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  1. AU="Ge, Xiaomeng"
  2. AU="Michaloliakos, I"
  3. AU="Rayce, Signe Boe"
  4. AU="Heiman Joel"
  5. AU=Rashedi Jalil
  6. AU="Rodríguez-Tovar, Aída Verónica"

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  1. Artikel ; Online: Gut microbiome and mycobiome in inflammatory bowel disease patients with

    Yu, Si / Ge, Xiaomeng / Xu, Hui / Tan, Bei / Tian, Bowen / Shi, Yujie / Dai, Yimin / Li, Yue / Hu, Songnian / Qian, Jiaming

    Frontiers in cellular and infection microbiology

    2023  Band 13, Seite(n) 1129043

    Abstract: Background: Clostridium difficile: Methods: We collected fecal samples from patients with active IBD and concomitant CDI (IBD-CDI group, n=25), patients with active IBD and no CDI (IBD-only group, n=51), and healthy subjects (HC, n=40). Patients' ... ...

    Abstract Background: Clostridium difficile
    Methods: We collected fecal samples from patients with active IBD and concomitant CDI (IBD-CDI group, n=25), patients with active IBD and no CDI (IBD-only group, n=51), and healthy subjects (HC, n=40). Patients' characteristics including demographic data, disease severity, and medication history were collected. Metagenomic sequencing, taxonomic and functional analysis were carried out in the samples.
    Results: We found that the bacterial alpha diversity of the IBD-CDI group was decreased. The bacterial and fungal beta diversity variations between IBD patients and HC were significant, regardless of CDI status. But the IBD-CDI group did not significantly cluster separately from the IBD-only group. Several bacterial taxa, including
    Conclusion: IBD patients with CDI had pronounced microbial dysbiosis. Gut micro-ecological changes in IBD patients with CDI might provide insight into the pathological process and potential strategies for diagnosis and treatment in this subset of patients.
    Mesh-Begriff(e) Humans ; Gastrointestinal Microbiome ; Mycobiome ; Clostridioides difficile ; Inflammatory Bowel Diseases/microbiology ; Bacteria ; Clostridium Infections/microbiology
    Sprache Englisch
    Erscheinungsdatum 2023-02-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1129043
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl-2 in hepatic stellate cells.

    Pang, Huai / Wang, Cuizhe / Ye, Jing / Wang, Lulu / Zhou, Xiaoming / Ge, Xiaomeng / Zhang, Jun / Liu, Qinghua

    Journal of biochemical and molecular toxicology

    2022  Band 36, Heft 8, Seite(n) e23097

    Abstract: Hepatic fibrosis is an important early stage in the evolution of liver cirrhosis, and specific medicine and therapeutic measures are unavailable to date. Hepatic stellate cells (HSCs) are the main cells involved in the formation of hepatic fibrosis, and ... ...

    Abstract Hepatic fibrosis is an important early stage in the evolution of liver cirrhosis, and specific medicine and therapeutic measures are unavailable to date. Hepatic stellate cells (HSCs) are the main cells involved in the formation of hepatic fibrosis, and induction of the apoptosis of HSCs is an important strategy for the treatment of hepatic fibrosis. Diallyl trisulfide (DATS) is a natural product and is the main active ingredient in garlic. However, the exact molecular mechanisms underlying HSC apoptosis induced by DATS are not well understood. This study aimed to analyze the efficiency and mechanism of DATS in hepatic fibrosis. Different concentrations (25, 50, 100, and 200 μM) of DATS were used to treat HSCs. Changes in cell morphology and formation of apoptotic bodies were observed under an inverted microscope and an electric microscope. Bcl-2 signaling involving Bax, Caspase-3, Caspase-6, Caspase-8, Caspase-9, p53, Apaf-1, and Cyto-c in fibrosis were examined, which is a critical step in the evaluation of antihepatic fibrosis agents. We also evaluated the effect of DATS on the cellular morphology of HSCs and apoptosis-related factors under different Bcl-2 expression states. Our results suggest that DATS regulates hepatic fibrosis by blocking the Bcl-2 signaling pathway and upregulating the Bax/Bcl-2 ratio.
    Mesh-Begriff(e) Allyl Compounds ; Apoptosis ; Fibrosis ; Hepatic Stellate Cells ; Humans ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Sulfides ; bcl-2-Associated X Protein/metabolism
    Chemische Substanzen Allyl Compounds ; Sulfides ; bcl-2-Associated X Protein ; diallyl trisulfide (0ZO1U5A3XX)
    Sprache Englisch
    Erscheinungsdatum 2022-05-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1410020-4
    ISSN 1099-0461 ; 1095-6670
    ISSN (online) 1099-0461
    ISSN 1095-6670
    DOI 10.1002/jbt.23097
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Role of intestinal flora in the development of nonalcoholic fatty liver disease in children.

