Article ; Online: Dual-Setting Bone Cement Based On Magnesium Phosphate Modified with Glycol Methacrylate Designed for Biomedical Applications.
ACS applied materials & interfaces
2023 Volume 15, Issue 48, Page(s) 55533–55544
Abstract: Magnesium phosphate cement (MPC) is a suitable alternative for the currently used calcium phosphates, owing to beneficial properties like favorable resorption rate, fast hardening, and higher compressive strength. However, due to insufficient mechanical ... ...
| Abstract | Magnesium phosphate cement (MPC) is a suitable alternative for the currently used calcium phosphates, owing to beneficial properties like favorable resorption rate, fast hardening, and higher compressive strength. However, due to insufficient mechanical properties and high brittleness, further improvement is still expected. In this paper, we reported the preparation of a novel type of dual-setting cement based on MPC with poly(2-hydroxyethyl methacrylate) (pHEMA). The aim of our study was to evaluate the effect of HEMA addition, especially its concentration and premix time, on the selected properties of the composite. Several beneficial effects were found: better formability, shortened setting time, and improvement of mechanical strengths. The developed cements were hardening in ∼16-21 min, consisted of well-crystallized phases and polymerized HEMA, had porosity between ∼2-11%, degraded slowly by ∼0.1-4%/18 days, their wettability was ∼20-30°, they showed compressive and bending strength between ∼45-73 and 13-20 MPa, respectively, and, finally, their Young's Modulus was close to ∼2.5-3.0 GPa. The results showed that the optimal cement composition is MPC+15%HEMA and 4 min of polymer premixing time. Overall, our research suggested that this developed cement may be used in various biomedical applications. |
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| MeSH term(s) | Bone Cements ; Materials Testing ; Phosphates ; Calcium Phosphates ; Compressive Strength |
| Chemical Substances | magnesium phosphate (453COF7817) ; hydroxyethyl methacrylate (6E1I4IV47V) ; Bone Cements ; Phosphates ; Calcium Phosphates |
| Language | English |
| Publishing date | 2023-11-21 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1944-8252 |
| ISSN (online) | 1944-8252 |
| DOI | 10.1021/acsami.3c14491 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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