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  1. Article ; Online: Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults.

    Lee, Seohyuk / McAvay, Gail J / Geda, Mary / Chattopadhyay, Sumon / Acampora, Denise / Araujo, Katy / Charpentier, Peter / Gill, Thomas M / Hajduk, Alexandra M / Cohen, Andrew B / Ferrante, Lauren E

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2024  Volume 79, Issue 5

    Abstract: Background: Despite significant support system disruptions during the coronavirus 2019 (COVID-19) pandemic, little is known about the relationship between social support and symptom burden among older adults following COVID-19 hospitalization.: ... ...

    Abstract Background: Despite significant support system disruptions during the coronavirus 2019 (COVID-19) pandemic, little is known about the relationship between social support and symptom burden among older adults following COVID-19 hospitalization.
    Methods: From a prospective cohort of 341 community-living persons aged ≥60 years hospitalized with COVID-19 between June 2020 and June 2021 who underwent follow-up at 1, 3, and 6 months after discharge, we identified 311 participants with ≥1 follow-up assessment. Social support prehospitalization was ascertained using a 5-item version of the Medical Outcomes Study Social Support Survey (range, 5-25), with low social support defined as a score ≤15. At hospitalization and each follow-up assessment, 14 physical symptoms were assessed using a modified Edmonton Symptom Assessment System inclusive of COVID-19-relevant symptoms. Mental health symptoms were assessed using Patient Health Questionnaire-4. Longitudinal associations between social support and physical and mental health symptoms, respectively, were evaluated through multivariable regression.
    Results: Participants' mean age was 71.3 years (standard deviation, 8.5), 52.4% were female, and 34.2% were of Black race or Hispanic ethnicity. 11.8% reported low social support. Over the 6-month follow-up period, low social support was independently associated with higher burden of physical symptoms (adjusted rate ratio [aRR], 1.26; 95% confidence interval [CI], 1.05-1.52), but not mental health symptoms (aRR, 1.14; 95% CI, 0.85-1.53).
    Conclusions: Low social support is associated with greater physical, but not mental health, symptom burden among older survivors of COVID-19 hospitalization. Our findings suggest a potential need for social support screening and interventions to improve post-COVID-19 symptom management in this vulnerable group.
    MeSH term(s) Humans ; COVID-19/psychology ; COVID-19/epidemiology ; Aged ; Female ; Male ; Social Support ; Hospitalization/statistics & numerical data ; Prospective Studies ; SARS-CoV-2 ; Mental Health ; Middle Aged ; Aged, 80 and over ; Symptom Burden
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glae092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The association of neighborhood walkability with health outcomes in older adults after acute myocardial infarction: The SILVER-AMI study.

    Roy, Brita / Hajduk, Alexandra M / Tsang, Sui / Geda, Mary / Riley, Carley / Krumholz, Harlan M / Chaudhry, Sarwat I

    Preventive medicine reports

    2021  Volume 23, Page(s) 101391

    Abstract: Physical activity and social support are associated with better outcomes after surviving acute myocardial infarction (AMI), and greater walkability has been associated with activity and support. We used data from the SILVER-AMI study (November 2014-June ... ...

    Abstract Physical activity and social support are associated with better outcomes after surviving acute myocardial infarction (AMI), and greater walkability has been associated with activity and support. We used data from the SILVER-AMI study (November 2014-June 2017), a longitudinal cohort of community-living adults ≥ 75 years hospitalized for AMI to assess associations of neighborhood walkability with health outcomes, and to assess whether physical activity and social support mediate this relationship, if it exists. We included data from 1345 participants who were not bedbound, were discharged home, and for whom we successfully linked walkability scores (from Walk Score®) for their home census block. Our primary outcome was hospital-free survival time (HFST) at six months after discharge; secondary outcomes included physical and mental health at six months, assessed using SF-12. Physical activity and social support were measured at baseline. Covariates included cognition, functioning, comorbidities, participation in rehabilitation or physical therapy, and demographics. We employed survival analysis to examine associations between walkability and HFST, before and after adjustment for covariates; we repeated analyses using linear regression with physical and mental health as outcomes. In adjusted models, walkability was not associated with physical health (ß = 0.010; 95% CI: -0.027, 0.047), mental health (ß = -0.08; 95% CI: -0.175, -0.013), or HFST (ß = 0.008; 95% CI: -0.023, 0.009). Social support was associated with mental health in adjusted models. Neighborhood walkability was not predictive of outcomes among older adults with existing coronary disease, suggesting that among older adults, mobility limitations may supercede neighborhood walkability.
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2021.101391
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  3. Article ; Online: Presentation, Treatment, and Outcomes of Older Adults Hospitalized for Acute Myocardial Infarction According to Cognitive Status: The SILVER-AMI Study.

