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Article ; Online: The effects and drivers of green financial reform in promoting environmentally-biased technological progress.

Ge, Pengfei / Liu, Tan / Huang, Xiulu

2023 Volume 339, Page(s) 117915

Abstract: Promoting green financial reform is an important measure to support environmentally-biased technological progress (EBTP) and achieve sustainable economic and social development. Although China launched a green finance reform and innovation pilot zone ( ... ...

Abstract	Promoting green financial reform is an important measure to support environmentally-biased technological progress (EBTP) and achieve sustainable economic and social development. Although China launched a green finance reform and innovation pilot zone (GFRIPZ) policy in 2017, little is known about whether and how such a policy affects EBTP. Based on mathematical deduction, this paper studies the mechanism through which green financial reform influences EBTP. The analysis employs panel data of Chinese prefecture-level cities and a generalized synthetic control method to examine the policy effect of the establishment of GFRIPZ in EBTP. It is found that establishing GFRIPZ significantly promotes EBTP, and that the policy effect shows "ahead-of-policy" and dynamically increasing features. Potential mechanisms reside in the pilot policy's easing of financing constraints and upgrading of industrial structure. Further heterogeneity analyses reveal that great disparities exist in the policy effects of different pilot zones, with a steadily increasing policy effect in Zhejiang and Guangdong, a lagging policy effect in Jiangxi and Guizhou, and an inverse U-shaped policy effect in Xinjiang. Policy effects are much stronger in regions with a higher degree of marketization and a higher level of attention to education. Additional tests of economic performance indicate that the pilot policy, interweaved with its driving effect on EBTP, is conducive to promoting an energy-conservation and low-carbon-energy transition. The findings shed light on applying green financial reform to encourage environment-friendly technological research and development.
MeSH term(s)	Carbon ; China ; Cities ; Industry ; Policy ; Economic Development
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.117915
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Article ; Online: Assessing the role and driving mechanisms of the green financial reform on urban energy consumption and pollution emissions: a policy evaluation from the generalized synthetic control method.

Huang, Xiulu / Zhu, Rui / Wu, Xiaoxu / Ge, Pengfei

Environmental science and pollution research international

2023 Volume 30, Issue 56, Page(s) 119095–119116

Abstract: The Green Financial Reform and Innovation Pilot Areas (GFRIPA) policy is a key institutional arrangement that enables China's green finance to advance from theory to practice. Few studies have quantitatively evaluated the policy's environmental ... ...

Abstract	The Green Financial Reform and Innovation Pilot Areas (GFRIPA) policy is a key institutional arrangement that enables China's green finance to advance from theory to practice. Few studies have quantitatively evaluated the policy's environmental performance. This study uses a generalized synthetic control method (GSCM) alongside panel data from Chinese prefecture-level cities since 2007 to assess the effects of the GFRIPA policy on energy consumption and pollution emissions and to pinpoint the underlying mechanisms. Results show that establishing the GFRIPA significantly reduces energy consumption and pollution emissions, and that the effect emerges immediately in the policy's issuance year. Possible mechanisms consist of the increase in urban green innovation, the ease of financing constraints, the optimization of industrial structure, and the enhancement of environmental governance. Heterogeneity analyses reveal that policy effects are more profound in cities with a higher degree of marketization and a higher level of education. The findings provide valuable insights into consistently promoting the GFRIPA policy to meet environmental goals for energy conservation and pollution reduction and ultimately advance green economies in developing nations.
MeSH term(s)	China ; Cities ; Conservation of Natural Resources ; Economic Development ; Environmental Policy ; Fiscal Policy ; Policy
Language	English
Publishing date	2023-11-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-30482-z
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Article ; Online: Spatial Spillover and Convergent Mechanism of Urban–Rural Financial Imbalances: Evidence from China

Yu, Ying / Li, Yong / Ge, Pengfei / Rong, Hua

Land. 2023 July 23, v. 12, no. 7

2023

Abstract: Based on the perspective of financial geography, this study analyzed the convergent mechanism of urban–rural financial imbalances under the influence of spatial spillover through the theoretical framework of spatial process, spatial action, and spatial ... ...

