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  1. Article ; Online: A novel clinical artificial intelligence model for disease detection via retinal imaging.

    Fu, Yidian / Ma, Liang / Wan, Sheng / Ge, Shengfang / Yang, Zhi

    Innovation (Cambridge (Mass.))

    2024  Volume 5, Issue 2, Page(s) 100575

    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-6758
    ISSN (online) 2666-6758
    DOI 10.1016/j.xinn.2024.100575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Novel insight into RNA modifications in tumor immunity: Promising targets to prevent tumor immune escape.

    Kong, Yuxin / Yu, Jie / Ge, Shengfang / Fan, Xianqun

    Innovation (Cambridge (Mass.))

    2023  Volume 4, Issue 4, Page(s) 100452

    Abstract: An immunosuppressive state is a typical feature of the tumor microenvironment. Despite the dramatic success of immune checkpoint inhibitor (ICI) therapy in preventing tumor cell escape from immune surveillance, primary and acquired resistance have ... ...

    Abstract An immunosuppressive state is a typical feature of the tumor microenvironment. Despite the dramatic success of immune checkpoint inhibitor (ICI) therapy in preventing tumor cell escape from immune surveillance, primary and acquired resistance have limited its clinical use. Notably, recent clinical trials have shown that epigenetic drugs can significantly improve the outcome of ICI therapy in various cancers, indicating the importance of epigenetic modifications in immune regulation of tumors. Recently, RNA modifications (N
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-6758
    ISSN (online) 2666-6758
    DOI 10.1016/j.xinn.2023.100452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy.

    Yu, Yilin / Yu, Jie / Ge, Shengfang / Su, Yun / Fan, Xianqun

    International journal of biological sciences

    2023  Volume 19, Issue 3, Page(s) 811–828

    Abstract: Currently, cancer treatment mainly consists of surgery, radiotherapy, chemotherapy, immunotherapy, and molecular targeted therapy, of which radiotherapy is one of the major pillars. However, the occurrence of radioresistance largely limits its ... ...

    Abstract Currently, cancer treatment mainly consists of surgery, radiotherapy, chemotherapy, immunotherapy, and molecular targeted therapy, of which radiotherapy is one of the major pillars. However, the occurrence of radioresistance largely limits its therapeutic effect. Metabolic reprogramming is an important hallmark in cancer progression and treatment resistance. In radiotherapy, DNA breakage is the major mechanism of cell damage, and in turn, cancer cells are prone to increase the metabolic flux of glucose, glutamine, serine, arginine, fatty acids etc., thus providing sufficient substrates and energy for DNA damage repair. Therefore, studying the linkage between metabolic reprogramming and cancer radioresistance may provide new ideas for improving the efficacy of tumor therapy. This review mainly focuses on the role of metabolic alterations, including glucose, amino acid, lipid, nucleotide and other ion metabolism, in radioresistance, and proposes possible therapeutic targets to improve the efficacy of cancer radiotherapy.
    MeSH term(s) Humans ; Radiation Tolerance/genetics ; Neoplasms/genetics ; Neoplasms/radiotherapy ; DNA Repair/genetics ; Glucose
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-01-01
    Publishing country Australia
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.79928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Publication Trends of Research on Head and Neck Squamous Cell Carcinoma During 2002 to 2022: A 20-Year Bibliometric Study.

    Xu, Mingpeng / Gu, Xiang / Yang, Ludi / Ge, Shengfang / Zhao, Peiquan

    The Journal of craniofacial surgery

    2023  Volume 34, Issue 8, Page(s) 2379–2383

    Abstract: Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Our study attempted to analyze the research trends in HNSCC and compare contributions from different countries, institutions, journals, and authors.: ... ...

    Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Our study attempted to analyze the research trends in HNSCC and compare contributions from different countries, institutions, journals, and authors.
    Materials and methods: The authors extracted publications in this field from 2002 to 2022 from the Web of Science database. Microsoft Excel and VOSviewer were performed to collect data on publication numbers, analyze publication trends, and visualize relevant results.
    Results: A total of 1903 publications were screened. In the past 20 years, the United States contributed the most publications and citations in the HNSCC research. China ranked second in the number of publications. The Ophthalmic Plastic and Reconstructive Surgery was the most productive journal concerning HNSCC. ESMAELIB of the University of Texas System and ROSENTHAL EL of Stanford University had published the most publications in this field. Keywords were categorized into 3 clusters: basic study, clinical feature study, and treatment-related study. The keywords "reflectance confocal microscopy", "raman-spectroscopy", and "confocal laser endomicroscopy" were most frequently emerged in the recent years. Management-related research has been recognized as a potential focus in the HNSCC.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck ; Bibliometrics ; China ; Databases, Factual ; Head and Neck Neoplasms/surgery
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000009666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3761: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 175: Show issues

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  5. Article ; Online: Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification.