    Hajduk, Alexandra M / Saczynski, Jane S / Tsang, Sui / Geda, Mary E / Dodson, John A / Ouellet, Gregory M / Goldberg, Robert J / Chaudhry, Sarwat I

    The American journal of medicine

    2021  Volume 134, Issue 7, Page(s) 910–917

    Abstract: Background: While survival after acute myocardial infarction has improved substantially, older adults remain at heightened risk for hospital readmissions and death. Evidence for the role of cognitive impairment in older myocardial infarction survivors' ... ...

    Abstract Background: While survival after acute myocardial infarction has improved substantially, older adults remain at heightened risk for hospital readmissions and death. Evidence for the role of cognitive impairment in older myocardial infarction survivors' risk for these outcomes is limited.
    Methods: 3041 patients aged ≥75 years hospitalized with acute myocardial infarction (mean age 82 ± 5 years, 56% male) recruited from 94 US hospitals. Cognition was assessed using the Telephone Interview for Cognitive Status; scores of <27 and <22 indicated mild and moderate/severe impairment, respectively. Readmissions and death at 6 months post-discharge were ascertained via participant report and medical record review. Associations between cognition and outcomes were evaluated with multivariable-adjusted logistic regression.
    Results: Mild and moderate/severe cognitive impairment were present in 11% and 6% of the cohort, respectively. Readmission and death at 6 months occurred in 41% and 9% of participants, respectively. Mild and moderate/severe cognitive impairment were associated with increased risk of readmission (odds ratio [OR] 1.36; 95% confidence interval [CI], 1.08-1.72 and OR 1.58; 95% CI, 1.18-2.12, respectively) and death (OR 2.19; 95% CI, 1.54-3.11 and OR 3.82; 95% CI, 2.63-5.56, respectively) in unadjusted analyses. Significant associations between moderate/severe cognitive impairment and death (OR 1.69; 95% CI, 1.10-2.59) persisted after adjustment for demographics, myocardial infarction characteristics, comorbidity burden, functional status, and depression, but not for readmissions.
    Conclusions: Moderate-to-severe cognitive impairment is associated with heightened risk of death in older acute myocardial infarction patients in the months after hospitalization, but not with readmission. Routine cognitive screening may identify older myocardial infarction survivors at risk for poor outcomes who may benefit from closer oversight and support in the post-discharge period.
    MeSH term(s) Aged ; Aged, 80 and over ; Cognition/physiology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Logistic Models ; Longitudinal Studies ; Male ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; Odds Ratio ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/statistics & numerical data ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2021.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development and Implementation of the Military Treatment Facility Engagement Committee (MTFEC) to Support Pragmatic Clinical Trials in the Military Health System.

    Scarton, Dylan V / Roddy, William T / Taylor, Jerika A / Geda, Mary / Brandt, Cynthia A / Peduzzi, Peter / Kerns, Robert D / Pasquina, Paul F

    Military medicine

    2021  Volume 186, Issue Suppl 1, Page(s) 70–75

    Abstract: Introduction: Within the population of military service members and veterans, chronic pain is highly prevalent, often complex, and frequently related to traumatic experiences that are more likely to occur to members of this demographic, such as ... ...

