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  1. Book: Treatment of bipolar disorder in childhood and adolescence

    Geller, Barbara

    2008  

    Author's details ed. by Barbara Geller
    Keywords Bipolar Disorder / drug therapy ; Bipolar Disorder / complications ; Bipolar Disorder / psychology ; Child ; Adolescent ; Manic-depressive illness in children ; Manic-depressive illness in adolescence
    Language English
    Size XIV, 418 S. : Ill., graph. Darst.
    Publisher Guilford Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015494076
    ISBN 978-1-59385-678-6 ; 1-59385-678-4
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Bipolar disorder in childhood and early adolescence

    Geller, Barbara

    2003  

    Author's details ed. by Barbara Geller
    Keywords Bipolar Disorder ; Child ; Adolescent
    Language English
    Size X, 342 S. : Ill., graph. Darst.
    Edition 1. print
    Publisher Guilford Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013657282
    ISBN 1-57230-837-0 ; 978-1-57230-837-4
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Antipsychotics, Excess Deaths, and Paradoxes of Child Psychiatry.

    Geller, Barbara

    JAMA psychiatry

    2018  Volume 76, Issue 2, Page(s) 111–112

    MeSH term(s) Adolescent ; Antipsychotic Agents ; Child ; Child Psychiatry ; Humans ; Psychiatry
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2018-12-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2018.3409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Treatment of bipolar disorder in children and adolescents

    Geller, Barbara / DelBello, Melissa P

    2008  

    Author's details edited by Barbara Geller, Melissa P. DelBello
    MeSH term(s) Bipolar Disorder/drug therapy ; Bipolar Disorder/complications ; Bipolar Disorder/psychology ; Child ; Adolescent
    Language English
    Size xiv, 418 p. :, ill.
    Publisher Guilford Press
    Publishing place New York
    Document type Book
    ISBN 9781593856786 ; 1593856784
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article ; Online: Diagnostic characteristics of child bipolar I disorder: does the "Treatment of Early Age Mania (team)" sample generalize?

    Tillman, Rebecca / Geller, Barbara

    The Journal of clinical psychiatry

    2007  Volume 68, Issue 2, Page(s) 307–314

    Abstract: Objective: To examine the representativeness of a randomized controlled trial (RCT) sample versus one obtained by consecutive new case ascertainment, for subjects with child bipolar I disorder.: Method: Subjects (N = 247) were outpatients who ... ...

    Abstract Objective: To examine the representativeness of a randomized controlled trial (RCT) sample versus one obtained by consecutive new case ascertainment, for subjects with child bipolar I disorder.
    Method: Subjects (N = 247) were outpatients who participated in either the National Institute of Mental Health-funded Phenomenology and Course of Pediatric Bipolar Disorders study or the Treatment of Early Age Mania (TEAM) study. Both studies required that subjects have current DSM-IV bipolar I disorder (manic or mixed phase) and a Children's Global Assessment Scale (CGAS) score <or=60. All subjects had elation and/or grandiosity. Subjects in the Phenomenology study were obtained from 1995 to 1998 by consecutive new case ascertainment from designated pediatric and psychiatric facilities. Subjects in the TEAM RCT were recruited from media and community sources between March 2003 and March 2005. Assessment instruments included the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia, given separately to parents about their children and to children about themselves, and the CGAS. Logistic regression was used for comparisons.<br />Results: The TEAM and Phenomenology groups were similar in age (10.4 [SD = 2.3], 10.9 [SD = 2.3] years, respectively) and other demography. Both had long current episode duration (4.8 [SD = 2.4], 3.2 [SD = 2.3] years) and low lifetime use of any mood stabilizer (23.6%, 35.0%). Many mania symptoms and ultradian rapid cycling, psychosis, and suicidality were significantly more prevalent in the RCT sample.
    Conclusions: Generalization of the RCT sample was supported, because only 7.8% of Phenomenology subjects did not fit the RCT criteria. Nevertheless, because the RCT subjects were more severely ill, it is unclear if treatment findings from the RCT will be applicable to children with less severe mania.
    Clinical trials registration: ClinicalTrials.gov identifier NCT00057681 (TEAM study).
    MeSH term(s) Adolescent ; Bipolar Disorder/diagnosis ; Bipolar Disorder/psychology ; Bipolar Disorder/therapy ; Child ; Female ; Humans ; Male ; Matched-Pair Analysis ; Reference Values ; Reproducibility of Results ; Severity of Illness Index
    Language English
    Publishing date 2007-01-01
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/jcp.v68n0218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Controlled study of switching from attention-deficit/hyperactivity disorder to a prepubertal and early adolescent bipolar I disorder phenotype during 6-year prospective follow-up: rate, risk, and predictors.

    Tillman, Rebecca / Geller, Barbara

    Development and psychopathology

    2006  Volume 18, Issue 4, Page(s) 1037–1053

    Abstract: Rate, risk, and predictors of switching from attention-deficit/hyperactivity disorder (ADHD) to a prepubertal and early adolescent bipolar I disorder phenotype (PEA-BP-I) were examined in a blindly rated, controlled, prospective 6-year follow-up that ... ...

    Abstract Rate, risk, and predictors of switching from attention-deficit/hyperactivity disorder (ADHD) to a prepubertal and early adolescent bipolar I disorder phenotype (PEA-BP-I) were examined in a blindly rated, controlled, prospective 6-year follow-up that included assessments at 2-year intervals. Subjects were outpatients obtained by consecutive new case ascertainment. There were 81 subjects who were 9.7 +/- 2.0 years. Subjects had DSM-IV ADHD (hyperactive or combined subtypes); a Children's Global Assessment Scale (CGAS) score of < or =60, consistent with moderate-severe impairment; and no BP or major depressive disorder (MDD) diagnoses. PEA-BP-I was defined as DSM-IV BP I (manic or mixed phase), with cardinal symptoms (elation and/or grandiosity), to avoid diagnosing mania by symptoms that overlapped with those of ADHD, and by a CGAS score of < or =60. Morbid risk of switching to PEA-BP-I was 28.5%. Significant predictors of switching in a multivariate Cox model were more severe baseline CGAS, paternal recurrent MDD, and less stimulant use. BP I in first-degree relatives, antidepressants, psychosocial measures, and life events were not predictive.
    MeSH term(s) Adolescent ; Aging/genetics ; Aging/psychology ; Antidepressive Agents/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/psychology ; Bipolar Disorder/drug therapy ; Bipolar Disorder/genetics ; Bipolar Disorder/psychology ; Central Nervous System Stimulants/therapeutic use ; Child ; Female ; Follow-Up Studies ; Humans ; Male ; Nuclear Family ; Outpatients ; Phenotype ; Puberty ; Social Behavior
    Chemical Substances Antidepressive Agents ; Central Nervous System Stimulants
    Language English
    Publishing date 2006
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1036173-x
    ISSN 1469-2198 ; 0954-5794
    ISSN (online) 1469-2198
    ISSN 0954-5794
    DOI 10.1017/S0954579406060512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pharmacological and non-drug treatment of child bipolar I disorder during prospective eight-year follow-up.

    Geller, Barbara / Tillman, Rebecca / Bolhofner, Kristine / Zimerman, Betsy

    Bipolar disorders

    2010  Volume 12, Issue 2, Page(s) 164–171

    Abstract: Objectives: The Phenomenology and Course of Pediatric Bipolar Disorders study, a National Institute of Mental Health-funded study of child bipolar I disorder (BP-I) begun in 1995, is a prospective follow-up study that included collecting pharmacological ...

