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Article: Chinese expert consensus on the clinical application of drug-coated balloon (2

Ge, Jun-Bo / Chen, Yun-Dai

2024 Volume 21, Issue 2, Page(s) 135–152

Abstract: Percutaneous coronary interventions have progressed through the era of plain balloon dilation, bare-metal stent insertion to drug-eluting stent treatment, which has significantly reduced the acute occlusion and restenosis rates of target vessels and ... ...

Abstract	Percutaneous coronary interventions have progressed through the era of plain balloon dilation, bare-metal stent insertion to drug-eluting stent treatment, which has significantly reduced the acute occlusion and restenosis rates of target vessels and improved patient prognosis, making drug-eluting stents the mainstream interventional treatment for coronary artery disease. In recent years, drug-coated balloons (DCBs) have become a new treatment strategy for coronary artery disease, and the drugs used in the coating and the coating technology have progressed in the past years. Without permanent implant, a DCB delivers antiproliferative drugs rapidly and uniformly into the vessel wall via the excipient during a single balloon dilation. Many evidence suggests that DCB angioplasty is an effective measure for dealing with in-stent restenosis and
Language	English
Publishing date	2024-02-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2421391-3
ISSN	1671-5411
ISSN	1671-5411
DOI	10.26599/1671-5411.2024.02.001
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Article ; Online: Fallacies and Possible Remedies of the SYNTAX Score.

He, Yong-Ming / Shen, Li / Ge, Jun-Bo

Journal of interventional cardiology

2020 Volume 2020, Page(s) 8822308

Abstract: Quite a few studies have revealed the clinical values regarding the outcome predictions in the cohort of the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial and decision-making with the SYNTAX score. The ... ...

Abstract	Quite a few studies have revealed the clinical values regarding the outcome predictions in the cohort of the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) trial and decision-making with the SYNTAX score. The Evaluation of Xience Everolimus-Eluting Stent Versus Coronary Artery Bypass Surgery for Effectiveness of Left-Main Revascularization (EXCEL) and Nordic-Baltic-British left main revascularization (NOBLE) studies are the largest international randomized studies so far, comparing percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) in the treatment of left main coronary artery disease. Unfortunately, both studies failed to validate the value of the SYNTAX score in the selection of revascularization strategies for patients with coronary artery diseases (CAD).. This scenario prompted us to reconsider the inherent fallacies of the SYNTAX score in its derivation. We pointed out eight fallacies for the SYNTAX score in this paper. A recently developed Coronary Artery Tree description and Lesion EvaluaTion (CatLet) score, available at http://www.catletscore.com, a novel angiographic scoring system, could be the remedies for the SYNTAX score.
MeSH term(s)	Comparative Effectiveness Research ; Coronary Angiography/methods ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods ; Coronary Artery Disease/classification ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/pathology ; Drug-Eluting Stents ; Humans ; Patient Selection ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/instrumentation ; Percutaneous Coronary Intervention/methods ; Reproducibility of Results ; Research Design/standards
Language	English
Publishing date	2020-12-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1036325-7
ISSN	1540-8183 ; 0896-4327
ISSN (online)	1540-8183
ISSN	0896-4327
DOI	10.1155/2020/8822308
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Zs.A 2719: Show issues

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Article ; Online: New diagnostic and therapeutic strategies for myocardial infarction via nanomaterials.

Shi, Hong-Tao / Huang, Zi-Hang / Xu, Tian-Zhao / Sun, Ai-Jun / Ge, Jun-Bo

EBioMedicine

2022 Volume 78, Page(s) 103968

Abstract: Myocardial infarction is lethal to patients because of insufficient blood perfusion to vital organs. Several attempts have been made to improve its prognosis, among which nanomaterial research offers an opportunity to address this problem at the ... ...