    Abstract Introduction: Within the population of military service members and veterans, chronic pain is highly prevalent, often complex, and frequently related to traumatic experiences that are more likely to occur to members of this demographic, such as individuals with traumatic brain injury or limb loss. In September 2017, the National Institutes of Health (NIH), Department of Defense (DOD), and Department of Veterans Affairs (VA) Pain Management Collaboratory (PMC) was formed as a significant and innovative inter-government agency partnership to support a multicomponent research initiative focusing on nonpharmacological approaches for pain management addressing the needs of service members, their dependents, and veterans.
    Methods: A Pain Management Collaboratory Coordinating Center (PMC3) was also established to facilitate collective learning across 11 individually funded pragmatic clinical trials (PCTs) designed to optimize the impact of the PMC as an integrated whole. Although the DOD and VA health care systems are ideal sites for the enactment of PCTs, executing these trials within the local context of DOD military treatment facilities (MTFs) can present unique challenges. The Military Treatment Facility Engagement Committee (MTFEC) was created to support the efforts of the PMC3 in its role as a national resource for development and refinement of innovative tools, best practices, and other resources in the conduct of high impact PCTs.
    Results: The MTFEC is composed of experts from each service who bring experiences in executing clinical pain management trials that can enhance the planning and execution of the PCTs. It provides expertise and leadership in the execution of research studies at within MTFs and within the DOD health care system, with guidance from PMC3 Directors and in collaboration with NIH, DOD, and VA program and scientific officers.
    Discussion/conclusion: Considering the importance of enacting large-scale, pragmatic studies to implement effective strategies in clinical practice for chronic pain management, the MTFEC has begun to actualize its purpose by identifying potential barriers and challenges to study implementation and exploring how the PMC can support and aid in the execution of PCTs by applying similar approaches to stakeholder and subject matter engagement for their research.
    MeSH term(s) Chronic Pain ; Humans ; Military Health Services ; Pain Management ; United States ; United States Department of Veterans Affairs ; Veterans
    Language English
    Publishing date 2021-01-23
    Publishing country England
    Document type Journal Article ; Pragmatic Clinical Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usaa368
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  5. Article ; Online: Factors Associated With Cardiac Rehabilitation Participation in Older Adults After Myocardial Infarction: THE SILVER-AMI STUDY.

    Goldstein, David W / Hajduk, Alexandra M / Song, Xuemei / Tsang, Sui / Geda, Mary / Dodson, John A / Forman, Daniel E / Krumholz, Harlan / Chaudhry, Sarwat I

    Journal of cardiopulmonary rehabilitation and prevention

    2022  Volume 42, Issue 2, Page(s) 109–114

    Abstract: Purpose: Cardiac rehabilitation (CR) is a key aspect of secondary prevention following acute myocardial infarction (AMI). While there is growing evidence of unique benefits of CR in older adults, it remains underutilized. We aimed to examine specific ... ...

    Abstract Purpose: Cardiac rehabilitation (CR) is a key aspect of secondary prevention following acute myocardial infarction (AMI). While there is growing evidence of unique benefits of CR in older adults, it remains underutilized. We aimed to examine specific demographic, clinical, and functional factors associated with utilization of CR among older adults hospitalized with AMI.
    Methods: Our project used data from the SILVER-AMI study, a nationwide prospective cohort study of patients age ≥75 yr hospitalized with AMI and followed them up for 6 mo after discharge. Extensive baseline data were collected on demographics, clinical and psychosocial factors, and functional and sensory impairments. The utilization of CR was collected by a survey at 6 mo. Backward selection was employed in a multivariable-adjusted logistic regression model to identify independent predictors of CR use.
    Results: Of the 2003 participants included in this analysis, 779 (39%) reported participating in CR within 6 mo of discharge. Older age, longer length of hospitalization, having ≤12 yr of education, visual impairment, cognitive impairment, and living alone were associated with decreased likelihood of CR participation; receipt of diagnostic and interventional procedures (ie, cardiac catheterization, percutaneous coronary intervention, and coronary artery bypass graft) was associated with increased likelihood of CR participation.
    Conclusions: Demographic and clinical factors, as well as select functional and sensory impairments common in aging, were associated with CR participation at 6 mo post-discharge in older AMI patients. These results highlight opportunities to increase CR usage among older adults and identify those at risk for not participating.
    MeSH term(s) Aftercare ; Aged ; Cardiac Rehabilitation ; Humans ; Myocardial Infarction ; Patient Discharge ; Prospective Studies
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2272063-7
    ISSN 1932-751X ; 1932-7501
    ISSN (online) 1932-751X
    ISSN 1932-7501
    DOI 10.1097/HCR.0000000000000627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rationale, Design, and Characteristics of the VALIANT (COVID-19 in Older Adults: A Longitudinal Assessment) Cohort.

