Article ; Online: The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature.
PloS one
2021 Volume 16, Issue 3, Page(s) e0248174
Abstract: Background: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well- ... ...
Abstract | Background: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well-documented, little published evidence describes the effects of MDR/RR-TB treatment on HIV disease. Methods: We conducted a review of literature published prior to June 2020. We searched Pubmed, CINAHL, and EMBASE using variations of the terms "multidrug-resistant tuberculosis," "HIV," and either "CD4" or "viral load." Two reviewers independently completed title and abstract screening, full-text screening, article evaluation, and data extraction. We also included five published articles evaluated as evidence by the World Health Organization (WHO) in preparation for the 2019 MDR/RR-TB treatment guideline update. Results: A total of 459 references were returned, with 362 remaining after duplicate removal. Following article screening, six manuscripts were included. Articles reported CD4 count and/or viral load results for MDR/RR-TB and HIV co-infected patients during and/or after MDR/RR-TB treatment. The additional five references identified from the WHO guideline revision did not report HIV disease indicators after MDR/RR-TB initiation. Conclusion: There is a paucity of evidence on HIV disease indicators following MDR/RR-TB treatment. Researchers should report longitudinal HIV disease indicators in co-infected patients in publications. |
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MeSH term(s) | Anti-HIV Agents/therapeutic use ; Antitubercular Agents/therapeutic use ; Coinfection/blood ; Coinfection/drug therapy ; Coinfection/epidemiology ; HIV Infections/blood ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Tuberculosis, Multidrug-Resistant/blood ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology |
Chemical Substances | Anti-HIV Agents ; Antitubercular Agents |
Language | English |
Publishing date | 2021-03-05 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Systematic Review |
ISSN | 1932-6203 |
ISSN (online) | 1932-6203 |
DOI | 10.1371/journal.pone.0248174 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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