Abstract	Myocardial infarction is lethal to patients because of insufficient blood perfusion to vital organs. Several attempts have been made to improve its prognosis, among which nanomaterial research offers an opportunity to address this problem at the molecular level and has the potential to improve disease prevention, diagnosis, and treatment significantly. Up to now, nanomaterial-based technology has played a crucial role in broad novel diagnostic and therapeutic strategies for cardiac repair. This review summarizes various nanomaterial applications in myocardial infarction from multiple aspects, including high precision detection, pro-angiogenesis, regulating immune homeostasis, and miRNA and stem cell delivery vehicles. We also propose promising research hotspots that have not been reported much yet, such as conjugating pro-angiogenetic elements with nanoparticles to construct drug carriers, developing nanodrugs targeting other immune cells except for macrophages in the infarcted myocardium or the remote region. Though most of those strategies are preclinical and lack clinical trials, there is tremendous potential for their further applications in the future.
MeSH term(s)	Drug Carriers ; Humans ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Myocardial Infarction/therapy ; Myocardium ; Nanoparticles ; Stem Cells/physiology
Chemical Substances	Drug Carriers
Language	English
Publishing date	2022-03-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.103968
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Zs.A 7090: Show issues

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Article ; Online: Evolocumab attenuate pericoronary adipose tissue density via reduction of lipoprotein(a) in type 2 diabetes mellitus: a serial follow-up CCTA study.

Yu, Meng-Meng / Zhao, Xin / Chen, Yin-Yin / Tao, Xin-Wei / Ge, Jun-Bo / Jin, Hang / Zeng, Meng-Su

Cardiovascular diabetology

2023 Volume 22, Issue 1, Page(s) 121

Abstract: Background: Pericoronary adipose tissue (PCAT) density is a biomarker of vessel inflammation, which is supposed to be increased in patients with type 2 diabetes mellitus (T2DM). However, whether the coronary inflammation revealed by this novel index ... ...

Abstract	Background: Pericoronary adipose tissue (PCAT) density is a biomarker of vessel inflammation, which is supposed to be increased in patients with type 2 diabetes mellitus (T2DM). However, whether the coronary inflammation revealed by this novel index could be alleviated after evolocumab treatment in T2DM remains unknown. Methods: From January 2020 to December 2022, consecutive T2DM patients with low-density lipoprotein cholesterol ≥ 70 mg/dL on maximally tolerated statin and taking evolocumab were prospectively included. In addition, patients with T2DM who were taking statin alone were recruited as control group. The eligible patients underwent baseline and follow-up coronary CT angiography with an interval of 48-week. To render patients with evolocumab as comparable to those controls, a propensity-score matching design was used to select the matched pairs with a 1:1 ratio. Obstructive lesion was defined as the extent of coronary artery stenosis ≥ 50%; the numbers inside the brackets were interquartile ranges. Results: A total of 170 T2DM patients with stable chest pain were included [(mean age 64 ± 10.6 [range 40-85] years; 131 men). Among those patients, 85 were in evolocumab group and 85 were in control group. During follow-up, low-density lipoprotein cholesterol (LDL-C) level (2.02 [1.26, 2.78] vs. 3.34 [2.53, 4.14], p < 0.001), and lipoprotein(a) (12.1 [5.6, 21.8] vs. 18.9 [13.2, 27.2], p = 0.002) were reduced after evolocumab treatment. The prevalence of obstructive lesions and high-risk plaque features were significantly decreased (p < 0.05 for all). Furthermore, the calcified plaque volume were significantly increased (188.3 [115.7, 361.0] vs. 129.3 [59.5, 238.3], p = 0.015), while the noncalcified plaque volume and necrotic volume were diminished (107.5 [40.6, 180.6] vs. 125.0 [65.3, 269.7], p = 0.038; 0 [0, 4.7] vs. 0 [0, 13.4], p < 0.001, respectively). In addition, PCAT density of right coronary artery was significantly attenuated in evolocumab group (- 85.0 [- 89.0, - 82.0] vs. - 79.0 [- 83.5, - 74.0], p < 0.001). The change in the calcified plaque volume inversely correlated with achieved LDL-C level (r = - 0.31, p < 0.001) and lipoprotein(a) level (r = - 0.33, p < 0.001). Both the changes of noncalcified plaque volume and necrotic volume were positively correlated with achieved LDL-C level and Lp(a) (p < 0.001 for all). However, the change of PCAT Conclusions: In patients with T2DM, evolocumab is an effective therapy to decrease noncalcified plaque volume necrotic volume, and increase calcified plaque volume. Furthermore, evolocumab could attenuate PCAT density, at least in part, via the reduction of lipoprotein(a).
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Adipose Tissue ; Cholesterol, LDL ; Computed Tomography Angiography ; Coronary Angiography ; Coronary Artery Disease ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/pathology ; Follow-Up Studies ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Inflammation ; Lipoprotein(a) ; Plaque, Atherosclerotic/pathology ; Female
Chemical Substances	Cholesterol, LDL ; evolocumab (LKC0U3A8NJ) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipoprotein(a)
Language	English
Publishing date	2023-05-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-023-01857-w
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Article: Preinfarction angina: old story initiates new attention.