    Zhang, Jing / Shi, Mengxuan / Zhao, Chunna / Liang, Guangcai / Li, Chuan / Ge, Xiaomeng / Pei, Caixia / Kong, Yawei / Li, Dongdan / Yang, Wenli / Cao, Bingyan / Fu, Libing / Yan, Yinkun / Wu, Jie / Zhou, Jin / Fang, Yongli / Meng, Xi / Li, Yong / Wang, Liming

    Microbiology spectrum

    2024  Band 12, Heft 2, Seite(n) e0100623

    Abstract: In China, 45% of adolescents with obesity develop fatty liver disease, a condition that increases the long-term risk of developing cirrhosis and liver cancer. Although the factors triggering nonalcoholic fatty liver disease (NAFLD) vary in children, the ... ...

    Abstract In China, 45% of adolescents with obesity develop fatty liver disease, a condition that increases the long-term risk of developing cirrhosis and liver cancer. Although the factors triggering nonalcoholic fatty liver disease (NAFLD) vary in children, the composition of intestinal microflora has been found to play an increasingly important role. However, evidence is limited on the prevalence of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) in Chinese children. Therefore, this study aimed to evaluate the fecal microbiome of Chinese children with NAFLD and further analyze the potential of flora in regulating NAFLD-related symptoms and metabolic functions. Specifically, the study applied a 16S rRNA and metagenomic sequencing to the fecal samples of pediatric patients with NAFLD, NASH, and NAFL, as well as healthy controls, to explore the correlation among NAFLD-related indexes, metabolic pathways, and gut flora. The findings showed that some fecal microbiota had a negative correlation with body mass index, and various NAFLD-related bacteria, including
    Mesh-Begriff(e) Adult ; Adolescent ; Humans ; Child ; Non-alcoholic Fatty Liver Disease ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S ; Follow-Up Studies ; Biomarkers/metabolism ; Liver/metabolism
    Chemische Substanzen RNA, Ribosomal, 16S ; Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2024-01-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01006-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: A gene catalogue for post-diapause development of an anhydrobiotic arthropod Artemia franciscana

    Yu Jun / Wang Weiwei / Ge Xiaomeng / Chen Wie-Hua / Hu Songnian

    BMC Genomics, Vol 10, Iss 1, p

    2009  Band 52

    Abstract: Abstract Background Diapause is a reversible state of developmental suspension and found among diverse taxa, from plants to animals, including marsupials and some other mammals. Although previous work has accumulated ample data, the molecular mechanism ... ...

