevalence and predictors of SABA overuse and exacerbations in patients with asthma in a nationwide database of prescription purchase records. Material and methods: The prevalence of excessive SABA use (≥ 12 canisters) and overuse (≥ 3 canisters) was analysed among patients aged 18-64 years who purchased asthma medications in 2018. Predictors of excessive SABA use and SABA overuse were examined by quasi-Poisson regression. Negative binomial regression was used to study the association of excessive SABA use or overuse to the risk of asthma exacerbation defined as a prescription for oral corticosteroids. Results: Of 91,763 patients with asthma, 42,189 (46%) were SABA users (mean age, 47 years; 58% female). Among them, 34% purchased ≥ 3 SABA canisters, and 6% purchased ≥ 12 canisters. The risk (risk ratio, 95% CI) of excessive SABA use was lower in patients with concomitant prescriptions for inhaled corticosteroids (0.41, 0.34-0.48) or inhaled corticosteroids and long-acting β Conclusions: Excessive SABA use is highly prevalent in asthma management, is associated with lack of prescriptions for inhaled corticosteroids, and substantially increases the exacerbation risk.
Language	English
Publishing date	2024-01-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2023.133454
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Article ; Online: Farmakoekonomiczne aspekty zastosowania immunoterapii alergenowej w leczeniu alergicznego nieżytu nosa i astmy

Gawlik, Radosław / Zagórny, Grzegorz / Bożek, Andrzej

Alergologia Polska- Polish Journal of Allergology. 2017,

2017

Abstract: Allergic rhinitis is a most common allergic disease affecting 40% of the population. The impact of AR on health-related quality of life (QoL) and productivity results in a significant economic burden. Allergen immunotherapy is the only causative ... ...

Abstract	Allergic rhinitis is a most common allergic disease affecting 40% of the population. The impact of AR on health-related quality of life (QoL) and productivity results in a significant economic burden. Allergen immunotherapy is the only causative treatment of allergic rhinitis and asthma. However, it is still unclear whether AIT is more cost-effective than the other treatments of AR without long-term cost-effectiveness studies. There is a need for further economic evaluations comparing different ways of immunotherapy and immunotherapy with pharmacotherapy.
Keywords	astma ; alergiczny nieżyt nosa ; immunoterapia alergenowa ; efektywność ; kosztów ; Asthma ; Allergic rhinitis ; Allergen immunotherapy ; Cost-effectiveness
Language	English
Publishing place	Elsevier Urban & Partner Sp. z o.o.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2847948-8
ISSN	2391-6052 ; 2353-3854 ; 2353-3854
ISSN (online)	2391-6052 ; 2353-3854
ISSN	2353-3854
DOI	10.1016/j.alergo.2017.05.002
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Allergen immunotherapy against house dust mites in patients with local allergic rhinitis and asthma.

Bozek, Andrzej / Galuszka, Beata / Gawlik, Radosław / Misiolek, Maciej / Scierski, Wojciech / Grzanka, Alicja / Canonica, Giorgio Walter

The Journal of asthma : official journal of the Association for the Care of Asthma

2021 Volume 59, Issue 9, Page(s) 1850–1858

Abstract: Methods: The study was a prospective, double-blind, placebo-controlled trial with patients diagnosed with LAR to HDMs and with concomitant asthma who underwent a 12-month treatment course of SLIT for HDM allergies. Seventeen patients were randomized to ... ...

Abstract	Methods: The study was a prospective, double-blind, placebo-controlled trial with patients diagnosed with LAR to HDMs and with concomitant asthma who underwent a 12-month treatment course of SLIT for HDM allergies. Seventeen patients were randomized to SLIT with the use of allergen extracts of D. pteronyssinus and D. farinae (50/50%) in SQ-HDM SLIT tablets and 15 patients were randomized to the placebo group. The total rhinitis score (TRSS), total asthma symptom score (TASS), combined total symptom score (TSS), total medication score (TMS), and FEV1 were analyzed.Results: In the final analysis, 16 patients who received SLIT and 14 who received placebo who completed the study protocol were included. Significant reductions in TRSS, TASS, TSS, and TMS after 12 months of treatment were observed in patients after SLIT (p < 0.05). A significant increase in the mean FEV1 between baseline and after 12 months of therapy was observed in the study, with p = 0.03 in the study group. Conclusion: SLIT can improve nasal and bronchial symptoms and reduce symptomatic treatment in patients with LAR and asthma and with hyperresponsiveness to HDMs.
MeSH term(s)	Allergens ; Animals ; Antigens, Dermatophagoides ; Asthma/drug therapy ; Dermatophagoides pteronyssinus ; Desensitization, Immunologic/methods ; Double-Blind Method ; Humans ; Prospective Studies ; Pyroglyphidae ; Rhinitis/complications ; Rhinitis, Allergic/complications ; Sublingual Immunotherapy/adverse effects ; Sublingual Immunotherapy/methods ; Treatment Outcome
Chemical Substances	Allergens ; Antigens, Dermatophagoides
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2021.1971701
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Article ; Online: Current allergy educational needs in primary care. Results of the EAACI working group on primary care survey exploring the confidence to manage and the opportunity to refer patients with allergy.