Ge, Jun-bo

Chinese medical journal

2012 Volume 125, Issue 6, Page(s) 968–969

MeSH term(s)	Angina, Unstable/physiopathology ; Angioplasty, Balloon, Coronary ; Drug-Eluting Stents ; Electrocardiography ; Humans ; Myocardial Infarction/therapy
Language	English
Publishing date	2012-03
Publishing country	China
Document type	Editorial
ZDB-ID	127089-8
ISSN	0366-6999 ; 1002-0187
ISSN	0366-6999 ; 1002-0187
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Article ; Online: Current status of percutaneous coronary intervention of chronic total occlusion.

Ge, Jun-bo

Journal of Zhejiang University. Science. B

2012 Volume 13, Issue 8, Page(s) 589–602

Abstract: This paper describes the current status of percutaneous coronary intervention (PCI) for totally occluded coronary arteries. Chronic total occlusion is associated with 10%-20% of all PCI procedures. Results show that opening an occluded vessel, especially ...

Abstract	This paper describes the current status of percutaneous coronary intervention (PCI) for totally occluded coronary arteries. Chronic total occlusion is associated with 10%-20% of all PCI procedures. Results show that opening an occluded vessel, especially one supplying a considerable area of myocardium, may be beneficial for a patient's angina relief and heart function. We describe the devices used currently in re-canalization such as new wires, microcatheters (including Tonus and Cosair) and intravascular ultrasound guidance. Different techniques to improve the success rate and reduce complications are discussed in detail.
MeSH term(s)	Angina Pectoris/therapy ; Angioplasty, Balloon, Coronary/methods ; Cardiology/instrumentation ; Cardiology/methods ; Catheters ; Coronary Stenosis/complications ; Coronary Stenosis/therapy ; Coronary Vessels/pathology ; Echocardiography/methods ; Equipment Design ; Heart/physiopathology ; Humans ; Myocardium/pathology ; Percutaneous Coronary Intervention/methods
Language	English
Publishing date	2012-07-28
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2247290-3
ISSN	1862-1783 ; 1673-1581
ISSN (online)	1862-1783
ISSN	1673-1581
DOI	10.1631/jzus.B1201009
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Article ; Online: Association of Lipoprotein(a) Levels With Myocardial Infarction in Patients With Low-Attenuation Plaque.

Yu, Meng-Meng / Wang, Ming-Liang / Wang, Jin-Jin / Lin, Bo-Li / Zhao, Xin / Tao, Xin-Wei / Chen, Yin-Yin / Li, Peng-Yang / Zhang, Jing-Kun / Ge, Jun-Bo / Jin, Hang / Zeng, Meng-Su

Journal of the American College of Cardiology

2024 Volume 83, Issue 18, Page(s) 1743–1755

Abstract: Background: Lipoprotein(a) (Lp[a]) is associated with an increased risk of myocardial infarction (MI). However, the mechanism underlying this association has yet to be fully elucidated.: Objectives: This multicenter study aimed to investigate whether ...