    Abstract Abstract Background Diapause is a reversible state of developmental suspension and found among diverse taxa, from plants to animals, including marsupials and some other mammals. Although previous work has accumulated ample data, the molecular mechanism underlying diapause and reactivation from it remain elusive. Results Using Artemia franciscana , a model organism to study the development of post-diapause embryos in Arthropod, we sequenced random clones up to a total of 28,039 ESTs from four cDNA libraries made from dehydrated cysts and three time points after rehydration/reactivation, which were assembled into 8,018 unigene clusters. We identified 324 differentially-expressed genes (DEGs, P < 0.05) based on pairwise comparisons of the four cDNA libraries. We identified a group of genes that are involved in an anti-water-deficit system, including proteases, protease inhibitors, heat shock proteins, and several novel members of the late embryogenesis abundant (LEA) protein family. In addition, we classified most of the up-regulated genes after cyst reactivation into metabolism, biosynthesis, transcription, and translation, and this result is consistent with the rapid development of the embryo. Some of the specific expressions of DEGs were confirmed experimentally based on quantitative real-time PCR. Conclusion We found that the first 5-hour period after rehydration is most important for embryonic reactivation of Artemia . As the total number of expressed genes increases significantly, the majority of DEGs were also identified in this period, including a group of water-deficient-induced genes. A group of genes with similar functions have been described in plant seeds; for instance, one of the novel LEA members shares ~70% amino-acid identity with an Arabidopsis EM (embryonic abundant) protein, the closest animal relative to plant LEA families identified thus far. Our findings also suggested that not only nutrition, but also mRNAs are produced and stored during cyst formation to support rapid development after reactivation.
    Schlagwörter Genetics ; QH426-470 ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Genetics ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Biotechnology ; TP248.13-248.65
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2009-01-01T00:00:00Z
    Verlag BioMed Central
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells.

    Jin, Jun / Li, Rujiao / Jiang, Chunlai / Zhang, Ruosi / Ge, Xiaomeng / Liang, Fang / Sheng, Xin / Dai, Wenwen / Chen, Meili / Wu, Jiayan / Xiao, Jingfa / Su, Weiheng

    BMC genomics

    2017  Band 18, Heft Suppl 1, Seite(n) 933

    Abstract: Background: Coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) are two of the major causes of hand, foot and mouth disease (HFMD) world-wide. Although many studies have focused on infection and pathogenic mechanisms, the transcriptome profile of the ... ...

    Abstract Background: Coxsackievirus A16 (CVA16) and enterovirus 71 (EV71) are two of the major causes of hand, foot and mouth disease (HFMD) world-wide. Although many studies have focused on infection and pathogenic mechanisms, the transcriptome profile of the host cell upon CVA16 infection is still largely unknown.
    Results: In this study, we compared the mRNA and miRNA expression profiles of human embryonic kidney 293T cells infected and non-infected with CVA16. We highlighted that the transcription of SCARB2, a cellular receptor for both CVA16 and EV71, was up-regulated by nearly 10-fold in infected cells compared to non-infected cells. The up-regulation of SCARB2 transcription induced by CVA16 may increase the possibility of subsequent infection of CVA16/EV71, resulting in the co-infection with two viruses in a single cell. This explanation would partly account for the co-circulation and genetic recombination of a great number of EV71 and CVA16 viruses. Based on correlation analysis of miRNAs and genes, we speculated that the high expression of SCARB2 is modulated by down-regulation of miRNA has-miR-3605-5p. At the same time, we found that differentially expressed miRNA target genes were mainly reflected in the extracellular membrane (ECM)-receptor interaction and circadian rhythm pathways, which may be related to clinical symptoms of patients infected with CVA16, such as aphthous ulcers, cough, myocarditis, somnolence and potentially meningoencephalitis. The miRNAs hsa-miR-149-3p and hsa-miR-5001-5p may result in up-regulation of genes in these morbigenous pathways related to CVA16 and further cause clinical symptoms.
    Conclusions: The present study elucidated the changes in 293T cells upon CVA16 infection at transcriptome level, containing highly up-regulated SCARB2 and genes in ECM-receptor interaction and circadian rhythm pathways, and key miRNAs in gene expression regulation. These results provided novel insight into the pathogenesis of HFMD induced by CVA16 infection.
    Mesh-Begriff(e) Cells, Cultured ; Cluster Analysis ; Enterovirus/physiology ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Regulatory Networks ; HEK293 Cells ; High-Throughput Nucleotide Sequencing ; Humans ; Lysosomal Membrane Proteins/genetics ; MicroRNAs/genetics ; RNA, Messenger/genetics ; Receptors, Scavenger/genetics ; Transcriptome
    Chemische Substanzen Lysosomal Membrane Proteins ; MicroRNAs ; RNA, Messenger ; Receptors, Scavenger ; SCARB2 protein, human
    Sprache Englisch
    Erscheinungsdatum 2017-01-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-016-3253-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Transcriptomic profiling of mature embryo from an elite super-hybrid rice LYP9 and its parental lines