Abstract	Based on the perspective of financial geography, this study analyzed the convergent mechanism of urban–rural financial imbalances under the influence of spatial spillover through the theoretical framework of spatial process, spatial action, and spatial convergence. Then, we empirically tested the spatial spillover, spatial difference, and spatial convergence of urban–rural financial imbalances in China from 1991 to 2021. We found that urban–rural financial imbalances showed significant spillover effects and heterogeneous characteristics. Spillovers based on financial radiation and exclusion were apparent during the urban financial agglomeration stage, decreasing with geographical distance, and had an essential impact on the convergence of provincial urban–rural financial imbalance. As such spillovers declined during the financial diffusion period, new spillovers at the technology and information dimensions, which were less geographically constrained, came into play and contributed to urban–rural financial convergence. The policy implications are that it is necessary to pay attention to the spatial interaction of urban–rural financial inequality, correctly use their spillover effects to achieve financial convergence, and activate new spatial spillover channels according to their spatial interaction mode changes for further urban and rural financial convergence.
Keywords	geography ; issues and policy ; land ; China
Language	English
Dates of publication	2023-0723
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2682955-1
ISSN	2073-445X
ISSN	2073-445X
DOI	10.3390/land12071467
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The effects and drivers of green financial reform in promoting environmentally-biased technological progress

Ge, Pengfei / Liu, Dan / Huang, Xiulu

Journal of Environmental Management. 2023 Aug., v. 339 p.117915-

2023

Abstract	Promoting green financial reform is an important measure to support environmentally-biased technological progress (EBTP) and achieve sustainable economic and social development. Although China launched a green finance reform and innovation pilot zone (GFRIPZ) policy in 2017, little is known about whether and how such a policy affects EBTP. Based on mathematical deduction, this paper studies the mechanism through which green financial reform influences EBTP. The analysis employs panel data of Chinese prefecture-level cities and a generalized synthetic control method to examine the policy effect of the establishment of GFRIPZ in EBTP. It is found that establishing GFRIPZ significantly promotes EBTP, and that the policy effect shows “ahead-of-policy” and dynamically increasing features. Potential mechanisms reside in the pilot policy's easing of financing constraints and upgrading of industrial structure. Further heterogeneity analyses reveal that great disparities exist in the policy effects of different pilot zones, with a steadily increasing policy effect in Zhejiang and Guangdong, a lagging policy effect in Jiangxi and Guizhou, and an inverse U-shaped policy effect in Xinjiang. Policy effects are much stronger in regions with a higher degree of marketization and a higher level of attention to education. Additional tests of economic performance indicate that the pilot policy, interweaved with its driving effect on EBTP, is conducive to promoting an energy-conservation and low-carbon-energy transition. The findings shed light on applying green financial reform to encourage environment-friendly technological research and development.
Keywords	control methods ; economic performance ; education ; energy conservation ; environmental management ; finance ; issues and policy ; research and development ; China ; Green financial reform ; Environmentally-biased technological progress ; Generalized synthetic control method ; Policy effect evaluation ; G18 ; O32
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.117915
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Parthanatos in the pathogenesis of nervous system diseases.

Wang, Xuanzhong / Ge, Pengfei

Neuroscience

2020 Volume 449, Page(s) 241–250

Abstract: Parthanatos is a modality of regulated cell death initiated by poly(ADP-ribose) polymerase 1 (PARP-1) hyperactivation and characterized by apoptosis inducing factor (AIF)-dependent and microphage migration inhibitory factor (MIF)-dependent DNA ... ...

Abstract	Parthanatos is a modality of regulated cell death initiated by poly(ADP-ribose) polymerase 1 (PARP-1) hyperactivation and characterized by apoptosis inducing factor (AIF)-dependent and microphage migration inhibitory factor (MIF)-dependent DNA degradation. It is a caspase-independent, mitochondrial-linked paradigm of cell death and has been demonstrated to be related to the pathogenesis of various nervous system diseases. An in-depth understanding of the role that parthanatos plays in the pathological processes of these diseases can provide new targets for nervous system diseases treatments. In this review, on the basis of parthanatos mechanism, the involvement of parthanatos in the pathogenesis of nervous system diseases including neurodegenerative disorders, cerebrovascular diseases, spinal cord injury and glioma will be summarized in detail.
MeSH term(s)	Apoptosis ; Apoptosis Inducing Factor/metabolism ; Cell Death ; Glioma ; Humans ; Mitochondria/metabolism ; Parthanatos ; Poly (ADP-Ribose) Polymerase-1/metabolism
Chemical Substances	Apoptosis Inducing Factor ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30)
Language	English
Publishing date	2020-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2020.09.049
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Article ; Online: Parthanatos participates in glutamate-mediated HT22 cell injury and hippocampal neuronal death in kainic acid-induced status epilepticus rats.

