LIVIVO - Search results -

Search results

Result 1 - 10 of total 229

Search options

Article ; Online: Saving children from man-made acute malnutrition in Tigray, Ethiopia: a call to action.

Mulugeta, Afework / Gebregziabher, Mulugeta

2022 Volume 10, Issue 4, Page(s) e469–e470

MeSH term(s)	Child ; Cross-Sectional Studies ; Ethiopia/epidemiology ; Humans ; Malnutrition/epidemiology
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(22)00023-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Some comments on "The analysis of multivariate longitudinal data: A review".

Gebregziabher, Mulugeta

Statistical methods in medical research

2016 Volume 26, Issue 1, Page(s) 108–111

Abstract: We provide a commentary on "The analysis of multivariate longitudinal data: a review" by Verbeke et al. The authors provide a comprehensive review of the issues in the analysis of multivariate longitudinal data and use examples to demonstrate the pros ... ...

Abstract	We provide a commentary on "The analysis of multivariate longitudinal data: a review" by Verbeke et al. The authors provide a comprehensive review of the issues in the analysis of multivariate longitudinal data and use examples to demonstrate the pros and cons of several approaches. In this commentary, we indicate some important omissions in their review paper.
Language	English
Publishing date	2016-07-11
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1136948-6
ISSN	1477-0334 ; 0962-2802
ISSN (online)	1477-0334
ISSN	0962-2802
DOI	10.1177/0962280214539863
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3564: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Outcomes of discordant HIV screening test results at a southern academic medical center.

Colbrunn, Danielle K / Jacks, Courtney / Curry, Scott R / Gebregziabher, Mulugeta / Meissner, Eric G

AIDS (London, England)

2024

Abstract: Objective: The aim of this study was to examine outcomes of follow-up for persons with discordant fourth-generation HIV screening test results.: Design: A retrospective chart review.: Methods: We analyzed the electronic health record at the ... ...

Abstract	Objective: The aim of this study was to examine outcomes of follow-up for persons with discordant fourth-generation HIV screening test results. Design: A retrospective chart review. Methods: We analyzed the electronic health record at the Medical University of South Carolina for a 10-year period spanning 2012-2022 to identify instances of discordant HIV screening test results, wherein initial antigen/antibody screening was positive, but reflex confirmatory testing for HIV-1 and HIV-2 antibodies was negative. We reviewed individual records to evaluate clinical follow-up and determine if the discordant test represented an acute HIV infection, a false-positive result, or was unresolved. Results: We identified 199 testing instances with discordant results. Most discordant results (n = 115) were subsequently determined to reflect a false-positive test, while 56 were unresolved without documented follow-up testing. Twenty-eight cases of acute HIV infection were identified of which 26 were linked to care within a month of initial testing. Two acute HIV cases were not identified in real time leading to delay in diagnosis and care. Testing done in the context of infectious symptoms and testing performed in the emergency department were associated with increased odds of a discordant test ultimately reflecting acute HIV infection. Conclusion: These results demonstrate the importance of appropriate and timely follow-up for discordant HIV screening test results.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003884
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2228: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Toward Precision Medicine Using a "Digital Twin" Approach: Modeling the Onset of Disease-Specific Brain Atrophy in Individuals with Multiple Sclerosis.

Cen, Steven / Gebregziabher, Mulugeta / Moazami, Saeed / Azevedo, Christina / Pelletier, Daniel

Research square

2023

Abstract: Digital Twin (DT) is a novel concept that may bring a paradigm shift for precision medicine. In this study we demonstrate a DT application for estimating the age of onset of disease-specific brain atrophy in individuals with multiple sclerosis (MS) using ...

