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Article ; Online: Erratum to: Efficacy and safety of vagus nerve stimulation on upper extremity motor function in patients with stroke: A meta-analysis of randomized controlled trials.

Wei, Tianqi / Ge, Xiangyang / Lu, Lingfeng / Li, Jing / Xu, Panpan / Wu, Qinfeng

2024 Volume 54, Issue 2, Page(s) 347

Language	English
Publishing date	2024-02-15
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1087912-2
ISSN	1878-6448 ; 1053-8135
ISSN (online)	1878-6448
ISSN	1053-8135
DOI	10.3233/NRE-236008
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Article ; Online: The Effects of Light Therapy on Sleep, Agitation and Depression in People With Dementia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Fong, Kenneth Nk / Ge, Xiangyang / Ting, K H / Wei, Minchen / Cheung, Hilda

American journal of Alzheimer's disease and other dementias

2023 Volume 38, Page(s) 15333175231160682

Abstract: Objective: To evaluate the effects of light therapy on the alleviation of sleep disturbances, agitation and depression in people with dementia.: Methods: A search was performed in PubMed, Medline, SCOPUS, Web of Science, EMBASE, CINAHL, Cochrane ... ...

Abstract	Objective: To evaluate the effects of light therapy on the alleviation of sleep disturbances, agitation and depression in people with dementia. Methods: A search was performed in PubMed, Medline, SCOPUS, Web of Science, EMBASE, CINAHL, Cochrane Library, for studies published between 2000 and 2021. Results: A total of 4315 articles were screened. Sixteen articles were eligible for this review and 11 randomized controlled studies were included in the meta-analysis. Light therapy had a significant effect on reducing the number of awakenings in sleep ( Conclusion: Light therapy appeared to be more effective in terms of alleviating sleep disturbances, rather than reducing agitation and depression, but its long-term effects remain unclear.
MeSH term(s)	Humans ; Depression/therapy ; Randomized Controlled Trials as Topic ; Phototherapy ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/therapy ; Sleep ; Dementia/complications ; Dementia/therapy
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1283069-0
ISSN	1938-2731 ; 0895-5336 ; 1082-5207 ; 1533-3175
ISSN (online)	1938-2731
ISSN	0895-5336 ; 1082-5207 ; 1533-3175
DOI	10.1177/15333175231160682
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Article ; Online: Efficacy and safety of vagus nerve stimulation on upper extremity motor function in patients with stroke: A meta-analysis of randomized controlled trials.

Wei, Tianqi / Ge, Xiangyang / Lu, Lingfeng / Li, Jing / Xu, Panpan / Wu, Qinfeng

NeuroRehabilitation

2023 Volume 53, Issue 3, Page(s) 253–267

Abstract: Background: In 2021, the U.S. Food and Drug Administration (FDA) approved paired vagus nerve stimulation (VNS) for patients with moderate-to-severe upper extremity motor impairments following chronic ischemic stroke.: Objective: Previous meta- ... ...

