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  1. Article ; Online: Eryptosis and Malaria: New Experimental Guidelines and Re-Evaluation of the Antimalarial Potential of Eryptosis Inducers.

    Boulet, Coralie / Gaynor, Taylah L / Carvalho, Teresa G

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 630812

    Abstract: Erythrocytes possess an unusual programmed cell death mechanism termed eryptosis, and several compounds have been previously claimed to induce ... ...

    Abstract Erythrocytes possess an unusual programmed cell death mechanism termed eryptosis, and several compounds have been previously claimed to induce eryptosis
    MeSH term(s) Antimalarials ; Eryptosis ; Erythrocytes ; Humans ; Malaria/drug therapy ; Malaria, Falciparum ; Plasmodium ; Plasmodium falciparum
    Chemical Substances Antimalarials
    Language English
    Publishing date 2021-03-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.630812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Red Blood Cell BCL-x

    Boulet, Coralie / Siddiqui, Ghizal / Gaynor, Taylah L / Doerig, Christian / Creek, Darren J / Carvalho, Teresa G

    Microorganisms

    2022  Volume 10, Issue 4

    Abstract: The development of antimalarial drug resistance is an ongoing problem threatening progress towards the elimination of malaria, and antimalarial treatments are urgently needed for drug-resistant malaria infections. Host-directed therapies (HDT) represent ... ...

    Abstract The development of antimalarial drug resistance is an ongoing problem threatening progress towards the elimination of malaria, and antimalarial treatments are urgently needed for drug-resistant malaria infections. Host-directed therapies (HDT) represent an attractive strategy for the development of new antimalarials with untapped targets and low propensity for resistance. In addition, drug repurposing in the context of HDT can lead to a substantial decrease in the time and resources required to develop novel antimalarials. Host BCL-x
    Language English
    Publishing date 2022-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10040824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mapping the cellular and molecular landscape of cardiac non-myocytes in murine diabetic cardiomyopathy.

    Cohen, Charles D / De Blasio, Miles J / Farrugia, Gabriella E / Dona, Malathi S I / Hsu, Ian / Prakoso, Darnel / Kiriazis, Helen / Krstevski, Crisdion / Nash, David M / Li, Mandy / Gaynor, Taylah L / Deo, Minh / Drummond, Grant R / Ritchie, Rebecca H / Pinto, Alexander R

    iScience

    2023  Volume 26, Issue 10, Page(s) 107759

    Abstract: Diabetes is associated with a significantly elevated risk of heart failure. However, despite extensive efforts to characterize the phenotype of the diabetic heart, the molecular and cellular protagonists that underpin cardiac pathological remodeling in ... ...

    Abstract Diabetes is associated with a significantly elevated risk of heart failure. However, despite extensive efforts to characterize the phenotype of the diabetic heart, the molecular and cellular protagonists that underpin cardiac pathological remodeling in diabetes remain unclear, with a notable paucity of data regarding the impact of diabetes on non-myocytes within the heart. Here we aimed to define key differences in cardiac non-myocytes between spontaneously type-2 diabetic (
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A protocol for rapid and parallel isolation of myocytes and non-myocytes from multiple mouse hearts.

    Farrugia, Gabriella E / McLellan, Micheal A / Weeks, Kate L / Matsumoto, Aya / Cohen, Charles D / Krstevski, Crisdion / Gaynor, Taylah L / Parslow, Adam C / McMullen, Julie R / Pinto, Alexander R

    STAR protocols

    2021  Volume 2, Issue 4, Page(s) 100866

    Abstract: This protocol features parallel isolation of myocytes and non-myocytes from murine hearts. It was designed with considerations for (1) time required to extract cardiac cells, (2) cell viability, and (3) protocol scalability. Here, a peristaltic pump and ... ...

    Abstract This protocol features parallel isolation of myocytes and non-myocytes from murine hearts. It was designed with considerations for (1) time required to extract cardiac cells, (2) cell viability, and (3) protocol scalability. Here, a peristaltic pump and 3D-printed elements are combined to perfuse the heart with enzymes to dissociate cells. Myocytes and non-myocytes extracted using this protocol are separated by centrifugation and/or fluorescence-activated cell sorting for use in downstream applications including single-cell omics or other bio-molecular analyses. For complete details on the use and execution of this protocol, please refer to McLellan et al. (2020).
    MeSH term(s) Animals ; Cell Culture Techniques ; Cell Separation/methods ; Cells, Cultured ; Genomics ; Male ; Mice ; Mice, Inbred C57BL ; Myocardium/cytology ; Myocytes, Cardiac/classification ; Myocytes, Cardiac/cytology ; Single-Cell Analysis/methods
    Language English
    Publishing date 2021-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2021.100866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy.