Abstract	Digital Twin (DT) is a novel concept that may bring a paradigm shift for precision medicine. In this study we demonstrate a DT application for estimating the age of onset of disease-specific brain atrophy in individuals with multiple sclerosis (MS) using brain MRI. We first augmented longitudinal data from a well-fitted spline model derived from a large cross-sectional normal aging data. Then we compared different mixed spline models through both simulated and real-life data and identified the mixed spline model with the best fit. Using the appropriate covariate structure selected from 52 different candidate structures, we augmented the thalamic atrophy trajectory over the lifespan for each individual MS patient and a corresponding hypothetical twin with normal aging. Theoretically, the age at which the brain atrophy trajectory of an MS patient deviates from the trajectory of their hypothetical healthy twin can be considered as the onset of progressive brain tissue loss. With a 10-fold cross validation procedure through 1000 bootstrapping samples, we found the onset age of progressive brain tissue loss was, on average, 5-6 years prior to clinical symptom onset. Our novel approach also discovered two clear patterns of patient clusters: earlier onset vs. simultaneous onset of brain atrophy.
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-2833532/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: The international humanitarian response to famine in Tigray, Ethiopia:lessons from the Nigerian Civil War, 1967-1970.

Phillips, James F / Roy, Charlotte M / Gebregziabher, Mulugeta

Global health action

2022 Volume 15, Issue 1, Page(s) 2107203

Abstract: The Tigray crisis in Ethiopia is a grave humanitarian catastrophe with causes and consequences that resemble the Nigerian Civil War that ended with the defeat of secessionist Biafra five decades ago. As in the Biafra example, an ethnically distinct and ... ...

Abstract	The Tigray crisis in Ethiopia is a grave humanitarian catastrophe with causes and consequences that resemble the Nigerian Civil War that ended with the defeat of secessionist Biafra five decades ago. As in the Biafra example, an ethnically distinct and embattled enclave is surrounded by hostile forces and cut off from commerce of any kind, producing starvation, forced migrant encampments, and pervasive dependence on externally provided food relief. Relief action strategies developed during the Nigerian Civil War were comprised of operational components that were often insufficiently integrated into a unified system for nutritional screening, referral, acute care, nutritional rehabilitation, and team deployment. This lack of strategic integration for post-conflict relief actions merits review for possible lessons that could avert its recurrence in Tigray. If evidence-based systems for relief organization had been comprehensively applied in Biafra, the pace of post-conflict nutritional recovery could have been accelerated. Although component strategies of the Biafra-Nigeria Relief Action are being replicated by various agencies that are providing humanitarian assistance in Tigray, their collective impact could be enhanced if these strategies were integrated into a unified, evidence-driven systems response to the emergency. The elements of such a systems approach for assisting Tigray are reviewed.
MeSH term(s)	Altruism ; Ethiopia ; Famine ; Humans ; Nigeria ; Nutrition Assessment ; Nutritional Status ; Warfare
Language	English
Publishing date	2022-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540569-X
ISSN	1654-9880 ; 1654-9880
ISSN (online)	1654-9880
ISSN	1654-9880
DOI	10.1080/16549716.2022.2107203
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Estimating missing concentrations of p,p'-DDT in the 1999-2004 National Health and Nutrition Examination Survey using multiple imputation.

Everett, Charles J / Gebregziabher, Mulugeta

Environmental science and pollution research international

2019 Volume 26, Issue 6, Page(s) 5885–5891

Abstract: We investigated the association between diabetes and p,p'-DDT (dichlorodiphenyltrichloroethane) in blood of Mexican Americans who participated in the 1999-2004 National Health and Nutrition Examination Survey (NHANES). In this sample, p,p'-DDT were ... ...

