Article: [Study on in vitro release and percutaneous absorption for Zhitong cataplasm].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2013 Volume 38, Issue 14, Page(s) 2306–2308
Abstract: To evaluate in vitro release and transdermal behaviors of Zhitong cataplasm, modified Franz diffusion cell method was applied to investigate in vitro transdermal absorption of Zhitong cataplasm and the content of tetrahydropalmatine was determined by ... ...
| Abstract | To evaluate in vitro release and transdermal behaviors of Zhitong cataplasm, modified Franz diffusion cell method was applied to investigate in vitro transdermal absorption of Zhitong cataplasm and the content of tetrahydropalmatine was determined by HPLC. In 24 hours, accumulative release rate of tetrahydropalmatine was 81. 9%, transmission rate was 2.26 microg x cm(-2) x h(-1). In 48 hours, accumulative transdermal rate and transmission rate of tetrahydropalmatine were 20.31%, 0.22 pg x cm(-2) x h(-1). So Zhitong cataplasm had a good release and transdermal properties and transdermal actions were consistent with zero-order kinetics process. |
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| MeSH term(s) | Administration, Cutaneous ; Animals ; Berberine Alkaloids/administration & dosage ; Berberine Alkaloids/chemistry ; Berberine Alkaloids/pharmacokinetics ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Male ; Mice ; Plant Extracts/administration & dosage ; Plant Extracts/chemistry ; Plant Extracts/pharmacokinetics ; Skin/metabolism ; Skin Absorption | |||||
| Chemical Substances | Berberine Alkaloids ; Drugs, Chinese Herbal ; Plant Extracts ; tetrahydropalmatine (3X69CO5I79) | |||||
| Language | Chinese | |||||
| Publishing date | 2013-07 | |||||
| Publishing country | China | |||||
| Document type | English Abstract ; Journal Article | |||||
| ZDB-ID | 1004649-5 | |||||
| ISSN | 1001-5302 ; 0254-0029 | |||||
| ISSN | 1001-5302 ; 0254-0029 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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