    Fu, Yidian / Yu, Jie / Li, Fang / Ge, Shengfang

    Journal of experimental & clinical cancer research : CR

    2022  Volume 41, Issue 1, Page(s) 144

    Abstract: Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal metabolite accumulation. These metabolites mainly generate energy or serve as ... ...

    Abstract Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal metabolite accumulation. These metabolites mainly generate energy or serve as signal transduction mediators via noncovalent interactions. After the development of highly sensitive mass spectrometry technology, various metabolites were shown to covalently modify proteins via forms of lysine acylation, including lysine acetylation, crotonylation, lactylation, succinylation, propionylation, butyrylation, malonylation, glutarylation, 2-hydroxyisobutyrylation and β-hydroxybutyrylation. These modifications can regulate gene expression and intracellular signalling pathways, highlighting the extensive roles of metabolites. Lysine acetylation is not discussed in detail in this review since it has been broadly investigated. We focus on the nine aforementioned novel lysine acylations beyond acetylation, which can be classified into two categories: histone acylations and nonhistone acylations. We summarize the characteristics and common functions of these acylation types and, most importantly, provide a glimpse into their fine-tuned control of tumorigenesis and potential value in tumour diagnosis, monitoring and therapy.
    MeSH term(s) Acetylation ; Acylation ; Carcinogenesis/genetics ; Histones/metabolism ; Humans ; Lysine/chemistry ; Protein Processing, Post-Translational
    Chemical Substances Histones ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2022-04-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-022-02338-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2065: Show issues Location:
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  6. Article ; Online: Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT.

    Tian, Hao / Shi, Hanhan / Yu, Jie / Ge, Shengfang / Ruan, Jing

    Global challenges (Hoboken, NJ)

    2022  Volume 6, Issue 6, Page(s) 2100094

    Abstract: Oncological diseases have become the second leading cause of death from noncommunicable diseases worldwide and a major threat to human health. With the continuous progress in cancer research, the mechanical cues from the tumor microenvironment ... ...

    Abstract Oncological diseases have become the second leading cause of death from noncommunicable diseases worldwide and a major threat to human health. With the continuous progress in cancer research, the mechanical cues from the tumor microenvironment environment (TME) have been found to play an irreplaceable role in the progression of many cancers. As the main extracellular mechanical signal carrier, extracellular matrix (ECM) stiffness may influence cancer progression through biomechanical transduction to modify downstream gene expression, promote epithelial-mesenchymal transition (EMT), and regulate the stemness of cancer cells. EMT is an important mechanism that induces cancer cell metastasis and is closely influenced by ECM stiffness, either independently or in conjunction with other molecules. In this review, the unique role of ECM stiffness in EMT in different kinds of cancers is first summarized. By continually examining the significance of ECM stiffness in cancer progression, a biomimetic culture system based on 3D manufacturing and novel material technologies is developed to mimic ECM stiffness. The authors then look back on the novel development of the ECM stiffness biomimetic culture systems and finally provide new insights into ECM stiffness in cancer progression which can broaden the fields' horizons with a view toward developing new cancer diagnosis methods and therapies.
    Language English
    Publishing date 2022-03-20
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2056-6646
    ISSN (online) 2056-6646
    DOI 10.1002/gch2.202100094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Publication trends of research on conjunctival melanoma during 1997-2022: A 25-year bibliometric study.

    Xu, Wei / Yang, Ludi / Ge, Shengfang / Jia, Shichong / Gu, Fen

    Frontiers in oncology

    2022  Volume 12, Page(s) 960494

    Abstract: Background: Conjunctival melanoma (CM) is a life-threatening ocular tumor with a high rate of local recurrence and metastasis. Our objective is to analyze research trends in CM field and compare contributions from different countries, institutions and ... ...