    Cohen, Andrew B / McAvay, Gail J / Geda, Mary / Chattopadhyay, Sumon / Lee, Seohyuk / Acampora, Denise / Araujo, Katy / Charpentier, Peter / Gill, Thomas M / Hajduk, Alexandra M / Ferrante, Lauren E

    Journal of the American Geriatrics Society

    2022  Volume 71, Issue 3, Page(s) 832–844

    Abstract: Background: Most older adults hospitalized with COVID-19 survive their acute illness. The impact of COVID-19 hospitalization on patient-centered outcomes, including physical function, cognition, and symptoms, is not well understood. To address this ... ...

    Abstract Background: Most older adults hospitalized with COVID-19 survive their acute illness. The impact of COVID-19 hospitalization on patient-centered outcomes, including physical function, cognition, and symptoms, is not well understood. To address this knowledge gap, we collected longitudinal data about these issues from a cohort of older survivors of COVID-19 hospitalization.
    Methods: We undertook a prospective study of community-living persons age ≥ 60 years who were hospitalized with COVID-19 from June 2020-June 2021. A baseline interview was conducted during or up to 2 weeks after hospitalization. Follow-up interviews occurred at one, three, and six months post-discharge. Participants completed comprehensive assessments of physical and cognitive function, symptoms, and psychosocial factors. An abbreviated assessment could be performed with a proxy. Additional information was collected from the electronic health record.
    Results: Among 341 participants, the mean age was 71.4 (SD 8.4) years, 51% were women, and 37% were of Black race or Hispanic ethnicity. Median length of hospitalization was 8 (IQR 6-12) days. All but 4% of participants required supplemental oxygen, and 20% required care in an intensive care unit or stepdown unit. At enrollment, nearly half (47%) reported at least one preexisting disability in physical function, 45% demonstrated cognitive impairment, and 67% were pre-frail or frail. Participants reported a mean of 9 of 14 (SD 3) COVID-19-related symptoms. At the six-month follow-up interview, more than a third of participants experienced a decline from their pre-hospitalization function, nearly 20% had cognitive impairment, and burdensome symptoms remained highly prevalent.
    Conclusions: We enrolled a diverse cohort of older adults hospitalized with COVID-19 and followed them after discharge. Functional decline was common, and there were high rates of persistent cognitive impairment and symptoms. Future analyses of these data will advance our understanding of patient-centered outcomes among older COVID-19 survivors.
    MeSH term(s) Humans ; Female ; Aged ; Male ; COVID-19/epidemiology ; Patient Discharge ; Prospective Studies ; Aftercare ; Hospitalization
    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18146
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  7. Article ; Online: Reply to: "Comment on: Falls in older adults after hospitalization for acute myocardial infarction".

    Goldstein, David W / Hajduk, Alexandra M / Song, Xuemei / Tsang, Sui / Geda, Mary / McClurken, James B / Tinetti, Mary E / Krumholz, Harlan M / Chaudhry, Sarwat I

    Journal of the American Geriatrics Society

    2022  Volume 70, Issue 6, Page(s) 1880–1881

    MeSH term(s) Accidental Falls ; Aged ; Hospitalization ; Humans ; Myocardial Infarction ; Risk Factors
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.17742
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  8. Article ; Online: Comorbid vision and cognitive impairments in older adults hospitalized for acute myocardial infarction.

    Whitson, Heather E / Hajduk, Alexandra M / Song, Xuemei / Geda, Mary / Tsang, Sui / Brush, John / Chaudhry, Sarwat I

    Journal of comorbidity

    2020  Volume 10, Page(s) 2235042X20940493

    Abstract: Older patients presenting with acute myocardial infarction (AMI) often have comorbidities. Our objective was to examine how outcomes differ by cognitive and vision status in older AMI patients. We use data from a prospective cohort study conducted at 94 ... ...

