Artikel ; Online: Gut microbiome and mycobiome in inflammatory bowel disease patients with
Frontiers in cellular and infection microbiology
2023 Band 13, Seite(n) 1129043
Abstract: Background: Clostridium difficile: Methods: We collected fecal samples from patients with active IBD and concomitant CDI (IBD-CDI group, n=25), patients with active IBD and no CDI (IBD-only group, n=51), and healthy subjects (HC, n=40). Patients' ... ...
Abstract | Background: Clostridium difficile Methods: We collected fecal samples from patients with active IBD and concomitant CDI (IBD-CDI group, n=25), patients with active IBD and no CDI (IBD-only group, n=51), and healthy subjects (HC, n=40). Patients' characteristics including demographic data, disease severity, and medication history were collected. Metagenomic sequencing, taxonomic and functional analysis were carried out in the samples. Results: We found that the bacterial alpha diversity of the IBD-CDI group was decreased. The bacterial and fungal beta diversity variations between IBD patients and HC were significant, regardless of CDI status. But the IBD-CDI group did not significantly cluster separately from the IBD-only group. Several bacterial taxa, including Conclusion: IBD patients with CDI had pronounced microbial dysbiosis. Gut micro-ecological changes in IBD patients with CDI might provide insight into the pathological process and potential strategies for diagnosis and treatment in this subset of patients. |
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Mesh-Begriff(e) | Humans ; Gastrointestinal Microbiome ; Mycobiome ; Clostridioides difficile ; Inflammatory Bowel Diseases/microbiology ; Bacteria ; Clostridium Infections/microbiology |
Sprache | Englisch |
Erscheinungsdatum | 2023-02-06 |
Erscheinungsland | Switzerland |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2619676-1 |
ISSN | 2235-2988 ; 2235-2988 |
ISSN (online) | 2235-2988 |
ISSN | 2235-2988 |
DOI | 10.3389/fcimb.2023.1129043 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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