    McLellan, Micheal A / Skelly, Daniel A / Dona, Malathi S I / Squiers, Galen T / Farrugia, Gabriella E / Gaynor, Taylah L / Cohen, Charles D / Pandey, Raghav / Diep, Henry / Vinh, Antony / Rosenthal, Nadia A / Pinto, Alexander R

    Circulation

    2020  Volume 142, Issue 15, Page(s) 1448–1463

    Abstract: Background: Cardiac fibrosis is a key antecedent to many types of cardiac dysfunction including heart failure. Physiological factors leading to cardiac fibrosis have been recognized for decades. However, the specific cellular and molecular mediators ... ...

    Abstract Background: Cardiac fibrosis is a key antecedent to many types of cardiac dysfunction including heart failure. Physiological factors leading to cardiac fibrosis have been recognized for decades. However, the specific cellular and molecular mediators that drive cardiac fibrosis, and the relative effect of disparate cell populations on cardiac fibrosis, remain unclear.
    Methods: We developed a novel cardiac single-cell transcriptomic strategy to characterize the cardiac cellulome, the network of cells that forms the heart. This method was used to profile the cardiac cellular ecosystem in response to 2 weeks of continuous administration of angiotensin II, a profibrotic stimulus that drives pathological cardiac remodeling.
    Results: Our analysis provides a comprehensive map of the cardiac cellular landscape uncovering multiple cell populations that contribute to pathological remodeling of the extracellular matrix of the heart. Two phenotypically distinct fibroblast populations, Fibroblast-
    Conclusions: These results offer a valuable resource for exploring the cardiac cellular landscape in health and after chronic cardiovascular stress. These data provide insights into the cellular and molecular mechanisms that promote pathological remodeling of the mammalian heart, highlighting early transcriptional changes that precede chronic cardiac fibrosis.
    MeSH term(s) Animals ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Fibrosis ; Gene Expression Profiling ; Mice ; Myocardium/metabolism ; Myocardium/pathology ; Pyrophosphatases/metabolism ; Single-Cell Analysis ; Stress, Physiological ; Thrombospondins/metabolism
    Chemical Substances Thrombospondins ; thrombospondin 4 ; CILP protein, mouse (EC 3.6.1.-) ; Pyrophosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.119.045115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Diastolic dysfunction in a pre-clinical model of diabetes is associated with changes in the cardiac non-myocyte cellular composition.

    Cohen, Charles D / De Blasio, Miles J / Lee, Man K S / Farrugia, Gabriella E / Prakoso, Darnel / Krstevski, Crisdion / Deo, Minh / Donner, Daniel G / Kiriazis, Helen / Flynn, Michelle C / Gaynor, Taylah L / Murphy, Andrew J / Drummond, Grant R / Pinto, Alexander R / Ritchie, Rebecca H

    Cardiovascular diabetology

    2021  Volume 20, Issue 1, Page(s) 116

    Abstract: Background: Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with cellular changes accompanying ... ...

    Abstract Background: Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with cellular changes accompanying diabetes yet to be examined in detail. This study aims to characterise the changes in the cardiac cellular landscape in murine diabetes to identify potential cellular protagonists in the diabetic heart.
    Methods: Diabetes was induced in male FVB/N mice by low-dose streptozotocin and a high-fat diet for 26-weeks. Cardiac function was measured by echocardiography at endpoint. Flow cytometry was performed on cardiac ventricles as well as blood, spleen, and bone-marrow at endpoint from non-diabetic and diabetic mice. To validate flow cytometry results, immunofluorescence staining was conducted on left-ventricles of age-matched mice.
    Results: Mice with diabetes exhibited hyperglycaemia and impaired glucose tolerance at endpoint. Echocardiography revealed reduced E:A and e':a' ratios in diabetic mice indicating diastolic dysfunction. Systolic function was not different between the experimental groups. Detailed examination of cardiac cellularity found resident mesenchymal cells (RMCs) were elevated as a result of diabetes, due to a marked increase in cardiac fibroblasts, while smooth muscle cells were reduced in proportion. Moreover, we found increased levels of Ly6C
    Conclusions: Murine diabetes results in distinct changes in cardiac cellularity. These changes-in particular increased levels of fibroblasts-offer a framework for understanding how cardiac cellularity changes in diabetes. The results also point to new cellular mechanisms in this context, which may further aid in development of pharmacotherapies to allay the progression of cardiomyopathy associated with diabetes.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/pathology ; Diabetic Cardiomyopathies/physiopathology ; Diastole ; Diet, High-Fat ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Male ; Mice ; Monocytes/metabolism ; Monocytes/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Streptozocin ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/metabolism ; Ventricular Dysfunction, Left/pathology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left
    Chemical Substances Blood Glucose ; Streptozocin (5W494URQ81)
    Language English
    Publishing date 2021-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1475-2840
    ISSN (online) 1475-2840
    DOI 10.1186/s12933-021-01303-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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