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  1. Article ; Online: Isolation and identification of active components from Grifola frondosa and its anti-EV71 virus effect.

    Xiong, Wenyu / Jiang, Xiaoqin / He, Junqiang / Zhong, Yue / Ge, Xiaodong / Liu, Bin / Zeng, Feng

    Journal of the science of food and agriculture

    2024  Volume 104, Issue 7, Page(s) 4453–4464

    Abstract: Background: It is reported that anti-enterovirus 71 (EV71) drugs have some side effects on human health. Notably, fungi plays a crucial role in promoting human health and anti-virus. Grifola frondosa is a type of large medicinal and edible fungi, rich ... ...

    Abstract Background: It is reported that anti-enterovirus 71 (EV71) drugs have some side effects on human health. Notably, fungi plays a crucial role in promoting human health and anti-virus. Grifola frondosa is a type of large medicinal and edible fungi, rich in active substances. The present study aimed to investigate the anti-EV71 effect of G. frondosa and the potential active substances.
    Results: In the present study, the water extract of G. frondosa was subjected to ethanol precipitation to obtain the water-extracted supernatant of G. frondosa (GFWS) and water-extracted precipitation of G. frondosa. Their inhibitory effects on EV71 virus were studied based on a cell model. The results showed that GFWS had stronger security and anti-EV71 effects. In addition, the chemical constituents of GFWS were identified by ultra-high performance liquid chromatography-tandem mass spectrometry, which were selected for further separation and purification. Three compounds, N-butylaniline, succinic acid and l-tryptophan, were isolated from GFWS by NMR spectroscopy. It is noteworthy that N-butylaniline and l-tryptophan were isolated and identified from the G. frondosa fruiting bodies for the first time. Our study found that l-tryptophan has anti-EV71 virus activity, which reduced EV71-induced apoptosis and significantly inhibited the replication process after virus adsorption. Furthermore, it could also bind to capsid protein VP1 to prevent the virus from attaching to the cells.
    Conclusion: l-tryptophan was an inhibitor of the EV71 virus, which could be used in infant nutrition and possibly provide a new drug to treat hand, foot and mouth disease. © 2024 Society of Chemical Industry.
    MeSH term(s) Humans ; Grifola/chemistry ; Tryptophan ; Water/chemistry ; Chromatography, High Pressure Liquid
    Chemical Substances Tryptophan (8DUH1N11BX) ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.13332
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  2. Article ; Online: A review on polysaccharide biosynthesis in Cordyceps militaris.

    Wu, Na / Ge, Xiaodong / Yin, Xuemei / Yang, Lei / Chen, Ligen / Shao, Rong / Xu, Wei

    International journal of biological macromolecules

    2024  Volume 260, Issue Pt 1, Page(s) 129336

    Abstract: Cordyceps militaris (C. militaris) is an edible parasitic fungus with medicinal properties. Its bioactive polysaccharides are structurally diverse and exhibit various metabolic and biological activities, including antitumor, hypoglycemic, antioxidant, ... ...

    Abstract Cordyceps militaris (C. militaris) is an edible parasitic fungus with medicinal properties. Its bioactive polysaccharides are structurally diverse and exhibit various metabolic and biological activities, including antitumor, hypoglycemic, antioxidant, hypolipidemic, anti-inflammatory, immunostimulatory, and anti-atherosclerotic effects. These properties make C. militaris-derived polysaccharides a promising candidate for future development. Recent advancements in microbial fermentation technology have enabled successful laboratory cultivation and extraction of these polysaccharides. These polysaccharides are structurally diverse and exhibit various biological activities, such as immunostimulatory, antioxidant, antitumor, hypolipidemic, and anti-atherosclerotic effects. This review aims to summarize the structure and production mechanisms of polysaccharides from C. militaris, covering extraction methods, key genes and pathways involved in biosynthesis, and fermentation factors that influence yield and activity. Furthermore, the future potential and challenges of utilizing polysaccharides in the development of health foods and pharmaceuticals are addressed. This review serves as a valuable reference in the fields of food and medicine, and provides a theoretical foundation for the study of polysaccharides.
    MeSH term(s) Cordyceps/chemistry ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Polysaccharides/chemistry ; Fermentation ; Hypoglycemic Agents/metabolism
    Chemical Substances Antioxidants ; Polysaccharides ; Hypoglycemic Agents
    Language English
    Publishing date 2024-01-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129336
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  3. Book ; Online: S2CTrans

    Zhao, Zihao / Ge, Xiaodong / Shen, Zhihong

    Building a bridge from SPARQL to Cypher

    2023  

    Abstract: In graph data applications, data is primarily maintained using two models: RDF (Resource Description Framework) and property graph. The property graph model is widely adopted by industry, leading to property graph databases generally outperforming RDF ... ...