Abstract	Background: In 2021, the U.S. Food and Drug Administration (FDA) approved paired vagus nerve stimulation (VNS) for patients with moderate-to-severe upper extremity motor impairments following chronic ischemic stroke. Objective: Previous meta-analyses have shown that VNS may impact stroke rehabilitation, but each has some limitations. Methods: PubMed, Ovid, Cochrane Library, ScienceDirect, Web of Science and WHO ICTRP databases were searched until July 14, 2022 for randomized controlled trials (RCTs). We defined primary outcomes as Fugl-Meyer Assessment for Upper Extremity (FMA-UE) and Wolf Motor Function Test (WMFT). Subgroup analyses included types of VNS, time since onset and long-term effects. Secondary outcomes included adverse events of VNS. Results: Eight RCTs involving 266 patients were analyzed, of which five used direct VNS and three transcutaneous auricular VNS. The results revealed that VNS enhanced upper extremity function via FMA-UE (SMD = 0.73; 95% CI: 0.48 to 0.99; P < 0.00001) and WMFT (SMD = 0.82; 95% CI:0.52 to 1.13; P < 0.00001) in comparison to the control group, but showed no significant change on long-term effects of FMA-UE (SMD = 0.69; 95% CI: - 0.06 to 1.44; P = 0.07). There was no difference in adverse events between the VNS and control groups (RR = 1.16; 95% CI: 0.46 to 2.92; P = 0.74). Conclusion: For stroke victims with upper limb disabilities, VNS paired with rehabilitation was significantly safe and effective. More high-quality multicentric RCTs are needed to validate this conclusion.
MeSH term(s)	Humans ; Randomized Controlled Trials as Topic ; Recovery of Function ; Stroke/complications ; Stroke Rehabilitation/methods ; Upper Extremity ; Vagus Nerve Stimulation/methods
Language	English
Publishing date	2023-09-11
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	1087912-2
ISSN	1878-6448 ; 1053-8135
ISSN (online)	1878-6448
ISSN	1053-8135
DOI	10.3233/NRE-230106
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Article ; Online: Metagenomic analyses reveal microbial communities and functional differences between Daqu from seven provinces.

Zhu, Chutian / Cheng, Yuxin / Shi, Qili / Ge, Xiangyang / Yang, Yong / Huang, Yongguang

Food research international (Ottawa, Ont.)

2023 Volume 172, Page(s) 113076

Abstract: Microbial communities perform the brewing function in Daqu. Macrogenomics and PICRUST II analyses revealed the differences in microbes and metabolic functions among Daqu from the seven Baijiu-producing provinces. Jiang-flavored Daqu (Guizhou, Shandong, ... ...

Abstract	Microbial communities perform the brewing function in Daqu. Macrogenomics and PICRUST II analyses revealed the differences in microbes and metabolic functions among Daqu from the seven Baijiu-producing provinces. Jiang-flavored Daqu (Guizhou, Shandong, and Hubei provinces) generally forms an aroma-producing functional microbiota with Kroppenstedtia, Bacillus, Thermoascus, Virgibacillus, and Thermomyces as the core, which promotes the metabolism of various amino acids and aroma compounds. Light-flavored Daqu (Shanxi Province) enriched the Saccharomycopsis, Saccharomyces, and lactic acid bacteria (LAB) microbiota through low-temperature fermentation. These microbes can synthesize alcohol and lactic acid but inhibit amino acid metabolism within the Light-flavored Daqu. Bifidobacterium and Saccharomycopsis were dominant in the Tao-flavored Daqu (Henan province). This unique microbial structure is beneficial for pyruvate fermentation to lactate. Research also found that Strong-flavored Daqu from Jiangsu and Sichuan provinces differed significantly. The microbial communities and metabolic pathways within Jiangsu Daqu were similar to those within Jiang-flavored Daqu, but Sichuan Daqu was dominated by Thermoascus, LAB, and Thermoactinomyces. In addition, Spearman correlation analysis indicated that Kroppenstedtia, Bacillus, and Thermomyces were not only positively related to flavor metabolism but also negatively correlated with Saccharomycopsis. This research will help establish a systematic understanding of the microbial community and functional characteristics in Daqu.
MeSH term(s)	Metagenome ; Microbiota ; Bacillus ; Amino Acids ; Lactic Acid ; Lactobacillales/genetics
Chemical Substances	Amino Acids ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-06-02
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.113076
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Article: Chinese Baijiu distiller's grains resourcing: Current progress and future prospects

Liu, Yizhou / Liu, Shuangping / Huang, Caihong / Ge, Xiangyang / Xi, Beidou / Mao, Jian

Resources, conservation, and recycling. 2022 Jan., v. 176

2022

Abstract: Distiller's grains (DGS) as a typical organic solid waste in Chinese Baijiu production, with high water content, nutrient and various high-value components. Conventional waste management causes environmental issues and bioresource wasting. With the ... ...