Abstract	We investigated the association between diabetes and p,p'-DDT (dichlorodiphenyltrichloroethane) in blood of Mexican Americans who participated in the 1999-2004 National Health and Nutrition Examination Survey (NHANES). In this sample, p,p'-DDT were missing in 50% of subjects and we used multiple imputation (MI) to address the problem. Compared to ignoring the missing data, MI led to a more robust threshold for the p,p'-DDT reference category. Whereas previously p,p'-DDT ≤ 0.0860 ng/g was used as the reference category, using MI, we were able to use p,p'-DDT < 0.0574 ng/g as the reference category to study the association between p,p'-DDT and diabetes via logistic regression. In this analysis, p,p'-DDT ≥ 0.0750 ng/g was associated with an odds ratio of 1.99 (95% CI 1.09-3.61) for diabetes and 4.20 (95% CI 1.93-9.12) for diabetic nephropathy. The reference category for diabetes without nephropathy outcome stayed consistent after MI but our analysis confirmed that p,p'-DDT > 0.0860 ng/g was associated with diabetes without nephropathy with an odds ratio of 1.89 (95% CI 1.09-3.27). Our study showed that MI can be effectively used to deal with missing at random data in persistent organic pollutants measured in the 1999-2004 NHANES.
MeSH term(s)	Adult ; DDT/analysis ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/metabolism ; Environmental Exposure/statistics & numerical data ; Environmental Pollutants/analysis ; Female ; Humans ; Hydrocarbons, Chlorinated ; Logistic Models ; Male ; Mexican Americans/statistics & numerical data ; Nutrition Surveys ; Odds Ratio ; United States/epidemiology
Chemical Substances	Environmental Pollutants ; Hydrocarbons, Chlorinated ; DDT (CIW5S16655)
Language	English
Publishing date	2019-01-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-018-04078-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 5915: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Shared parameter and copula models for analysis of semicontinuous longitudinal data with nonrandom dropout and informative censoring.

Jaffa, Miran A / Gebregziabher, Mulugeta / Jaffa, Ayad A

Statistical methods in medical research

2021 Volume 31, Issue 3, Page(s) 451–474

Abstract: Analysis of longitudinal semicontinuous data characterized by subjects' attrition triggered by nonrandom dropout is complex and requires accounting for the within-subject correlation, and modeling of the dropout process. While methods that address the ... ...

Abstract	Analysis of longitudinal semicontinuous data characterized by subjects' attrition triggered by nonrandom dropout is complex and requires accounting for the within-subject correlation, and modeling of the dropout process. While methods that address the within-subject correlation and missing data are available, approaches that incorporate the nonrandom dropout, also referred to informative right censoring, in the modeling step are scarce due to the computational intensity and possible intractable integration needed for its implementation. Appreciating the complexity of this problem and the need for a new methodology that is feasible for implementation, we propose to extend a framework of likelihood-based marginalized two-part models to account for informative right censoring. The censoring process is modeled using two approaches: (1) Poisson censoring for the count of visits before dropout and (2) survival time to dropout. Novel consideration was given to the proposed joint modeling approaches for the semicontinuous and censoring components of the likelihood function which included (1) shared parameter, and (2) Clayton copula. The cross-part and within-part correlations were accounted for through a complex random effect structure that models correlated random intercepts and slopes. Feasibility of implementation, and accuracy of these approaches were investigated using extensive simulation studies and clinical application.
MeSH term(s)	Computer Simulation ; Humans ; Likelihood Functions ; Longitudinal Studies ; Models, Statistical ; Patient Dropouts
Language	English
Publishing date	2021-11-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1136948-6
ISSN	1477-0334 ; 0962-2802
ISSN (online)	1477-0334
ISSN	0962-2802
DOI	10.1177/09622802211060519
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3564: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Impact of Race and Ethnicity on Severe Hypoglycemia Associated with Sulfonylurea Use for Type 2 Diabetes among Veterans.

Weeda, Erin R / Ward, Ralph / Gebregziabher, Mulugeta / Axon, R Neal / Taber, David J

Journal of racial and ethnic health disparities

2023

Abstract: Sulfonylureas are associated with hypoglycemia. Whether a racial/ethnic disparity in this safety outcome exists is unknown. We sought to assess the impact of race/ethnicity on severe hypoglycemia associated with sulfonylurea use for type 2 diabetes (T2D). ...