Abstract	Background: Lipoprotein(a) (Lp[a]) is associated with an increased risk of myocardial infarction (MI). However, the mechanism underlying this association has yet to be fully elucidated. Objectives: This multicenter study aimed to investigate whether association between Lp(a) and MI risk is reinforced by the presence of low-attenuation plaque (LAP) identified by coronary computed tomography angiography (CCTA). Methods: In a derivation cohort, a total of 5,607 patients with stable chest pain suspected of coronary artery disease who underwent CCTA and Lp(a) measurement were prospectively enrolled. In validation cohort, 1,122 patients were retrospectively collected during the same period. High Lp(a) was defined as Lp(a) ≥50 mg/dL. The primary endpoint was a composite of time to fatal or nonfatal MI. Associations were estimated using multivariable Cox proportional hazard models. Results: During a median follow-up of 8.2 years (Q1-Q3: 7.2-9.3 years), the elevated Lp(a) levels were associated with MI risk (adjusted HR [aHR]: 1.91; 95% CI: 1.46-2.49; P < 0.001). There was a significant interaction between Lp(a) and LAP (P Conclusions: Elevated Lp(a) augmented the risk of MI during 8 years of follow-up, especially in patients with LAP identified by CCTA. The presence of LAP could reinforce the relationship between Lp(a) and future MI occurrence.
MeSH term(s)	Humans ; Male ; Female ; Lipoprotein(a)/blood ; Myocardial Infarction/blood ; Myocardial Infarction/epidemiology ; Middle Aged ; Plaque, Atherosclerotic/blood ; Plaque, Atherosclerotic/diagnostic imaging ; Aged ; Computed Tomography Angiography ; Coronary Angiography ; Retrospective Studies ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Prospective Studies ; Follow-Up Studies ; Biomarkers/blood
Chemical Substances	Lipoprotein(a) ; Biomarkers
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2024.03.367
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Article: An unexpected electrocardiogram sign of subacute left ventricular free wall rupture: Its early awareness may be lifesaving.

Wu, Hong-Yi / Qian, Ju-Ying / Wang, Qi-Bing / Ge, Jun-Bo

World journal of emergency medicine

2020 Volume 11, Issue 2, Page(s) 117–119

Abstract: Background: Post-infarct left ventricular free wall rupture (LVFWR) is not always an immediately catastrophic complication. The rupture can be subacute, allowing time for diagnosis and intervention. Accordingly, early recognition of the entity may be ... ...

Abstract	Background: Post-infarct left ventricular free wall rupture (LVFWR) is not always an immediately catastrophic complication. The rupture can be subacute, allowing time for diagnosis and intervention. Accordingly, early recognition of the entity may be lifesaving. Methods: We present an electrocardiogram (ECG) change pattern in two cases, which was erroneously attributed to ischemia. Two women in their 80s were admitted to our institute after experiencing the sudden onset of chest pain. They were managed as anterior ST-segment elevation myocardial infarction without reperfusion treatment. Unfortunately, they experienced a recurrence of severe chest pain with cardiogenic shock during hospitalisation. The ECG recorded at that time showed a ST-segment re-elevation in infract-related leads. Results: The two cases were regrettably received a misjudgement of reinfarction at first, and one of the patients even was administrated with tirofiban. Afterwards the diagnosis of subacute LVFWR was made through antemortem echocardiography. Conclusion: New ST-segment elevation (STE) in infarct-associated leads, coupled with recurrence of chest pain and new-onset hypotension, may constitute the premonitory signs of a subacute LVFWR.
Language	English
Publishing date	2020-01-31
Publishing country	China
Document type	Journal Article
ZDB-ID	2753264-1
ISSN	1920-8642
ISSN	1920-8642
DOI	10.5847/wjem.j.1920-8642.2020.02.009
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Article ; Online: Improving public defibrillator use in China.

Shi, Hong-Tao / Ge, Jun-Bo

Lancet (London, England)

2016 Volume 388, Issue 10050, Page(s) 1156–1157

MeSH term(s)	Adult ; Cardiopulmonary Resuscitation/education ; Cardiopulmonary Resuscitation/instrumentation ; China/epidemiology ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/prevention & control ; Defibrillators/supply & distribution ; Defibrillators/trends ; Health Behavior ; Humans ; Life Style ; Male
Language	English
Publishing date	2016-09-17
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(16)31609-9
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Zs.MG 94: Show issues

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Article: Gender difference in patients with acute myocardial infarction treated by primary percutaneous coronary intervention in drug-eluting stent era.

Ge, Jun-Bo

Chinese medical journal

2010 Volume 123, Issue 7, Page(s) 776–777

MeSH term(s)	Aged ; Aged, 80 and over ; Angioplasty, Balloon, Coronary ; Anti-Bacterial Agents/therapeutic use ; China ; Drug-Eluting Stents ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/mortality ; Myocardial Infarction/therapy ; Prospective Studies ; Registries ; Sex Factors ; Sirolimus/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2010-04-05
Publishing country	China
Document type	Comment ; Editorial
ZDB-ID	127089-8
ISSN	0366-6999 ; 1002-0187
ISSN	0366-6999 ; 1002-0187
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