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  1. Article ; Online: Phosphodiesterase 4 Inhibitors, Basophils, and Atopic Dermatitis.

    Das, Mrinmoy / Mukherjee, Saikat / Geha, Raif S

    The Journal of investigative dermatology

    2024  Volume 144, Issue 5, Page(s) 924–926

    MeSH term(s) Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/immunology ; Phosphodiesterase 4 Inhibitors/therapeutic use ; Phosphodiesterase 4 Inhibitors/pharmacology ; Humans ; Basophils/immunology ; Basophils/drug effects ; Animals
    Chemical Substances Phosphodiesterase 4 Inhibitors
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.12.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
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  2. Book ; Conference proceedings: Hepatitis C and intravenous immunoglobulin

    Geha, Raif S.

    [papers from the Symposium "Hepatitis C and Intravenous Immunoglobulin" held April 29 and 30, 1995, in Orlando, Florida]

    (Clinical therapeutics ; 18, Suppl. B)

    1996  

    Institution Symposium Hepatitis C and Intravenous Immunoglobulin
    Author's details Raif S. Geha, ed
    Series title Clinical therapeutics ; 18, Suppl. B
    Collection
    Keywords Immunoglobulins, Intravenous / adverse effects / congresses ; Hepatitis C-Like Viruses / congresses ; Hepatitis C / transmission / congresses
    Language English
    Size 139 S. : graph. Darst.
    Publisher Excerpta Medica
    Publishing place Belle Mead, NJ
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007600921
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1435 -18,Suppl.B- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Inborn Errors of the Immune System Associated With Atopy.

    Nelson, Ryan W / Geha, Raif S / McDonald, Douglas R

    Frontiers in immunology

    2022  Volume 13, Page(s) 860821

    Abstract: Atopic disorders, including atopic dermatitis, food and environmental allergies, and asthma, are increasingly prevalent diseases. Atopic disorders are often associated with eosinophilia, driven by T helper type 2 (Th2) immune responses, and triggered by ... ...

    Abstract Atopic disorders, including atopic dermatitis, food and environmental allergies, and asthma, are increasingly prevalent diseases. Atopic disorders are often associated with eosinophilia, driven by T helper type 2 (Th2) immune responses, and triggered by disrupted barrier function leading to abnormal immune priming in a susceptible host. Immune deficiencies, in contrast, occur with a significantly lower incidence, but are associated with greater morbidity and mortality. A subset of atopic disorders with eosinophilia and elevated IgE are associated with monogenic inborn errors of immunity (IEI). In this review, we discuss current knowledge of IEI that are associated with atopy and the lessons these immunologic disorders provide regarding the fundamental mechanisms that regulate type 2 immunity in humans. We also discuss further mechanistic insights provided by animal models.
    MeSH term(s) Animals ; Dermatitis, Atopic ; Disease Susceptibility ; Eosinophilia ; Immune System ; Immunologic Deficiency Syndromes
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.860821
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  4. Article ; Online: Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors.

    Leyva-Castillo, Juan-Manuel / Geha, Raif S

    JID innovations : skin science from molecules to population health

    2021  Volume 1, Issue 3, Page(s) 100059

    Abstract: In a new article published ... ...

    Abstract In a new article published in
    Language English
    Publishing date 2021-09-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-0267
    ISSN (online) 2667-0267
    DOI 10.1016/j.xjidi.2021.100059
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  5. Article ; Online: Macabre T

    Janssen, Erin / Wilkie, Hazel / Geha, Raif S

    The Journal of allergy and clinical immunology

    2021  Volume 148, Issue 1, Page(s) 73–75

    MeSH term(s) Guanine Nucleotide Exchange Factors/genetics ; Humans ; Job Syndrome
    Chemical Substances DOCK8 protein, human ; Guanine Nucleotide Exchange Factors
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.02.025
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  6. Article ; Online: Basophil: The cell that itches.