    Abstract Background: Conjunctival melanoma (CM) is a life-threatening ocular tumor with a high rate of local recurrence and metastasis. Our objective is to analyze research trends in CM field and compare contributions from different countries, institutions and authors.
    Methods: We extracted all CM-related publications published from 1997 to 2022 from the Web of Science database and applied Microsoft Excel and VOSviewer to review publication data, analyze publication trends, and visualize relevant data.
    Results: A total of 708 publications were identified. The United States contributed the most publications (280) and citations (8,781 times) with the highest H-index value (47). The
    Conclusion: In the past 25 years, the United States, Germany, England and the Netherlands held the leading position in the CM research. A group of scholars made important contributions to CM research and will continue to guide cutting-edge research. Treatments that have been shown to be effective for advanced cutaneous melanoma, such as targeted therapy and immunotherapy, are potential focuses for future CM research.
    Language English
    Publishing date 2022-08-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.960494
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  8. Article ; Online: Novel insights into RB1 mutation.

    Yao, Yiran / Gu, Xiang / Xu, Xiaofang / Ge, Shengfang / Jia, Renbing

    Cancer letters

    2022  Volume 547, Page(s) 215870

    Abstract: Since the discovery of the retinoblastoma susceptibility gene (RB1) decades ago, RB1 has been regarded as a prototype tumor suppressor gene providing a paradigm for tumor genetic research. Constant research has updated the understanding of RB1-related ... ...

    Abstract Since the discovery of the retinoblastoma susceptibility gene (RB1) decades ago, RB1 has been regarded as a prototype tumor suppressor gene providing a paradigm for tumor genetic research. Constant research has updated the understanding of RB1-related pathways and their impact on tumor and nontumor diseases. Mutation of RB1 gene has been observed in multiple types of malignant tumors including prostate cancer, lung cancer, breast cancer, and almost every familial and sporadic case of retinoblastoma. Even if well-known and long-investigated, the application potential of RB1 mutation has not been fully tapped. In this review, we focus on the mechanism underlying RB1 mutation during oncogenesis. Therapeutically, we have further discussed potential clinical strategies by targeting RB1-mutated cancers. The unsolved problems and prospects of RB1 mutation are also discussed.
    MeSH term(s) Genes, Retinoblastoma ; Genes, cdc ; Humans ; Male ; Mutation ; Retinal Neoplasms/genetics ; Retinoblastoma/genetics ; Retinoblastoma Binding Proteins/genetics ; Retinoblastoma Binding Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances RB1 protein, human ; Retinoblastoma Binding Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2022-08-12
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2022.215870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
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  9. Article: Publication Trends of Research on Retinoblastoma During 2001-2021: A 20-Year Bibliometric Analysis.

    Gu, Xiang / Xie, Minyue / Jia, Renbing / Ge, Shengfang

    Frontiers in medicine

    2021  Volume 8, Page(s) 675703

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-05-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.675703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Novel Forkhead Box L2 Missense Mutation, c.1068G>C, in a Chinese Family With Blepharophimosis/Ptosis/ Epicanthus Inversus Syndrome.

    Wang, Shaoyun / Ge, Shengfang / Zhuang, Ai

    The Journal of craniofacial surgery

    2021  Volume 33, Issue 3, Page(s) e238–e240

    Abstract: Abstract: The aim of the study was to report a novel forkhead box L2 (FOXL2) missense mutation in a Chinese blepharophimosis/ ptosis/epicanthus inversus syndrome family. Three generations of the Chinese family with blepharophimosis/ptosis/epicanthus ... ...

    Abstract Abstract: The aim of the study was to report a novel forkhead box L2 (FOXL2) missense mutation in a Chinese blepharophimosis/ ptosis/epicanthus inversus syndrome family. Three generations of the Chinese family with blepharophimosis/ptosis/epicanthus inversus syndrome were enrolled in this study. Blood samples from patients of this family were collected and then analyzed by whole-exome sequencing. Confocal microscopy was performed to detect the subcellular location of FOXL2. Transactivation studies were performed and verified with real time polymerase chain reaction. A novel mutation (c.1068G>C) located in the downstream of deoxyribonucleic acid-binding forkhead domain was identified. Confocal photos showed the novel mutation did not disturb FOXL2 function, and the mutant protein could still transactivate steroidogenic acute regulatory protein, a key regulator of primary ovarian failure (POF). Our study revealed a novel missense mutation (c.1068G>C) and expanded the spectrum of FOXL2 gene mutations.
    MeSH term(s) Blepharophimosis/diagnosis ; Blepharophimosis/genetics ; China ; Forkhead Box Protein L2/genetics ; Humans ; Mutation, Missense ; Pedigree ; Skin Abnormalities/diagnosis ; Skin Abnormalities/genetics ; Urogenital Abnormalities/diagnosis ; Urogenital Abnormalities/genetics
    Chemical Substances FOXL2 protein, human ; Forkhead Box Protein L2
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000008042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3761: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 175: Show issues

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