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  1. Article: Chemotherapy combined with targeted therapy and immunotherapy is an option in advanced biliary tract cancer.

    Ge, Penglei / Wu, Yang

    Therapeutic advances in gastroenterology

    2024  Volume 17, Page(s) 17562848241234509

    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2440710-0
    ISSN 1756-2848 ; 1756-283X
    ISSN (online) 1756-2848
    ISSN 1756-283X
    DOI 10.1177/17562848241234509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of Pre-Pandemic Trivalent COBRA HA Vaccine in Mice Pre-Immune to Historical H1N1 and H3N2 Influenza Viruses.

    Ge, Pan / Ross, Ted M

    Viruses

    2023  Volume 15, Issue 1

    Abstract: Initial exposure to influenza virus(es) during early childhood produces protective antibodies that may be recalled following future exposure to subsequent viral infections or vaccinations. Most influenza vaccine research studies use immunologically naïve ...

    Abstract Initial exposure to influenza virus(es) during early childhood produces protective antibodies that may be recalled following future exposure to subsequent viral infections or vaccinations. Most influenza vaccine research studies use immunologically naïve animal models to assess vaccine effectiveness. However, most people have an extensive influenza immune history, with memory cells produced by viruses or vaccines representing multiple influenza viruses. In this study, we explored the effect influenza seasonal virus-induced immunity has on pre-pandemic influenza virus vaccination. The mice that were pre-immune to historical H1N1 and H3N2 seasonal influenza viruses were vaccinated with adjuvanted pre-pandemic (H2, H5, and H7) HA-based computationally optimized broadly reactive antigen (COBRA) vaccines, and were fully protected from lethal challenge, whereas the mock-vaccinated mice, with or without pre-immunity, were not protected from morbidity or mortality. Detectable antibody titers were present in the pre-immune mice vaccinated with a single dose of vaccine, but not in the immunologically naïve mice. The mice vaccinated twice with the trivalent COBRA HA vaccine had similar antibody titers regardless of their pre-immune status. Overall, seasonal pre-immunity did not interfere with the immune responses elicited by pre-pandemic COBRA HA vaccines or the protection against pre-pandemic viruses.
    MeSH term(s) Child, Preschool ; Humans ; Animals ; Mice ; Influenza, Human ; Influenza Vaccines ; Influenza A Virus, H3N2 Subtype ; Influenza A Virus, H1N1 Subtype ; Orthomyxoviridae Infections ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Vaccines, Virus-Like Particle
    Chemical Substances Influenza Vaccines ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Vaccines, Virus-Like Particle
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15010203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Case report: Myocardial noncompaction causing massive cerebral infarction in 1 patient with eyelid edema as an early manifestation and literature review.

    Ge, Pingping / Zhu, Yafei

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1108570

    Abstract: Objective: To summarize and analyze the early clinical manifestations, risk factors, treatment and prognosis of myocardial noncompaction in children, and to provide scientific basis for early and effective intervention.: Methods: Combined with a case ...

    Abstract Objective: To summarize and analyze the early clinical manifestations, risk factors, treatment and prognosis of myocardial noncompaction in children, and to provide scientific basis for early and effective intervention.
    Methods: Combined with a case of myocardial noncompaction with massive cerebral infarction in a child, the related research reports of myocardial noncompaction in children were analyzed retrospectively.
    Results: Myocardial noncompaction in children is cardiomyopathy caused by abnormal myocardial compaction during embryonic development. Feeding intolerance, dyspnea, chest tightness, fatigue, eyelid edema and other non-specific manifestations may occur in the early stage. It is easy to miss the diagnosis and misdiagnosis in clinical diagnosis and treatment, leading to intractable heart failure, nausea and arrhythmia, thromboembolism and even sudden death and other serious complications. Early diagnosis, symptomatic treatment, control of complications and regular follow-up can prevent the occurrence of serious complications and reduce mortality.
    Conclusion: There is no specific clinical manifestation in the early stage of myocardial noncompaction in children. If it is not detected early and treated symptomatically, the prognosis is poor and the mortality is high. Therefore, clinicians should fully improve the understanding of the early clinical manifestations of this disease, give early diagnosis and early intervention to children, reduce the occurrence of serious complications and improve the survival rate.
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1108570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multi-Object Trajectory Prediction Based on Lane Information and Generative Adversarial Network.

