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Article ; Online: Exercise-Induced Dyspnea in Collegiate Athletes: Are We Missing the Diagnosis?

Gaylord, J Nikki / Schaaf, Stephanie / Frederick, Eric

Journal of voice : official journal of the Voice Foundation

2021 Volume 37, Issue 5, Page(s) 722–728

Abstract: Objectives: Exercise-induced dyspnea (EID) can disrupt an athlete's participation and performance in their given sport. Differential diagnosis of EID is often completed using subjective report and may be inaccurate, therefore increasing the frustration ... ...

Abstract	Objectives: Exercise-induced dyspnea (EID) can disrupt an athlete's participation and performance in their given sport. Differential diagnosis of EID is often completed using subjective report and may be inaccurate, therefore increasing the frustration and stress of the athlete. This nonexperimental research study was used to determine prevalence of EID and related respiratory symptoms in athletes at a small, Division I university. Methods: An anonymous survey was provided to athletes at Murray State University as they registered for participation in sports for the 2020-2021 school year. Data from this survey was analyzed as to reported physician-given diagnosis of a respiratory disorder as well as reported symptoms of EID. Results: Results showed that athletes with a physician-given diagnosis often did not report symptoms or responses to medications that support that diagnosis. Additionally, athletes frequently reported symptoms of EID without a formal diagnosis of a respiratory disorder. Conclusions: These findings provide preliminary insight and pilot data that may be used to understand the prevalence of EID in collegiate athletes and the need for improved methods of diagnosis for etiologies of EID.
MeSH term(s)	Humans ; Asthma, Exercise-Induced/complications ; Asthma, Exercise-Induced/diagnosis ; Asthma, Exercise-Induced/epidemiology ; Dyspnea/diagnosis ; Dyspnea/epidemiology ; Dyspnea/etiology ; Athletes ; Sports ; Surveys and Questionnaires
Language	English
Publishing date	2021-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	17459-2
ISSN	1873-4588 ; 1557-8658 ; 0892-1997
ISSN (online)	1873-4588 ; 1557-8658
ISSN	0892-1997
DOI	10.1016/j.jvoice.2021.05.003
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Article ; Online: Struggling to Breathe: Inspiratory Muscle Training in Adolescent Athletes.

Gaylord, J Nikki / Peterson, Susie / Ray, Jayanti

Journal of voice : official journal of the Voice Foundation

2020 Volume 36, Issue 2, Page(s) 232–241

Abstract: Objective: Dyspnea is a primary characteristic of exercise-induced laryngeal obstruction and prevents individuals from inhaling and exhaling without effort. This single subject research study investigated the effects of inspiratory muscle training (IMT) ...

Abstract	Objective: Dyspnea is a primary characteristic of exercise-induced laryngeal obstruction and prevents individuals from inhaling and exhaling without effort. This single subject research study investigated the effects of inspiratory muscle training (IMT) on exercise-induced symptoms characteristic of exercise-induced laryngeal obstruction in adolescent athletes. Methods: Five weeks of IMT was provided to five adolescent athletes, four females and one male, aged 10 to 16. Variables that were measured prior to, during, and after completion of IMT program included maximum phonation time, maximum perceived breathlessness, duration of running, and quality of life regarding dyspnea. Results: Results showed a reduction in maximum perceived breathlessness as well as a significant increase in maximum phonation time across participants. The majority of participants rated their quality of life regarding dyspnea as significant improved after IMT. Conclusions: These findings contribute to the increasing body of literature investigating the use of alternative therapy strategies for treatment of symptoms of exercise-induced laryngeal obstruction in adolescent athletes.
MeSH term(s)	Adolescent ; Athletes ; Breathing Exercises/methods ; Child ; Dyspnea/diagnosis ; Dyspnea/etiology ; Dyspnea/therapy ; Exercise Tolerance/physiology ; Female ; Humans ; Inspiratory Capacity ; Male ; Quality of Life ; Respiratory Muscles/physiology
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	17459-2
ISSN	1873-4588 ; 1557-8658 ; 0892-1997
ISSN (online)	1873-4588 ; 1557-8658
ISSN	0892-1997
DOI	10.1016/j.jvoice.2020.05.002
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Article ; Online: Damage modeling and statistical analysis of optics damage performance in MJ-class laser systems.

Liao, Zhi M / Raymond, B / Gaylord, J / Fallejo, R / Bude, J / Wegner, P

Optics express

2014 Volume 22, Issue 23, Page(s) 28845–28856

Abstract: Modeling the lifetime of a fused silica optic is described for a multiple beam, MJ-class laser system. This entails combining optic processing data along with laser shot data to account for complete history of optic processing and shot exposure. ... ...