    Abstract Objectives: The Phenomenology and Course of Pediatric Bipolar Disorders study, a National Institute of Mental Health-funded study of child bipolar I disorder (BP-I) begun in 1995, is a prospective follow-up study that included collecting pharmacological and non-drug treatment data.
    Methods: There were 115 first-episode subjects who fit full DSM-IV criteria for BP-I, mixed or manic phase, with severity scores in the clinically impaired range, ascertained by consecutive new case ascertainment. Subjects were assessed with the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS), given separately to parents about their children and to children about themselves. All treatment was provided by the subjects' own community practitioners, exactly as if they had not been in the research study. Thus, families were only seen for research assessments, and research staff were not at all involved in their treatment. Data on type, dose, and duration of pharmacological and non-drug treatment were collected. During follow-up, 93.9% (n = 108) were assessed at each of the nine assessment times.
    Results: During the eight years, only 62.6% received any antimanic medication (antipsychotic, anticonvulsant, lithium) at any time. Percents who received non-antimanic medication included 77.4% medication for attention-deficit hyperactivity disorder and 64.3% antidepressants. A total of 67.8% of subjects were taking two or more concurrent medication classes. Subjects ascertained from psychiatric versus pediatric sites received antimanics significantly more frequently (p = 0.006). Earlier recovery during eight-year follow-up was predicted by greater percent of weeks on lithium (p = 0.017).
    Conclusions: Given these findings, and the poor prognosis from prospective follow-up of this sample reported elsewhere, there is a need for further research that informs the development of effective treatment strategies.
    MeSH term(s) Anticonvulsants/therapeutic use ; Antidepressive Agents/therapeutic use ; Antimanic Agents/therapeutic use ; Antipsychotic Agents/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Bipolar Disorder/drug therapy ; Bipolar Disorder/psychology ; Child ; Depression/drug therapy ; Diagnostic and Statistical Manual of Mental Disorders ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Lithium Compounds/therapeutic use ; Male ; National Institute of Mental Health (U.S.) ; Prognosis ; Prospective Studies ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Treatment Outcome ; United States
    Chemical Substances Anticonvulsants ; Antidepressive Agents ; Antimanic Agents ; Antipsychotic Agents ; Lithium Compounds
    Language English
    Publishing date 2010-04-15
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/j.1399-5618.2010.00791.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Prepubertal and early adolescent bipolar I disorder: review of diagnostic validation by Robins and Guze criteria.

    Geller, Barbara / Tillman, Rebecca

    The Journal of clinical psychiatry

    2005  Volume 66 Suppl 7, Page(s) 21–28

    Abstract: The phenomenology of pediatric bipolar disorder is a controversial topic in the field of child psychiatry. The first National Institute of Mental Health-funded study in the field, Phenomenology and Course of Pediatric Bipolar Disorders, selected a ... ...

    Abstract The phenomenology of pediatric bipolar disorder is a controversial topic in the field of child psychiatry. The first National Institute of Mental Health-funded study in the field, Phenomenology and Course of Pediatric Bipolar Disorders, selected a conservative phenotype for credibility in a contentious field. To address the problems of differentiation of mania from attention-deficit/hyperactivity disorder (ADHD) and of the ubiquitous manifestation of irritability across child psychiatry diagnoses, a prepubertal and early adolescent bipolar I disorder phenotype (PEA-BP) was defined by DSM-IV bipolar I disorder (manic or mixed phase) with elation and/or grandiosity as one criterion. This criterion avoided diagnosing mania by symptoms that overlapped with those of ADHD (e.g., hyperactivity, distractibility) and ensured that subjects had at least 1 of the cardinal symptoms of mania (i.e., elation or grandiosity). This definition was analogous to the requirement that DSM-IV major depressive disorder include at least 1 of the cardinal symptoms of depression (i.e., sad mood or anhedonia). Subjects were 93 children with a mean +/- SD age of 10.9 +/- 2.6 years. Validation of the phenotype was shown according to Robins and Guze criteria: unique symptoms that did not overlap with those of ADHD, stability of the diagnosis (did not become ADHD or other disorders on follow-up) as shown by a 4-year prospective longitudinal study, significantly higher familial aggregation of bipolar disorder in relatives of PEA-BP versus ADHD and healthy control probands, and family-based linkage disequilibrium of the brain-derived neurotrophic factor Val66 allele in PEA-BP probands. Furthermore, PEA-BP resembled the most severe adult bipolar disorder, manifested by a chronic, ultradian-cycling, mixed manic, psychotic course. A conservatively defined child mania phenotype met the Robins and Guze criteria for establishing diagnostic validity in psychiatric illness. Continuities between PEA-BP and adult bipolar disorder and relationships of PEA-BP to other descriptions of child mania are discussed.
    MeSH term(s) Adolescent ; Age Factors ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/genetics ; Bipolar Disorder/classification ; Bipolar Disorder/diagnosis ; Bipolar Disorder/genetics ; Child ; Child Psychiatry/statistics & numerical data ; Diagnosis, Differential ; Diagnostic and Statistical Manual of Mental Disorders ; Family Health ; Follow-Up Studies ; Humans ; Irritable Mood ; Linkage Disequilibrium ; Pedigree ; Phenotype ; Psychiatric Status Rating Scales/statistics & numerical data ; Psychometrics ; Reproducibility of Results
    Language English
    Publishing date 2005
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A brief screening tool for a prepubertal and early adolescent bipolar disorder phenotype.

