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  1. Article: Dietary Patterns in Relation to Cardiovascular Disease Incidence and Risk Markers in a Middle-Aged British Male Population: Data from the Caerphilly Prospective Study

    Geleijnse, Johanna Marianna / Lovegrove, Julie

    Nutrients, 9(1):75

    2017  

    Abstract: Dietary behaviour is an important modifiable factor in cardiovascular disease (CVD) prevention. The study aimed to identify dietary patterns (DPs) and explore their association with CVD incidence and risk markers. A follow-up of 1838 middle-aged men, ... ...

    Abstract Dietary behaviour is an important modifiable factor in cardiovascular disease (CVD) prevention. The study aimed to identify dietary patterns (DPs) and explore their association with CVD incidence and risk markers. A follow-up of 1838 middle-aged men, aged 47–67 years recruited into the Caerphilly Prospective Cohort Study at phase 2 (1984–1988) was undertaken. Principal component analysis identified three DPs at baseline, which explained 24.8% of the total variance of food intake. DP1, characterised by higher intakes of white bread, butter, lard, chips and sugar-sweetened beverages and lower intake of wholegrain bread, was associated with higher CVD (HR 1.35: 95% CI: 1.10, 1.67) and stroke (HR 1.77; 95% CI: 1.18, 2.63) incidence. DP3, characterised by higher intakes of sweet puddings and biscuits, wholegrain breakfast cereals and dairy (excluding cheese and butter) and lower alcohol intake, was associated with lower CVD (HR 0.76; 95% CI: 0.62, 0.93), coronary heart disease (HR: 0.68; 95% CI: 0.52, 0.90) and stroke (HR: 0.68; 95% CI: 0.47, 0.99) incidence and a beneficial CVD profile at baseline, while DP1 with an unfavourable profile, showed no clear associations after 12 years follow-up. Dietary pattern 2 (DP2), characterised by higher intake of pulses, fish, poultry, processed/red meat, rice, pasta and vegetables, was not associated with the aforementioned outcomes. These data may provide insight for development of public health initiatives focussing on feasible changes in dietary habits.
    Keywords Caerphilly Prospective Study (CaPS) ; cardiovascular incidence ; cardiovascular risk markers ; dietary patterns ; principal component analysis
    Language English
    Document type Article
    Database Repository for Life Sciences

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  2. Article ; Online: Vitamin D and hypertension: does the women's health initiative solve the question?

    Geleijnse, Johanna Marianna

    Hypertension (Dallas, Tex. : 1979)

    2008  Volume 52, Issue 5, Page(s) 803–804

    MeSH term(s) Calcium/administration & dosage ; Calcium/therapeutic use ; Dietary Supplements ; Female ; Humans ; Hypertension/drug therapy ; Hypertension/physiopathology ; Randomized Controlled Trials as Topic ; Vitamin D/administration & dosage ; Vitamin D/physiology ; Vitamin D/therapeutic use ; Women's Health
    Chemical Substances Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2008-11
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.108.117259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mediterranean Style Diet and Kidney Function Loss in Kidney Transplant Recipients.

    Gomes-Neto, António W / Osté, Maryse C J / Sotomayor, Camilo G / van den Berg, Else / Geleijnse, Johanna Marianna / Berger, Stefan P / Gans, Reinold O B / Bakker, Stephan J L / Navis, Gerjan J

    Clinical journal of the American Society of Nephrology : CJASN

    2020  Volume 15, Issue 2, Page(s) 238–246

    Abstract: Background and objectives: Despite improvement of short-term graft survival over recent years, long-term graft survival after kidney transplantation has not improved. Studies in the general population suggest the Mediterranean diet benefits kidney ... ...

    Abstract Background and objectives: Despite improvement of short-term graft survival over recent years, long-term graft survival after kidney transplantation has not improved. Studies in the general population suggest the Mediterranean diet benefits kidney function preservation. We investigated whether adherence to the Mediterranean diet is associated with kidney outcomes in kidney transplant recipients.
    Design, setting, participants, & measurements: We included 632 adult kidney transplant recipients with a functioning graft for ≥1 year. Dietary intake was inquired using a 177-item validated food frequency questionnaire. Adherence to the Mediterranean diet was assessed using a nine-point Mediterranean Diet Score. Primary end point of the study was graft failure and secondary end points included kidney function decline (doubling of serum creatinine or graft failure) and graft loss (graft failure or death with a functioning graft). Cox regression analyses were used to prospectively study the associations of the Mediterranean Diet Score with study end points.
    Results: During median follow-up of 5.4 (interquartile range, 4.9-6.0) years, 76 participants developed graft failure, 119 developed kidney function decline, and 181 developed graft loss. The Mediterranean Diet Score was inversely associated with all study end points (graft failure: hazard ratio [HR], 0.68; 95% confidence interval [95% CI], 0.50 to 0.91; kidney function decline: HR, 0.68; 95% CI, 0.55 to 0.85; and graft loss: HR, 0.74; 95% CI, 0.63 to 0.88 per two-point increase in Mediterranean Diet Score) independent of potential confounders. We identified 24-hour urinary protein excretion and time since transplantation to be an effect modifier, with stronger inverse associations between the Mediterranean Diet Score and kidney outcomes observed in participants with higher urinary protein excretion and participants transplanted more recently.
    Conclusions: Adherence to the Mediterranean diet is associated with better kidney function outcomes in kidney transplant recipients.
    MeSH term(s) Adult ; Aged ; Diet, Mediterranean ; Female ; Graft Survival ; Humans ; Kidney/physiopathology ; Kidney Diseases/etiology ; Kidney Diseases/mortality ; Kidney Diseases/physiopathology ; Kidney Diseases/prevention & control ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Patient Compliance ; Prospective Studies ; Protective Factors ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2020-01-02
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.06710619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mediterranean style diet and kidney function loss in kidney transplant recipients

    Gomes-Neto, António W. / Osté, Maryse C.J. / Sotomayor, Camilo G. / van den Berg, Else / Geleijnse, Johanna Marianna / Berger, Stefan P. / Gans, Reinold O.B. / Bakker, Stephan J.L. / Navis, Gerjan J.