Abstract	Modeling the lifetime of a fused silica optic is described for a multiple beam, MJ-class laser system. This entails combining optic processing data along with laser shot data to account for complete history of optic processing and shot exposure. Integrating with online inspection data allows for the construction of a performance metric to describe how an optic performs with respect to the model. This methodology helps to validate the damage model as well as allows strategic planning and identifying potential hidden parameters that are affecting the optic's performance.
MeSH term(s)	Color ; Lasers ; Lenses ; Models, Theoretical ; Optics and Photonics ; Statistics as Topic ; Stress, Mechanical
Language	English
Publishing date	2014-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.22.028845
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Article ; Online: Age-dependent response of murine female bone marrow cells to hyperbaric oxygen.

Gomez, Christian R / Knutson, Gaylord J / Clifton, Kari B / Schreiber, Claire A / Vuk-Pavlović, Stanimir

Biogerontology

2012 Volume 13, Issue 3, Page(s) 287–297

Abstract: Consequences of age on the effects of hyperbaric oxygen (HBO) on bone marrow (BM) derived stem cells and progenitors (SCPs) are largely unknown. We treated 2- and 18-month old C57BL/6 female mice by HBO. Hematopoietic stem cells and progenitors, ... ...

Abstract	Consequences of age on the effects of hyperbaric oxygen (HBO) on bone marrow (BM) derived stem cells and progenitors (SCPs) are largely unknown. We treated 2- and 18-month old C57BL/6 female mice by HBO. Hematopoietic stem cells and progenitors, enumerated as colony-forming units in culture, were doubled only in peripheral leukocytes and BM cells of young mice receiving HBO. In old mice colony-forming unit fibroblast numbers, a measure of mesenchymal stromal cells (MSCs) from BM, were high but unaffected by HBO. To further explore this finding, in BM-MSCs we quantified the transcripts of adipocyte early-differentiation genes peroxisome proliferator-activated receptor-γ, CCAAT/enhancer binding protein-β and fatty-acid binding protein 4; these transcripts were not affected by age or HBO. However, osteoblast gene transcripts runt-related transcription factor 2, osterix (OSX) and alkaline phosphatase (AP) were twofold to 20-fold more abundant in MSCs from old control mice relative to those of young control mice. HBO affected expression of osteoblast markers only in old MSCs (OSX gene expression was reduced by twofold and AP expression was increased threefold). Our data demonstrate the impact of aging on the response of BM SCPs to HBO and indicate the potentially different age-related benefit of HBO in wound healing and tissue remodeling.
MeSH term(s)	Aging/metabolism ; Animals ; Base Sequence ; Bone Marrow Cells/cytology ; Cytokines/metabolism ; DNA Primers ; Female ; Hyperbaric Oxygenation ; Inflammation Mediators/metabolism ; Macrophage Activation ; Macrophages/cytology ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Real-Time Polymerase Chain Reaction
Chemical Substances	Cytokines ; DNA Primers ; Inflammation Mediators
Language	English
Publishing date	2012-01-24
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-012-9373-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Factory information systems

Gaylord, John

design and implementation for CIM management and control

(Manufacturing engineering and materials processing ; 23)

1987

Author's details	John Gaylord
Series title	Manufacturing engineering and materials processing ; 23
Language	English
Size	XI, 243 S, Ill., graph. Darst
Publisher	Dekker
Publishing place	New York u.a.
Document type	Book
Note	Literaturangaben
ISBN	0824773896 ; 9780824773892
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Interpreting and defensively responding to threat: examining appraisals and coping with acquaintance sexual aggression.

Nurius, P S / Norris, J / Young, D S / Graham, T L / Gaylord, J

Violence and victims

2000 Volume 15, Issue 2, Page(s) 187–208

Abstract: Resistance and prevention programming aimed at strengthening women's ability to protect themselves against acquaintance sexual aggression has lacked attention to the cognitive and emotional processes women engage in when encountering such threats. ... ...

Abstract	Resistance and prevention programming aimed at strengthening women's ability to protect themselves against acquaintance sexual aggression has lacked attention to the cognitive and emotional processes women engage in when encountering such threats. Building upon current theory related to cognitive appraisal and coping processes, this study applies a theoretical model of how women evaluate and respond to sexual aggression by male acquaintances. Two hundred and two college women who had been sexually victimized by male acquaintances responded to a questionnaire that assessed their cognitive appraisals of and emotional and behavioral responses to the incident, in addition to aggression characteristics. Path analytic regression analyses examined theorized relationships among primary and secondary appraisal and emotional response variables in addition to their collective prediction of behavioral responding. The hypothesized model accounted for significant variance in behavioral responding and indicated different patterns of appraisals, emotions, and aggression characteristics predicting women's assertive and diplomatic behavioral responses to their assaults. These findings are consistent with research and theory related to individuals' appraisal of and coping with threatening events. Theoretical and intervention implications for resistance and prevention efforts are discussed.
MeSH term(s)	Adaptation, Psychological ; Adult ; Aggression ; Emotions ; Female ; Humans ; Interpersonal Relations ; Male ; Models, Psychological ; Regression Analysis ; Sexual Behavior ; Surveys and Questionnaires ; Women/psychology
Language	English
Publishing date	2000
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	639280-5
ISSN	1945-7073 ; 0886-6708
ISSN (online)	1945-7073
ISSN	0886-6708
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Article ; Online: Effects of oxygen on the antigenic landscape of prostate cancer cells.

