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  1. Article ; Online: The macrophage genetic cassette

    Juarez-Carreño, Sergio / Geissmann, Frederic

    Science advances

    2023  Volume 9, Issue 38, Page(s) eadh0589

    Abstract: A small number of signaling molecules, used reiteratively, control differentiation programs, but the mechanisms that adapt developmental timing to environmental cues are less understood. We report here that a ... ...

    Abstract A small number of signaling molecules, used reiteratively, control differentiation programs, but the mechanisms that adapt developmental timing to environmental cues are less understood. We report here that a macrophage
    MeSH term(s) Animals ; Nutritional Status ; Arthropods ; Cues ; Drosophila ; Larva/genetics ; Macrophages ; Vascular Endothelial Growth Factors
    Chemical Substances Pvf2 protein, Drosophila ; Vascular Endothelial Growth Factors
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adh0589
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  2. Article ; Online: Publisher Correction: Physiology and diseases of tissue-resident macrophages.

    Lazarov, Tomi / Juarez-Carreño, Sergio / Cox, Nehemiah / Geissmann, Frederic

    Nature

    2023  Volume 619, Issue 7970, Page(s) E51

    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06386-w
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  3. Article ; Online: Physiology and diseases of tissue-resident macrophages.

    Lazarov, Tomi / Juarez-Carreño, Sergio / Cox, Nehemiah / Geissmann, Frederic

    Nature

    2023  Volume 618, Issue 7966, Page(s) 698–707

    Abstract: Embryo-derived tissue-resident macrophages are the first representatives of the haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages originate from early yolk sac progenitors and are specified into tissue-specific subsets ... ...

    Abstract Embryo-derived tissue-resident macrophages are the first representatives of the haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages originate from early yolk sac progenitors and are specified into tissue-specific subsets during organogenesis-establishing stable spatial and functional relationships with specialized tissue cells-and persist in adults. Resident macrophages are an integral part of tissues together with specialized cells: for instance, microglia reside with neurons in brain, osteoclasts reside with osteoblasts in bone, and fat-associated macrophages reside with white adipocytes in adipose tissue. This ancillary cell type, which is developmentally and functionally distinct from haematopoietic stem cell and monocyte-derived macrophages, senses and integrates local and systemic information to provide specialized tissue cells with the growth factors, nutrient recycling and waste removal that are critical for tissue growth, homeostasis and repair. Resident macrophages contribute to organogenesis, promote tissue regeneration following damage and contribute to tissue metabolism and defence against infectious disease. A correlate is that genetic or environment-driven resident macrophage dysfunction is a cause of degenerative, metabolic and possibly inflammatory and tumoural diseases. In this Review, we aim to provide a conceptual outline of our current understanding of macrophage physiology and its importance in human diseases, which may inform and serve the design of future studies.
    MeSH term(s) Animals ; Humans ; Cell Differentiation ; Cell Lineage ; Hematopoietic Stem Cells/cytology ; Macrophages/cytology ; Macrophages/metabolism ; Macrophages/pathology ; Macrophages/physiology ; Microglia/cytology ; Monocytes/cytology ; Organ Specificity ; Disease
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06002-x
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  4. Article ; Online: The real thing: how to make human DC subsets.

    Geissmann, Frederic

    The Journal of experimental medicine

    2015  Volume 212, Issue 3, Page(s) 285

    MeSH term(s) Animals ; Antigens, CD1/metabolism ; Antigens, Surface/metabolism ; Dendritic Cells/cytology ; Dendritic Cells/metabolism ; Fetal Blood/cytology ; Glycoproteins/metabolism ; Humans ; Monocytes/cytology ; Thrombomodulin
    Chemical Substances Antigens, CD1 ; Antigens, Surface ; CD1C protein, human ; Glycoproteins ; THBD protein, human ; Thrombomodulin
    Language English
    Publishing date 2015-03-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.2123insight2
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  5. Article ; Online: Editorial overview: Innate immunity from a phylogenic perspective.

    Sun, Joseph C / Geissmann, Frederic

    Current opinion in immunology

    2020  Volume 62, Page(s) iii–v

    MeSH term(s) Animals ; Humans ; Immunity, Innate/immunology ; Phylogeny
    Language English
    Publishing date 2020-03-11
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.02.003
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  6. Article ; Online: Origins, Biology, and Diseases of Tissue Macrophages.

    Cox, Nehemiah / Pokrovskii, Maria / Vicario, Rocio / Geissmann, Frederic

    Annual review of immunology

    2021  Volume 39, Page(s) 313–344

    Abstract: Tissue-resident macrophages are present in most tissues with developmental, self-renewal, or functional attributes that do not easily fit into a textbook picture of a plastic and multifunctional macrophage originating from hematopoietic stem cells; nor ... ...