    Wang Weiwei / Song Shuhui / Chen Weihua / Ge Xiaomeng / Hu Songnian / Yu Jun

    BMC Plant Biology, Vol 8, Iss 1, p

    2008  Band 114

    Abstract: Abstract Background The mature embryo of rice ( Oryza sativa, L .) is a synchronized and integrated tissue mass laying the foundation at molecular level for its growth, development, and differentiation toward a developing and ultimately a mature plant. ... ...

    Abstract Abstract Background The mature embryo of rice ( Oryza sativa, L .) is a synchronized and integrated tissue mass laying the foundation at molecular level for its growth, development, and differentiation toward a developing and ultimately a mature plant. We carried out an EST (expressed-sequence-tags)-based transcriptomic study, aiming at gaining molecular insights into embryonic development of a rice hybrid triad–an elite hybrid rice LYP 9 and its parental lines ( 93-11 and PA64s )–and possible relatedness to heterosis. Results We generated 27,566 high-quality ESTs from cDNA libraries made from mature rice embryos. We classified these ESTs into 7,557 unigenes (2,511 contigs and 5,046 singletons) and 7,250 (95.9%) of them were annotated. We noticed that the high-abundance genes in mature rice embryos belong to two major functional categories, stress-tolerance and preparation-for-development, and we also identified 191 differentially-expressed genes (General Chi-squared test, P -value <= 0.05) between LYP9 and its parental lines, representing typical expression patterns including over-dominance, high- and low-parent dominance, additivity, and under-dominance. In LYP9 , the majority of embryo-associated genes were found not only abundantly and specifically enriched but also significantly up-regulated. Conclusion Our results suggested that massively strengthening tissue-(or stage-) characteristic functions may contribute to heterosis rather than a few simple mechanistic explanations at the individual gene level. In addition, the large collection of rice embryonic ESTs provides significant amount of data for future comparative analyses on plant development, especially for the important crops of the grass family.
    Schlagwörter Botany ; QK1-989 ; Science ; Q ; DOAJ:Botany ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2008-11-01T00:00:00Z
    Verlag BioMed Central
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Human functional genetic studies are biased against the medically most relevant primate-specific genes

    Lercher Martin J / Hu Songnian / Wan Haolei / Ge Xiaomeng / Hao Lili / Yu Jun / Chen Wei-Hua

    BMC Evolutionary Biology, Vol 10, Iss 1, p

    2010  Band 316

    Abstract: Abstract Background Many functional, structural and evolutionary features of human genes have been observed to correlate with expression breadth and/or gene age. Here, we systematically explore these correlations. Results Gene age and expression breadth ... ...