Ma, Tangeng / Schreiber, Claire A / Knutson, Gaylord J / Khattouti, Abdelouahid El / Sakiyama, Marcelo J / Hassan, Mohamed / Charlesworth, Mary Christine / Madden, Benjamin J / Zhou, Xinchun / Vuk-Pavlović, Stanimir / Gomez, Christian R

BMC research notes

2015 Volume 8, Page(s) 687

Abstract: Background: Use of allogeneic cancer cells-based immunotherapy for treatment of established prostate cancer (PCa) has only been marginally effective. One reason for failure could stem from the mismatch of antigenic signatures of vaccine cells and cancer ...

Abstract	Background: Use of allogeneic cancer cells-based immunotherapy for treatment of established prostate cancer (PCa) has only been marginally effective. One reason for failure could stem from the mismatch of antigenic signatures of vaccine cells and cancer in situ. Hence, it is possible that vaccine cells expressed antigens differently than tumor cells in situ. We hypothesized that cells grown in vitro at low oxygen tension (pO2) provide a better antigen match to tumors in situ and could reveal a more relevant antigenic landscape than cells grown in atmospheric pO2. Methods: We tested this hypothesis by comparing PCa cells propagated at pO2 = 2 kPa and 20 kPa. To identify potential tumor-associated antigens (TAAs), we prepared PCa cell lysates, resolved them by two-dimensional electrophoresis and immunoblotting using spontaneous antibodies from plasma derived from PCa patients and control subjects. Antibody-labeled spots were analyzed by MALDI-TOF mass spectrometry and validated by ELISA. We selected hypoxia-regulated HSP70 and hnRNP L and hypoxia-independent HSP60 and determined the frequency of plasma samples reacting with these molecules. Results: Frequency of HSP60-reactive plasma was low in healthy controls [1.3 % (1/76)], while it was elevated in PCa patients [13.0 % (7/54); p < 0.05]. These data suggest a humoral immune response to HSP60 in PCa. Levels of autoantibodies to HSP70 did not differ from healthy controls [3.7 % (2/54)] in PCa patients [5.3 % (2/38)]. Similarly, hnRNP L autoantibodies did no differ between healthy controls [6.1 % (3/49)] and PCa patients [5.3 % (2/38)]. Conclusions: Overall our results suggest the value of hypoxia as a modifier of the cellular and antigenic landscape of PCa cells. By modifying the immune reactivity of PCa cells in culture, manipulation of pO2 can be proposed as a new avenue for improving diagnosis, prognosis and immunotherapy for PCa.
MeSH term(s)	Aged ; Antigens, Neoplasm/blood ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/metabolism ; Autoantibodies/blood ; Autoantibodies/immunology ; Biomarkers, Tumor/immunology ; Biomarkers, Tumor/metabolism ; Blotting, Western ; Cell Hypoxia ; Cell Line, Tumor ; Chaperonin 60/immunology ; Chaperonin 60/metabolism ; Cytokines/immunology ; Cytokines/metabolism ; Electrophoresis, Gel, Two-Dimensional ; Enzyme-Linked Immunosorbent Assay ; HSP70 Heat-Shock Proteins/immunology ; HSP70 Heat-Shock Proteins/metabolism ; Heterogeneous-Nuclear Ribonucleoprotein L/immunology ; Heterogeneous-Nuclear Ribonucleoprotein L/metabolism ; Humans ; Male ; Middle Aged ; Oxygen/immunology ; Oxygen/metabolism ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Tumor Cells, Cultured
Chemical Substances	Antigens, Neoplasm ; Autoantibodies ; Biomarkers, Tumor ; Chaperonin 60 ; Cytokines ; HSP70 Heat-Shock Proteins ; Heterogeneous-Nuclear Ribonucleoprotein L ; Oxygen (S88TT14065)
Language	English
Publishing date	2015-11-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-015-1633-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Water-resources appraisal of the Camp Swift lignite area, central Texas

Gaylord, J. L

(Water-resources investigations report ; 84-4333)

1985

Institution	Geological Survey (U.S.)
Author's details	by J.L. Gaylord ... [et al.]. --
Series title	Water-resources investigations report ; 84-4333
Keywords	Groundwater ; Coal mines and mining/Environmental aspects
Language	English
Size	v, 164 p. :, ill., maps (some col.) ;, 28 cm. --
Publisher	U.S. Dept. of Interior, Geological Survey ; Open-File Services Section, Western Distribution Branch distributor
Publishing place	Austin, Tex ; Denver, CO
Document type	Book
Note	Chiefly tables.
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Prognostic value of discs large homolog 7 transcript levels in prostate cancer.