Cabrera, Martha / Ryan, Dermot / Angier, Elisabeth / Losappio, Laura / Flokstra-de Blok, Bertine M J / Gawlik, Radoslaw / Purushotam, Dan / Bosnic-Anticevich, Sinthia

Allergy

2021 Volume 77, Issue 2, Page(s) 378–387

Abstract: The aim of this survey was to explore the specific educational needs of a cohort of European GPs with regards to allergy training so that future educational initiatives may better support the delivery of allergy services in primary care.: Method: This ...

Abstract	The aim of this survey was to explore the specific educational needs of a cohort of European GPs with regards to allergy training so that future educational initiatives may better support the delivery of allergy services in primary care. Method: This study took the form of a cross-sectional observational study in which a structured electronic questionnaire was distributed to primary care providers, in eight languages, across 8 European countries between September 2019 and November 2019. Data associated with demographic parameters, professional qualifications, type of employment, level of confidence regarding competencies for diagnosis and treatment of allergic diseases, referral of patients to allergist and preferred method of learning and assessment were collected. A 5-point Likert scale was used to assess level of confidence. Exploratory analysis was carried out. Results: A total of 687 responses were available for analysis, with 99.3% of responders working within Europe. 70.1% of participants were female; and 48.0% and 48.0% of participants respectively had received some undergraduate and/or postgraduate allergy education. Confidence in dealing with different aspect of allergy management differed between countries. The main reason for specialist referral was a perceived need for tertiary assessment (54.3%), and the main barrier for referral was the consideration that the patient's condition could be appropriately diagnosed and treated in a primary care facility. Up to 44.7% and 55.3% of participants reported that they preferred e-Learning over traditional learning. Conclusions: This study identified the specific areas of skills training and educational needs of GPs in managing allergic conditions in primary care, and provided insights into possible strategies for more feasible and cost-effective approaches.
MeSH term(s)	Cross-Sectional Studies ; Female ; Humans ; Hypersensitivity ; Primary Health Care ; Referral and Consultation ; Surveys and Questionnaires
Language	English
Publishing date	2021-09-17
Publishing country	Denmark
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15084
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Article ; Online: Upper Respiratory Tract Diseases in Athletes in Different Sports Disciplines

Gałązka-Franta Anna / Jura-Szołtys Edyta / Smółka Wojciech / Gawlik Radosław

Journal of Human Kinetics, Vol 53, Iss 1, Pp 99-

2016 Volume 106

Abstract: Upper respiratory tract diseases in athletes are a very common medical problem. Training conditions in different sports disciplines increase the risk of upper respiratory disease. Epidemiological evidence suggests that heavy acute or chronic exercise is ... ...

Abstract	Upper respiratory tract diseases in athletes are a very common medical problem. Training conditions in different sports disciplines increase the risk of upper respiratory disease. Epidemiological evidence suggests that heavy acute or chronic exercise is related to an increased incidence of upper respiratory tract infections in athletes. Regular physical exercise at high intensity may lead to transient immunosuppression due to high prevalence of allergic diseases in athletes. Regardless of the cause they can exclude athletes from the training program and significantly impair their performance. In the present work, the most common upper respiratory tract diseases in athletes taking into account the disciplines in which they most often occur were presented. The focus was laid on symptoms, diagnostic methods and pharmacotherapy. Moreover, preventive procedures which can help reduce the occurrence of upper respiratory tract disease in athletes were presented. Management according to anti-doping rules, criteria for return to training and competition as an important issues of athlete’s health were discussed.
Keywords	upper respiratory tract infection ; allergy ; immunity ; Sports medicine ; RC1200-1245
Subject code	796
Language	English
Publishing date	2016-12-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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