    Abstract Abstract Background Many functional, structural and evolutionary features of human genes have been observed to correlate with expression breadth and/or gene age. Here, we systematically explore these correlations. Results Gene age and expression breadth are strongly correlated, but contribute independently to the variation of functional, structural and evolutionary features, even when we take account of variation in mRNA expression level. Human genes without orthologs in distant species ('young' genes) tend to be tissue-specific in their expression. As computational inference of gene function often relies on the existence of homologs in other species, and experimental characterization is facilitated by broad and high expression, young, tissue-specific human genes are often the least characterized. At the same time, young genes are most likely to be medically relevant. Conclusions Our results indicate that functional characterization of human genes is biased against young, tissue-specific genes that are mostly medically relevant. The biases should not be taken lightly because they may pose serious obstacles to our understanding of the molecular basis of human diseases. Future studies should thus be designed to specifically explore the properties of primate-specific genes.
    Schlagwörter Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Evolution ; QH359-425
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2010-10-01T00:00:00Z
    Verlag BioMed Central
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: A gene catalogue for post-diapause development of an anhydrobiotic arthropod Artemia franciscana.

    Chen, Wie-Hua / Ge, Xiaomeng / Wang, Weiwei / Yu, Jun / Hu, Songnian

    BMC genomics

    2009  Band 10, Seite(n) 52

    Abstract: Background: Diapause is a reversible state of developmental suspension and found among diverse taxa, from plants to animals, including marsupials and some other mammals. Although previous work has accumulated ample data, the molecular mechanism ... ...

    Abstract Background: Diapause is a reversible state of developmental suspension and found among diverse taxa, from plants to animals, including marsupials and some other mammals. Although previous work has accumulated ample data, the molecular mechanism underlying diapause and reactivation from it remain elusive.
    Results: Using Artemia franciscana, a model organism to study the development of post-diapause embryos in Arthropod, we sequenced random clones up to a total of 28,039 ESTs from four cDNA libraries made from dehydrated cysts and three time points after rehydration/reactivation, which were assembled into 8,018 unigene clusters. We identified 324 differentially-expressed genes (DEGs, P < 0.05) based on pairwise comparisons of the four cDNA libraries. We identified a group of genes that are involved in an anti-water-deficit system, including proteases, protease inhibitors, heat shock proteins, and several novel members of the late embryogenesis abundant (LEA) protein family. In addition, we classified most of the up-regulated genes after cyst reactivation into metabolism, biosynthesis, transcription, and translation, and this result is consistent with the rapid development of the embryo. Some of the specific expressions of DEGs were confirmed experimentally based on quantitative real-time PCR.
    Conclusion: We found that the first 5-hour period after rehydration is most important for embryonic reactivation of Artemia. As the total number of expressed genes increases significantly, the majority of DEGs were also identified in this period, including a group of water-deficient-induced genes. A group of genes with similar functions have been described in plant seeds; for instance, one of the novel LEA members shares ~70% amino-acid identity with an Arabidopsis EM (embryonic abundant) protein, the closest animal relative to plant LEA families identified thus far. Our findings also suggested that not only nutrition, but also mRNAs are produced and stored during cyst formation to support rapid development after reactivation.
    Mesh-Begriff(e) Animals ; Artemia/embryology ; Artemia/genetics ; Cluster Analysis ; Embryo, Nonmammalian/metabolism ; Expressed Sequence Tags ; Gene Expression Profiling/methods ; Gene Expression Regulation, Developmental ; Gene Library
    Sprache Englisch
    Erscheinungsdatum 2009-01-27
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2164
    ISSN (online) 1471-2164
    DOI 10.1186/1471-2164-10-52
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: A proteomic study on postdiapaused embryonic development of brine shrimp (Artemia franciscana)

    Wang, Weiwei / Meng, Bo / Chen, Weihua / Ge, Xiaomeng / Liu, Siqi / Yu, Jun

    Proteomics. 2007 Oct., v. 7, no. 19

    2007  

    Abstract: Encysted gastrula of brine shrimp (Artemia, Crustacea, and Anostraca) provides an excellent model for studying molecular processes of diapause. We report a proteomic study on early molecular responses of Artemia's postdiapaused cysts and found that ... ...