Christian R Gomez / Farhad Kosari / Jan-Marie Munz / Claire A Schreiber / Gaylord J Knutson / Cristiane M Ida / Abdelouahid El Khattouti / R Jeffrey Karnes / John C Cheville / George Vasmatzis / Stanimir Vuk-Pavlović

PLoS ONE, Vol 8, Iss 12, p e

2013 Volume 82833

Abstract: Hypoxia has been associated with malignant progression, metastasis and resistance to therapy. Hence, we studied expression of hypoxia-regulated genes in 100 prostate cancer (CaP) bulk tissues and 71 adjacent benign tissues. We found 24 transcripts ... ...

Abstract	Hypoxia has been associated with malignant progression, metastasis and resistance to therapy. Hence, we studied expression of hypoxia-regulated genes in 100 prostate cancer (CaP) bulk tissues and 71 adjacent benign tissues. We found 24 transcripts significantly overexpressed (p ≤ 0.02). Importantly, higher transcript levels of disc large (drosophila) homolog-associated protein 5 (DLGAP5)/discs large homolog 7 (DLG7)/hepatoma up-regulated protein (HURP), hyaluronan-mediated motility receptor (HMMR) and cyclin B1 (CCNB1) were associated with higher Gleason score and more advanced systemic progression. Since the products of HMMR and CCNB1 have been identified recently as molecular markers of CaP progression, we postulated that DLG7 has prognostic value too. To test this hypothesis, we measured transcript levels for DLG7 in a 150-pair case-control cohort. The cases (progression to systemic disease within six years of surgery) and controls (no progression within eight years) were matched for clinical and pathologic prognostic variables, including grade, stage, and preoperative serum levels of PSA. The overall prognostic ability of DLG7, as tested in receiver operating characteristic analysis was of 0.74 (95% CI, 0.68 to 0.8). Overall, our data indicate that expression of DLG7, a hypoxia-controlled gene, holds prognostic potential in high-risk CaP; this also demonstrates that variation of oxygen tension may constitute a tool for identification of novel biomarkers for CaP.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prescription: office automation.

Gaylord, J / Jordan, R / Kualness, M

Journal of medical systems

1986 Volume 10, Issue 1, Page(s) 25–30

Abstract: The mission statement of Minneapolis Children's Medical Center reads, in part, "Mindful of the unique characteristics of children, MCMC's missions is to provide a team of health care professionals attuned to the special needs of the total child, at all ... ...

Abstract	The mission statement of Minneapolis Children's Medical Center reads, in part, "Mindful of the unique characteristics of children, MCMC's missions is to provide a team of health care professionals attuned to the special needs of the total child, at all ages from prenatal through adolescent, in a uniquely designed facility." Therefore an "open" professional staff, rather than a medical staff, was established consisting of physicians, dentists, and other health professionals with advanced degrees at the master's level or above, including, but not limited to, psychologists, social workers, clinical nurse specialists, chaplains, audiologists, and speech pathologists. This professional staff has grown to 650 members, extremely large for a 122-bed hospital. The professional staff office needed help in managing the volume of information associated with this large staff. To meet that need, in addition to the needs of other hospital areas, MCMC's administration made the decision to purchase office automation equipment and established a committee of hospital-wide users, rather than managerial staff, to survey their own needs, select vendors, and make the final recommendation. The word-processing system selected now maintains 650 physician profiles, each with 44 variables. Whereas prior to automation 25 separate lists needed to be updated each time a professional staff member was either added or deleted, now only individual physician profiles need to be adjusted. Programs were then designed to automate the many reports that must be done. In this paper we propose to describe this selection process and relate how the system developed has streamlined and simplified the work of the professional staff office to enable it to increase its output by over 300% without adding staff.
MeSH term(s)	Electronic Data Processing/methods ; Hospital Bed Capacity, 100 to 299 ; Hospitals, Pediatric/organization & administration ; Hospitals, Special/organization & administration ; Information Systems ; Management Information Systems ; Minnesota
Language	English
Publishing date	1986-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	423488-1
ISSN	1573-689X ; 0148-5598
ISSN (online)	1573-689X
ISSN	0148-5598
DOI	10.1007/bf00992947
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