    Guo, Lie / Ge, Pingshu / Shi, Zhenzhou

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 4

    Abstract: Nowadays, most trajectory prediction algorithms have difficulty simulating actual traffic behavior, and there is still a problem of large prediction errors. Therefore, this paper proposes a multi-object trajectory prediction algorithm based on lane ... ...

    Abstract Nowadays, most trajectory prediction algorithms have difficulty simulating actual traffic behavior, and there is still a problem of large prediction errors. Therefore, this paper proposes a multi-object trajectory prediction algorithm based on lane information and foresight information. A Hybrid Dilated Convolution module based on the Channel Attention mechanism (CA-HDC) is developed to extract features, which improves the lane feature extraction in complicated environments and solves the problem of poor robustness of the traditional PINet. A lane information fusion module and a trajectory adjustment module based on the foresight information are developed. A socially acceptable trajectory with Generative Adversarial Networks (S-GAN) is developed to reduce the error of the trajectory prediction algorithm. The lane detection accuracy in special scenarios such as crowded, shadow, arrow, crossroad, and night are improved on the CULane dataset. The average F1-measure of the proposed lane detection has been increased by 4.1% compared to the original PINet. The trajectory prediction test based on D
    Language English
    Publishing date 2024-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24041280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The role of proteomics in acute pancreatitis: new and old knowledge.

    Ge, Peng / Luo, Yalan / Zhang, Guixin / Chen, Hailong

    Expert review of proteomics

    2024  Volume 21, Issue 1-3, Page(s) 115–123

    Abstract: Introduction: Around 20% of individuals diagnosed with acute pancreatitis (AP) may develop severe acute pancreatitis (SAP), possibly resulting in a mortality rate ranging from 15% to 35%. There is an urgent need to thoroughly understand the molecular ... ...

    Abstract Introduction: Around 20% of individuals diagnosed with acute pancreatitis (AP) may develop severe acute pancreatitis (SAP), possibly resulting in a mortality rate ranging from 15% to 35%. There is an urgent need to thoroughly understand the molecular phenotypes of SAP resulting from diverse etiologies. The field of translational research on AP has seen the use of several innovative proteomic methodologies via the ongoing improvement of isolation, tagging, and quantification methods.
    Areas covered: This paper provides a comprehensive overview of differentially abundant proteins (DAPs) identified in AP by searching the PubMed/MEDLINE database (2003-2023) and adds significantly to the current theoretical framework.
    Expert opinion: DAPs for potentially diagnosing AP based on proteomic identification need to be confirmed by multi-center studies that include larger samples. The discovery of DAPs in various organs at different AP stages via proteomic technologies is essential better to understand the pathophysiology of AP-related multiple organ dysfunction syndrome. Regarding the translational research of AP, novel approaches like single-cell proteomics and imaging using mass spectrometry may be used as soon as they become available.
    MeSH term(s) Humans ; Pancreatitis/diagnosis ; Pancreatitis/complications ; Pancreatitis/metabolism ; Proteomics ; Acute Disease ; Multiple Organ Failure
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2299100-1
    ISSN 1744-8387 ; 1478-9450
    ISSN (online) 1744-8387
    ISSN 1478-9450
    DOI 10.1080/14789450.2024.2320810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Complete synchronization of three-layer Rulkov neuron network coupled by electrical and chemical synapses.

    Ge, Penghe / Cheng, Libo / Cao, Hongjun

    Chaos (Woodbury, N.Y.)

    2024  Volume 34, Issue 4

    Abstract: This paper analyzes the complete synchronization of a three-layer Rulkov neuron network model connected by electrical synapses in the same layers and chemical synapses between adjacent layers. The outer coupling matrix of the network is not Laplacian as ... ...

