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Article ; Online: Targeting the AKT/mTOR/p70S6K Pathway for Oligodendrocyte Differentiation and Myelin Regeneration in Neurological Disorders.

Ge, Chen / Li, Changwei

2023 Volume 20, Issue 4, Page(s) 453–463

Abstract: Background: The AKT/mTOR/p70S6K pathway has been shown to potentially promote spinal cord injury (SCI) repair in rats. However, its exact mechanism and beyond needs to be further explored.: Objective: This study aims to explore the AKT/mTOR/p70S6K ... ...

Abstract	Background: The AKT/mTOR/p70S6K pathway has been shown to potentially promote spinal cord injury (SCI) repair in rats. However, its exact mechanism and beyond needs to be further explored. Objective: This study aims to explore the AKT/mTOR/p70S6K pathway in oligodendrocyte precursor cell (OPC) differentiation, microglial polarization differentiation, and the role of these in myelin regeneration in vitro. Methods: The isolation, induction and characterization of rat primary neuronal stem cells, OPCs and oligodendrocytes were investigated with immunofluorescence and RT-qPCR. Then, the role of AKT/mTOR/p70S6K signaling was explored using western blotting and immunofluorescence, the effect on myelination was examined with OPC-dorsal root ganglion (DRG) neurons co-culture, and the influence of M1/M2 polarization status of microglia on myelin formation was also observed by adding M1/M2 supernatants into OPC-DRG neurons co-culture. Results: Activation of the AKT/mTOR/p70S6K pathway elevated the expression of oligodendrocyte differentiation markers, including MBP, PLP and MOG, which also promoted the colocalization of MBP and NFH in OPC-DRG neurons co-culture. More interestingly, stimulation of the AKT/mTOR/p70S6K pathway facilitated M2 polarization of rat microglia. M2 polarization of microglia enhanced OPC differentiation to oligodendrocytes and myelin formation. Conclusion: Our findings highlight the potential of targeting the AKT/mTOR/p70S6K pathway in promoting oligodendrocyte differentiation and myelin regeneration in neurological disorders such as SCI.
MeSH term(s)	Rats ; Animals ; Myelin Sheath/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/pharmacology ; Rats, Sprague-Dawley ; TOR Serine-Threonine Kinases/metabolism ; Oligodendroglia/metabolism ; Cell Differentiation ; Spinal Cord Injuries/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; mTOR protein, rat (EC 2.7.1.1)
Language	English
Publishing date	2023-10-11
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2296350-9
ISSN	1875-5739 ; 1567-2026
ISSN (online)	1875-5739
ISSN	1567-2026
DOI	10.2174/0115672026274954230919070115
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Article: Design of Inner Matching Three-Stage High-Power Doherty Power Amplifier Based on GaN HEMT Model.

Li, Renyi / Ge, Chen / Liang, Chenwei / Zhong, Shichang

Micromachines

2024 Volume 15, Issue 3

Abstract: This paper introduces the structure and characteristics of an internal-matching high-power Doherty power amplifier based on GaN HEMT devices with 0.25 μm process platforms from the Nanjing Electronic Devices Institute. Through parameter extraction and ... ...

Abstract	This paper introduces the structure and characteristics of an internal-matching high-power Doherty power amplifier based on GaN HEMT devices with 0.25 μm process platforms from the Nanjing Electronic Devices Institute. Through parameter extraction and load-pull testing of the model transistor, an EE_HEMT model for the 1.2 mm gate-width GaN HEMT device was established. This model serves as the foundation for designing a high-power three-stage Doherty power amplifier. The amplifier achieved a saturated power gain exceeding 9 dB in continuous wave mode, with a saturated power output of 49.7 dBm. The drain efficiency was greater than 65% at 2.6 GHz. At 9 dB power back-off point, corresponding to an output power of 40.5 dBm, the drain efficiency remained above 55%. The performance of the amplifier remains consistent within the 2.55-2.62 GHz frequency range. The measured power, efficiency, and gain of the designed Doherty power amplifier align closely with the simulation results based on the EE_HEMT model, validating the accuracy of the established model. Furthermore, the in-band matching design reduces the size and weight of the amplifier. The amplifier maintains normal operation even after high and low-temperature testing, demonstrating its reliability. In conjunction with DPD (digital pre-distortion) for the modulated signal test, the amplifier exhibits extremely high linearity (ACLR < -50.93 dBc). This Doherty power amplifier holds potential applications in modern wireless communication scenarios.
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi15030388
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Article ; Online: A case report of rare complication after microwave ablation.