Abstract	Sulfonylureas are associated with hypoglycemia. Whether a racial/ethnic disparity in this safety outcome exists is unknown. We sought to assess the impact of race/ethnicity on severe hypoglycemia associated with sulfonylurea use for type 2 diabetes (T2D). Using Veterans Affairs and Medicare data, Veterans initially receiving metformin monotherapy for T2D between 2004 and 2006 were identified. Sulfonylurea use (either alone or via the addition of a prescription for a sulfonylurea to metformin) was captured and compared to remaining on metformin alone during the follow-up period (2007-2016). Hazard ratios (HR) and 95% confidence intervals (CI) from longitudinal competing risk Cox models were used to measure the association between sulfonylurea use and severe hypoglycemia defined as hospitalization for hypoglycemia. A total of 113,668 Veterans with T2D were included. A higher risk of severe hypoglycemia was associated with the receipt of sulfonylurea prescriptions versus remaining on metformin alone across all groups. The effect was largest among Hispanic Veterans (HR: 7.59, 95%CI:4.32-13.33), followed by Veterans in the other race/ethnicity cohort (HR: 4.57, 95%CI:2.50-8.36) and Non-Hispanic Black Veterans (HR: 3.67, 95%CI:2.78-4.85). The effect was smallest among Non-Hispanic White Veterans (HR: 3.11, 95%CI:2.77-3.48). In conclusion, a higher risk of severe hypoglycemia associated with sulfonylurea prescriptions was observed across all analyses. The relationship was most pronounced for Hispanic Veterans, who had nearly 8 times the risk of severe hypoglycemia with sulfonylureas versus remaining on metformin alone.
Language	English
Publishing date	2023-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2760524-3
ISSN	2196-8837 ; 2197-3792
ISSN (online)	2196-8837
ISSN	2197-3792
DOI	10.1007/s40615-023-01619-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Author Correction: Toward precision medicine using a "digital twin" approach: modeling the onset of disease-specific brain atrophy in individuals with multiple sclerosis.

Cen, Steven / Gebregziabher, Mulugeta / Moazami, Saeed / Azevedo, Christina J / Pelletier, Daniel

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22334

Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47966-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Toward precision medicine using a "digital twin" approach: modeling the onset of disease-specific brain atrophy in individuals with multiple sclerosis.

Cen, Steven / Gebregziabher, Mulugeta / Moazami, Saeed / Azevedo, Christina J / Pelletier, Daniel

Scientific reports

2023 Volume 13, Issue 1, Page(s) 16279

Abstract	Digital Twin (DT) is a novel concept that may bring a paradigm shift for precision medicine. In this study we demonstrate a DT application for estimating the age of onset of disease-specific brain atrophy in individuals with multiple sclerosis (MS) using brain MRI. We first augmented longitudinal data from a well-fitted spline model derived from a large cross-sectional normal aging data. Then we compared different mixed spline models through both simulated and real-life data and identified the mixed spline model with the best fit. Using the appropriate covariate structure selected from 52 different candidate structures, we augmented the thalamic atrophy trajectory over the lifespan for each individual MS patient and a corresponding hypothetical twin with normal aging. Theoretically, the age at which the brain atrophy trajectory of an MS patient deviates from the trajectory of their hypothetical healthy twin can be considered as the onset of progressive brain tissue loss. With a tenfold cross validation procedure through 1000 bootstrapping samples, we found the onset age of progressive brain tissue loss was, on average, 5-6 years prior to clinical symptom onset. Our novel approach also discovered two clear patterns of patient clusters: earlier onset versus simultaneous onset of brain atrophy.
MeSH term(s)	Humans ; Child, Preschool ; Child ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/pathology ; Cross-Sectional Studies ; Precision Medicine ; Brain/diagnostic imaging ; Brain/pathology ; Magnetic Resonance Imaging/methods ; Central Nervous System Diseases/pathology ; Seizures/pathology ; Atrophy/pathology
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43618-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito