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  1. Article ; Online: Pathophysiology of renal anaemia.

    Geddes, Colin C

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2019  Volume 34, Issue 6, Page(s) 921–922

    Language English
    Publishing date 2019-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfy266
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  2. Article: Paper chase.

    Geddes, Colin

    Scottish medical journal

    2017  Volume 62, Issue 2, Page(s) 74–75

    Language English
    Publishing date 2017-05
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 414085-0
    ISSN 2045-6441 ; 0036-9330
    ISSN (online) 2045-6441
    ISSN 0036-9330
    DOI 10.1177/0036933017697527
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  3. Article ; Online: Diagnostic and prognostic significance of extent of subepithelial electron dense deposits in membranous glomerulonephritis.

    Kipgen, David / Geddes, Colin

    Ultrastructural pathology

    2021  Volume 45, Issue 3, Page(s) 224–235

    Abstract: There are limited data concerning the range and diagnostic significance of the extent of subepithelial electron dense deposits (SEEDD) in membranous glomerulonephritis (MGN). We described the range, and assessed the diagnostic and prognostic significance ...

    Abstract There are limited data concerning the range and diagnostic significance of the extent of subepithelial electron dense deposits (SEEDD) in membranous glomerulonephritis (MGN). We described the range, and assessed the diagnostic and prognostic significance of extent of SEEDD, particularly in patients with sparse SEEDD, where diagnostic difficulty can arise. Adult renal biopsies with a confident or suspected histological diagnosis of MGN between 2013 and 2020 were included. Patients were classified based on extent of SEEDD as having either global MGN (GMGN, >75% SEEDD), segmental MGN (SMGN, 25%-75% SEEDD), or sparse-SEEDD (<25% SEEDD). Clinical and other features were compared. One hundred and eleven (74%) patients had GMGN; 23 (15%) had SMGN; and 16 (11%) had sparse-SEEDD. Patients with sparse-SEEDD had a significantly shorter duration of nephrotic syndrome prior to biopsy. 53% of patients with GMGN and 14% with SMGN had serum anti-phospholipase A2 receptor (PLA2r) antibodies. Patients with sparse-SEEDD did not have anti-PLA2r antibodies. Urine protein:creatinine ratio was significantly lower in sparse-SEEDD patients after 3, 6, 9, and 12 months. The proportion of sparse-SEEDD patients in complete remission from nephrotic range proteinuria at 6 and 12 months was significantly higher than that of GMGN patients. Analysis of a subgroup suggested sparse-SEEDD patients responded more rapidly to steroid containing immunosuppression than GMGN patients. There is a wide range of extent of SEEDD in patients with MGN. Sparse-SEEDD appears distinct from SMGN and GMGN and may be either an early form of MGN, or an epiphenomenon associated with another primary disease process, particularly minimal change disease.
    MeSH term(s) Adult ; Electrons ; Glomerulonephritis ; Glomerulonephritis, Membranous/diagnosis ; Humans ; Prognosis ; Proteinuria ; Receptors, Phospholipase A2
    Chemical Substances Receptors, Phospholipase A2
    Language English
    Publishing date 2021-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 603269-2
    ISSN 1521-0758 ; 0191-3123
    ISSN (online) 1521-0758
    ISSN 0191-3123
    DOI 10.1080/01913123.2021.1919263
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  4. Article ; Online: The relationship between histopathological features, immunosuppression and outcome in patients undergoing native kidney biopsies.

    Kipgen, David / Crosby, Jana / Dey, Vishal / Kelly, Michael / McQuarrie, Emily / Geddes, Colin

    Histopathology

    2023  Volume 84, Issue 4, Page(s) 671–682

    Abstract: Aims: To assess retrospectively the association between histopathological lesions on renal biopsy and subsequent impairment of renal function across the spectrum of kidney diseases and to explore the influence of immunosuppressive therapy within the ... ...