Ge, Chen-Yan / Zhang, Xi-Yao / Guan, Li-Jun

Asian journal of surgery

2024

Language	English
Publishing date	2024-05-08
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.04.147
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Article ; Online: Medium-range forecasting of oceanic eddy trajectory

Xiaoyan Chen / Ge Chen / Linyao Ge / Chuanchuan Cao / Baoxiang Huang

International Journal of Digital Earth, Vol 17, Iss

2024 Volume 1

Abstract: ABSTRACTThe capability of continuous eddy tracking has been significantly advanced over the past decades, thanks to the availability of sea surface height measurements routinely collected by satellite altimeters. However, due to the complexity of eddy ... ...

Abstract	ABSTRACTThe capability of continuous eddy tracking has been significantly advanced over the past decades, thanks to the availability of sea surface height measurements routinely collected by satellite altimeters. However, due to the complexity of eddy kinematic mechanisms and underlying oceanic processes, a medium-range forecast of individual eddy trajectories is a challenging task. This study develops an algorithm to effectively achieve a precise prediction of eddy propagation with a ten-day lead time by building a physics-embedded temporal evolution model. The theoretical eddy phase speed, current field, and eddy properties are incorporated as physical constraints. Compared to only considering eddy past/climatological velocities, the forecast accuracy of embedded physics constraints is improved by 21%. Forecasting of 2.3 million altimeter-derived eddy tracks globally shows that trajectory predictions are valid for eddies moving towards any direction, and the forecast error achieves 9.9 km on a ten-day average. After systematically evaluating the global forecast error, we conclude that the forecasting accuracy is geographically correlated and affected by external forcings (topography and wind) and eddy properties (geostrophy and life stage). Achieving accurate eddy trajectory prediction is expected to provide critical guidance for in-situ eddy observations, and bring substantial improvements for understanding oceanic substance transportations and biogeochemical processes.
Keywords	Mesoscale eddy ; medium-range trajectory forecast ; physics-embedded model ; quasi-geostrophic theory ; altimeter and numerical model products ; Mathematical geography. Cartography ; GA1-1776
Subject code	551
Language	English
Publishing date	2024-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ESPC-BCS-Net

Zhenyue Li / Ge Chen / Fangjie Yu

Frontiers in Marine Science, Vol

A network-based CS method for underwater image compression and reconstruction

2023 Volume 10

Abstract: The Internet of Underwater Things (IoUT) is a typical energy-limited and bandwidth-limited system where the technical bottleneck is the asymmetry between the massive demand for information access and the limited communication bandwidth. Therefore, ... ...

Abstract	The Internet of Underwater Things (IoUT) is a typical energy-limited and bandwidth-limited system where the technical bottleneck is the asymmetry between the massive demand for information access and the limited communication bandwidth. Therefore, storing and transmitting high-quality underwater images is a challenging task. The data measured by cameras need to be effectively compressed before transmission to reduce storage and reconstruc-ted with minor errors, which is the best solution. Compressed sensing (CS) theory breaks through the Nyquist sampling theorem and has been widely used to reconstruct sparse signals accurately. For adaptive sampling underwater images and improving the reconstruction performance, we propose the ESPC-BCS-Net by combining the advantages of CS and Deep Learning. The ESPC-BCS-Net consists of three parts: Sampling-Net, ESPC-Net, and BCS-Net. The parameters (e.g. sampling matrix, sparse transforms, shrinkage thresholds, etc.) in ESPC-BCS-Net are learned end-to-end rather than hand-crafted. The Sampling-Net achieves adaptive sampling by replacing the sampling matrix with a convolutional layer. The ESPC-Net implements image upsampling, while the BCS-Net is used to image reconstruction. The efficient sub-pixel layer of ESPC-Net effectively avoids blocking artifacts. The visual and quantitative evaluation of the experimental results shows that the underwater image reconstruction still performs well when the CS ratio is 0.1 and the PSNR of the reconstructed underwater images is above 29.
Keywords	internet of underwater things ; underwater image ; compressed sensing ; deep learning ; convolutional neural networks ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Southwestern Atlantic ocean fronts detected from the fusion of multi-source remote sensing data by a deep learning model

Zhi Wang / Ge Chen / Chunyong Ma / Yalong Liu

Frontiers in Marine Science, Vol

2023 Volume 10

Abstract: In the Southwestern Atlantic, the Falkland Current intrudes onto the South American shelf, resulting in the meeting of two water masses which are completely different in temperature and dynamic characteristics, thus generating the Southwestern Atlantic ... ...

Abstract	In the Southwestern Atlantic, the Falkland Current intrudes onto the South American shelf, resulting in the meeting of two water masses which are completely different in temperature and dynamic characteristics, thus generating the Southwestern Atlantic Front (SAF). Therefore, the SAF has prominent characteristics of thermal and dynamics. The current ocean front detection is mainly by performing gradient operations on sea surface temperature (SST) data, where regions with large temperature gradients are considered as ocean fronts. The thermal gradient method largely ignores the dynamical features, leading to inaccurate manifestation of SAF. This study develops a deep learning model, SAFNet, to detect the SAF through the synergy of 10-year (2010-2019) satellite-derived SST and sea surface height (SSH) observations to achieve high accuracy detection of SAF with fused thermal and dynamic characteristics. The comparative experimental results show that the detection accuracy of SAFNet reaches 99.45%, which is significantly better than other models. By comparing the frontal probability (FP) obtained by SST, SSH and SST-SSH fusion data respectively, it is proved that the necessity of fusion multi-source remote sensing data for SAF detection. The detection results of fusion data can reflect the spatial distribution of SAF more comprehensively and accurately. According to the meridional variation of FP, the main reason for the seasonal variation of the SAF is the change in its thermal characteristics, and the SAF has stable dynamic characteristics.
Keywords	Southwestern Atlantic fronts ; multi-source remote sensing data ; deep learning ; ocean dynamics ; ocean thermodynamics ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	551
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy of percutaneous kyphoplasty on vertebral compression fractures with different bone mineral densities: a retrospective study.

Ge, Chen / Chen, Zhe / Cao, Peng

BMC musculoskeletal disorders

2023 Volume 24, Issue 1, Page(s) 276

Abstract: Background: This study was performed to investigate the clinical efficacy of percutaneous kyphoplasty (PKP) for vertebral compression fractures with different bone mineral densities (BMD).: Methods: We performed a retrospective analysis of 232 ... ...

Abstract	Background: This study was performed to investigate the clinical efficacy of percutaneous kyphoplasty (PKP) for vertebral compression fractures with different bone mineral densities (BMD). Methods: We performed a retrospective analysis of 232 patients with single-segment vertebral compression fractures who underwent PKP. Patients were divided into the normal BMD, osteopenia, and osteoporosis groups according to their average lumbar BMD before surgery. The visual analog scale (VAS) was used to compare differences in pain relief before and after surgery in each group. Corrections of the wedge angle and kyphotic angle before and after surgery were observed using anteroposterior and lateral radiographs and compared among the groups, as was the incidence of bone cement leakage. Results: Patients were followed up for 6-12 months, with an average follow-up time of 9.12 ± 1.68 months. The VAS score, wedge angle, and kyphotic angle of the three groups of patients decreased significantly at the end of the follow-up (P < 0.05). The changes in VAS score and wedge angle correction in the osteoporosis group were significantly larger than those in the normal BMD and osteopenia groups (P < 0.05). There were no significant differences among the three groups in terms of kyphotic angle correction or bone cement leakage rates (P > 0.05). Conclusions: PKP has a positive effect on vertebral compression fractures with different BMD, and is especially suitable for osteoporotic vertebral compression fractures.
MeSH term(s)	Humans ; Kyphoplasty/adverse effects ; Retrospective Studies ; Fractures, Compression/diagnostic imaging ; Fractures, Compression/surgery ; Fractures, Compression/complications ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery ; Spinal Fractures/complications ; Bone Density ; Bone Cements/therapeutic use ; Osteoporotic Fractures/diagnostic imaging ; Osteoporotic Fractures/surgery ; Osteoporotic Fractures/etiology ; Osteoporosis/complications ; Treatment Outcome ; Kyphosis/diagnostic imaging ; Kyphosis/etiology ; Kyphosis/surgery
Chemical Substances	Bone Cements
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-06341-w
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Article ; Online: Ultrathin Ti3C2Tx MXene sheets with high electrochemically active area anchored Pt boosting hydrogen evolution

Zicong Yang / Yanhui Chen / Ge Chen / Jinshu Wang / Hongyi Li

Heliyon, Vol 9, Iss 9, Pp e19197- (2023)

2023

Abstract: To reduce platinum usage, ultrathin MXene sheets with little restacking effect were prepared. The ultrathin MXene was prepared by a two-step etching process, which showed high specific surface area with low charge transfer resistance. The sample showed a ...

Abstract	To reduce platinum usage, ultrathin MXene sheets with little restacking effect were prepared. The ultrathin MXene was prepared by a two-step etching process, which showed high specific surface area with low charge transfer resistance. The sample showed a double layer capacity of 64.98 mF cm−2, which is 14 times as large as that of ordinary HF prepared MXene, indicating a larger electrochemically active surface area. It showed a much better HER performance of ∼190 mV at 10 mA cm−2. The better performance attributes to 0.4 wt% Pt loaded. The Pt loaded MXene exhibited a better HER performance of ∼75 mV at 10 mA cm−2 and a Tafel slope of 61.7 mV·dec−1 close to 40 wt% commercial Pt/C. The sample performed better than Pt/C in a 3 h chronopotentiometry test and hardly changed in ECSA after the cyclic experiment. With more Pt loading, the sample delivered better HER performance than Pt/C in the LSV test (∼51 mV at 10 mA cm−2). This work provides an effective route for the preparation of ultrathin MXene sheets with larger electrochemically active area and more active sites for Pt loading, leading to superior HER performance.
Keywords	Hydrogen evolution reaction ; Ultrathin MXene ; Electrochemically active area ; Little restacking ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Liver and Kidney Surgical Anatomy to Verify the Effect of miR-221 on Organ Damage in Septic Rats