    Abstract Tissue-resident macrophages are present in most tissues with developmental, self-renewal, or functional attributes that do not easily fit into a textbook picture of a plastic and multifunctional macrophage originating from hematopoietic stem cells; nor does it fit a pro- versus anti-inflammatory paradigm. This review presents and discusses current knowledge on the developmental biology of macrophages from an evolutionary perspective focused on the function of macrophages, which may aid in study of developmental, inflammatory, tumoral, and degenerative diseases. We also propose a framework to investigate the functions of macrophages in vivo and discuss how inherited germline and somatic mutations may contribute to the roles of macrophages in diseases.
    MeSH term(s) Animals ; Biology ; Hematopoietic Stem Cells ; Humans ; Macrophages
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-093019-111748
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  7. Article ; Online: Macrophage ontogeny in the control of adipose tissue biology.

    Cox, Nehemiah / Geissmann, Frederic

    Current opinion in immunology

    2019  Volume 62, Page(s) 1–8

    Abstract: Macrophages are found in large numbers in the adipose tissue where they closely associate with the adipocytes and the vasculature. Adipose tissue macrophages are a heterogenous population of cells with 'hard wired' diversity brought upon by distinct ... ...

    Abstract Macrophages are found in large numbers in the adipose tissue where they closely associate with the adipocytes and the vasculature. Adipose tissue macrophages are a heterogenous population of cells with 'hard wired' diversity brought upon by distinct developmental lineages. The purpose of this review is to provide a brief history of macrophages in control of adipose tissue metabolism with the emphasis on the importance of macrophage ontogeny.
    MeSH term(s) Adipocytes/metabolism ; Adipose Tissue/metabolism ; Animals ; Humans ; Macrophages/metabolism
    Language English
    Publishing date 2019-10-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2019.08.002
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  8. Article ; Online: The development and maintenance of resident macrophages.

    Perdiguero, Elisa Gomez / Geissmann, Frederic

    Nature immunology

    2016  Volume 17, Issue 1, Page(s) 2–8

    Abstract: The molecular and cellular mechanisms that underlie the many roles of macrophages in health and disease states in vivo remain poorly understood. The purpose of this Review is to present and discuss current knowledge on the developmental biology of ... ...

    Abstract The molecular and cellular mechanisms that underlie the many roles of macrophages in health and disease states in vivo remain poorly understood. The purpose of this Review is to present and discuss current knowledge on the developmental biology of macrophages, as it underlies the concept of a layered myeloid system composed of 'resident' macrophages that originate mainly from progenitor cells generated in the yolk sac and of 'passenger' or 'transitory' myeloid cells that originate and renew from bone marrow hematopoietic stem cells, and to provide a framework for investigating the functions of macrophages in vivo.
    MeSH term(s) Animals ; Cell Differentiation ; Cell Lineage ; Humans ; Macrophages/cytology
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.3341
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  9. Article: The origin of dendritic cells.

    Geissmann, Frederic

    Nature immunology

    2007  Volume 8, Issue 6, Page(s) 558–560

    MeSH term(s) Animals ; Antigen Presentation ; Cell Differentiation ; Cell Proliferation ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Humans ; Macrophages/cytology ; Macrophages/immunology
    Language English
    Publishing date 2007-05-18
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni0607-558
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  10. Article ; Online: The nuclear factor ID3 endows macrophages with a potent anti-tumour activity.

    Deng, Zihou / Loyher, Pierre-Louis / Lazarov, Tomi / Li, Li / Shen, Zeyang / Bhinder, Bhavneet / Yang, Hairu / Zhong, Yi / Alberdi, Araitz / Massague, Joan / Sun, Joseph C / Benezra, Robert / Glass, Christopher K / Elemento, Olivier / Iacobuzio-Donahue, Christine A / Geissmann, Frederic

    Nature

    2024  Volume 626, Issue 8000, Page(s) 864–873

    Abstract: Macrophage activation is controlled by a balance between activating and inhibitory ... ...

    Abstract Macrophage activation is controlled by a balance between activating and inhibitory receptors
    MeSH term(s) Animals ; Humans ; Mice ; Bone Marrow Cells/cytology ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Cell Lineage ; Induced Pluripotent Stem Cells/cytology ; Inhibitor of Differentiation Proteins/deficiency ; Inhibitor of Differentiation Proteins/genetics ; Inhibitor of Differentiation Proteins/metabolism ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Kupffer Cells/cytology ; Kupffer Cells/immunology ; Kupffer Cells/metabolism ; Liver/immunology ; Liver/pathology ; Macrophage Activation ; Neoplasm Proteins ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Phagocytosis
    Chemical Substances ELK1 protein, human ; Elk1 protein, mouse ; ID3 protein, human (147785-34-0) ; Inhibitor of Differentiation Proteins ; Neoplasm Proteins ; TCF3 protein, human ; Tcf3 protein, mouse ; Idb3 protein, mouse (135845-89-5)
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06950-4
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