Abstract	Distiller's grains (DGS) as a typical organic solid waste in Chinese Baijiu production, with high water content, nutrient and various high-value components. Conventional waste management causes environmental issues and bioresource wasting. With the development of Chinese Baijiu companies, the demand for effective DGS treatment is urgent. There were various approaches for DGS resourcing, such as feeding, high-value components extraction, biogas production and composting. This review focus on the efficiency and existed limitations of these methods, includes the effects of feeds in livestock and poultry breeding, extraction efficiency and utilization, biogas yield and purity, and substance variation and stabilization in composting. As a prospect, process for DGS cascade and full utilization should be designed in further study. Combining and organizing the methods in different studies, decreasing the waste and discharge in process, optimizing the approaches in high value component extraction, promoting the utilization in different production, the value of DGS can be increased. The remained materials after cascade utilization can be further treated by full utilization in bioresource energy and composting. Therefore, Chinese Baijiu companies can achieve zero organic solid waste discharge and cleaner production.
Keywords	biogas ; energy ; gas production (biological) ; livestock ; solid wastes ; water content
Language	English
Dates of publication	2022-01
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1498716-8
ISSN	0921-3449
ISSN	0921-3449
DOI	10.1016/j.resconrec.2021.105900
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Article ; Online: Omicron BQ.1.1 and XBB.1 unprecedentedly escape broadly neutralizing antibodies elicited by prototype vaccination.

Ju, Bin / Fan, Qing / Liu, Congcong / Shen, Senlin / Wang, Miao / Guo, Huimin / Zhou, Bing / Ge, Xiangyang / Zhang, Zheng

Cell reports

2023 Volume 42, Issue 6, Page(s) 112532

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants have seriously attacked the antibody barrier established by natural infection and/or vaccination, especially the recently emerged BQ.1.1 and XBB.1. However, crucial ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants have seriously attacked the antibody barrier established by natural infection and/or vaccination, especially the recently emerged BQ.1.1 and XBB.1. However, crucial mechanisms underlying the virus escape and the broad neutralization remain elusive. Here, we present a panoramic analysis of broadly neutralizing activity and binding epitopes of 75 monoclonal antibodies isolated from prototype inactivated vaccinees. Nearly all neutralizing antibodies (nAbs) partly or totally lose their neutralization against BQ.1.1 and XBB.1. We report a broad nAb, VacBB-551, that effectively neutralizes all tested subvariants including BA.2.75, BQ.1.1, and XBB.1. We determine the cryoelectron microscopy (cryo-EM) structure of VacBB-551 complexed with the BA.2 spike and perform detailed functional verification to reveal the molecular basis of N460K and F486V/S mutations mediating the partial escape of BA.2.75, BQ.1.1, and XBB.1 from the neutralization of VacBB-551. Overall, BQ.1.1 and XBB.1 raised the alarm over SARS-CoV-2 evolution with unprecedented antibody evasion from broad nAbs elicited by prototype vaccination.
MeSH term(s)	Humans ; Broadly Neutralizing Antibodies ; COVID-19/prevention & control ; Cryoelectron Microscopy ; SARS-CoV-2 ; Antibodies, Neutralizing ; Vaccination ; Antibodies, Viral
Chemical Substances	Broadly Neutralizing Antibodies ; Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112532
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Article ; Online: Additional mutations based on Omicron BA.2.75 mediate its further evasion from broadly neutralizing antibodies.

Guo, Huimin / Jiang, Jie / Shen, Senlin / Ge, Xiangyang / Fan, Qing / Zhou, Bing / Cheng, Lin / Ju, Bin / Zhang, Zheng

iScience

2023 Volume 26, Issue 4, Page(s) 106283

Abstract: SARS-CoV-2 Omicron BA.2.75 subvariant has evolved to a series of progeny variants carrying several additional mutations in the receptor-binding domain (RBD). Here, we investigated whether and how these single mutations based on BA.2.75 affect the ... ...