    Tillman, Rebecca / Geller, Barbara

    The American journal of psychiatry

    2005  Volume 162, Issue 6, Page(s) 1214–1216

    Abstract: Objective: Although there has recently been increased interest in child mania, there is as yet no brief screening tool that separates a prepubertal and early adolescent bipolar disorder phenotype from attention deficit hyperactivity disorder (ADHD), the ...

    Abstract Objective: Although there has recently been increased interest in child mania, there is as yet no brief screening tool that separates a prepubertal and early adolescent bipolar disorder phenotype from attention deficit hyperactivity disorder (ADHD), the most relevant differential diagnosis.
    Method: Parents of 268 consecutively ascertained subjects (93 with a prepubertal and early adolescent bipolar disorder phenotype, 81 with ADHD, 94 in a healthy comparison group) completed the 10-item Conners' Abbreviated Parent Questionnaire, before separate Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia interviews of parents and children. Data from the Conners' Abbreviated Parent Questionnaire were analyzed by using receiver operating characteristic methods.
    Results: A screening algorithm that yielded a sensitivity of 0.73 and a specificity of 0.86 was developed from the Conners' Abbreviated Parent Questionnaire.
    Conclusions: The Conners' Abbreviated Parent Questionnaire is a promising tool as a screen for a prepubertal and early adolescent bipolar disorder phenotype and has similar sensitivity and specificity to screening tools for adult bipolar disorder.
    MeSH term(s) Adolescent ; Age Factors ; Algorithms ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Bipolar Disorder/diagnosis ; Bipolar Disorder/epidemiology ; Bipolar Disorder/genetics ; Child ; Comorbidity ; Diagnosis, Differential ; Female ; Humans ; Male ; Mass Screening/methods ; Parents/psychology ; Phenotype ; Psychiatric Status Rating Scales ; Psychometrics ; ROC Curve ; Sensitivity and Specificity ; Surveys and Questionnaires
    Language English
    Publishing date 2005-06
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.162.6.1214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Family-based association study of early growth response gene 3 with child bipolar I disorder.

    Gallitano, Amelia L / Tillman, Rebecca / Dinu, Valentin / Geller, Barbara

    Journal of affective disorders

    2012  Volume 138, Issue 3, Page(s) 387–396

    Abstract: Background: The risk for relapse of child bipolar I disorder (BP-I) is highly correlated with environmental factors. Immediate early genes of the early growth response (EGR) gene family are activated at high levels in the brain in response to ... ...

    Abstract Background: The risk for relapse of child bipolar I disorder (BP-I) is highly correlated with environmental factors. Immediate early genes of the early growth response (EGR) gene family are activated at high levels in the brain in response to environmental events, including stress, and mediate numerous neurobiological processes that have been associated with mental illness risk. The objective of this study is to evaluate whether single nucleotide polymorphisms (SNPs) in EGR genes are associated with the risk to develop child bipolar I disorder.
    Methods: To investigate whether EGR genes may influence susceptibility to child bipolar I disorder (BP-I), we used Family Based Association Tests to examine whether SNPs in each of the EGR genes were associated with illness in 49 families.
    Results: Two SNPs in EGR3 displayed nominally significant associations with child BP-I (p=0.027 and p=0.028); though neither was statistically significant following correction for multiple comparisons. Haplotype association analysis indicated that these SNPs are in linkage disequilibrium (LD). None of the SNPs tested in EGR1, EGR2, or EGR4 was associated with child BP-I.
    Limitations: This study was limited by small sample size, which resulted in it being underpowered to detect a significant association after correction for multiple comparisons.
    Conclusions: Our study revealed a preliminary finding suggesting that EGR3, a gene that translates environmental stimuli into long-term changes in the brain, warrants further investigation for association with risk for child BP-I disorder in a larger sample. Such studies may help reveal mechanisms by which environment can interact with genetic predisposition to influence this severe mental illness.
    MeSH term(s) Adolescent ; Bipolar Disorder/genetics ; Child ; Early Growth Response Protein 3/genetics ; Early Growth Response Transcription Factors/genetics ; Family ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Polymorphism, Single Nucleotide ; Risk Factors
    Chemical Substances Early Growth Response Transcription Factors ; Early Growth Response Protein 3 (144516-98-3)
    Language English
    Publishing date 2012-02-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2012.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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