Wang, Xue / Zhang, Wuqiong / Ge, Pengfei / Yu, Miaomiao / Meng, Hongmei

CNS neuroscience & therapeutics

2022 Volume 28, Issue 12, Page(s) 2032–2043

Abstract: Aims: Epileptic seizures or status epilepticus (SE) can cause hippocampal neuronal death, which has detrimental effects. Parthanatos, a new form of programmed cell death, is characterized by hyperactivation of poly (ADP-ribose) polymerase-1 (PARP-1), ... ...

Abstract	Aims: Epileptic seizures or status epilepticus (SE) can cause hippocampal neuronal death, which has detrimental effects. Parthanatos, a new form of programmed cell death, is characterized by hyperactivation of poly (ADP-ribose) polymerase-1 (PARP-1), excessive synthesis of poly ADP-ribose polymer, mitochondrial depolarization, and nuclear translocation of apoptosis-inducing factor, observed in various neurodegenerative disorders but rarely reported in epilepsy. We aimed to investigate whether parthanatos participates in the mechanism of seizure-induced hippocampal neuronal death. Methods: Glutamate-mediated excitotoxicity cell model was used to study the mechanism of seizure-induced cell injury. Injection of kainic acid into the amygdala was used to establish the epileptic rat model. Corresponding biochemical tests were carried out on hippocampal tissues and HT22 cells following indicated treatments. Results: In vitro, glutamate time-dependently induced HT22 cell death, accompanied by parthanatos-related biochemical events. Pretreatment with PJ34 (PARP-1 inhibitor) or small interfering RNA-mediated PARP-1 knockdown effectively protected HT22 cells against glutamate-induced toxic effects and attenuated parthanatos-related biochemical events. Application of the antioxidant N-acetylcysteine (NAC) rescued HT22 cell death and reversed parthanatos-related biochemical events. In vivo, PJ34 and NAC afforded protection against SE-induced hippocampal neuronal damage and inhibited parthanatos-related biochemical events. Conclusion: Parthanatos participates in glutamate-induced HT22 cell injury and hippocampal neuronal damage in rats following epileptic seizures. ROS might be the initiating factor during parthanatos.
MeSH term(s)	Rats ; Animals ; Parthanatos ; Kainic Acid ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Glutamic Acid ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly (ADP-Ribose) Polymerase-1/pharmacology ; Cell Death ; Hippocampus/metabolism ; Status Epilepticus ; Acetylcysteine/pharmacology
Chemical Substances	N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride ; Kainic Acid (SIV03811UC) ; Poly(ADP-ribose) Polymerase Inhibitors ; Glutamic Acid (3KX376GY7L) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2022-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2423461-8
ISSN	1755-5949 ; 1755-5930
ISSN (online)	1755-5949
ISSN	1755-5930
DOI	10.1111/cns.13934
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Article ; Online: Ubenimex Combined with Pemetrexed Upregulates SOCS1 to Inhibit Lung Adenocarcinoma Progression via the JAK2-STAT3 Signaling Pathway.

Chen, Quan / Wu, Bingbing / Ge, Pengfei / Zhang, Peng / Chen, Xia

Disease markers

2022 Volume 2022, Page(s) 5614939

Abstract: To study the effects of ubenimex (UBE) combined with pemetrexed (PEM) on lung adenocarcinoma cell behavior and its molecular mechanism, the tissue samples from lung adenocarcinoma patients who received PEM chemotherapy, those with PEM combined with UBE ... ...