    Abstract In graph data applications, data is primarily maintained using two models: RDF (Resource Description Framework) and property graph. The property graph model is widely adopted by industry, leading to property graph databases generally outperforming RDF databases in graph traversal query performance. However, users often prefer SPARQL as their query language, as it is the W3C's recommended standard. Consequently, exploring SPARQL-to-Property-Graph-Query-Language translation is crucial for enhancing graph query language interoperability and enabling effective querying of property graphs using SPARQL. Despite the substantial differences in semantic representation and processing logic between SPARQL and property graph query languages like Cypher, this paper demonstrates the feasibility of translating SPARQL to Cypher for graph traversal queries using graph relational algebra. We present the S2CTrans framework, which achieves SPARQL-to-Cypher translation while preserving the original semantics. Experimental results with the Berlin SPARQL Benchmark (BSBM) datasets show that S2CTrans successfully converts most SELECT queries in the SPARQL 1.1 specification into type-safe Cypher statements, maintaining result consistency and improving the efficiency of data querying using SPARQL.
    Keywords Computer Science - Databases
    Subject code 511
    Publishing date 2023-04-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: HOXC6: A promising biomarker linked to an immunoevasive microenvironment in colorectal cancer based on TCGA analysis and cohort validation.

    Weng, Meilin / Lai, Yuling / Ge, Xiaodong / Gu, Wenchao / Zhang, Xixue / Li, Lihong / Sun, Minli

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23500

    Abstract: ... ...

    Abstract HOXC6
    Language English
    Publishing date 2023-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: High-resolution maps of critical loads for sulfur and nitrogen in China.

    Ge, Xiaodong / Yu, Qian / Duan, Lei / Zhao, Yu / Posch, Maximilian / Hao, Jiming

    Scientific data

    2023  Volume 10, Issue 1, Page(s) 339

    Abstract: The critical load concept is an important scientific guideline for acid deposition control. It was not only a crucial scientific basis to determine the emission reduction targets in Europe, but also used in China's air pollution control, especially the ... ...

    Abstract The critical load concept is an important scientific guideline for acid deposition control. It was not only a crucial scientific basis to determine the emission reduction targets in Europe, but also used in China's air pollution control, especially the designation of two control zones. Currently, critical loads of sulfur and nitrogen are still exceeded in Europe, America, and East Asia (mainly in China), and need to be continuously updated to meet the demands of further emission reductions. Critical loads of China were calculated and mapped in the 2000s, but are not sufficiently accurate due to methodological and data limitations. Here we present the latest high-quality critical loads for China, based on high-resolution basic data on soil, vegetation, and atmospheric base cations deposition, and up-to-date knowledge on important parameters. Our data, which is going to be included in GAINS-China, can be used to assess the ecological benefits of nitrogen and sulfur reductions in China at a regional or national scale, and to develop mitigation strategies in the future.
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Dataset ; Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-023-02178-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fluxes of H2S and SO2 above a subtropical forest under natural and disturbed conditions induced by temporal land-use change

    Ke, Piaopiao / Yu, Qian / Ge, Xiaodong / Wu, Wenzhao / Kang, Ronghua / Zhao, Bin / Duan, Lei

    Science of the Total Environment. 2022 Mar., v. 811 p.152084-

    2022  

    Abstract: Hydrogen sulfide (H₂S) is one of predominant biogenic sulfur gases, influencing aerosol formation and climate change. There is considerable uncertainty of the global budget of H₂S due to limited field data, especially in subtropical forests. In addition, ...