    Abstract Older patients presenting with acute myocardial infarction (AMI) often have comorbidities. Our objective was to examine how outcomes differ by cognitive and vision status in older AMI patients. We use data from a prospective cohort study conducted at 94 hospitals in the United States between January 2013 and October 2016 that enrolled men and women aged ≥75 years with AMI. Cognitive impairment (CI) was defined as telephone interview for cognitive status (TICS) score <27; vision impairment (VI) and activities of daily living (ADLs) were assessed by questionnaire. Of 2988 senior AMI patients, 260 (8.7%) had CI but no VI, 858 (28.7%) had VI but no CI, and 251 (8.4%) had both CI/VI. Patients in the VI/CI group were most likely to exhibit geriatric syndromes. More severe VI was associated with lower (worse) scores on the TICS (
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2831678-2
    ISSN 2235-042X ; 2235-042X
    ISSN (online) 2235-042X
    ISSN 2235-042X
    DOI 10.1177/2235042X20940493
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  9. Article ; Online: Clinician Perspectives on Incorporating Patients' Values-Based Health Priorities in Decision-Making.

    Ouellet, Gregory M / Kiwak, Eliza / Costello, Darcé M / Green, Ariel R / Geda, Mary / Naik, Aanand D / Tinetti, Mary E

    Journal of the American Geriatrics Society

    2020  Volume 69, Issue 1, Page(s) 267–269

    MeSH term(s) Decision Making ; Female ; Health Priorities ; Humans ; Male ; Patient Care Planning ; Patient Participation ; Patient Preference
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.16914
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  10. Article: 180-day readmission risk model for older adults with acute myocardial infarction: the SILVER-AMI study.

    Dodson, John A / Hajduk, Alexandra M / Murphy, Terrence E / Geda, Mary / Krumholz, Harlan M / Tsang, Sui / Nanna, Michael G / Tinetti, Mary E / Ouellet, Gregory / Sybrant, Deborah / Gill, Thomas M / Chaudhry, Sarwat I

    Open heart

    2021  Volume 8, Issue 1

    Abstract: Objective: To develop a 180-day readmission risk model for older adults with acute myocardial infarction (AMI) that considered a broad range of clinical, demographic and age-related functional domains.: Methods: We used data from ComprehenSIVe ... ...

    Abstract Objective: To develop a 180-day readmission risk model for older adults with acute myocardial infarction (AMI) that considered a broad range of clinical, demographic and age-related functional domains.
    Methods: We used data from ComprehenSIVe Evaluation of Risk in Older Adults with AMI (SILVER-AMI), a prospective cohort study that enrolled participants aged ≥75 years with AMI from 94 US hospitals. Participants underwent an in-hospital assessment of functional impairments, including cognition, vision, hearing and mobility. Clinical variables previously shown to be associated with readmission risk were also evaluated. The outcome was 180-day readmission. From an initial list of 72 variables, we used backward selection and Bayesian model averaging to derive a risk model (N=2004) that was subsequently internally validated (N=1002).
    Results: Of the 3006 SILVER-AMI participants discharged alive, mean age was 81.5 years, 44.4% were women and 10.5% were non-white. Within 180 days, 1222 participants (40.7%) were readmitted. The final risk model included 10 variables: history of chronic obstructive pulmonary disease, history of heart failure, initial heart rate, first diastolic blood pressure, ischaemic ECG changes, initial haemoglobin, ejection fraction, length of stay, self-reported health status and functional mobility. Model discrimination was moderate (0.68 derivation cohort, 0.65 validation cohort), with good calibration. The predicted readmission rate (derivation cohort) was 23.0% in the lowest quintile and 65.4% in the highest quintile.
    Conclusions: Over 40% of participants in our sample experienced hospital readmission within 180 days of AMI. Our final readmission risk model included a broad range of characteristics, including functional mobility and self-reported health status, neither of which have been previously considered in 180-day risk models.
    MeSH term(s) Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Myocardial Infarction/epidemiology ; Myocardial Infarction/therapy ; Patient Readmission/trends ; Prospective Studies ; Risk Assessment/methods ; Risk Factors ; Time Factors ; United States/epidemiology
    Language English
    Publishing date 2021-01-13
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2020-001442
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