Abstract	To study the effects of ubenimex (UBE) combined with pemetrexed (PEM) on lung adenocarcinoma cell behavior and its molecular mechanism, the tissue samples from lung adenocarcinoma patients who received PEM chemotherapy, those with PEM combined with UBE chemotherapy, and healthy volunteers were retrieved and analyzed. The expression levels of the suppressor of cytokine signaling 1 (SOCS1) in the human lung adenocarcinoma cancer cell lines A549 and PC-9 and tissues were detected by qRT-PCR. MTT assay was performed for cell proliferation. Cell apoptosis was detected by flow cytometry. Cell invasion ability was assessed using the Transwell assay. The expression levels of the JAK2/STAT3 signaling pathway proteins and apoptosis-related proteins were detected by Western blot. The antitumor effect of PEM combined with UBE was tested in nude mice using the tumor formation assay. Our results showed that UBE treatment, alone or combined with PEM, inhibited lung adenocarcinoma cell migration, invasion, and proliferation; promoted apoptosis; significantly increased the G0/G1-phase cell ratio; reduced the S-phase cell ratio; and inhibited the
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma of Lung/drug therapy ; Animals ; Humans ; Janus Kinase 2 ; Leucine/analogs & derivatives ; Lung Neoplasms/drug therapy ; Mice ; Mice, Nude ; Pemetrexed ; STAT3 Transcription Factor ; Signal Transduction ; Suppressor of Cytokine Signaling 1 Protein/genetics
Chemical Substances	SOCS1 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Socs1 protein, mouse ; Suppressor of Cytokine Signaling 1 Protein ; Pemetrexed (04Q9AIZ7NO) ; JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; Leucine (GMW67QNF9C) ; ubenimex (I0J33N5627)
Language	English
Publishing date	2022-06-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2022/5614939
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Article: Induction of Pyroptosis: A Promising Strategy for Cancer Treatment.

Wang, Lei / Qin, Xiaowei / Liang, Jianmin / Ge, Pengfei

Frontiers in oncology

2021 Volume 11, Page(s) 635774

Abstract: Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of ... ...

Abstract	Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of pyroptosis. Emerging evidence has revealed a complicated relationship between pyroptosis and cancer. On the one hand, as inflammatory cell death, pyroptosis provides a comfortable environment for tumor proliferation. On the other hand, excessive activation of pyroptosis can inhibit the development of tumor cells. In this review, we first summarized the latest progress about the molecular mechanism of pyroptosis. Then, members from gasdermin family, the central molecules of pyroptosis which formed pores on the cell membrane, were highlighted. In the second part of this review, we summarized drugs that induced pyroptosis in different tumors and their concrete mechanisms based on recent literature reports. In the final section, we discussed several hotspots in pyroptosis and cancer therapy, which will point out the direction of sequent research. In brief, inducing pyroptosis in cancer cells is a promising strategy for cancer therapy.
Language	English
Publishing date	2021-02-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.635774
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Article ; Online: Correction to: MiR-126 Regulates the ERK Pathway via Targeting KRAS to Inhibit the Glioma Cell Proliferation and Invasion.

Li, Yang / Li, Yunqian / Ge, Pengfei / Ma, Chengyuan

Molecular neurobiology

2021 Volume 58, Issue 4, Page(s) 1872

Language	English
Publishing date	2021-01-26
Publishing country	United States
Document type	Published Erratum
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-021-02302-3
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Article ; Online: Maltol inhibits oxygen glucose deprivation‑induced chromatinolysis in SH‑SY5Y cells by maintaining pyruvate level.

Zhang, Shuyan / Zhang, Xinyue / Wang, Xuanzhong / Li, Chen / He, Chuan / Luo, Tianfei / Ge, Pengfei

Molecular medicine reports

2023 Volume 27, Issue 3

Abstract: Maltol, a chemical isolated from ginseng root, has shown treatment effects on several pathological processes including osteoarthritis, diabetic peripheral neuropathy and liver fibrosis. Nevertheless, its effect on ischemia‑induced neuron death remains ... ...

Abstract	Maltol, a chemical isolated from ginseng root, has shown treatment effects on several pathological processes including osteoarthritis, diabetic peripheral neuropathy and liver fibrosis. Nevertheless, its effect on ischemia‑induced neuron death remains elusive. In the present study, the treatment effect of maltol on ischemia‑induced neuron damage was investigated by using oxygen and glucose deprivation (OGD) model in SH‑SY5Y cells.
MeSH term(s)	Humans ; Oxygen/metabolism ; Reactive Oxygen Species/metabolism ; Pyruvic Acid ; Glucose/metabolism ; Catalase ; Neuroblastoma ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Oxygen (S88TT14065) ; Reactive Oxygen Species ; maltol (3A9RD92BS4) ; Pyruvic Acid (8558G7RUTR) ; Glucose (IY9XDZ35W2) ; Catalase (EC 1.11.1.6) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-02-17
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2023.12962
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