    Abstract Hydrogen sulfide (H₂S) is one of predominant biogenic sulfur gases, influencing aerosol formation and climate change. There is considerable uncertainty of the global budget of H₂S due to limited field data, especially in subtropical forests. In addition, an interaction between soil-emitted H₂S and ambient sulfur dioxide (SO₂) might exist within forest ecosystems. In this study, the aerodynamic gradient method was applied to consecutively measure H₂S and SO₂ fluxes above a subtropical forest canopy in Southwest China under natural and disturbed conditions induced by temporal land-use changes. The average H₂S concentration and flux under natural conditions were 0.79 ± 0.07 ppbv and 0.04 ± 0.01 g S m⁻² yr⁻¹, respectively. The emission was larger than that in most croplands and freshwater wetlands. Vegetation emissions might account for about 26% of the total forest H₂S emissions at this site. The deposition of SO₂ was likely balanced by H₂S oxidization under the forest canopy, with the mean concentration and net flux as 1.23 ± 0.11 ppbv and −0.03 ± 0.10 g S m⁻² yr⁻¹, respectively. Under disturbed conditions with soils excavation and scattering on the forest floor, simultaneously high emissions of H₂S and SO₂ were observed above the canopy, reaching 5.78 ± 0.16 and 1.60 ± 0.87 g S m⁻² yr⁻¹, respectively. This suggested that land-use change in subtropical forests might lead to release of legacy S in subsoils to the atmosphere in the form of H₂S and SO₂. Regarding the widely documented large S accumulation and expanding deforestation across subtropical forests, potentially high emissions of H₂S and SO₂ from subtropical forests should be carefully considered in regional air quality control and forest management.
    Keywords aerodynamics ; aerosols ; air quality ; climate change ; deforestation ; environment ; forest canopy ; forest litter ; forest management ; freshwater ; hydrogen sulfide ; land use change ; quality control ; sulfur ; sulfur dioxide ; tropical forests ; uncertainty ; China ; Aerodynamic gradient ; Flux observation ; Canopy exchange ; Land-use change ; Global S cycle
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.152084
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Effect of perioperative use of parecoxib on chronic post-surgical pain in elderly patients after hepatectomy: a prospective randomized controlled study.

    Ge, Xiaodong / Pan, Yan / Jin, Danfeng / Wang, Ying / Ge, Shengjin

    BMC pharmacology & toxicology

    2021  Volume 22, Issue 1, Page(s) 35

    Abstract: Background: Chronic post-surgical pain (CPSP) has a negative impact on the recovery, quality of life, and physical functioning of elderly patients. This study aimed to test the superiority of parecoxib vs. placebo in preventing chronic post-hepatectomy ... ...

    Abstract Background: Chronic post-surgical pain (CPSP) has a negative impact on the recovery, quality of life, and physical functioning of elderly patients. This study aimed to test the superiority of parecoxib vs. placebo in preventing chronic post-hepatectomy pain in elderly patients under combined general-epidural anesthesia.
    Methods: A total of 105 elderly patients undergoing hepatectomy under combined general-epidural anesthesia were randomized into the parecoxib or placebo group. The primary outcome was the proportion of patients with CPSP 3 months postoperatively. The secondary outcomes included the Short-Form McGill Pain Questionnaire score in CPSP-positive responders, acute pain intensity, postoperative analgesic demand, inflammatory markers change, and postoperative complications within 28 days.
    Results: The parecoxib group provided a non-significant absolute 9.1% reduction in the rate of CPSP compared to the placebo group (P = 0.34). The average chronic pain visual analog scale in the parecoxib group was lower than that in the placebo group (P = 0.04). Significantly less moderate-to-severe acute pain at rest (P = 0.04) and with coughing (P < 0.001), less patient-controlled epidural analgesia (PCEA) consumption (P = 0.01), and less rescue analgesia (P < 0.001) were observed in the parecoxib group compared to the placebo group. Furthermore, no between-group difference was observed in inflammatory markers (P > 0.05) and postoperative complications (P = 0.65).
    Conclusions: Parecoxib reduced the prevalence of CPSP in elderly patients after hepatectomy under combined general-epidural anesthesia from 44.4 to 35.3% with no statistical significance. Moreover, significantly alleviated CPSP intensity and improved acute pain management were observed.
    Trial registration: This study was retrospectively registered in the Chinese Clinical Trial Registry (URL: http://www.chictr.org.cn/edit.aspx?pid=56961&htm=4 ) on August 3, 2020 ( ChiCTR-2,000,035,198 ).
    MeSH term(s) Aged ; Aged, 80 and over ; Analgesia, Patient-Controlled ; Analgesics/therapeutic use ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Double-Blind Method ; Female ; Hepatectomy/adverse effects ; Humans ; Isoxazoles/therapeutic use ; Male ; Pain Measurement ; Pain, Postoperative/drug therapy ; Perioperative Care
    Chemical Substances Analgesics ; Cyclooxygenase 2 Inhibitors ; Isoxazoles ; parecoxib (9TUW81Y3CE)
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2680259-4
    ISSN 2050-6511 ; 2050-6511
    ISSN (online) 2050-6511
    ISSN 2050-6511
    DOI 10.1186/s40360-021-00501-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fagopyrum tataricum