    Abstract Aims: To assess retrospectively the association between histopathological lesions on renal biopsy and subsequent impairment of renal function across the spectrum of kidney diseases and to explore the influence of immunosuppressive therapy within the first 6 months after biopsy on this association.
    Methods and results: Clinical data from 488 adult patients having a renal biopsy reported at a single centre from 2017 to 2019 were obtained during a median follow-up period of 786 days. Seventeen semi-quantitative histology parameters were recorded at the time of biopsy, 14 of which were suitable for assessment of association with loss of eGFR by multivariable Cox regression analysis, measurement of eGFR slope and measurement of eGFR 12 months after biopsy. A widely used histopathological chronicity score was also assessed. Clinical baseline variables including prescription of immunosuppression were recorded. Seven of 14 histology parameters: mesangial matrix expansion, global glomerulosclerosis, tubular atrophy, interstitial fibrosis, arteriolosclerosis, mesangial hypercellularity and acute tubular injury; and the chronicity score, predicted loss of kidney function by all three measures. Prescription of immunosuppression was more likely in patients with active inflammatory pathology and less likely in patients with chronic fibrotic pathology, and was associated with reduced risk of loss of eGFR.
    Conclusions: This retrospective study demonstrates the prognostic significance and complex relationship with immunosuppression of routinely reported histopathological variables in patients having native kidney biopsies, across the spectrum of kidney diseases. It provides useful information for renal biopsy prognostication and design of retrospective studies, including machine learning models.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Biopsy ; Immunosuppression Therapy ; Kidney/pathology ; Kidney Diseases/pathology
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.15115
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  5. Article ; Online: Clinical factors associated with severe hypophosphataemia after kidney transplant.

    Ralston, Maximilian R / Stevenson, Karen S / Mark, Patrick B / Geddes, Colin C

    BMC nephrology

    2021  Volume 22, Issue 1, Page(s) 407

    Abstract: Background: The mechanism by which hypophosphataemia develops following kidney transplantation remains debated, and limited research is available regarding risk factors. This study aimed to assess the association between recipient and donor variables, ... ...

    Abstract Background: The mechanism by which hypophosphataemia develops following kidney transplantation remains debated, and limited research is available regarding risk factors. This study aimed to assess the association between recipient and donor variables, and the severity of post-transplantation hypophosphataemia.
    Methods: We performed a single-centre retrospective observational study. We assessed the association between demographic, clinical and biochemical variables and the development of hypophosphataemia. We used linear regression analysis to assess association between these variables and phosphate nadir.
    Results: 87.6% of patients developed hypophosphataemia. Patients developing hypophosphataemia were younger, had a shorter time on renal replacement therapy, were less likely to have had a parathyroidectomy or to experience delayed graft function, were more likely to have received a living donor transplant, from a younger donor. They had higher pre-transplantation calcium levels, and lower alkaline phosphatase levels. Receipt of a living donor transplant, lower donor age, not having had a parathyroidectomy, receiving a transplant during the era of tacrolimus-based immunosuppression, not having delayed graft function, higher pre-transplantation calcium, and higher pre-transplantation phosphate were associated with lower phosphate nadir by multiple linear regression.
    Conclusions: This analysis demonstrates an association between variables relating to better graft function and hypophosphataemia. The links with biochemical measures of mineral-bone disease remain less clear.
    MeSH term(s) Adult ; Female ; Humans ; Hypophosphatemia/etiology ; Kidney Transplantation ; Male ; Middle Aged ; Postoperative Complications/etiology ; Retrospective Studies ; Severity of Illness Index
    Language English
    Publishing date 2021-12-09
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-021-02624-3
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  6. Article ; Online: SARS-CoV-2 and Tacrolimus Blood Concentration in Kidney Transplant Recipients.

    McMinn, Jason / Black, Heather / Harrison, Luis Loureiro / Geddes, Colin

    Kidney international reports

    2021  Volume 6, Issue 10, Page(s) 2694–2697

    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.07.012
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  7. Article ; Online: Transplantation of kidneys after normothermic perfusion: A single center experience.

    Pearson, Robert / Geddes, Colin / Mark, Patrick / Clancy, Marc / Asher, John

    Clinical transplantation

    2021  Volume 35, Issue 10, Page(s) e14431

    Abstract: Background: In order to expand the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional perfusion (NRP) to assess and improve liver viability.: Methods: Data was obtained from a prospectively ... ...