    Clinical Journal of the American Society of Nephrology

    2020  Volume 15, Issue 2

    Abstract: Background and objectives Despite improvement of short-term graft survival over recent years, long-term graft survival after kidney transplantation has not improved. Studies in the general population suggest the Mediterranean diet benefits kidney ... ...

    Abstract Background and objectives Despite improvement of short-term graft survival over recent years, long-term graft survival after kidney transplantation has not improved. Studies in the general population suggest the Mediterranean diet benefits kidney function preservation. We investigated whether adherence to the Mediterranean diet is associated with kidney outcomes in kidney transplant recipients. Design, setting, participants, & measurements We included 632 adult kidney transplant recipients with a functioning graft for ≥1 year. Dietary intake was inquired using a 177-item validated food frequency questionnaire. Adherence to the Mediterranean diet was assessed using a nine-point Mediterranean Diet Score. Primary end point of the study was graft failure and secondary end points included kidney function decline (doubling of serum creatinine or graft failure) and graft loss (graft failure or death with a functioning graft). Cox regression analyses were used to prospectively study the associations of the Mediterranean Diet Score with study end points. Results During median follow-up of 5.4 (interquartile range, 4.9–6.0) years, 76 participants developed graft failure, 119 developed kidney function decline, and 181 developed graft loss. The Mediterranean Diet Score was inversely associated with all study end points (graft failure: hazard ratio [HR], 0.68; 95% confidence interval [95% CI], 0.50 to 0.91; kidney function decline: HR, 0.68; 95% CI, 0.55 to 0.85; and graft loss: HR, 0.74; 95% CI, 0.63 to 0.88 per two-point increase in Mediterranean Diet Score) independent of potential confounders. We identified 24-hour urinary protein excretion and time since transplantation to be an effect modifier, with stronger inverse associations between the Mediterranean Diet Score and kidney outcomes observed in participants with higher urinary protein excretion and participants transplanted more recently. Conclusions Adherence to the Mediterranean diet is associated with better kidney function outcomes in kidney transplant ...
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2226665-3
    ISSN 1555-9041
    ISSN 1555-9041
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial.

    van Dijk, Suzanne C / Enneman, Anke W / Swart, Karin M A / van Wijngaarden, Janneke P / Ham, Annelies C / Brouwer-Brolsma, Elske M / van der Zwaluw, Nikita L / Blom, Henk J / Feskens, Edith J / Geleijnse, Johanna Marianna / van Schoor, Natasja M / Dhonukshe-Rutten, Rosalie A M / de Jongh, Renate T / Lips, Paul / de Groot, Lisette C P G M / Uitterlinden, Andre G / Smulders, Yvo M / van den Meiracker, Anton H / Mattace Raso, Francesco U S /
    van der Velde, Nathalie

    Journal of hypertension

    2015  Volume 33, Issue 9, Page(s) 1897–906; discussion 1906

    Abstract: Introduction: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old, and is associated with elevated arterial stiffness in this age group. Since several intervention trials reported a lack of benefit of B-vitamin ... ...

    Abstract Introduction: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old, and is associated with elevated arterial stiffness in this age group. Since several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and atherosclerosis in hyperhomocysteinemic elderly patients.
    Methods: The B-PROOF study is a double-blind, randomized controlled trial, including 2919 elderly aged at least 65 years, with hyperhomocysteinemia (12-50  μmol/l), treated with B-vitamins (500  μg vitamin B12 and 400  μg folic acid) or placebo for 2 years. In a subgroup (n = 569), the effect of B-vitamins on pulse wave velocity (PWV) was investigated as a measurement of arterial stiffness. To measure atherosclerosis, carotid intima-media thickness (IMT) measures had been used. Incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires, and blood pressure was also measured.
    Results: Compared to placebo, B-vitamin supplementation lowered serum homocysteine by 3.6  μmol/l (P < 0.001). Analysis of covariance showed no effect of supplementation on PWV levels, and this was not different for patients without increased arterial stiffness at baseline. Furthermore, no effect on carotid IMT was observed.
    Discussion: Vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly patients have no effect on PWV or carotid IMT. Further research will still be necessary to unravel the effects and pathways of homocysteine-lowering treatment on cardiovascular outcomes.
    MeSH term(s) Aged ; Aged, 80 and over ; Atherosclerosis/mortality ; Atherosclerosis/physiopathology ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Carotid Intima-Media Thickness ; Dietary Supplements ; Double-Blind Method ; Female ; Folic Acid/administration & dosage ; Humans ; Hyperhomocysteinemia/mortality ; Hyperhomocysteinemia/physiopathology ; Male ; Pulse Wave Analysis ; Risk Factors ; Treatment Outcome ; Vascular Stiffness/drug effects ; Vascular Stiffness/physiology ; Vitamin B 12/administration & dosage
    Chemical Substances Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000000647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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