    Das, Mrinmoy / Leyva-Castillo, Juan-Manuel / Geha, Raif S

    The Journal of allergy and clinical immunology

    2021  Volume 148, Issue 3, Page(s) 708–709

    MeSH term(s) Basophils ; Dermatitis, Atopic ; Humans ; Leukocyte Count ; Pruritus
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2021.06.010
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  7. Article ; Online: DOCK8 is essential for neutrophil mediated clearance of cutaneous S. aureus infection.

    Wilkie, Hazel / Timilshina, Maheshwor / Rahmayanti, Siti / Das, Mrinmoy / Pelovitz, Tyler / Geha, Raif S

    Clinical immunology (Orlando, Fla.)

    2023  Volume 254, Page(s) 109681

    Abstract: DOCK8 deficient patients are susceptible to skin infection with Staphylococcus aureus which is normally cleared by neutrophils. We examined the mechanism of this susceptibility in mice. ... ...

    Abstract DOCK8 deficient patients are susceptible to skin infection with Staphylococcus aureus which is normally cleared by neutrophils. We examined the mechanism of this susceptibility in mice. Dock8
    MeSH term(s) Animals ; Mice ; Neutrophils/metabolism ; Staphylococcus aureus/physiology ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections ; Skin ; Skin Diseases, Infectious ; Mice, Inbred C57BL ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism
    Chemical Substances Dock8 protein, mouse ; Guanine Nucleotide Exchange Factors
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109681
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  8. Article ; Online: Primary immunodeficiencies caused by mutations in actin regulatory proteins.

    Janssen, Erin / Geha, Raif S

    Immunological reviews

    2018  Volume 287, Issue 1, Page(s) 121–134

    Abstract: The identification of patients with monogenic gene defects have illuminated the function of different proteins in the immune system, including proteins that regulate the actin cytoskeleton. Many of these actin regulatory proteins are exclusively ... ...

    Abstract The identification of patients with monogenic gene defects have illuminated the function of different proteins in the immune system, including proteins that regulate the actin cytoskeleton. Many of these actin regulatory proteins are exclusively expressed in leukocytes and regulate the formation and branching of actin filaments. Their absence or abnormal function leads to defects in immune cell shape, cellular projections, migration, and signaling. Through the study of patients' mutations and generation of mouse models that recapitulate the patients' phenotypes, our laboratory and others have gained a better understanding of the role these proteins play in cell biology and the underlying pathogenesis of immunodeficiencies and immune dysregulatory syndromes.
    MeSH term(s) Actin Cytoskeleton/genetics ; Actin Cytoskeleton/metabolism ; Animals ; Cell Movement/genetics ; Cell Surface Extensions/genetics ; Disease Models, Animal ; Humans ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/immunology ; Mice ; Microfilament Proteins/genetics ; Mutation/genetics ; Phenotype ; Signal Transduction/genetics
    Chemical Substances Microfilament Proteins
    Language English
    Publishing date 2018-12-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.12716
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    Se 160: Show issues Location:
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  9. Book: Current therapy in allergy, immunology, and rheumatology

    Lichtenstein, Lawrence M. / Busse, William W. / Geha, Raif S.

    2004  

    Title variant Allergy, immunology, and rheumatology
    Author's details Lawrence M. Lichtenstein ; William W. Busse ; Raif S. Geha
    Keywords Hypersensitivity / therapy ; Immunologic Diseases / therapy ; Rheumatic Diseases / therapy
    Language English
    Size XX, 443 S: Ill., graph. Darst.
    Edition 6. ed.
    Publisher Mosby
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT013920283
    ISBN 0-323-01742-8 ; 978-0-323-01742-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 306 order for loan Magazin

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  10. Book: Case studies in immunology

    Rosen, Fred S. / Geha, Raif S.

    a clinical companion

    1996  

    Author's details Fred S. Rosen ; Raif S. Geha
    Keywords Immunologic Diseases / case studies ; Immunity / genetics / case studies ; Allergy and Immunology / case studies ; Immunologie
    Subject Klinische Immunologie
    Language English
    Size VII, 134 S. : zahlr. Ill.
    Publisher CB, Current Biology u.a.
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007439133
    ISBN 0-8153-2174-0 ; 978-0-8153-2174-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 1710 order for loan Magazin

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