Abstract	SARS-CoV-2 Omicron BA.2.75 subvariant has evolved to a series of progeny variants carrying several additional mutations in the receptor-binding domain (RBD). Here, we investigated whether and how these single mutations based on BA.2.75 affect the neutralization of currently available anti-RBD monoclonal antibodies (mAbs) with well-defined structural information. Approximately 34% of mAbs maintained effective neutralizing activities against BA.2.75, consistent with those against BA.2, BA.4/5, and BA.2.12.1. Single additional R346T, K356T, L452R, or F486S mutations further facilitated BA.2.75-related progeny variants to escape from broadly neutralizing antibodies (bnAbs) at different degree. Only LY-CoV1404 (bebtelovimab) displayed a first-class neutralization potency and breadth against all tested Omicron subvariants. Overall, these data make a clear connection between virus escape and antibody recognizing antigenic epitopes, which facilitate to develop next-generation universal bnAbs against emerging SARS-CoV-2 variants.
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.106283
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Article ; Online: Akkermansia muciniphila Protects Against Antibiotic-Associated Diarrhea in Mice.

Liu, Shenyin / Zhao, Suying / Cheng, Zhiwei / Ren, Yilin / Shi, Xinyi / Mu, Jing / Ge, Xiangyang / Dai, Yuan / Li, Lei / Zhang, Zhan

Probiotics and antimicrobial proteins

2023

Abstract: Probiotics are used to prevent antibiotic-associated diarrhea (AAD) via the restoration of the gut microbiota. However, the precise effects of Akkermansia muciniphila (Akk), which is a promising probiotics, on AAD are unknown. Here, AAD models were ... ...

Abstract	Probiotics are used to prevent antibiotic-associated diarrhea (AAD) via the restoration of the gut microbiota. However, the precise effects of Akkermansia muciniphila (Akk), which is a promising probiotics, on AAD are unknown. Here, AAD models were established via the administration of lincomycin and ampicillin with or without pasteurized Akk or Amuc_1100 treatment. A diffusion test revealed that Akk was susceptible to the majority of the antibiotics, such as ampicillin. These effects were confirmed by the reduced Akk abundance in AAD model mice. Pasteurized Akk or Amuc_1100 significantly decreased the diarrhea status score and colon injury of AAD model mice. Additionally, these treatments significantly decreased the relative abundance of Citrobacter at genus level and reshaped the metabolic function of gut microbiota. Notably, pasteurized Akk or Amuc_1100 significantly changed the serum metabolome of AAD model mice. In addition, pasteurized Akk or Amuc_1100 suppressed intestinal inflammation by upregulating the expression of GPR109A and SLC5A8 and downregulating the expression of TNFα, IFNγ, IL1β, and IL6. Furthermore, they enhanced water and electrolyte absorption by upregulating AQP4, SLC26A3, and NHE3. Pasteurized Akk or Amuc_1100 also restored intestinal barrier function by ameliorating the downregulation of ZO-1, OCLN, CLDN4, and Muc2 in AAD model mice. In summary, optimizing intestinal health with pasteurized Akk or Amuc_1100 may serve as an approach for preventing AAD.
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-023-10101-6
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Article: Comprehensive utilization of palm kernel cake for producing mannose and manno-oligosaccharide mixture and yeast culture

Dong, Weiwei / Dong, Shengqi / Li, Yongxu / Lei, Yutian / Peng, Nan / Liang, Yunxiang / Zhao, Shumiao / Ge, Xiangyang

Applied microbiology and biotechnology. 2022 Feb., v. 106, no. 3

2022

Abstract: Palm kernel cake (PKC) is an agricultural waste derived from palm kernel oil manufacturing, and its production is increasing year by year. It is very urgent to process this agricultural waste in an environmentally friendly way. Here, PKC was used to ... ...