Bingtao Shi / Jialing Zhang / QiaoGe Chen

Journal of Healthcare Engineering, Vol

2022 Volume 2022

Abstract: Background. Related studies have shown that miR-221 has the ability to promote inflammatory response. This experiment mainly discusses the effect of miR-221 on acute liver and kidney injury in septic rats. Method. Thirty Sprague Dawley (SD) rats were ... ...

Abstract	Background. Related studies have shown that miR-221 has the ability to promote inflammatory response. This experiment mainly discusses the effect of miR-221 on acute liver and kidney injury in septic rats. Method. Thirty Sprague Dawley (SD) rats were randomly divided into a (1) control group, (2) sepsis group, (3) miR-221 overexpression group, (4) miR-221 inhibition group, (5) HECTD2 inhibition group, and (6) miR-221 overexpression + HECTD2 inhibition group. The sepsis rat model was prepared by cecal ligation and puncture (CLP). The expression levels of miR-221 and HECTD2 were detected by RT-qPCR. The levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the liver were detected by the IFCC method. The levels of blood urea nitrogen (BUN) were detected by the creatine oxidase method. The levels of inflammatory factors were detected by ELISA. The apoptosis rate of liver and kidney cells was detected by flow cytometry. The expression of p65 protein was detected by western blotting. Result. RT-qPCR results showed that the expressions of miR-221 and HECTD2 were upregulated in septic rats (P<0.05). Compared with group 1, the liver function index, kidney function index, liver and kidney apoptosis rate, serum inflammatory factor level, and p65 protein expression in each group were increased (P<0.05). Compared with group 2, the liver function index, kidney function index, liver and kidney apoptosis rate, serum inflammatory factor level, and p65 protein expression in groups 4 and 5 were decreased (P<0.05). Compared with group 2, the expression of HECTD2 was upregulated in group 3 (P<0.05). Compared with group 3, the liver function index, renal function index, liver and kidney apoptosis rate, serum inflammatory factor level, and p65 protein expression were decreased in group 6 (P<0.05). Conclusion. MiR-221 promotes the expression of HECTD2 in septic rats, and inhibition of miR-221 expression can reduce the degree of liver and kidney injury in septic rats.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Subject code	500
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of HY-2 Series Satellites Mapping Capability on Mesoscale Eddies

Fangjie Yu / Juanjuan Qi / Yongjun Jia / Ge Chen

Remote Sensing, Vol 14, Iss 4262, p

2022 Volume 4262

Abstract: With the launches of HY-2B, HY-2C and HY-2D, the National Satellite Ocean Application Service (NSOAS) successfully established the first batch of HY-2 constellation on 19 May 2021, dedicated to detecting the marine dynamic environment. While the ... ...

Abstract	With the launches of HY-2B, HY-2C and HY-2D, the National Satellite Ocean Application Service (NSOAS) successfully established the first batch of HY-2 constellation on 19 May 2021, dedicated to detecting the marine dynamic environment. While the validation and calibration of HY-2 series satellites have been well studied, using both in situ and cross-track measurements, further evaluation is required of HY-2 series satellites mapping capability on mesoscale eddies. In this study, we conducted two groups of pseudo-observations obtained by ocean models output at positions and times of the satellite along ground tracks. The two altimetry satellite combinations are the Jason-3+Sentinel-3A/B configuration (reference group) and the Jason-3+Sentinel-3A/B+HY-2B/C/D configuration (evaluation group). Three regions at different latitudes were selected as the study areas. Then, we gridded the satellite along ground tracks into synthetic SSH products for each satellite configuration group. Finally, the attributes of mesoscale eddies extracted from gridded products were analyzed to evaluate the mapping capability of HY-2 series satellites. Our results suggest that the gridded products of evaluation groups are more similar to model data compared to reference groups, with a maximum difference reduced by 23%. In terms of eddy identification, the evaluation groups using HY-2 series satellites can alleviate eddy incorrect estimation and add more details to the spatial distribution of eddy radius and amplitude. Additionally, the evaluation groups displayed better performance in mesoscale eddy detection, with a maximum enhancement of 14% and 16% in eddy recognition rate and accuracy.
Keywords	HY-2 series satellites ; mesoscale eddy ; sea surface height ; optimal interpolation ; Science ; Q
Subject code	551
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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