Article ; Online: Atomoxetine in the treatment of adults with subthreshold and/or late onset attention-deficit hyperactivity disorder-not otherwise specified (ADHD-NOS): a prospective open-label 6-week study.
CNS neuroscience & therapeutics
2010 Volume 16, Issue 1, Page(s) 6–12
Abstract: The objective of this study was to evaluate the efficacy and tolerability of atomoxetine hydrochloride (ATX) in the treatment of adults with atypical manifestations of attention-deficit hyperactivity disorder (ADHD) (not otherwise specified [NOS]). We ... ...
| Abstract | The objective of this study was to evaluate the efficacy and tolerability of atomoxetine hydrochloride (ATX) in the treatment of adults with atypical manifestations of attention-deficit hyperactivity disorder (ADHD) (not otherwise specified [NOS]). We hypothesized that treatment with ATX will be safe and efficacious for the treatment of adults with ADHD-NOS. This was a 6-week, open-label, prospective treatment study of ATX monotherapy in 45 adult patients with ADHD-NOS assessed using standardized instruments for diagnosis and a robust oral daily dose of up to 1.2 mg/kg/day or 120 mg/day. Symptom severity was assessed with the adult ADHD Investigator Symptom Report Scale (AISRS) and Clinical Global Impression Scale. Treatment with ATX at an average daily dose of 78.7 +/- 27.8 mg was associated with a statistically and clinically significant reduction in ADHD symptoms relative to baseline as assessed through the (AISRS) (-12.1 +/- 8.4; P < 0.001). Using a categorical definition of response (CGI-I much or very much improved), a majority (N = 29; 64%) of subjects were rated as improved at study endpoint. Treatment with ATX was relatively well tolerated. These open-label results suggest that ATX may be safe and effective in the treatment of adults meeting criteria for ADHD-NOS and support the need for further controlled clinical trials of ATX in this population. |
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| MeSH term(s) | Adrenergic Uptake Inhibitors/therapeutic use ; Adult ; Atomoxetine Hydrochloride ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/physiopathology ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pilot Projects ; Propylamines/therapeutic use ; Prospective Studies ; Severity of Illness Index ; Treatment Outcome ; Young Adult |
| Chemical Substances | Adrenergic Uptake Inhibitors ; Propylamines ; Atomoxetine Hydrochloride (57WVB6I2W0) |
| Language | English |
| Publishing date | 2010-01-08 |
| Publishing country | England |
| Document type | Clinical Trial ; Journal Article |
| ZDB-ID | 2423461-8 |
| ISSN | 1755-5949 ; 1755-5930 |
| ISSN (online) | 1755-5949 |
| ISSN | 1755-5930 |
| DOI | 10.1111/j.1755-5949.2009.00124.x |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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