Abstract	Palm kernel cake (PKC) is an agricultural waste derived from palm kernel oil manufacturing, and its production is increasing year by year. It is very urgent to process this agricultural waste in an environmentally friendly way. Here, PKC was used to produce mannose and manno-oligosaccharides mixture (MMOM) and yeast culture (YC) through enzymolysis and solid-state fermentation (SSF). In enzymolysis, five factors were optimized separately and a response surface methodology analysis was performed. Then, enzymolysis of PKC was carried out at the optimal condition, and the extraction efficiency of mannose and manno-oligosaccharides reached 68.90% with mannose concentration achieving 60.27 g/L. After enzymolysis, the enzymatic hydrolysate was dried by spray drying, and the contents of MMOM reached 42.9%. In SSF, the enzymolysis residues were utilized with inoculating Saccharomyces cerevisiae for yielding YC. After optimization, the cells number of S. cerevisiae reached 2.08 × 10⁹ cells/g and the crude protein content was increased to 27.31%. Therefore, a novel approach to produce feed additives, including MMOM and YC, with high value by comprehensive utilization of PKC was proposed, which has good application prospects in the breeding industry. KEY POINTS: • New idea for the comprehensive utilization of PKC is proposed. • PKC was used to produce mannose and mannan-oligosaccharides mixture (MMOM) by enzymolysis and spray drying. • The enzymolysis residues were reused via SSF for producing yeast culture (YC).
Keywords	Saccharomyces cerevisiae ; agricultural wastes ; biotechnology ; crude protein ; hydrolysates ; mannose ; palm kernel cake ; palm kernel oil ; response surface methodology ; solid state fermentation ; yeasts
Language	English
Dates of publication	2022-02
Size	p. 1045-1056.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-022-11780-x
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Article ; Online: Levels of antibodies against the monkeypox virus compared by HIV status and historical smallpox vaccinations: a serological study.

Li, Dapeng / Wang, Haiyan / Sun, Liqin / Feng, Jiamin / Li, Wenting / Cheng, Lin / Liao, Xuejiao / Zhang, Yangzhen / Xu, Zhongxian / Ge, Xiangyang / Zhou, Bing / Zhao, Juanjuan / Ju, Bin / Lu, Hongzhou / Zhang, Zheng

Emerging microbes & infections

2024 , Page(s) 2356153

Abstract: Men who have sex with men and people living with HIV are disproportionately affected in the 2022 multi-country monkeypox epidemic. The smallpox vaccine can induce cross-reactive antibodies against the monkeypox virus (MPXV) and reduce the risk of ... ...

Abstract	Men who have sex with men and people living with HIV are disproportionately affected in the 2022 multi-country monkeypox epidemic. The smallpox vaccine can induce cross-reactive antibodies against the monkeypox virus (MPXV) and reduce the risk of infection. Data on antibodies against MPXV induced by historic smallpox vaccination in people with HIV are scarce. In this observational study, plasma samples were collected from people living with and without HIV in Shenzhen, China. We measured antibodies binding to two representative proteins of vaccinia virus (VACV; A27L and A33R) and homologous proteins of MPXV (A29L and A35R) using an enzyme-linked immunosorbent assay. We compared the levels of these antibodies between people living with and without HIV. Stratified analyses were performed based on the year of birth of 1981 when the smallpox vaccination was stopped in China. Plasma samples from 677 people living with HIV and 746 people without HIV were tested. A consistent pattern was identified among the four antibodies, regardless of HIV status. VACV antigen-reactive and MPXV antigen-reactive antibodies induced by historic smallpox vaccination were detectable in the people born before 1981, and antibody levels reached a nadir during or after 1981. The levels of smallpox vaccine-induced antibodies were comparable between people living with HIV and those without HIV. Our findings suggest that the antibody levels against MPXV decreased in both people living with and without HIV due to the cessation of smallpox vaccination.
Language	English
Publishing date	2024-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2024.2356153
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