    Abstract This paper analyzes the complete synchronization of a three-layer Rulkov neuron network model connected by electrical synapses in the same layers and chemical synapses between adjacent layers. The outer coupling matrix of the network is not Laplacian as in linear coupling networks. We develop the master stability function method, in which the invariant manifold of the master stability equations (MSEs) does not correspond to the zero eigenvalues of the connection matrix. After giving the existence conditions of the synchronization manifold about the nonlinear chemical coupling, we investigate the dynamics of the synchronization manifold, which will be identical to that of a synchronous network by fixing the same parameters and initial values. The waveforms show that the transient chaotic windows and the transient approximate periodic windows with increased or decreased periods occur alternatively before asymptotic behaviors. Furthermore, the Lyapunov exponents of the MSEs indicate that the network with a periodic synchronization manifold can achieve complete synchronization, while the network with a chaotic synchronization manifold can not. Finally, we simulate the effects of small perturbations on the asymptotic regimes and the evolution routes for the synchronous periodic and the non-synchronous chaotic network.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472677-4
    ISSN 1089-7682 ; 1054-1500
    ISSN (online) 1089-7682
    ISSN 1054-1500
    DOI 10.1063/5.0177771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Surgery is the means of treatment, but high-quality survival is the ultimate goal.

    Ge, Penglei / Wu, Yang

    Hepatobiliary surgery and nutrition

    2022  Volume 11, Issue 2, Page(s) 308–310

    Language English
    Publishing date 2022-04-18
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-2022-05
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Designing Urchin-Like S@SiO

    Wang, Xi / Zeng, Zihao / Dong, Zeyu / Ge, Peng / Yang, Yue

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2400164

    Abstract: Captured by high theoretical capacity and low-cost, Sodium-Sulfur (Na-S) batteries have been deemed as promising energy-storage systems. However, their electrochemical properties, containing both cycling and rate properties, still suffer from the ... ...

    Abstract Captured by high theoretical capacity and low-cost, Sodium-Sulfur (Na-S) batteries have been deemed as promising energy-storage systems. However, their electrochemical properties, containing both cycling and rate properties, still suffer from the notorious "shuttle effect" of polysulfide. Herein, through the effective regulation of pore sizes, a series of S@SiO
    Language English
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202400164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Randomized Controlled Trial of the LMA® Gastro™ Compared to Nasal Cannula for Endoscopic Retrograde Cholangiopancreatography.

    Hagan, Katherine B / Coronel, Emmanuel / Ge, Phillip / Hagberg, Carin

    Anaesthesia, critical care & pain medicine

    2024  , Page(s) 101379

    Language English
    Publishing date 2024-03-18
    Publishing country France
    Document type Letter
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2024.101379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Machine learning assisted coarse-grained molecular dynamics modeling of meso-scale interfacial fluids.

    Ge, Pei / Zhang, Linfeng / Lei, Huan

    The Journal of chemical physics

    2023  Volume 158, Issue 6, Page(s) 64104

    Abstract: A hallmark of meso-scale interfacial fluids is the multi-faceted, scale-dependent interfacial energy, which often manifests different characteristics across the molecular and continuum scale. The multi-scale nature imposes a challenge to construct ... ...

    Abstract A hallmark of meso-scale interfacial fluids is the multi-faceted, scale-dependent interfacial energy, which often manifests different characteristics across the molecular and continuum scale. The multi-scale nature imposes a challenge to construct reliable coarse-grained (CG) models, where the CG potential function needs to faithfully encode the many-body interactions arising from the unresolved atomistic interactions and account for the heterogeneous density distributions across the interface. We construct the CG models of both single- and two-component polymeric fluid systems based on the recently developed deep coarse-grained potential [Zhang et al., J. Chem. Phys. 149, 034101 (2018)] scheme, where each polymer molecule is modeled as a CG particle. By only using the training samples of the instantaneous force under the thermal equilibrium state, the constructed CG models can accurately reproduce both the probability density function of the void formation in bulk and the spectrum of the capillary wave across the fluid interface. More importantly, the CG models accurately predict the volume-to-area scaling transition for the apolar solvation energy, illustrating the effectiveness to probe the meso-scale collective behaviors encoded with molecular-level fidelity.
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0131567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 49/16: Show issues

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