    Ge, Xiaodong / Liu, Tingting / Chen, Zhuo / Zhang, Jiawei / Yin, Xuemei / Huang, Zirui / Chen, Ligen / Zhao, Chao / Shao, Rong / Xu, Wei

    Food & function

    2023  Volume 14, Issue 18, Page(s) 8487–8503

    Abstract: Type 2 diabetes mellitus (T2DM) is typically accompanied by sudden weight loss, dyslipidemia-related indicators, decreased insulin sensitivity, and altered gut microbial communities. ...

    Abstract Type 2 diabetes mellitus (T2DM) is typically accompanied by sudden weight loss, dyslipidemia-related indicators, decreased insulin sensitivity, and altered gut microbial communities.
    MeSH term(s) Animals ; Mice ; Gastrointestinal Microbiome ; Diabetes Mellitus, Type 2/drug therapy ; Fagopyrum ; Proto-Oncogene Proteins c-akt ; Hyperglycemia/drug therapy ; Hypoglycemic Agents ; Firmicutes ; Lactobacillales ; Bacteroidetes ; Clostridiales ; Ethanol ; Plant Extracts
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Hypoglycemic Agents ; Ethanol (3K9958V90M) ; Plant Extracts
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo02385k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Onchidium struma

    Zhao, Yunfeng / Song, Peilin / Yin, Shuai / Fan, Tianyong / Li, Fengwei / Ge, Xiaodong / Liu, Tingting / Xu, Wei / Xu, Su / Chen, Ligen

    Food & function

    2023  Volume 14, Issue 4, Page(s) 1937–1951

    Abstract: Onchidium ... ...

    Abstract Onchidium struma
    MeSH term(s) Mice ; Animals ; Hypoglycemic Agents/pharmacology ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Gastrointestinal Microbiome ; Polysaccharides/pharmacology ; Blood Glucose/metabolism
    Chemical Substances Hypoglycemic Agents ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Polysaccharides ; Blood Glucose
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo02450k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Carbon Sequestration Potential of Biomass Production along Highways in China.

    Ge, Xiaodong / Zhang, Jiayu / Wen, Yifan / Yu, Qian / Liu, Min / Huang, Yongmei / Zhang, Shaojun / Duan, Lei

    Environmental science & technology

    2023  Volume 57, Issue 37, Page(s) 13818–13827

    Abstract: In response to climate change, China is making great efforts to increase the green area for carbon sequestration. Road verges, as marginal land with favorable conditions for plant growth and ease of transportation, can be used for biomass production, but ...

    Abstract In response to climate change, China is making great efforts to increase the green area for carbon sequestration. Road verges, as marginal land with favorable conditions for plant growth and ease of transportation, can be used for biomass production, but the biomass production and carbon sequestration potential have not been assessed. Here, we mapped the biomass production potential of road verges in China by combining a biomass model and Geographic Information System and then evaluated the effect of road runoff and CO
    MeSH term(s) Biomass ; Carbon Dioxide ; Carbon Sequestration ; Vehicle Emissions ; China
    Chemical Substances Carbon Dioxide (142M471B3J) ; Vehicle Emissions
    Language English
    Publishing date 2023-09-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c06267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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