    Abstract Encysted gastrula of brine shrimp (Artemia, Crustacea, and Anostraca) provides an excellent model for studying molecular processes of diapause. We report a proteomic study on early molecular responses of Artemia's postdiapaused cysts and found that dehydrated cysts actually store more proteins, in both kind and amount, than developing cysts. We identified 75 differentially expressed proteins over a course of cyst development, and also exploited PTMs of dehydrate cysts. We further surveyed gene expression of postdiapaused cysts in early developmental phases in a 0.5 h interval up to the seventh hour, and discovered that the activation of cellular activities is ignited as early as 0.5 h after rehydration. We traced nine differentially expressed proteins (COXI, COXIII, heat shock proteins (HSP26, HSP60, and HSP70), CDC48, late embryogenesis abundant (LEA), GS1-like protein, and cathepsin L-associated protein (CLAP)) for quantitative transcriptional changes, monitored by real-time PCR, and found these proteins exhibiting distinct expression patterns that suggest complex gene regulations for cyst reactivation after diapause breakage. Future experiments should be designed to focus on early activation concerning signal transduction, energy generation, and PTMs.
    Sprache Englisch
    Erscheinungsverlauf 2007-10
    Umfang p. 3580-3591.
    Erscheinungsort Wiley-VCH Verlag
    Dokumenttyp Artikel
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.200700259
    Datenquelle NAL Katalog (AGRICOLA)

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  10. Artikel ; Online: Transcriptomic profiling of mature embryo from an elite super-hybrid rice LYP9 and its parental lines.

    Ge, Xiaomeng / Chen, Weihua / Song, Shuhui / Wang, Weiwei / Hu, Songnian / Yu, Jun

    BMC plant biology

    2008  Band 8, Seite(n) 114

    Abstract: Background: The mature embryo of rice (Oryza sativa, L.) is a synchronized and integrated tissue mass laying the foundation at molecular level for its growth, development, and differentiation toward a developing and ultimately a mature plant. We carried ...

    Abstract Background: The mature embryo of rice (Oryza sativa, L.) is a synchronized and integrated tissue mass laying the foundation at molecular level for its growth, development, and differentiation toward a developing and ultimately a mature plant. We carried out an EST (expressed-sequence-tags)-based transcriptomic study, aiming at gaining molecular insights into embryonic development of a rice hybrid triad-an elite hybrid rice LYP9 and its parental lines (93-11 and PA64s)-and possible relatedness to heterosis.
    Results: We generated 27,566 high-quality ESTs from cDNA libraries made from mature rice embryos. We classified these ESTs into 7,557 unigenes (2,511 contigs and 5,046 singletons) and 7,250 (95.9%) of them were annotated. We noticed that the high-abundance genes in mature rice embryos belong to two major functional categories, stress-tolerance and preparation-for-development, and we also identified 191 differentially-expressed genes (General Chi-squared test, P-value <= 0.05) between LYP9 and its parental lines, representing typical expression patterns including over-dominance, high- and low-parent dominance, additivity, and under-dominance. In LYP9, the majority of embryo-associated genes were found not only abundantly and specifically enriched but also significantly up-regulated.
    Conclusion: Our results suggested that massively strengthening tissue-(or stage-) characteristic functions may contribute to heterosis rather than a few simple mechanistic explanations at the individual gene level. In addition, the large collection of rice embryonic ESTs provides significant amount of data for future comparative analyses on plant development, especially for the important crops of the grass family.
    Mesh-Begriff(e) Breeding ; Chi-Square Distribution ; Cluster Analysis ; Databases, Genetic ; Expressed Sequence Tags ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Gene Library ; Genes, Plant ; Genome, Plant ; Hybrid Vigor ; Oryza/embryology ; Oryza/genetics ; RNA, Plant/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Seeds/embryology ; Seeds/genetics ; Sequence Alignment ; Sequence Analysis, DNA ; Species Specificity
    Chemische Substanzen RNA, Plant
    Sprache Englisch
    Erscheinungsdatum 2008-11-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2229
    ISSN (online) 1471-2229
    DOI 10.1186/1471-2229-8-114
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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