    Abstract Background: In order to expand the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional perfusion (NRP) to assess and improve liver viability.
    Methods: Data was obtained from a prospectively maintained database between December 2012 and September 2018. Primary endpoints were incidence of delayed graft function (DGF) and estimated glomerular filtration rate (eGFR).
    Results: Six-hundred and thirty-two decease donor kidneys were transplanted, 229 from DCD donors, 29 of which had NRP. The DGF rate was lower for NRP versus DCD (six of 29, 20.7% vs. 70 of 200, 35.0%) with reduced duration of DGF. Multivariate analysis demonstrated transplant type to be a statistically significant independent predictor of eGFR at 7 and 14 days. Early transplant function in NRP kidneys was comparable to DBD. There were no graft losses within 30 days in the NRP group. One-year graft loss rate was 3.4% for NRP and 6.0% for standard DCD.
    Conclusion: This data suggests NRP is safe, and reduces rates of DGF and improves early renal transplant function.
    MeSH term(s) Delayed Graft Function/etiology ; Graft Survival ; Humans ; Kidney ; Organ Preservation ; Perfusion ; Tissue Donors
    Language English
    Publishing date 2021-08-03
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14431
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  8. Article ; Online: Correction: The impact of renal artery stenting on therapeutic aims.

    Edgar, Ben / Pearson, Robert / Kasthuri, Ram / Gillis, Keith / Geddes, Colin / Rostron, Maggie / Brady, Adrian / Hussey, Keith / Roditi, Giles / Delles, Christian / McCallum, Linsay / Mark, Patrick / Kingsmore, David

    Journal of human hypertension

    2024  Volume 38, Issue 2, Page(s) 191

    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-024-00893-7
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  9. Article ; Online: UK experience of ofatumumab in recurrence of focal segmental glomerulosclerosis post-kidney transplant.

    Reynolds, Ben C / Lamb, Angela / Jones, Caroline A / Yadav, Pallavi / Tyerman, Kay S / Geddes, Colin C

    Pediatric nephrology (Berlin, Germany)

    2021  Volume 37, Issue 1, Page(s) 199–207

    Abstract: Background: Steroid-resistant nephrotic syndrome (SRNS), commonly caused by focal segmental glomerulosclerosis (FSGS), is associated with progression to stage 5 chronic kidney disease, requirement for kidney replacement therapy and a risk of disease ... ...

    Abstract Background: Steroid-resistant nephrotic syndrome (SRNS), commonly caused by focal segmental glomerulosclerosis (FSGS), is associated with progression to stage 5 chronic kidney disease, requirement for kidney replacement therapy and a risk of disease recurrence post-kidney transplantation. Ofatumumab (OFA) is a fully humanised monoclonal antibody to CD20, with similar mechanisms of action to rituximab (RTX).
    Methods: We report a case series of seven UK patients (five paediatric, two adult), all of whom developed FSGS recurrence after kidney transplantation and received OFA as part of their therapeutic intervention. All also received concomitant plasmapheresis. The 2-year outcome of these seven patients is reported, describing clinical course, kidney function and proteinuria.
    Results: Four patients (all paediatric) achieved complete urinary remission with minimal proteinuria 12 months post-treatment. Three of those four also had normal graft function. Two patients showed partial remission-brief improvement to non-nephrotic proteinuria (197 mg/mmol) in one patient, maintained improvement in kidney function (estimated glomerular filtration rate 76 ml/min/1.73 m
    Conclusions: OFA may represent a useful addition to therapeutic options in the management of FSGS recurrence post-transplantation, including where RTX has shown no benefit. Concomitant plasmapheresis in all patients prevents any definitive conclusion that OFA was the beneficial intervention.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Child ; Glomerulosclerosis, Focal Segmental/epidemiology ; Glomerulosclerosis, Focal Segmental/prevention & control ; Humans ; Kidney Transplantation/adverse effects ; Recurrence ; Secondary Prevention ; United Kingdom/epidemiology
    Chemical Substances Antibodies, Monoclonal, Humanized ; ofatumumab (M95KG522R0)
    Language English
    Publishing date 2021-08-12
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-021-05248-9
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  10. Article: Kidney transplantation – the journey continues.

    Stoumpos, Sokratis / Geddes, Colin C

    Scottish medical journal

    2015  Volume 60, Issue 1, Page(s) 1–2

    MeSH term(s) Graft Rejection/prevention & control ; Graft Survival/immunology ; History, 20th Century ; History, 21st Century ; Humans ; Kidney Transplantation/methods ; Kidney Transplantation/trends ; T-Lymphocytes/immunology ; Transplantation Tolerance
    Language English
    Publishing date 2015-02
    Publishing country Scotland
    Document type Editorial ; Historical Article
    ZDB-ID 414085-0
    ISSN 2045-6441 ; 0036-9330
    ISSN (online) 2045-6441
    ISSN 0036-9330
    DOI 10.1177/0036933014567839
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